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    SYNTHETIC TRIVALENT HAPTENS, COMPLEXES THEREOF, AND USES THEREFOR
    182.
    发明申请
    SYNTHETIC TRIVALENT HAPTENS, COMPLEXES THEREOF, AND USES THEREFOR 审中-公开
    合成TRIVALENT HAPTENS，其复合物及其用途

    公开(公告)号：WO2008140595A3

    公开(公告)日：2009-05-14

    申请号：PCT/US2007086163

    申请日：2007-11-30

    Applicant: HARVARD COLLEGE ,  BILGICER ZIHNI BASAR ,  MOUSTAKAS DEMETRI T ,  WHITESIDES GEORGE M

    Inventor： BILGICER ZIHNI BASAR ,  MOUSTAKAS DEMETRI T ,  WHITESIDES GEORGE M

    IPC: G01N33/531

    CPC classification number: G01N33/531 ,  A61K47/646

    Abstract: The invention provides trivalent hapten molecules (trihapten molecules) and complexes thereof. The trivalent hapten molecules are useful for forming relatively stable complexes comprising hapten molecules and divalent ligands (e.g., antibodies) for the hapten molecules. Such trihapten molecules are useful for assays, e.g., of antibodies, or for depleting a ligand from a sample, e.g., for treating a disease by binding an undesirable receptor such as an antibody. Complexes of trivalent hapten molecules are useful for selectively targeting relatively high density, multivalent presentations of haptens, such as occur on cells overexpressing a molecule on their surfaces, such as cancer cells.

    Abstract translation: 本发明提供三价半抗原分子（trihapten分子）及其复合物。 三价半抗原分子可用于形成包含用于半抗原分子的半抗原分子和二价配体（例如抗体）的相对稳定的复合物。 这种三阴离子分子可用于例如抗体的测定，或用于从样品中消耗配体，例如通过结合不期望的受体例如抗体来治疗疾病。 三价半抗原分子的复合物可用于选择性靶向半抗原的相对高密度多价表现，例如发生在其表面上的分子如癌细胞上的细胞上。

    MICROFLUIDIC LASERS
    184.
    发明申请
    MICROFLUIDIC LASERS 审中-公开
    微流感激光

    公开(公告)号：WO2006086551A2

    公开(公告)日：2006-08-17

    申请号：PCT/US2006004577

    申请日：2006-02-08

    Applicant: HARVARD COLLEGE ,  MASSACHUSETTS INST TECHNOLOGY ,  MAYERS BRIAN T ,  CONROY RICHARD S ,  VEZENOV DMITRI V ,  SNEE PRESTON ,  CHAN YINTHAI ,  BAWENDI MOUNGI G ,  WHITESIDES GEORGE M

    Inventor： MAYERS BRIAN T ,  CONROY RICHARD S ,  VEZENOV DMITRI V ,  SNEE PRESTON ,  CHAN YINTHAI ,  BAWENDI MOUNGI G ,  WHITESIDES GEORGE M

    CPC classification number: H01S3/05 ,  H01S3/213

    Abstract: The present invention generally relates to lasers comprising fluidic channels, such as microfluidic channels. In some instances, the channel contains two or more fluids. The fluids may remain non-mixed within the channel, for example, due to immiscibility and/or laminar flow within the channel. The fluids may be arranged in the channel such that light propagating in a first fluid is prevented by the second fluid from exiting the first fluid, for example, due to differences in the indexes of refraction (e.g., causing internal reflection of the fluid to occur). Thus, in one embodiment, a first fluid may be at least partially surrounded by a second fluid having a second index of refraction lower than the index of refraction of the first fluid. In some embodiments, the fluidic channel is used as a laser, for instance, a dye laser, i.e., a laser created by directing light at a dye to produce coherent light. The dye may be present in one or more fluids within the fluidic channel. The incident light (for example, created by another laser) may be directed at the channel from any angle. In some cases, laser light may be produced in a direction substantially aligned with the longitudinal axis of the channel. In some embodiments, the laser is free of mirrors, prisms, or gratings, or the laser may produce coherent light using a non-resonant photonic pathway. However, in other cases, mirrors, prisms, or gratings may be used to reflect light along the channel to enhance stimulated emission of coherent light. Another aspect of the invention includes optical diffractors, such as prisms or gratings, which can contain a fluid. The optical diffractors, in certain embodiments, are positioned to diffract light, such as coherent light, emanating from the fluidic channel. Still other aspects of the invention provide devices, kits, and methods of making and using such lasers.

    Abstract translation: 本发明一般涉及包括流体通道的激光器，例如微流体通道。 在一些情况下，通道包含两种或更多种流体。 流体可以在通道内保持不混合，例如，由于通道内的不混溶和/或层流。 流体可以布置在通道中，使得通过第二流体从第一流体中排出的光例如由于折射率的差异（例如，引起流体的内部反射）而被阻止在第一流体中传播的光 ）。 因此，在一个实施例中，第一流体可以至少部分地被具有低于第一流体的折射率的第二折射率的第二流体包围。 在一些实施例中，流体通道用作激光器，例如染料激光器，即通过在染料处引导光以产生相干光而产生的激光。 染料可存在于流体通道内的一种或多种流体中。 入射光（例如，由另一激光产生的）可以从任何角度指向通道。 在一些情况下，可以在与通道的纵向轴线基本对准的方向上产生激光。 在一些实施例中，激光器不含镜子，棱镜或光栅，或者激光可以使用非共振光子通道产生相干光。 然而，在其他情况下，可以使用反射镜，棱镜或光栅来沿着通道反射光以增强相干光的受激发射。 本发明的另一方面包括可以包含流体的光学衍射器，例如棱镜或光栅。 在某些实施例中，光衍射器被定位成衍射从流体通道发出的光，例如相干光。 本发明的其它方面提供了制造和使用这种激光器的装置，套件和方法。

    SURFACES THAT RESIST THE ADSORPTION OF BIOLOGICAL SPECIES
    185.
    发明申请
    SURFACES THAT RESIST THE ADSORPTION OF BIOLOGICAL SPECIES 审中-公开
    抗生物物种吸附的表面

    公开(公告)号：WO0206407A9

    公开(公告)日：2003-10-23

    申请号：PCT/US0122455

    申请日：2001-07-17

    Applicant: HARVARD COLLEGE

    Inventor： CHAPMAN ROBERT G ,  OSTUNI EMANUELE ,  LIANG MICHAEL N ,  YAN LIN ,  WHITESIDES GEORGE M

    IPC: A61F2/28 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  C08J7/12 ,  B05D1/18

    CPC classification number: B82Y30/00 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  B82Y5/00 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/268 ,  Y10T428/269 ,  Y10T428/31504 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31725 ,  Y10T428/31855

    Abstract: The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

    Abstract translation: 本发明提供了抗蛋白质，细胞和细菌吸附的制品。 制品可以具有键合在其上的化学链，其中化学链可以包含不含氢键供体的末端基团，或者氢键供体被充分掩埋以使得包括化学链的制品的暴露表面不含 氢键供体。 化学链或多个化学链可以包括单层，例如可以是均质的（一种类型的SAM）或混合的，即或更多不同类型的SAM的自组装单层（SAM）。 提供了其他更具体的化学链的例子。 多个化学链可以包含聚合物如多胺。 在许多方面，多个化学链充分地没有交联或分支。 本发明还提供了能够特异性结合期望的生物分子，同时防止生物分子的非特异性结合的制品。

    MICROLENS FOR PROJECTION LITHOGRAPHY AND METHOD OF PREPARATION THEREOF
    186.
    发明申请
    MICROLENS FOR PROJECTION LITHOGRAPHY AND METHOD OF PREPARATION THEREOF 审中-公开
    投影光刻用微晶及其制备方法

    公开(公告)号：WO02084340B1

    公开(公告)日：2003-04-03

    申请号：PCT/US0211623

    申请日：2002-04-10

    Applicant: HARVARD COLLEGE

    Inventor： WU MING-HSIEN ,  WHITESIDES GEORGE M ,  PAUL KATERI E

    IPC: G02B3/00 ,  G03F7/20 ,  G03F7/00

    CPC classification number: G02B3/0031 ,  B82Y30/00 ,  G02B1/005 ,  G02B3/0012 ,  G02B3/0018 ,  G02B3/0056 ,  G02B7/025 ,  G02B7/027 ,  G03F7/70275

    Abstract: Methods and systems for effecting responses on surfaces utilizing microlens arrays including microoptical components embedded or supported by support element and positioned from the surface at a distance essentially equal to the image distance of the microoptical component with spacer elements are disclosed. Microlens arrays can be used to manipulate incident energy or radiation having a distribution in characteristic property(s) defining an object pattern to form a corresponding image pattern on a substrate surface. The energy can be light having a pattern or a specific wavelength, intensity or polarization or coherence alignment. The image pattern can have features of order 100 nn in size or less produced from corresponding object patterns having features in the order millimeters. The size of the object pattern can be reduced by the microlens arrays described by a factor of 100 or more using a single step process to form the image patterns.

    Abstract translation: 公开了利用微透镜阵列来影响表面上的响应的方法和系统，所述微透镜阵列包括由支撑元件嵌入或支撑并且以基本上等于微光学部件与间隔元件的图像距离的表面定位的微光学部件。 可以使用微透镜阵列来操纵具有限定对象图案的特性的分布的入射能量或辐射，以在衬底表面上形成对应的图像图案。 能量可以是具有图案或特定波长，强度或极化或相干对准的光。 图像图案可以具有尺寸为100nn的特征，或者具有从具有毫米级的特征的相应对象图案产生的特征。 通过使用单步骤处理形成图像图案的100倍或更大的微透镜阵列可以减小对象图案的尺寸。

    MICROCONTACT PRINTING ON SURFACES AND DERIVATIVE AMICROCONTACT PRINTING ON SURFACES AND DERIVATIVE ARTICLES RTICLES
    189.
    发明申请
    MICROCONTACT PRINTING ON SURFACES AND DERIVATIVE AMICROCONTACT PRINTING ON SURFACES AND DERIVATIVE ARTICLES RTICLES 审中-公开
    表面上的微孔印刷和表面和衍生物品上的衍生性AMICROCONTACT PRINTING

    公开(公告)号：WO9629629A3

    公开(公告)日：1997-04-17

    申请号：PCT/US9603073

    申请日：1996-03-01

    Applicant: HARVARD COLLEGE

    Inventor： WHITESIDES GEORGE M ,  XIA YOUNAN ,  WILBUR JAMES L ,  JACKMAN REBECCA J ,  KIM ENOCH ,  PRENTISS MARA G ,  MRKSICH MILAN ,  KUMAR AMIT ,  GORMAN CHRIS ,  BIEBUYCK HANS ,  BERGGREN KARL K

    IPC: B05D1/28 ,  G02B5/18 ,  G02B6/12 ,  G02B6/124 ,  G02B6/136 ,  G02B6/36 ,  G03F7/00 ,  G03F7/16 ,  H01L21/48 ,  G03F

    CPC classification number: B05D1/283 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G02B5/1857 ,  G02B6/124 ,  G02B6/136 ,  G02B2006/12102 ,  G02B2006/12104 ,  G02B2006/12107 ,  G03F7/0002 ,  G03F7/165 ,  H01L21/4867

    Abstract: Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding. A method for controlling the shape of a liquid on the surface of an article is provided, involving applying the liquid to a self-assembled monolayer on the surface, and controlling the electrical potential of the surface.

    Abstract translation: 提供了在表面和衍生物品上形成图案化自组装单层的改进方法。 根据一种方法，弹性印模在使用印模期间和/或之前变形，以在表面上印刷自组装分子单层。 根据另一种方法，在单层印刷过程中，表面与与分子单层形成物质不混溶的液体接触，以实现单层在表面上的受控的反应性扩散。 提供了在非平面表面和衍生物上印刷自组装分子单层的方法，以及用自组装单层蚀刻表面的方法，包括蚀刻硅的方法。 提供包括柔性衍射光栅，反射镜和透镜的光学元件，以及使用光刻成型的用于形成光学器件和其它制品的方法。 提供了一种用于控制制品表面上的液体形状的方法，包括将液体施加到表面上的自组装单层，并控制表面的电位。

    RESILIENT, UNTETHERED SOFT ROBOT
    190.
    发明申请
    RESILIENT, UNTETHERED SOFT ROBOT 审中-公开
    灵活，未来的软机器人

    公开(公告)号：WO2016053430A3

    公开(公告)日：2016-07-07

    申请号：PCT/US2015038492

    申请日：2015-06-30

    Applicant: HARVARD COLLEGE

    Inventor： TOLLEY MICHAEL T ,  SHEPHERD ROBERT F ,  MOSADEGH BOBAK ,  WOOD ROBERT J ,  WHITESIDES GEORGE M

    IPC: B25J19/00 ,  B25J15/12 ,  B25J19/02 ,  B62D57/02 ,  F15B15/00

    CPC classification number: B62D57/02 ,  B25J9/142 ,  B25J18/06 ,  Y10S901/01 ,  Y10S901/09 ,  Y10S901/22 ,  Y10S901/27

    Abstract: A pneumatically powered, fully untethered mobile soft robot is described. Composites consisting of silicone elastomer, polyaramid fabric, and hollow glass microspheres were used to fabricate a sufficiently large soft robot to carry the miniature air compressors, battery, valves, and controller needed for autonomous operation. Fabrication techniques were developed to mold a 0.65 meter long soft body with modified Pneumatic network actuators capable of operating at the elevated pressures (up to 138 kPa) required to actuate the legs of the robot and hold payloads of up to 8 kg. The soft robot is safe to handle, and its silicone body is innately resilient to a variety of adverse environmental conditions including snow, puddles of water, direct (albeit limited) exposure to flames, and the crushing force of being run over by an automobile.

    Abstract translation: 描述了一种气动的，完全无捆绑的移动软机器人。 使用由有机硅弹性体，聚芳酰胺织物和中空玻璃微球组成的复合材料来制造足够大的软机器人，以携带自主操作所需的微型空气压缩机，电池，阀门和控制器。 开发了制造技术以模拟一个0.65米长的软体，其具有改进的气动网络致动器，其能够在致动机器人的腿并保持高达8kg的有效载荷所需的高压（高达138kPa）下操作。 柔软的机器人可以安全地处理，其硅树脂对各种不利的环境条件（包括雪，水面水，直接（尽管有限的）暴露于火焰中，以及被汽车运行的破碎力都具有弹性。

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