公开(公告)号：WO1996013280A1

公开(公告)日：1996-05-09

申请号：PCT/US1995013719

申请日：1995-10-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  AIKUS, Albert, J. ,  MAYORAL, Joaquin

IPC: A61L02/04

CPC classification number: A61L2/0023 ,  A61L2/04

Abstract: The present invention provides a method of sterilizing a pharmaceutical composition, the method comprising providing a sterilization system including heat exchanger means for elevating and then lowering the temperature of the fluid in a time period; measuring temperature at an input of the heat exchanger means, measuring temperature at an output of the heat exchanger means and measuring temperature at least one point in the heat exchanger means intermediate to the input and output; calculating a coefficient of heat transfer for the sterilization system using the temperature measurements; calculating a degree of sterilization (Fo) using the coefficient; and adjusting the temperature of the heat exchanger means to minimize degradation of the pharmaceutical composition while maintaining an acceptable degree of sterilization.

Abstract translation: 本发明提供一种对药物组合物进行灭菌的方法，该方法包括提供一种灭菌系统，该灭菌系统包括用于在一段时间内升高并降低流体温度的换热器装置; 在所述热交换器装置的输入端处测量温度，测量所述热交换器装置的输出处的温度，并且将所述热交换器中至少一点的温度测量到所述输入和输出的中间; 使用温度测量计算灭菌系统的传热系数; 使用系数计算灭菌程度（Fo）; 以及调节热交换器装置的温度以使药物组合物的降解最小化，同时保持可接受的灭菌程度。

公开(公告)号：WO1996005180A1

公开(公告)日：1996-02-22

申请号：PCT/US1995009472

申请日：1995-07-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ZHAO, Chen ,  KEMPF, Dale, J. ,  SHAM, Hing, L. ,  NORBECK, Daniel, W. ,  BETEBENNER, David, A. ,  LIN, Shuqun

IPC: C07D255/02

CPC classification number: C07D405/06 ,  C07C281/02 ,  C07D255/02 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: A retriviral protease inhibiting compound of formula (A) is disclosed.

Abstract translation: 公开了式（A）的抗病毒蛋白酶抑制化合物。

公开(公告)号：WO1995032728A1

公开(公告)日：1995-12-07

申请号：PCT/US1995003789

申请日：1995-04-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MUKERJI, Pradip ,  SEO, Amanda, Eun-Yeong ,  ANDERSON, Steven, Neal ,  HARVEY, Linda, Ann

IPC: A61K38/17

CPC classification number: C07K14/4732 ,  A23L33/19 ,  A61K38/018 ,  A61K38/1709

Abstract: The attachment of H. influenzae to human cells, such as oropharyngeal cells, may be inhibited by native human beta -casein, a recombinant form of human beta -casein, and hydrolysates of both. The human beta -casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of otitis media in infants. The human beta -casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.

Abstract translation: 流感嗜血杆菌对人细胞如口咽细胞的附着可被天然人β-酪蛋白，人β-酪蛋白的重组形式和两者的水解产物所抑制。 人β-酪蛋白或水解产物可以包含在液体肠内营养产品如婴儿配方奶粉中。 肠内营养产品可用于例如预防和治疗婴幼儿中耳炎。 人类β-酪蛋白或水解产物也可以作为喉部喷雾剂或使用滴剂或喷雾剂鼻部施用。

公开(公告)号：WO1995031247A1

公开(公告)日：1995-11-23

申请号：PCT/US1995005924

申请日：1995-05-10

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MINICK, Steven, E. ,  LAWLESS, Michael, W. ,  SOBERON, Peter, A. ,  KAUL, Ashok ,  HERMANN, Robert, A.

IPC: A61M39/28

CPC classification number: A61M39/281 ,  A61M5/142 ,  A61M5/14224 ,  A61M39/284 ,  A61M2205/128

Abstract: A push button flow stop is mounted on a disposable infusion pumping cassette provided for use with a drug infusion pump. The flow stop is operative to enable or to block fluid flow through the cassette in a first mode and to monitor fluid pressure in the cassette in a second mode.

Abstract translation: 按钮式流动停止装置安装在一次性输液泵盒上，用于与药物输注泵一起使用。 流动停止器用于在第一模式中启用或阻止流经盒的流体并以第二模式监测盒中的流体压力。

公开(公告)号：WO1995028188A1

公开(公告)日：1995-10-26

申请号：PCT/US1995004382

申请日：1995-04-10

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KOLBER, Chris, M.

IPC: A61M05/14

CPC classification number: A61M5/14 ,  A61M25/0017 ,  A61M2005/1404

Abstract: This apparatus is intended for maintaining the patency of an indwelling vein access device (14). The apparatus includes a vein access device (14) such as a catheter (14) connected to a self-energized container (12) having a capacity to deliver an infusate to the vein access device (14) at a flow rate of approximately 0.01-1.0 ml per hour.

Abstract translation: 该装置用于维持留置静脉通路装置（14）的通畅。 该装置包括静脉通路装置（14），例如连接到自充电容器（12）的导管（14），该自给电容器（12）具有以大约0.01-5％的流速将输液输送到静脉通路装置（14） 每小时1.0毫升。

公开(公告)号：WO1995026646A1

公开(公告)日：1995-10-12

申请号：PCT/US1995002657

申请日：1995-03-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DEMICHELE, Stephen, Joseph ,  GARLEB, Keith, Allen ,  McEWEN, John, William ,  FULLER, Martha, Kay

IPC: A23L01/30

CPC classification number: A23L33/12 ,  A23L33/40

Abstract: An enteral nutritional product and method of treatment for a person having ulcerative colitis contains in combination (a) an oil blend which contains eicosapentaenoic acid (20:5n3) and/or docosahexaenoic acid (22:6n3), and (b) a source of indigestible carbohydrate which is metabolized to short chain fatty acids by microorganisms present in the human colon. Preferably the nutritional product also contains one or more nutrients which act as antioxidants.

Abstract translation: 具有溃疡性结肠炎的肠内营养产品和治疗方法组合（a）含有二十碳五烯酸（20:5n3）和/或二十二碳六烯酸（22：6n3）的油混合物和（b） 难以消化的碳水化合物，其通过存在于人结肠中的微生物代谢成短链脂肪酸。 优选地，营养产品还含有一种或多种作为抗氧化剂的营养物质。

公开(公告)号：WO1995024495A1

公开(公告)日：1995-09-14

申请号：PCT/US1995000967

申请日：1995-01-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  PRIETO, Pedro, Antonio ,  SMITH, David, Fletcher ,  CUMMINGS, Richard, Dale ,  KOPCHIK, John, Joseph ,  MUKERJI, Pradip ,  MOREMEN, Kelley, Wilson ,  PIERCE, James, Michael

IPC: C12N15/85

CPC classification number: C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/01 ,  A23C9/20 ,  C12N9/1077 ,  Y10S530/832

Abstract: The invention relates to the milk of a transgenic non-human mammal. The milk is characterized in that it contains heterologous components produced as the secondary gene products of a heterologous gene contained in the genome of the transgenic non-human mammal. The heterologous gene encodes a heterologous catalytic entity such as a human enzyme selected from the group consisting of glycosyltransferases, phosphorylases, hydroxylases, peptidases and sulfotransferases. Especially useful in the practice of the invention are human glycosyltransferases. The desired heterologous components include oligosaccharides, glycoconjugates. The oligosaccharides and glycoconjugates may be isolated from the milk of the transgenic mammals and used in the preparation of pharmaceuticals, diagnostic kits, nutritional products and the like. The whole transgenic milk may also be used to formulate nutritional products that provide special advantages. The transgenic milk may also be used in the production of specialized enteral nutritional products.

Abstract translation: 本发明涉及转基因非人哺乳动物的乳。 该乳的特征在于它含有作为转基因非人哺乳动物基因组中含有的异源基因的次要基因产物产生的异源成分。 异源基因编码异源催化实体，例如选自由糖基转移酶，磷酸酶，羟化酶，肽酶和磺基转移酶组成的组的人类酶。 在本发明的实践中特别有用的是人糖基转移酶。 所需的异源成分包括寡糖，糖缀合物。 寡糖和糖缀合物可以从转基因哺乳动物的乳中分离并用于制备药物，诊断试剂盒，营养产品等。 整个转基因乳也可用于配制提供特殊优点的营养产品。 转基因奶也可用于生产专门的肠内营养产品。

公开(公告)号：WO1995023973A2

公开(公告)日：1995-09-08

申请号：PCT/US1995002195

申请日：1995-02-21

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GALLARDA, James, L. ,  STONE, Barbara, L. ,  LIU, Douglas, J. ,  HARRINGTON, Susan, K. ,  DAWSON, George, J. ,  WU, Ping

IPC: G01N33/569

CPC classification number: G01N33/56988 ,  G01N33/68

Abstract: An assay to simultaneously detect the presence of HIV-1 antibody and/or HIV-2 antibody in a test sample is disclosed. The analytes are captured on either the same or different solid phases, and the presence of the analytes is determined by detecting a signal generated by using a cocktail of synthetic and recombinant antigen-containing indicator reagents.

Abstract translation: 公开了一种在测试样品中同时检测HIV-1抗体和/或HIV-2抗体的存在的测定法。 分析物被捕获在相同或不同的固相上，并且通过检测通过使用含有合成和重组抗原的指示剂试剂的混合物产生的信号来确定分析物的存在。

公开(公告)号：WO1995020664A2

公开(公告)日：1995-08-03

申请号：PCT/US1995001087

申请日：1995-01-27

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WATANABE, Shinichi ,  YAMAGUCHI, Julie ,  DESAI, Suresh, M. ,  DEVARE, Sushil, G.

IPC: C12N15/57

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K14/4711 ,  C07K2319/00 ,  C12N2770/24222 ,  Y10S436/82

Abstract: Mammalian expression systems for the production of HCV E1-E2 fusion proteins. Such expression systems provide high yields of HCV proteins extracellularly, and enable the development of diagnostic, vaccine and therapeutic reagents which contain glycosylated structural antigens and also allow for the isolation of the HCV etiological agent.

Abstract translation: 用于生产HCV E1-E2融合蛋白的哺乳动物表达系统。 这种表达系统在细胞外提供高产量的HCV蛋白质，并且能够开发含有糖基化结构抗原的诊断，疫苗和治疗试剂，并且还允许HCV病原体的分离。

公开(公告)号：WO1995018618A2

公开(公告)日：1995-07-13

申请号：PCT/US1995000090

申请日：1995-01-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MASOR, Marc, Leif ,  LEACH, James, Lee ,  MOLITOR, Bruce, Edward ,  BENSON, John, Durand ,  BAXTER, Jeffrey, Harris

IPC: A61K31/505

CPC classification number: A61K31/70 ,  A23D9/00 ,  A23L33/13 ,  A23L33/40

Abstract: An improved enteral nutritional formula containing nucleotide equivalents (RNA, mono-, di- and triphosphate nucleotides, nucleosides and adjuncts such as activated sugars) at a level of at least 10 mg/100 Kcal (kilocalorie) of formula is disclosed. The formula comprises carbohydrates, lipids, proteins, vitamins and minerals and four (4) nucleotide equivalents at specific levels and ratios. The invention also discloses novel methods of production and analytical techniques. This invention also provides a dietary formula that enhances the immune system and alleviates diarrhea.

Abstract translation: 公开了含有至少10mg / 100千卡（kilocalor）配方的水平的含有核苷酸等同物（RNA，单，二磷酸和三磷酸核苷酸，核苷和助剂如活性糖）的改良的肠内营养配方。 该配方包括碳水化合物，脂质，蛋白质，维生素和矿物质以及四（4）个核苷酸等同物在特定水平和比例下。 本发明还公开了新的生产方法和分析技术。 本发明还提供了增强免疫系统并减轻腹泻的饮食配方。