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    BIOSYNTHETIC CARTILAGINOUS MATRIX AND METHODS FOR THEIR PRODUCTION
    12.
    发明公开
    BIOSYNTHETIC CARTILAGINOUS MATRIX AND METHODS FOR THEIR PRODUCTION 审中-公开
    VERFAHREN ZU IHRER HERSTELLUNG的BIOSYNTHETISCHE KNORPELMATRIX

    公开(公告)号：EP2259806A1

    公开(公告)日：2010-12-15

    申请号：EP09714829.0

    申请日：2009-03-02

    Applicant: Coloplast A/S ,  Interface Biotech A/S

    Inventor： EVERLAND, Hanne ,  SAMUELSEN, Peter ,  VANGE, Jakob ,  CLAUSEN, Christian

    IPC: A61L27/38 ,  A61L27/54 ,  A61L27/58

    CPC classification number: A61L27/58 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/414

    Abstract: An isolated, acellular biosynthetic cartilaginous matrix substantially devoid of synthetic biodegradable scaffold structure is provided. Through a method with the steps of a) contacting
    in vitro a population of chondrogenic cells with a synthetic biodegradable scaffold; b) culturing
    in vitro for a period of time said chondrogenic cells within said synthetic biodegradable scaffold so that the chondrogenic cells produce a biosynthetic cartilaginous matrix; c) substantially removing any antigen derived from said chondrogenic cells a matrix suitable of implantation into a living individual mammal, such as a human being is obtained.

    Abstract translation: 提供了一种基本上没有合成可生物降解的脚手架结构的分离的，无细胞的生物合成软骨基质。 通过以下步骤的方法：a）将体细胞群体的软骨细胞与合成的可生物降解的支架接触; b）在体外培养所述合成可生物降解的支架内所述软骨形成细胞的一段时间，使得软骨形成细胞产生生物合成软骨基质; c）基本上除去源自所述软骨形成细胞的任何抗原，获得适合植入活体个体哺乳动物（例如人）的基质。

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