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181.
公开(公告)号:WO2010058314A1
公开(公告)日:2010-05-27
申请号:PCT/IB2009/054925
申请日:2009-11-05
Applicant: PFIZER INC. , DUPLANTIER, Allen Jacob , GAN, Xinmin , HU, Lain-Yen , LU, Jiemin , SHEEHAN, Susan Mary Kult
Inventor: DUPLANTIER, Allen Jacob , GAN, Xinmin , HU, Lain-Yen , LU, Jiemin , SHEEHAN, Susan Mary Kult
IPC: C07D201/00 , C07D215/06 , C07D215/18 , C07D261/00 , C07D277/60 , C07D307/77 , C07D333/00 , C07D401/04 , C07D231/00 , A61K31/34 , A61K31/381 , A61K31/407 , A61K31/4162 , A61K31/424 , A61K31/429
CPC classification number: A61K31/34 , A61K31/381 , A61K31/407 , A61K31/4162 , A61K31/424 , A61K31/429 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/4375 , C07D215/22 , C07D215/40 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
Abstract: This invention relates to known and novel hydroxyquinolin-2(1 H )-ones and derivatives thereof which are useful for the treatment of cognitive-related disorders and neuropathic pain disorders in a mammal, e.g., a human. The invention also relates to pharmaceutical compositions containing such compounds.
Abstract translation: 本发明涉及可用于治疗哺乳动物(例如人)中认知相关障碍和神经性疼痛病症的已知和新型羟基喹啉-2(1H)酮及其衍生物。 本发明还涉及含有这些化合物的药物组合物。
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公开(公告)号:WO9730028A3
公开(公告)日:1997-09-25
申请号:PCT/NL9700033
申请日:1997-02-05
Applicant: DSM NV , DU PONT , GUIT RUDOLF PHILIPPUS MARIA , FRENTZEN YVONNE HELENE
Inventor: GUIT RUDOLF PHILIPPUS MARIA , FRENTZEN YVONNE HELENE
IPC: C07D201/00 , C07D201/08 , C07D201/16 , C07D223/10
CPC classification number: C07D201/08 , C07D201/16
Abstract: Process to separate epsilon -caprolactam from an aqueous mixture containing epsilon -caprolactam and at least 0.5 wt.% oligomers, wherein the separation is performed by extraction using an organic extraction agent. The aqueous mixture may be obtained in a process to prepare epsilon -caprolactam starting from 6-aminocapronitrile or in a process to prepare epsilon -caprolactam starting from 6-aminocaproic acid. 00000
Abstract translation: 从含有ε-己内酰胺和至少0.5wt。%的低聚物的含水混合物中分离ε-己内酰胺的方法,其中通过使用有机萃取剂萃取进行分离。 水性混合物可以在从6-氨基己腈开始制备ε-己内酰胺或从6-氨基己酸开始制备ε-己内酰胺的方法中获得。 00000
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公开(公告)号:LU508484B1
公开(公告)日:2025-04-11
申请号:LU508484
申请日:2024-10-10
Applicant: UNIV ANHUI SCIENCE & TECH
Inventor: WANG BAOSHI , ZHAI LIGONG
IPC: F16M1/00 , C07D201/00 , H05K5/00
Abstract: The present invention discloses a bioreactor that uses microwave tubes to pretreat starch based raw materials input into a microwave reaction chamber, which is beneficial for opening the starch crystal structure during liquefaction and hydrolysis. After microwave pretreatment, the substrate raw materials enter an ultrasonic reaction chamber and are sprayed for liquefaction. Ultrasonic radiation is used in combination with heating, mixing, and stirring to destroy enzyme activity, which is beneficial for enzyme activity activation and hydrolysis. The characteristic of using ultrasonic radiation for auxiliary modification of starch is high reaction efficiency and strong performance.
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184.
公开(公告)号:LU508275B1
公开(公告)日:2025-03-25
申请号:LU508275
申请日:2024-09-14
Applicant: XU HONGYAN
Inventor: XU HONGYAN
IPC: F16M1/00 , C07D201/00 , H05K5/00
Abstract: A ceramic overglaze binder and a painting method for splashing and carving ceramic overglaze solve the problems that splashed overglaze new color is unstable, the explosive nature of the oil-based pigments is difficult to control, textures are unclear and the drying of the pigments is slow; the invention allows for the rapid achievement of complex and stable textures while ensuring that the pigments dry quickly, providing favorable conditions for ceramic overglaze creation; in addition, the invention combines splashing with carving, it enables the creation of clear, varied, and complex texture effects with large areas of pigments, and allows the carving needle pen to be used freely to carve images on the porcelain surface, opening up new aesthetic areas and decorative forms in ceramic art.
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公开(公告)号:MX382671B
公开(公告)日:2025-03-13
申请号:MX2018007022
申请日:2018-06-08
Applicant: PTC THERAPEUTICS INC
Inventor: BHATTACHARYYA ANURADHA , JANI MINAKSHI , SYDORENKO NADIYA , HWANG SEONGWOO , BABU SURESH , MOON YOUNG- CHOON
IPC: A61K31/506 , A61K33/00 , A61P25/00 , C07D201/00 , C07D237/20 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/10 , C07D487/10
Abstract: La presente descripción se relaciona con compuestos, formas, y composiciones farmacéuticas de los mismos y los métodos para utilizar ESTOS compuestos, formas, o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington. En particular, la presente descripción se relaciona con compuestos de heteroarilo monocíclico sustituido de la Fórmula (I), las formas y composiciones farmacéuticas de los mismos y los métodos para utilizar estos compuestos, formas, o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington.
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186.
公开(公告)号:LU507970B1
公开(公告)日:2025-02-10
申请号:LU507970
申请日:2024-08-09
Applicant: UNIV YANAN
Inventor: BAI WANQIAO
IPC: C07F1/00 , C07D201/00 , C09K9/00
Abstract: The present invention relates to the field of organic and analytical chemistry. To address issues of low selectivity, low sensitivity, and high cost in detecting different types of VOCs using existing technologies, this invention proposes an R6G@UiO-66-NH-CO-COOH fluorescent molecular probe, its preparation method, and its application. UiO-66-NH2 is prepared using ZrCl4, BDC-NH2, and DMF as raw materials. UiO-66-NH2 is then added to THF and TEA to obtain UiO-66-NH-CO-COOH. Finally, UiO-66-NH-CO-COOH powder is mixed with R6G, stirred, centrifuged, and dried to obtain R6G@UiO-66-NH- CO-COOH powder, which is the R6G@UiO-66-NH-CO-COOH fluorescent molecular probe. This is used to construct a ratiometric fluorescence sensor for detecting amine VOCs. The ratiometric fluorescence sensor constructed in this invention exhibits good selectivity for amine volatile organic compounds and can be used for detecting organic pollutants in the environment or indoor air.
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公开(公告)号:ES2929058T3
公开(公告)日:2022-11-24
申请号:ES16822054
申请日:2016-07-08
Applicant: WASHINGTON UNIVERSITY ST LOUIS , UNIV NOTRE DAME DU LAC
Inventor: DANTAS GAUTAM , GONZALES PATRICK , FORSBERG KEVIN , PESESKY MITCHELL , CHANG MAYLAND , MOBASHERY SHAHRIAR
IPC: A61K31/546 , A61K31/407 , A61K31/424 , A61K31/43 , A61K31/431 , A61K31/496 , A61K45/06 , A61P31/04 , C07D201/00 , C07D477/12
Abstract: La presente descripción abarca composiciones antibacterianas y métodos para tratar infecciones bacterianas provocadas por bacterias resistentes. (Traducción automática con Google Translate, sin valor legal)
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188.
公开(公告)号:AU2020358970A1
公开(公告)日:2022-04-14
申请号:AU2020358970
申请日:2020-10-02
Applicant: STEALTH BIOTHERAPEUTICS INC
Inventor: KEEFE DENNIS , ZHENG GUOZHU , ARSENJANS PAVELS
IPC: C07F7/08 , C07C50/28 , C07D201/00
Abstract: The disclosure provides therapeutic compositions (
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公开(公告)号:AU2018311307B9
公开(公告)日:2021-09-09
申请号:AU2018311307
申请日:2018-07-31
Applicant: SMALL PHARMA LTD
Inventor: PEARSON DAVID , SHARP LORRAINE , ARMSTRONG ALAN , MYERSON RICHARD , HULL JONATHAN , BLANEY PAUL , RANDS PETER , LAYZELL MARIE , JOEL ZELAH
IPC: C07D201/00 , A61K31/135 , A61P25/24
Abstract: The present invention provides novel, stable, processable and pharmaceutically acceptable salt forms of 2R,6R-hydroxynorketamineor 2S,6S-hydroxynorketamine with high aqueous solubility.
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公开(公告)号:AU2018311307B2
公开(公告)日:2021-08-12
申请号:AU2018311307
申请日:2018-07-31
Applicant: SMALL PHARMA LTD
Inventor: PEARSON DAVID , SHARP LORRAINE , ARMSTRONG ALAN , MYERSON RICHARD , HULL JONATHAN , BLANEY PAUL , RANDS PETER , LAYZELL MARIE , JOEL ZELAH
IPC: C07D201/00 , A61K31/135 , A61P25/24
Abstract: The present invention provides novel, stable, processable and pharmaceutically acceptable salt forms of 2R,6R-hydroxynorketamineor 2S,6S-hydroxynorketamine with high aqueous solubility.
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