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    METHODS AND APPARATUS FOR MOLECULAR DATA STORAGE, RETRIEVAL AND ANALYSIS
    175.
    发明申请
    METHODS AND APPARATUS FOR MOLECULAR DATA STORAGE, RETRIEVAL AND ANALYSIS 审中-公开
    用于分子数据存储，检索和分析的方法和装置

    公开(公告)号：WO2003089666A2

    公开(公告)日：2003-10-30

    申请号：PCT/CA2003/000574

    申请日：2003-04-17

    Applicant: UNIVERSITY OF SASKATCHEWAN TECHNOLOGIES INC. ,  LEE, Jeremy, S. ,  WETTIG, Shawn, D. ,  KRAATZ, Heinz-Bernhard

    Inventor： LEE, Jeremy, S. ,  WETTIG, Shawn, D. ,  KRAATZ, Heinz-Bernhard

    IPC: C12Q1/68

    CPC classification number: G01N33/48721 ,  B82Y10/00 ,  C12Q1/6825 ,  C12Q1/6827 ,  G11C13/0014 ,  G11C13/0019 ,  H01L51/0093 ,  H01L51/0595 ,  C12Q2565/629 ,  C12Q2565/631 ,  C12Q2563/137

    Abstract: In various aspects, the invention provides molecular systems for storing and retrieving information. In some embodiments, polymers capable of selectively binding metal ions, such as nucleic acids, are used to record information in the form of a particular molecular conformation. Electrochemical assay methods employing nanopores may be used to read and write information using such polymeric media. In some embodiments, information may be recorded in a nucleic acid polymer by magnetically modulating the translocation of the nucleic acid through a channel in a medium, while simultaneously modulating the electrostatic potential across the channel. In this way, the incorporation of a divalent metal ion in the nucleic acid duplex may be modulated to store information. In an alternative aspect, the invention provides analogous processes for detecting a base pair mismatch in a nucleic acid polymer.

    Abstract translation: 在各个方面，本发明提供用于存储和检索信息的分子系统。 在一些实施方案中，能够选择性地结合金属离子（例如核酸）的聚合物用于以特定分子构象的形式记录信息。 使用纳米孔的电化学测定方法可用于使用这种聚合物介质读取和写入信息。 在一些实施方案中，可以通过磁性调节核酸通过介质中的通道的易位，同时同时调节跨过该通道的静电势来将信息记录在核酸聚合物中。 以这种方式，可以调节在核酸双链体中引入二价金属离子以存储信息。 在另一方面，本发明提供用于检测核酸聚合物中碱基对错配的类似方法。

    NUCLEIC ACID CIRCUIT ELEMENTS AND METHODS
    178.
    发明申请
    NUCLEIC ACID CIRCUIT ELEMENTS AND METHODS 审中-公开
    核酸电路元件和方法

    公开(公告)号：WO2002095840A1

    公开(公告)日：2002-11-28

    申请号：PCT/CA2002/000769

    申请日：2002-05-24

    Applicant: UNIVERSITY OF SASKATCHEWAN TECHNOLOGIES INC. ,  LEE, Jeremy, Stuart ,  SKINNER, Ryan, John, Jr.

    Inventor： LEE, Jeremy, Stuart ,  SKINNER, Ryan, John, Jr.

    IPC: H01L51/20

    CPC classification number: H01L51/0595 ,  B82Y10/00 ,  G11C13/0014 ,  G11C13/0019 ,  H01L51/0077 ,  H01L51/0093

    Abstract: Organic circuit elements and methods are disclosed. An organic circuit element includes a plurality of members, each of which includes an oligonucleotide duplex. The plurality of members includes at least one donor member for receiving conduction electrons from an electron donor, at least one acceptor member for communicating with an electron acceptor to provide a region of attraction for the conduction electrons, and at least one regulator member intersecting with at least one of the plurality of members to define at least one electric field regulation junction, for cooperating with an electric field regulator to regulate an electric field at the junction. A method of regulating an electronic signal between first and second locations in a conductive nucleic acid material includes varying an electrostatic potential at a third location in the nucleic acid material interposed between the first and second locations. The third location may include the regulation junction.

    Abstract translation: 公开了有机电路元件和方法。 有机电路元件包括多个构件，每个构件包括寡核苷酸双链体。 多个构件包括用于从电子给体接收传导电子的至少一个施主构件，用于与电子受体连通以提供导电电子的吸引区域的至少一个受体构件，以及与传导电子相交的至少一个调节构件 所述多个构件中的至少一个构件限定至少一个电场调节结，用于与电场调节器配合以调节所述接合处的电场。 调节导电核酸材料中第一和第二位置之间的电子信号的方法包括改变介于第一和第二位置之间的核酸材料中的第三位置处的静电电位。 第三个位置可能包括调节接头。

    GnRH-LEUKOTOXIN CHIMERAS
    180.
    发明申请
    GnRH-LEUKOTOXIN CHIMERAS 审中-公开

    公开(公告)号：WO1996024675A1

    公开(公告)日：1996-08-15

    申请号：PCT/CA1996000049

    申请日：1996-01-24

    Applicant: UNIVERSITY OF SASKATCHEWAN

    Inventor： UNIVERSITY OF SASKATCHEWAN ,  POTTER, Andrew, A. ,  MANNS, John, G.

    IPC: C12N15/62

    CPC classification number: C07K5/1024 ,  A61K39/00 ,  A61K39/0006 ,  A61K47/62 ,  A61K47/646 ,  A61K47/6829 ,  A61K47/6833 ,  A61K2039/6037 ,  C07K5/1008 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/23 ,  C07K14/005 ,  C07K14/285 ,  C07K14/655 ,  C07K16/26 ,  C07K2319/00 ,  C12N2720/12322

    Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected GnRH multimer which consists essentially of at least one repeating GnRH decapepetide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimer fused thereto.

    Abstract translation: 公开了新的免疫载体系统，编码相同的DNA以及这些系统的使用。 载体体系包括嵌合蛋白，其包含与选定的GnRH多聚体融合的白细胞毒素多肽，所述GnRH多聚体基本上由至少一个重复的GnRH脱羧选择素序列组成，或至少一个对应于所选GnRH分子的至少一个表位的序列的重复单元。 根据本发明，所选择的GnRH序列可以全部相同，或者可以对应于GnRH的不同衍生物，类似物，变体或表位，只要GnRH序列能够引发免疫应答即可。 白细胞毒素的作用是增加与其融合的GnRH多聚体的免疫原性。

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