公开(公告)号：WO1993015394A1

公开(公告)日：1993-08-05

申请号：PCT/US1993000650

申请日：1993-01-25

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  GUTTMAN, Andras ,  SHIEH, Chia-Hui ,  KARGER, Barry, L. ,  PENTONEY, Stephen, L., Jr. ,  KONRAD, Kenneth, D. ,  RAMPAL, Sushma ,  GANZLER, Katalin

IPC: G01N27/447

CPC classification number: G01N27/44704 ,  G01N27/44747

Abstract: Disclosed herein are capillary columns for capillary electrophoretic analysis of sample constituents. In an embodiment, the columns comprise a bifunctional layer comprising a positively charged amine group adsorbed to the inner wall of the capillary and an active functional group; a gel composition; hydrophilic polymer; and a separation composition capable of being removed from the column, interspersed within the remainder of the column. The disclosed columns are particularly well suited for the analysis of surfactant/proteinaceous material complexes, nucleic acid sequence, and analysis of restriction fragments according to size.

Abstract translation: 本文公开了用于毛细管电泳分析样品成分的毛细管柱。 在一个实施方案中，柱包括双官能层，其包含吸附在毛细管内壁上的带正电胺基团和活性官能团; 凝胶组成; 亲水性聚合物; 以及能够从柱中除去，分散在塔的剩余部分内的分离组合物。 所公开的柱特别适用于根据尺寸分析表面活性剂/蛋白质物质复合物，核酸序列和限制性片段的分析。

公开(公告)号：WO1993007471A1

公开(公告)日：1993-04-15

申请号：PCT/US1992008274

申请日：1992-09-29

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  KAYE, Wilbur, I.

IPC: G01N21/64

CPC classification number: G01J3/02 ,  G01J1/04 ,  G01J1/0422 ,  G01J3/0216 ,  G01N21/645 ,  G01N21/65 ,  G01N21/76 ,  G01N21/85 ,  G01N27/44721 ,  G01N2021/1738 ,  G01N2021/4702

Abstract: Focusing a generated radiation signal on a detector is effected by a curvilinear surface. The radiation beam signal from the reflected surface is collimated or focused on the detector. Light scattered, Raman scattered, fluorescence, chemiluminescence, phosphorescence radiation signals from particles as a result of a chemical procedure or reaction is enhanced through this focusing technique. The enhanced signal which is detected is subsequently measured through different detection techniques.

Abstract translation: 将生成的辐射信号聚焦在检测器上由曲线表面实现。 来自反射面的辐射束信号被准直或聚焦在检测器上。 通过这种聚焦技术，增强了散射，拉曼散射，荧光，化学发光，来自颗粒的化学过程或反应的磷光辐射信号。 随后通过不同的检测技术测量检测到的增强信号。

公开(公告)号：WO1993005389A1

公开(公告)日：1993-03-18

申请号：PCT/US1992006364

申请日：1992-07-31

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  CHEN, Albert, Fu-Tai

IPC: G01N27/26

CPC classification number: G01N27/44752

Abstract: Disclosed herein is a dynamic coating buffer useful in the analysis of samples by open-tube capillary electrophoretic methods using untreated fused silica capillary columns. The dynamic coating buffer comprises at least one agent having at least two dissociation constants, and high ionic stength characteristics, said agent having a molarity range of from about 0.2 M and about 1.0 M and a pH range of from between about 3.0 and 11.0. A particularly preferred dynamic coating buffer comprises 0.5 M sodium phosphate.

公开(公告)号：WO1992007274A1

公开(公告)日：1992-04-30

申请号：PCT/US1991006998

申请日：1991-09-25

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  SHU, Frank, R. ,  CHIEN, Chen-Yie ,  KIM, Julie, S.

IPC: G01N33/84

CPC classification number: G01N33/84 ,  Y10T436/108331 ,  Y10T436/25625

Abstract: An indirect potentiometric method and diluent for the analysis of lithium are disclosed. The diluent includes effective amounts of a pH buffer and a non-cationic surfactant comprising at least one hydrophobic group, at least one hydrophillic group and being substantially free of polyoxyethylene groups. Most preferably, the pH buffer is tris-(hydroxymethyl) aminomethane-phosphate, and the surfactant is 2, 4, 7, 9-tetramethyl-5-decyn-4,7-diol. An indirect potentiometric determination of lithium in a clinical sample comprises the steps of mixing the sample with a diluent, contacting an aliquot of the diluted sample with a lithium specific ion selective electrode and at least one ion selective electrode specifically responsive to a monovalent interfering ion, and measuring both the response of the lithium specific ion selective electrode and the monovalent interfering ion specific ion selective electrode, the responses being an indication of the concentration of lithium in the sample.

公开(公告)号：WO1989007765A1

公开(公告)日：1989-08-24

申请号：PCT/US1989000350

申请日：1989-01-27

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  THRASHER, Caron

IPC: G01N33/564

CPC classification number: G01N33/564 ,  G01N33/5306 ,  G01N2800/102 ,  Y10S436/821 ,  Y10S436/825

Abstract: A novel buffer for use in immunoassays for rheumatoid factor (RF) is provided. The novel buffer contains heparin. Use of this buffer suppresses interference from the component Clq found in some test samples, and alleviates the need for a heat inactivation pretreatment of test samples to eliminate Clq interference.

公开(公告)号：WO1989003986A1

公开(公告)日：1989-05-05

申请号：PCT/US1988003683

申请日：1988-10-20

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  GIEBELER, Robert

IPC: G01N21/31

CPC classification number: G01N15/042 ,  G01J3/18 ,  G01J2003/1857 ,  G01N2015/045

Abstract: A centrifuge sample is optically scanned during centrifuging. The sample, placed in a centrifuge rotor having a cell with top and bottom windows, is spun until stratification and discrete layering occurs within the sample. Such layering occurs on layers that are precisely normal to the radius of the centrifuge at the point of sample and parallel to the spin axis of the centrifuge. A slit scanner having a slit normal to the sample plane transverses the width of the sample below the cell to detect with precision the precise location of the strata in the cell. A light source is reflected by a toroidal mirror having two radius of curvature. One radius of curvature is selected to collimate rays of light parallel to the layer of the sample. The mirror is ruled with respect to the other radius of curvature to chromatically classify light to preselect band width. Rotation of the mirror preserved collimation but enables selected scanning light frequency.

公开(公告)号：WO1988010412A1

公开(公告)日：1988-12-29

申请号：PCT/US1988001987

申请日：1988-06-09

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  LABRIOLA, Donald, Paul, II

IPC: G01F23/26

CPC classification number: G01N35/1009 ,  G01F23/263 ,  G01F23/266 ,  G01N2035/1025

Abstract: A liquid level sensing system comprising a probe and a reactive element carried by the probe. The reactive element forms a portion of a tuned circuit in a voltage-controlled oscillator. The output of the voltage-controlled oscillator is compared to a fixed frequency reference signal and a frequency/phase detector generates a signal indicative of any difference. The frequency/phase detector output is applied to the voltage-controlled oscillator to maintain the output frequency of the oscillator at the frequency of the reference signal. The output of the frequency/phase detector is also differentiated to develop a pulse when the frequency/phase detector output signal varies rapidly, indicating initial contact between the probe and the surface of a liquid held within a container.

公开(公告)号：WO1988010143A1

公开(公告)日：1988-12-29

申请号：PCT/US1988002020

申请日：1988-06-09

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  GOODALE, David, Leo ,  HESS, Bradford, K.

IPC: B01D19/00

CPC classification number: B01D19/0031 ,  B01D19/0063

Abstract: A liquid degassing system including a liquid reservoir (22) having an inlet (24) to receive a liquid to be degassed and an outlet (26) through which degassed liquid may flow. A vacuum source is controllably connected through a valve (16) to the reservoir to draw gas out of the liquid held within the reservoir. A valve (16) in a liquid inlet conduit supplying the reservoir may interrupt flow to the reservoir while vacuum is applied thereto. A second (32) valve in an outlet conduit connected to the reservoir may interrupt flow from the reservoir when vacuum is applied to the reservoir.

Abstract translation: 一种液体脱气系统，包括具有用于接收要脱气的液体的入口（24）的液体储存器（22）和脱气液体可以流过的出口（26）。 真空源通过阀（16）可控地连接到储存器，以将气体从保持在储存器内的液体中排出。 供给储存器的液体入口管道中的阀（16）可以在向其提供真空的同时中断到储存器的流动。 连接到储存器的出口导管中的第二（32）阀可能会在向储存器施加真空时中断来自储存器的流动。

公开(公告)号：WO1988008985A1

公开(公告)日：1988-11-17

申请号：PCT/US1988001507

申请日：1988-05-05

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  PFOST, Dale, R. ,  PFOST, R., Fred ,  LACHENMEIER, Eric, W.

IPC: G01N35/06

CPC classification number: G01F23/2966 ,  G01N35/10 ,  G01N35/1011 ,  G01N2035/1025 ,  G01N2035/103 ,  Y10S367/908

Abstract: A liquid boundary level detector employing an open-ended conduit which directs pressure waves toward a liquid boundary layer. The conduit is moved from a starting position toward the liquid boundary and, upon contact with the boundary, there is a change in acoustic impedance within the conduit. This change is monitored and a signal is generated indicative of such contact. Once the initial liquid boundary position is determined, that may become the reference position for subsequent liquid boundary measurements or motions.

公开(公告)号：WO1988008973A1

公开(公告)日：1988-11-17

申请号：PCT/US1988001526

申请日：1988-05-04

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  BLOUGH, William, H., Jr.

IPC: G01N27/28

CPC classification number: G01N27/403

Abstract: An improved ion selective electrode flow cell wherein the flow cell includes a first fluid conduit, at least two ion sensing electrodes (110, 112) each having ion sensing surfaces disposed within the first fluid conduit, a second fluid conduit, an ion sensing electrode (126) having an ion sensing tip disposed within the second conduit, and an electrically conducting bridge (150) connecting the first and second fluid conduits. The flow cell further includes a conductive member having at least portions thereof disposed within the first fluid conduit proximate the ion sensing surfaces of the at least two ion sensing electrodes and the bridge. The flow cell may further include a third fluid conduit intersecting the first fluid conduit and grounding means for grounding fluid flowing through the third fluid conduit. Capacitor means (174) may be connected between exit and entry ports of the first and second fluid conduits and ground to further reduce electrical noise within the flow cell.

Abstract translation: 一种改进的离子选择性电极流动池，其中流动池包括第一流体导管，至少两个离子感测电极（110,112），每个离子感测电极具有设置在第一流体导管内的离子感测表面，第二流体导管，离子感测电极 126），其具有设置在第二导管内的离子感测尖端，以及连接第一和第二流体导管的导电桥（150）。 流动池还包括导电构件，其至少部分设置在第一流体导管内，靠近至少两个离子感测电极和桥的离子感测表面。 流动池还可以包括与第一流体导管相交的第三流体导管和用于使流过第三流体导管的流体接地的接地装置。 电容器装置（174）可以连接在第一和第二流体导管的出口和入口之间并进行接地，以进一步降低流动池内的电噪声。