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公开(公告)号：KR1020120059672A
公开(公告)日：2012-06-11
申请号：KR1020100120142
申请日：2010-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/68 , A61Q17/04 , C12Q2600/148 , C12Q2600/158 , G01N33/5008
Abstract: PURPOSE: A method for evaluating the efficiency of a sun screen is provided to accurately evaluate efficiency of blocking blue/violet light. CONSTITUTION: A method for evaluating the efficiency of a sun screen comprises: a step of applying a subject on a sunlight permeable material; a step of irradiating skin cells with the sunlight; and a step of collecting the skin cells and measuring gene expression level in the cells. The sunlight is UV ray with 290-400 nm of wavelength or blue/violet light with 400-500 nm of wavelength. The sunlight permeable material is a quartz plate or band pass filter. The skin cells include keratinocytes, fibroblast, or melanocytes.
Abstract translation: 目的：提供一种评估遮阳效率的方法，以准确评估阻挡蓝/紫光的效率。 构成：用于评估遮阳效率的方法包括：将受试者施加于阳光透射材料上的步骤; 用阳光照射皮肤细胞的步骤; 以及收集皮肤细胞并测量细胞中的基因表达水平的步骤。 阳光是具有290-400nm波长的紫外线或具有400-500nm波长的蓝/紫光。 阳光透射材料是石英板或带通滤光片。 皮肤细胞包括角质形成细胞，成纤维细胞或黑素细胞。
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公开(公告)号：KR1020120058865A
公开(公告)日：2012-06-08
申请号：KR1020100120372
申请日：2010-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/73 , A61K8/97 , A61K35/28 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61Q19/00
Abstract: PURPOSE: A composition containing apple stem cell extract is provided to enhance the stemness of adipose-derived stem cells and to promote regeneration of the stem cells. CONSTITUTION: A composition for enhancing the stemness of adipose-derived stem cells contains apple stem cell extract as an active ingredient. The stem cells are human adipose drived stem cells(hADSCs). The composition enhances the expression level of CD29, CD44, CD73, CD90 or CD105. A composition for beauty or plastic surgery contains 0.0001-10 wt% of the apple stem cell extract as an active ingredient.
Abstract translation: 目的：提供含有苹果干细胞提取物的组合物，以增强脂肪来源的干细胞的干性，促进干细胞的再生。 构成：用于增强脂肪干细胞的干性的组合物含有苹果干细胞提取物作为活性成分。 干细胞是人类脂肪干细胞（hADSCs）。 该组合物增强CD29，CD44，CD73，CD90或CD105的表达水平。 用于美容或整形手术的组合物含有0.0001-10重量％的苹果干细胞提取物作为活性成分。
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公开(公告)号：KR101141907B1
公开(公告)日：2012-05-03
申请号：KR1020050069505
申请日：2005-07-29
Applicant: (주)아모레퍼시픽
Abstract: A method for inhibiting melanosome migration by using prohibitin siRNA(small interference RNA) is provided to inhibit expression of prohibitin in a melanin synthesis cell and uniformed distribution of melanosome in the melanin synthesis cell, so that the skin is whitened. The melanosome migration to the end of melanin synthesis cell is inhibited by administering prohibitin siRNA into the melanin synthesis cell, melan-a, thereby inhibiting binding of prohibitin to melanophilin as a melanosome vehicle and uniformed distribution of melanosome in the melanin synthesis cell.
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公开(公告)号：KR101069502B1
公开(公告)日：2011-09-30
申请号：KR1020060106362
申请日：2006-10-31
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/198 , A61K31/205 , A61K31/35 , A61K2300/00
Abstract: 본 발명은 비만 및 당뇨의 치료 및 증상의 개선에 관한 경구용 조성물로서, 보다 상세하게는 이소플라본을 함유하는 대두 추출물, L-카르니틴(L-carnitine), 카페인(caffeine) 및 아르기닌(arginine)을 유효성분으로 함유하는 비만 개선용 경구용 조성물로서, 상기 조성물은 당뇨병 개선용임을 특징으로 하는 비만 및 당뇨병 개선용 조성물에 관한 것이다. 본 발명의 조성물은 이소플라본을 함유하는 대두추출물과 카르니틴, 카페인 및 아르기닌을 혼합물의 형태로 함유하여 지방분해 및 지방연소 촉진효과와 더불어 아디포넥틴 및 Glut4 유전자 발현을 증가시켜 인슐린 감수성을 회복시킴으로써 혈당 상승을 억제하여 항비만·항당뇨 효과를 나타낸다.
대두 추출물, 이소플라본, 카르니틴, 카페인, 아르기닌, 지방분해, 지방연소, 인슐린 감수성, 아디포넥틴, Glut4, 비만, 당뇨병-
公开(公告)号：KR1020100059278A
公开(公告)日：2010-06-04
申请号：KR1020080117987
申请日：2008-11-26
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A method for manufacturing fermented tea using lactic acid bacteria strains is provided to manufacture the fermented tea safe from the pathogenic bacteria, and to improve flavor of the tea by fermenting green tea. CONSTITUTION: A method for manufacturing fermented tea using lactic acid bacteria strains comprises the following steps: removing a culture medium by washing the culture medium with salty water after centrifuging; culturing the lactic acid bacteria strains in a fermentation liquid without protein powder; and fermenting the lactic acid bacteria strains on leaves. The fermentation liquid includes sugar, fructose, lactose and water. The lactic acid bacteria strains is strain separated fermented food.
Abstract translation: 目的：提供使用乳酸菌菌株制造发酵茶的方法，从病原菌制造发酵茶，通过发酵绿茶来改善茶的风味。 构成：使用乳酸菌菌株制造发酵茶的方法包括以下步骤：通过在离心后用咸水洗涤培养基来除去培养基; 在没有蛋白粉的发酵液中培养乳酸菌菌株; 并在叶上发酵乳酸菌菌株。 发酵液包括糖，果糖，乳糖和水。 乳酸菌菌株是菌株分离的发酵食品。
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Patent Agency Ranking
公开(公告)号：KR1020090030497A
公开(公告)日：2009-03-25
申请号：KR1020070095848
申请日：2007-09-20
Applicant: (주)아모레퍼시픽
Abstract: A signal peptide targeting to nucleus is provided to move signal peptide to nucleus through the fusion of the signal peptide and to perform function of heterologous protein in nucleus. An expression vector comprises a gene coding the signal peptide of SEQ ID NO:1 and a gene coding heterologous protein. The heterologous protein is an orphan receptor or steroid receptor response element binding protein 1(SREBP1). The orphan receptor is retinoic acid receptor(RAR), peroxisome proliferator-activated receptor(PPAR) or Liver X receptor(LXR).
Abstract translation: 提供靶向细胞核的信号肽，以通过信号肽的融合将信号肽移动到细胞核，并在细胞核中进行异源蛋白质的功能。 表达载体包含编码SEQ ID NO：1的信号肽的基因和编码异源蛋白质的基因。 异源蛋白是孤儿受体或类固醇受体反应元件结合蛋白1（SREBP1）。 孤儿受体是视黄酸受体（RAR），过氧化物酶体增殖物激活受体（PPAR）或肝X受体（LXR）。
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公开(公告)号：KR1020090030070A
公开(公告)日：2009-03-24
申请号：KR1020070095389
申请日：2007-09-19
Applicant: (주)아모레퍼시픽
Abstract: A signal peptide targeting to lipid droplet for targeting a heterologous protein to lipid droplet is provided to cure and prevent lipid droplet-related diseases containing obesity, diabetes and arteriosclerosis. An expression vector comprises a gene coding signal peptide of SEQ ID NO:1 and a gene coding heterologous protein. The heterologous protein is the lipase or protein kinase A(PKA). The composition for targeting a heterologous protein to lipid droplet comprises the expression vector.
Abstract translation: 提供靶向脂滴以将异源蛋白质靶向脂质液滴的信号肽，以治愈和预防含有肥胖，糖尿病和动脉硬化的脂滴相关疾病。 表达载体包含SEQ ID NO：1的基因编码信号肽和编码异源蛋白质的基因。 异源蛋白是脂肪酶或蛋白激酶A（PKA）。 将异源蛋白质靶向脂滴的组合物包含表达载体。
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公开(公告)号：KR1020070072023A
公开(公告)日：2007-07-04
申请号：KR1020050135945
申请日：2005-12-30
Applicant: (주)아모레퍼시픽
IPC: A61K36/736 , A61P3/04
Abstract: A composition comprising at least one plant extract is provided to increase the expression of carnitine palmitoyl transferase 1A(CPT1A) gene expression by increasing the activity of the CPT1A promoter, playing an important role in controlling the oxidation of fatty acid in a human liver cell line, and promote the oxidation of the fatty acid in the liver, thereby being usefully used for preventing and treating obesity and hyperlipidemia. The composition comprises at least one extract selected from the group consisting of an extract of Persicae Semen, an extract of Sinapis Semen, an extract of Stemonae Radix, an extract of Peucedani Radix, an extract of Aconiti Tuber, an extract of Tiglii Semen, an extract of Patriniae Radix, and an extract of Styrax japonica. The composition is characterized in that it increases the expression of CPT1A gene by increasing the activity of CPT1A gene promoter in liver.
Abstract translation: 提供包含至少一种植物提取物的组合物以通过增加CPT1A启动子的活性来增加肉碱棕榈酰转移酶1A（CPT1A）基因表达的表达，在控制人肝细胞系中脂肪酸的氧化中起重要作用 并促进肝脏中脂肪酸的氧化，从而有效地用于预防和治疗肥胖症和高脂血症。 所述组合物包含至少一种提取物，所述提取物选自下列组中：芍药提取物，辛酸钠提取物，白僵菌提取物，芍药提取物，乌头提取物，提取精液， 枸杞提取物，of an提取物。 该组合物的特征在于通过增加肝脏中CPT1A基因启动子的活性来增加CPT1A基因的表达。
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公开(公告)号：KR100706279B1
公开(公告)日：2007-04-12
申请号：KR1020050108080
申请日：2005-11-11
Applicant: (주)아모레퍼시픽
IPC: A61K31/352 , A61K31/366 , A61P3/04
Abstract: 본 발명은 쿠메스트롤을 함유하여 카르니틴 팔미토일트랜스퍼라아제1A(Carnitine Palmitoyl Transferase1A) 유전자 발현을 촉진시킴으로써 지방산 베타 산화를 증가시키는 비만 개선 및 예방용 의약 조성물과 비만 개선 및 예방용 식품 조성물에 관한 것이다. 본 발명에 의한 비만 개선 및 예방용 의약 조성물과 비만 개선 및 예방용 식품 조성물은 쿠메스트롤을 함유하여 카르니틴 팔미토일트랜스퍼라아제1A의 발현을 세포 독성 없이 효과적으로 증가시킴으로써, 세포질 내 지방산이 미토콘드리아 내로 이동하는 것을 촉진하여 결과적으로 지방산의 베타 산화 증가에 도움이 된다. 따라서 본 발명에 의한 쿠메스트롤을 함유한 비만 개선용 조성물은 체지방의 과도한 축적을 예방 또는 개선하는데 도움이 된다.
쿠메스트롤, 제니스테인, 다이드제인, CPT1A, 지방산, 베타 산화Abstract translation: 本发明ク手术刀包含拖网肉碱棕榈酰基转移酶1A氮杂促进（肉碱棕榈酰Transferase1A）基因表达通过涉及肥胖，改善和预防食品组合物的药物组合物和肥胖改善和预防用于增加脂肪酸β-氧化 。 肥胖改善和预防肥胖改善和预防食品组合物用于根据本发明通过将含区手术刀拖网肉碱棕榈酰转移酶的增加氮杂有效细胞1A表达而没有毒性的药物组合物，此举是脂肪细胞质内进入线粒体 因此有助于增加脂肪酸的β氧化。 因此，根据本发明的用于改善含有cumestrol的肥胖症的组合物有助于预防或改善体脂过度积聚。
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180.发明公开ＣＰＴ-１ 유전자의 발현을 특이적으로 전사 단계에서조절하는 화학물질의 스크리닝 방법 및 그 방법으로검색된 제니스테인을 유효 성분으로 포함하는 ＣＰＴ-１발현 촉진제 有权特异性控制CPT-1基因转录表达的化合物的筛选方法和包含通过相同方法筛选的基因的CPT-1表达增强子
公开(公告)号：KR1020040060749A
公开(公告)日：2004-07-06
申请号：KR1020030095226
申请日：2003-12-23
Applicant: (주)아모레퍼시픽
IPC: C12N15/85
CPC classification number: C12N15/85 , C12N5/0693 , C12N9/1025 , G01N33/5044
Abstract: PURPOSE: A screening method of compounds specifically controlling transcriptional expression of CPT-1 gene, and a CPT-1 expression enhancer comprising genistein which is screened by the same method are provided, thereby easily screening natural compounds reducing fat of human. CONSTITUTION: The screening method of compounds specifically controlling transcriptional expression of CPT-1 gene comprises the steps of: constructing a recombinant plasmid pCPT-1P-luc containing CPT-1 promoter and luciferase; producing a transformant Huh7 cell line(KCLRF-BP-00090) transformed with the recombinant plasmid pCPT-1P-luc; contacting a compound with the transformant Huh7 cell line(KCLRF-BP-00090); quantification of the signal produced by the contact; and comparing the signal amount measured with that of a control.
Abstract translation: 目的：提供特异性控制CPT-1基因转录表达的化合物的筛选方法，以及通过相同方法筛选含有染料木素的CPT-1表达增强子，从而容易地筛选天然化合物，减少人的脂肪。 构成：特异性控制CPT-1基因转录表达的化合物的筛选方法包括以下步骤：构建含有CPT-1启动子和荧光素酶的重组质粒pCPT-1P-luc; 产生用重组质粒pCPT-1P-luc转化的转化体Huh7细胞系（KCLRF-BP-00090）; 使化合物与转化体Huh7细胞系（KCLRF-BP-00090）接触; 量化由接触产生的信号; 并将测量的信号量与对照的信号量进行比较。
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