公开(公告)号：WO2003058214A1

公开(公告)日：2003-07-17

申请号：PCT/DK2002/000839

申请日：2002-12-11

Applicant: FOSS ELECTRIC A/S ,  HANSEN, Per, Waaben

Inventor： HANSEN, Per, Waaben

IPC: G01N21/27

CPC classification number: G01N21/278 ,  G01N21/274 ,  G01N23/06 ,  G01N33/12

Abstract: The invention relates to measuring instruments, preferably of the kind measuring absorbances, in an object, of electromagnetic radiation in at least two spectral ranges, such as IR instruments, and DXR, meaning Dual X-ray instruments, and more specifically to the determination of properties of food or feed, such as the fat content in milk or meat. The invention relates in particular to a method of providing a correction for a slave instrument of the kind measuring properties of an object by exposing the object to electromagnetic radiation, in particular X-rays, in at least two spectral ranges and obtaining one or more object responses thereto. The responses obtained being preferably based on detecting attenuation and/or reflection and/or scatter of the electromagnetic radiation in/from the object by use of one or more detectors and are obtained in a form where they express properties of the object either directly or via a transformation.

Abstract translation: 本发明涉及在至少两个光谱范围内的电磁辐射（例如IR仪器）和DXR（即双X射线仪器）中的测量仪器，优选类似于测量吸光度的测量仪器，更具体地涉及测定 食物或饲料的性质，如牛奶或肉类中的脂肪含量。 本发明特别涉及通过在至少两个光谱范围内将物体暴露于电磁辐射特别是X射线来提供物体的种类测量属性的从属仪器的校正的方法，并获得一个或多个物体 回应。 获得的响应优选地基于通过使用一个或多个检测器来检测物体中的/从物体的电磁辐射的衰减和/或反射和/或散射，并且以其直接或经由 转型。

公开(公告)号：WO1994028163A1

公开(公告)日：1994-12-08

申请号：PCT/DK1994000211

申请日：1994-05-31

Applicant: FOSS ELECTRIC A/S ,  GLENSBJERG, Martin ,  HANSEN, Flemming

Inventor： FOSS ELECTRIC A/S

IPC: C12Q01/10

CPC classification number: G01N33/56916 ,  C12Q1/10 ,  G01N2333/255

Abstract: The invention provides methods for the rapid determination/detection of Salmonella in samples from sources such as processed and raw foods and feeds, the environment, body fluids and biopsies, etc. The methods comprise an enrichment step and a determination step. The enrichment procedure involves selective conditions, notably the use of the selective substances tetrathionate and/or novobiocin or an increase in culturing temperature to 39-43 DEG C, favouring the early detection of Salmonella. The selective conditions are instituted as early as possible in the enrichment, thereby allowing an early determination of high specificity and sensitivity. The determination involves a variety of assays which are all different from traditional agar plating techniques. Also provided are special enrichment procedures for Salmonella in processed products, i.e. products which have been heat-treated, dried, cured, acidified etc.. In general, determination/detection of Salmonella can be performed within 24 hours from the institution of enrichment.

Abstract translation: 本发明提供了用于快速测定/检测来自诸如加工和生食物和饲料，环境，体液和活组织检查等来源的样品中的沙门氏菌的方法。该方法包括富集步骤和确定步骤。 富集程序涉及选择性条件，特别是使用选择性物质四硫酸盐和/或新生霉素，或将培养温度升高至39-43℃，有利于早期检测沙门氏菌。 选择性条件是尽早在浓缩中提出的，从而允许早期确定高特异性和灵敏度。 测定涉及各种不同于传统琼脂电镀技术的测定。 还提供了加工产品中沙门氏菌的特殊富集程序，即经过热处理，干燥，固化，酸化等的产品。一般来说，确定/检测沙门氏菌可以在浓缩体系的24小时内进行。

公开(公告)号：EP0808450B1

公开(公告)日：2000-05-10

申请号：EP96901731.8

申请日：1996-02-09

Applicant: Foss Electric A/S

Inventor： VILLEMOES, Andersen, Hans ,  KJAER, Lisa ,  WAABEN, Hansen, Per ,  RIDDER, Carsten

IPC: G01N21/27

CPC classification number: G01J3/28 ,  G01J3/45 ,  G01N21/274

公开(公告)号：EP1031022A1

公开(公告)日：2000-08-30

申请号：EP98951293.4

申请日：1998-10-30

Applicant: Foss Electric A/S

Inventor： THOMSEN, Henrik ,  GR SKOV, Henning

IPC: G01N21/03

CPC classification number: G01N21/0303 ,  G01N21/05 ,  G01N21/359 ,  G01N33/04 ,  G01N33/18 ,  G01N2021/0346 ,  G01N2021/0378

Abstract: A cuvette for a spectrometric analysis instrument has two opposing windows (73, 76) made of a material, which is transparent to the light of the waveband used for the analysis. The windows define a limited light path of a light beam passing through a cavity inside the cuvette. When using cuvettes having windows of a material, such as diamond, having a refractive index considerably different from the fluid to be analysed, the window surfaces forming the cuvette cavity should not be parallel, thereby ensuring that the internal distances between opposed areas of the window surfaces will vary across the transparent windows. Thereby any internal reflections within the cavity will add in almost random phase, avoiding any tendency to resonance. This is very advantageous when the instrument is a member of a plurality of instruments, which must be standardised in order to be able to provide uniform calibrations for said plurality of instruments.

公开(公告)号：EP1017989A1

公开(公告)日：2000-07-12

申请号：EP98942513.7

申请日：1998-09-14

Applicant: Foss Electric A/S

Inventor： NYGAARD, Lars

IPC: G01N15/14

CPC classification number: G01N15/1012

Abstract: A method for correcting the settings of a flow cytometer, designed for fast sample handling and counting, allowing about 500 samples per hour to be counted. The couting is based on the provision of data representing a PHA diagram (Pulse Height Analysis) of registered pulses, each indicating a passed cell or particle. To check the settings the user measures a standard sample of uniform microbeads (161) on the flow cytometer, and insert information on a disk (162) in a computer arranged to process the measurement data and to calculate: a plurality of particle counts on the same sample, a mean count, a standard deviation (s) and/or Coefficient of Variation (CV), a signal mean value (SM), a signal width (width of the bell-curve in the PHA-diagram). The parameters are compared to preset limits (165, 166, 167, 168) and the PHAS curve is compared to an ideal curve PHA0. A user help program for adjusting the flow cytometer is arranged to display typical symptoms on a computer screen, to indicate the possible defects and to recommend actions to remedy the problems, based on information in a library stored in the computer. Thereby a visit by a service engineer can often be avoided.

公开(公告)号：EP0605662B1

公开(公告)日：1998-06-10

申请号：EP93906314.5

申请日：1992-09-25

Applicant: Foss Electric A/S

Inventor： SJAUNJA, Lars-Ove ,  ANDERSEN, Steen, Kjaer ,  ARNVIDARSON, Börkur ,  BREMS, Niels ,  LAPP, Torben ,  NYGAARD, Lars

IPC: G01N21/35

CPC classification number: G01N33/06 ,  G01N21/3577 ,  G01N33/04 ,  G01N2021/3595 ,  Y10S250/91

Abstract: An infrared attenuation measuring system for the quantitative determination of the concentration of one or more components in an aqueous fat-containing sample, such as milk, by an infrared attenuation technique, the system comprising infrared attenuation measuring means for measuring the infrared attenuation of the sample in a number of wavebands and calculating means which are adapted to calculate the concentrations of the components of the fat-containing sample from the measured infrared attenuation values of the sample using a set of waveband-related parameters, the parameter set containing information enabling the calculating means to ensure that the calculated concentrations are substantially independent on the degree of homogenization of the fat-containing sample, and/or to determine the degree of homogenization (or the mean diameter of the fat globules) of the sample.

公开(公告)号：EP0808450A1

公开(公告)日：1997-11-26

申请号：EP96901731.0

申请日：1996-02-09

Applicant: Foss Electric A/S

Inventor： VILLEMOES, Andersen, Hans ,  KJAER, Lisa ,  WAABEN, Hansen, Per ,  RIDDER, Carsten

IPC: G01J3 ,  G01N21

CPC classification number: G01J3/28 ,  G01J3/45 ,  G01N21/274

Abstract: A method for standardizing a spectrometer generating an optical spectrum from a sample, comprising generating at least one optical spectrum from at least one standardization sample each having a chemical composition resulting in the optical spectrum showing a characteristic pattern in a predetermined frequency range, comparing information relating to the pattern(s) to corresponding information relating to at least one reference pattern previously defined as the desired standard response from the at least one standardization sample, determining, based on the comparison, standardizing parameters describing the transition of the pattern(s) of the generated spectrum or spectra to the reference pattern(s) and storing said standardizing parameters in the spectrometer or a computer connected thereto, so that the spectrometer, when presented to an unknown sample, will, using the standardization parameters, generate an optical spectrum substantially identical to that which would be generated in a corresponding spectrometer standardized with a sample of the same chemical composition using the same previously defined reference pattern(s). The present method relates to standardization of the instrument to a well-defined state into which any number of instruments may be brought. In this state, calibrations may be transferred freely from instrument to instrument.

公开(公告)号：EP0701624B1

公开(公告)日：1997-08-27

申请号：EP94917572.3

申请日：1994-05-31

Applicant: Foss Electric A/S

Inventor： GLENSBJERG, Martin ,  HANSEN, Flemming

IPC: C12Q1/10 ,  G01N33/569 ,  C12Q1/68

CPC classification number: G01N33/56916 ,  C12Q1/10 ,  G01N2333/255

Abstract: The invention provides methods for the rapid determination/detection of Salmonella in samples from sources such as processed and raw foods and feeds, the environment, body fluids and biopsies, etc. The methods comprise an enrichment step and a determination step. The enrichment procedure involves selective conditions, notably the use of the selective substances tetrathionate and/or novobiocin or an increase in culturing temperature to 39-43 °C, favouring the early detection of Salmonella. The selective conditions are instituted as early as possible in the enrichment, thereby allowing an early determination of high specificity and sensitivity. The determination involves a variety of assays which are all different from traditional agar plating techniques. Also provided are special enrichment procedures for Salmonella in processed products, i.e. products which have been heat-treated, dried, cured, acidified etc.. In general, determination/detection of Salmonella can be performed within 24 hours from the institution of enrichment.

公开(公告)号：EP0629290B1

公开(公告)日：1996-01-10

申请号：EP93908832.4

申请日：1993-03-25

Applicant: Foss Electric A/S

Inventor： NYGAARD, Lars ,  LAPP, Torben ,  ARNVIDARSON, Börkur

IPC: G01N33/04

CPC classification number: G01N33/04 ,  G01N21/3577 ,  G01N2201/129 ,  Y10S250/91

Abstract: A method for determining, with an accuracy better than 0.007 %, expressed as Standard Error of Prediction, the concentration of urea in a concentration range of 0-0.1 % in a milk sample containing at least 1 % fat, at least 1 % dissolved lactose, and at least 1 % protein, by an infrared absorption measuring technique, comprising: (a) determining absorption in an infrared radiation waveband from 1000 cm-1 (10.0 um) to 4000 cm-1 (2.50 um) of the milk sample, wherein at least one determination is made in a waveband from 1000 cm-1 (10.0 um) to 1800 cm-1 (5.56 um), in which urea absorbs, at least one determination being made in a waveband in which fat absorbs, at least one determination being made in a waveband where lactose absorbs, and at least one determination being made in a waveband where protein absorbs; (b) determining, on the basis of the absorption determinations and predetermined parameters established by multivariate calibration, a contribution from fat, lactose, and protein in the waveband where urea absorbs, and (c) quantitatively assessing the concentration of urea in the sample on the basis of the absorption in the waveband where urea absorbs and on the basis of the determined contribution from fat, lactose, and protein in the waveband.

公开(公告)号：EP0646245A1

公开(公告)日：1995-04-05

申请号：EP93912680.0

申请日：1993-06-03

Applicant: Foss Electric A/S

Inventor： JORGENSEN, Henry ,  NIELSEN, Axel, Gronlund ,  ANDERSEN, Soren, Vindahl ,  DALSGAARD, Jorgen ,  SIE, Gunner ,  HANSEN, Flemming

IPC: B01L3 ,  G01N35

CPC classification number: B01L3/5082 ,  G01N35/0098 ,  G01N35/025 ,  G01N35/1002 ,  G01N35/1072 ,  G01N2035/00524 ,  G01N2035/0484 ,  G01N2035/102 ,  G01N2035/1076 ,  G01N2035/1086 ,  G01N2035/1088

Abstract: An apparatus for performing unit operations involving the handling of liquid samples comprises a number of sample containers (32), each having a portion in which a liquid sample can be contained, as well as means (38) for adding liquid to the sample containers and means (40) for removing liquid from the sample containers. When oscillatingly moving the holding means (28) holding the sample containers, some of the samples may be stirred by agitating their containers, while the samples in the remaining sample containers are not stirred to any substantial degree due to the sample containing part of these containers not being agitated to any substantial degree. The oscillating movement preferably takes place at different velocities in the two directions. High precision is obtained when dosing an amount of liquid from a pipette (38) when the pipette is given an upward acceleration at the end of a pipetting procedure so as to release from the pipette tip any part of any liquid drop in excess of an amount determined by the upward acceleration. Low carry-over due to flushing of and removal of liquid from a number of sample containers using the same suction pipette (40) is obtained using suction pipette means for sucking the liquid from the containers in combination with flushing liquid supply means (40) adapted to supply flushing liquid through an outer surface part (214) of the suction pipette means. Furthermore, a suitable pipette holding (36) and moving (422) means is disclosed for holding a plurality of pipettes and for moving any one of these to a position in which the pipette is capable of dosing liquid to a container or removing liquid from a container.

Abstract translation: 用于执行涉及处理液体样本的单元操作的设备包括多个样本容器（32），每个样本容器具有其中可容纳液体样本的部分以及用于将液体添加到样本容器的装置（38），以及 用于从样品容器中去除液体的装置（40）。 当摆动保持样品容器的保持装置（28）时，一些样品可以通过搅拌它们的容器来搅拌，而其余样品容器中的样品由于含有这些容器的一部分的样品而不会在很大程度上被搅拌 没有被激怒到任何实质性的程度。 摆动优选在两个方向上以不同的速度进行。 当移液器在移液过程结束时被给予向上加速度时，当从移液管（38）中定量供给一定量的液体时获得高精度，以便从移液管尖端释放超过任何液滴量的任何部分 由向上加速度决定。 使用用于从容器中抽吸液体的抽吸移液器装置与适合的冲洗液体供应装置（40）相结合，获得了由于使用相同的抽吸移液管（40）冲洗和从多个样品容器移除液体而导致的低携带 以通过吸管装置的外表面部分（214）供应冲洗液体。 此外，公开了一种合适的移液管夹持装置（36）和移动装置（422），用于夹持多个移液管并将这些移液管中的任何一个移动到移液管能够将液体定量给容器或从移液器移除液体的位置 容器。