公开(公告)号：EP1100966A1

公开(公告)日：2001-05-23

申请号：EP99935853.4

申请日：1999-07-23

Applicant: Applied Spectral Imaging Ltd.

Inventor： McNAMARA, George ,  SOENKSEN, Dirk ,  CABIB, Dario ,  BUCKWALD, Robert

IPC: C12Q1/68

CPC classification number: G01J3/457 ,  G01J3/2823 ,  G01J2003/2866 ,  G01N33/5005 ,  G01N33/56966

Abstract: A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected such that a spectral component associated with each of the N stains is collectable.

公开(公告)号：EP0884580A1

公开(公告)日：1998-12-16

申请号：EP98102138.9

申请日：1998-02-07

Applicant: ALV-Laser Vertriebsgesellschaft mbH

Inventor： Peters, Rainer

IPC: G01N21/47 ,  G01N15/02

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/4406 ,  G01J3/457 ,  G01J2003/2866 ,  G01N21/474 ,  G01N21/645 ,  G01N2021/6484 ,  G02B6/04 ,  G02B6/4298

Abstract: Es wird ein Faserdetektor zur Detektion des Streulichtes oder des Fluoreszenzlichtes einer flüssigen Suspension beschrieben, der

eine einmodige oder mehrmodige optische Faser mit Gradientenindexlinse am Faserausgang zur Erzeugung paralleler Lichtstrahlen,
eine Sammellinse oder ein Sammellinsensystem zur Fokussierung der parallelen Lichstrahlen auf einem Punkt innerhalb der Suspension,
eine weitere einmodige oder mehrmodige, mit Gradientenindexlinse am Fasereingang versehene und mit einem Photodetektor verbundene optische Faser zur Detektion des zurückgestreuten und durch dieselbe Sammellinse oder dasselbe Sammellinsensystem parallelisierten Lichtes
enthält.

Abstract translation: 我们将描述一个纤维检测器，用于检测所述散射光或光的液体悬浮液的荧光，单模或具有在光纤输出平行光的产生渐变折射率透镜的多模光纤的光束会聚透镜或用于将所述平行光束聚焦到一个点上该悬浮液中的会聚透镜系统， 包含附加的单模或多模，在光纤输入端提供用梯度折射率透镜和由相同的聚光透镜或相同的会聚透镜系统的光连接到光检测器的光纤检测反向散射的和并行化。

公开(公告)号：EP0747680A3

公开(公告)日：1998-04-22

申请号：EP96303440.0

申请日：1996-05-15

Applicant: Santa Barbara Research Center

Inventor： Stannard, John E. ,  Peterson, Cathy M. ,  West, Roger A. ,  Walter, Geoffrey A.

IPC: G01J3/26 ,  G01J3/51

CPC classification number: G01J3/36 ,  G01J3/457

Abstract: A differential spectrometry system detects very narrow-band spectral features, while providing much higher optical transmittance and signal-to-noise ratios than prior optical-filter-based spectrometer systems. A plurality of light detectors (10a, 10b) detect light that falls within respective wide wavebands. The wide wavebands have overlapping and non-overlapping portions, one of which is the desired narrow waveband. The detector outputs are operated upon to produce an output signal (22) which includes substantially only the desired narrow waveband. In the preferred embodiment, the light detectors (10a, 10b) are implemented with a pair of optical detectors (30a, 30b) and respective optical interference filters (24a, 24b). The filters have substantially identical cut-off wavelengths (λ 2 ) and cut-on wavelengths that are shifted by Δλ with respect to each other (λ 1 and (λ 1 +Δλ), respectively). The detector outputs are differenced with an operational amplifier (33), so that detector signals resulting from spectral features common to both detectors (30a, 30b) are canceled. The remaining signal (36) varies according to the amount of light that falls between wavelength boundaries [λ 1 and (λ 1 +Δλ)]. A preferred method of fabricating the optical interference filters (24a, 24b) is also provided.

公开(公告)号：EP0822395A2

公开(公告)日：1998-02-04

申请号：EP97113097.6

申请日：1997-07-30

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： Schrof, Wolfgang, Dr. ,  Klingler, Jürgen, Dr. ,  Horn, Dieter, Dr.

IPC: G01J3/44

CPC classification number: G01J3/457 ,  G01J3/44 ,  G01J2003/2866

Abstract: In dem Verfahren und der Vorrichtung zur Bestimmung von Diffusionsparametern, Konzentration, Größe oder Strömungsverhalten von Partikeln in einer Probe, werden Anregungslicht einer Lichtquelle in die Probe geleitet, Raman-Streulicht aus einem Beobachtungsvolumen der Probe aufgefangen und einem Spektrographen zugeführt wird, wo es in Spektrallinien zerlegt wird, wobei die Intensität mindestens einer Spektrallinie mindestens 10 mal pro Sekunde mit jeweils einem Photodetektor gemessen wird, und aus den gemessenen Intensitätswerten für die jeweilige Spektrallinie durch eine Fluktuationsanalyse, vorzugsweise eine Autokorrelation oder eine Frequenzanalyse, Diffusionsparameter, Konzentration, Größe oder Strömungsverhalten der Partikel, denen die jeweilige Spektrallinie zuzuordnen ist, berechnet. Bei diesem Verfahren können auch Signale verschiedener Spektrallinien oder -banden oder Signale von Raman-Streulicht, quasielastisch gestreutem Licht und Fluoreszenzlicht miteinander korreliert werden.

Abstract translation: 该方法使用激光光源（1）来照射样品（10），同时检测拉曼散射光并通过栅格光谱仪（6）将其划分成其光谱线。 使用光电检测器（8）测量至少一个光谱线的强度至少10次，其中测量的强度值具有波动分析，自相关或频率分析。

公开(公告)号：US20230317867A1

公开(公告)日：2023-10-05

申请号：US18023435

申请日：2021-05-26

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tatsuo DOUGAKIUCHI ,  Akio ITO ,  Masahiro HITAKA ,  Tadataka EDAMURA

IPC: H01L31/0352 ,  H01L23/482 ,  H01L31/02 ,  H01L31/0232 ,  H01L31/0304 ,  G01J3/10 ,  G01J3/45 ,  G01J3/457

CPC classification number: H01L31/035236 ,  H01L23/4821 ,  H01L31/02005 ,  H01L31/02325 ,  H01L31/035281 ,  H01L31/03046 ,  G01J3/10 ,  G01J3/45 ,  G01J3/457 ,  G01J2003/102

Abstract: A photodetection module includes a photodetector and a fixing member. The photodetector includes a semiconductor substrate, a mesa portion, a first contact layer, a second contact layer, and a first electrode formed in a planar shape on a major surface of the semiconductor substrate, and electrically connected to one of the first contact layer and the second contact layer. The fixing member includes an insulating substrate, and a first wiring formed in a planar shape on a major surface of the insulating substrate. A recessed portion is formed in the major surface of the insulating substrate, and at least a part of the mesa portion is disposed inside the recessed portion. The first electrode is electrically connected to the first wiring in a state where the first electrode is in surface contact with the first wiring.

公开(公告)号：US20230255493A1

公开(公告)日：2023-08-17

申请号：US18134805

申请日：2023-04-14

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Elizabeth M.C. HILLMAN ,  Sean A. BURGESS

IPC: A61B5/00 ,  G01J3/28 ,  G01J3/42 ,  G01J3/457 ,  G02B23/24 ,  G02B26/10

CPC classification number: A61B5/0064 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/444 ,  A61B5/445 ,  G01J3/2889 ,  G01J3/42 ,  G01J3/457 ,  G02B23/2476 ,  G02B26/101 ,  A61B5/0088 ,  A61B2562/0238 ,  A61B2562/0242

Abstract: Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM).

公开(公告)号：US11656164B2

公开(公告)日：2023-05-23

申请号：US17329017

申请日：2021-05-24

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  Chen Li ,  Changqin Ding

IPC: G01N15/02 ,  G01J3/02 ,  G01J3/457

CPC classification number: G01N15/0211 ,  G01J3/0224 ,  G01J3/457 ,  G01N15/0227

Abstract: A method of obtaining a measurement signal representative of the particle size distributions in nanocrystal suspensions that includes a step of providing a first light beam along a first axis to a first micro-retarder array to generate polarization wavefront shaped light. The shaped light is applied to an objective configured to focus two orthogonally polarized components of the polarization wavefront shaped light to produce first and second axially offset foci along the first axis. A sample having particles in suspension is disposed in one foci to produce a measurement optical signal having phase and intensity values corresponding to at least some of the particles in suspension. The method also includes determining intensity and quantitative phase information as a function of time based on the optical signals.

公开(公告)号：US09958570B2

公开(公告)日：2018-05-01

申请号：US15022892

申请日：2013-12-10

Applicant: Halliburton Energy Services, Inc.

Inventor： Megan R. Pearl ,  William C. Pearl, Jr.

IPC: G01V8/12 ,  G01N33/22 ,  G01J3/42 ,  G01J3/457 ,  G01N21/31 ,  E21B49/08 ,  G01V9/00 ,  G01J3/12 ,  G01N21/35 ,  G01N21/39 ,  G01N21/85 ,  G01N33/28

CPC classification number: G01V8/12 ,  E21B49/08 ,  E21B2049/085 ,  G01J3/42 ,  G01J3/457 ,  G01J2003/1213 ,  G01N21/31 ,  G01N21/35 ,  G01N21/39 ,  G01N21/85 ,  G01N33/22 ,  G01N33/2823 ,  G01V9/005

Abstract: A method of analyzing a reservoir fluid comprising: providing an analyzer, wherein the analyzer is a molecular factor computational system; and determining at least one property of the reservoir fluid using the analyzer, wherein the step of determining comprises: causing or allowing energy to interact with the reservoir fluid; and detecting the interaction between the energy and the reservoir fluid.

公开(公告)号：US20180073926A1

公开(公告)日：2018-03-15

申请号：US15812049

申请日：2017-11-14

Applicant: OSAKA UNIVERSITY

Inventor： Tsuyoshi KONISHI ,  Takema SATOH ,  Tomotaka NAGASHIMA

IPC: G01J3/457 ,  G01J3/18 ,  G02B6/12 ,  G01J3/02 ,  G01J3/28

CPC classification number: G01J3/457 ,  G01J3/0297 ,  G01J3/18 ,  G01J3/2803 ,  G01J2003/1861 ,  G01J2003/2866 ,  G02B6/12

Abstract: A light wavelength measurement method of measuring a wavelength of target light includes: receiving target light on a second dispersion device that disperses the target light into a plurality of second beams which reach a plurality of positions corresponding to the wavelength of the target light; and measuring the wavelength of the target light, by using the plurality of the second beams as a vernier scale for measuring the wavelength of the target light within a wavelength range specified by a main scale.

公开(公告)号：US20170254702A1

公开(公告)日：2017-09-07

申请号：US15600026

申请日：2017-05-19

Applicant: Hand Held Products, Inc.

Inventor： Patrick Anthony Giordano ,  Steven J. Colavito ,  Timothy Good ,  Erik Van Horn ,  Sean Philip Kearney

IPC: G01J3/457

CPC classification number: G01J3/457 ,  G01J3/506 ,  G06K7/1095

Abstract: A system and method of determining if a surface contains print or is a screen of a device is provided. The method is comprised of the steps of: acquiring a spectral wavelength signature of the surface; comparing the spectral wavelength signature of the surface to RGB triple-peak emission spectra; scanning the surface with an image-based scanner in non-illumination mode based upon the spectral wavelength signature of the surface corresponding to the RGB triple-peak emission spectra, and scanning the surface with an image-based scanner in illumination mode based upon the spectral wavelength signature of the surface not corresponding to the RGB triple-peak emission spectra.