公开(公告)号：WO2007028169A2

公开(公告)日：2007-03-08

申请号：PCT/US2006/034673

申请日：2006-09-05

Applicant: INTERFACE BIOTECH A/S ,  EVERLAND, Hanne ,  CLAUSEN, Christian ,  OSTHER, Kurt

Inventor： EVERLAND, Hanne ,  CLAUSEN, Christian ,  OSTHER, Kurt

IPC: A61K35/12

CPC classification number: A61K38/4833 ,  A61K35/32 ,  A61K38/363 ,  A61L27/3843 ,  A61K2300/00

Abstract: The present invention provides for a method for tissue engineering by cell implantation that involves the use of a scaffold in situ at the site of a defect, where the therapeutic cells are fixed in place into the scaffold only once the scaffold is inserted at the site of the tissue defect, thereby locking not only the cells to the scaffold, but also the scaffold to the tissue defect. The invention also provides a kit of parts suitable for performing the method of the invention.

Abstract translation: 本发明提供了一种通过细胞移植进行组织工程的方法，该方法涉及在缺损部位的原位使用支架，其中一旦将支架插入到位于 组织缺陷，从而不仅将细胞锁定到支架，而且将支架锁定到组织缺损。 本发明还提供适用于执行本发明方法的一组零件。

公开(公告)号：WO2009106642A1

公开(公告)日：2009-09-03

申请号：PCT/EP2009/052432

申请日：2009-03-02

Applicant: COLOPLAST A/S ,  EVERLAND, Hanne ,  SAMUELSEN, Peter ,  VANGE, Jakob ,  CLAUSEN, Christian ,  INTERFACE BIOTECH A/S

Inventor： EVERLAND, Hanne ,  SAMUELSEN, Peter ,  VANGE, Jakob ,  CLAUSEN, Christian

IPC: A61L27/38 ,  A61L27/54 ,  A61L27/58

CPC classification number: A61L27/58 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/414

Abstract: An isolated, acellular biosynthetic cartilaginous matrix substantially devoid of synthetic biodegradable scaffold structure is provided. Through a method with the steps of a) contacting in vitro a population of chondrogenic cells with a synthetic biodegradable scaffold; b) culturing in vitro for a period of time said chondrogenic cells within said synthetic biodegradable scaffold so that the chondrogenic cells produce a biosynthetic cartilaginous matrix; c) substantially removing any antigen derived from said chondrogenic cells a matrix suitable of implantation into a living individual mammal, such as a human being is obtained.

Abstract translation: 提供了一种基本上没有合成可生物降解的脚手架结构的分离的，无细胞的生物合成软骨基质。 通过以下步骤的方法：a）将体细胞群体的软骨细胞与合成的生物可降解支架接触; b）在体外培养所述合成可生物降解的支架内的所述软骨形成细胞的一段时间，使得软骨形成细胞产生生物合成的软骨基质; c）基本上除去源自所述软骨形成细胞的任何抗原，获得适合植入活体个体哺乳动物（例如人）的基质。

公开(公告)号：EP2259806A1

公开(公告)日：2010-12-15

申请号：EP09714829.0

申请日：2009-03-02

Applicant: Coloplast A/S ,  Interface Biotech A/S

Inventor： EVERLAND, Hanne ,  SAMUELSEN, Peter ,  VANGE, Jakob ,  CLAUSEN, Christian

IPC: A61L27/38 ,  A61L27/54 ,  A61L27/58

CPC classification number: A61L27/58 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/414

Abstract: An isolated, acellular biosynthetic cartilaginous matrix substantially devoid of synthetic biodegradable scaffold structure is provided. Through a method with the steps of a) contacting
in vitro a population of chondrogenic cells with a synthetic biodegradable scaffold; b) culturing
in vitro for a period of time said chondrogenic cells within said synthetic biodegradable scaffold so that the chondrogenic cells produce a biosynthetic cartilaginous matrix; c) substantially removing any antigen derived from said chondrogenic cells a matrix suitable of implantation into a living individual mammal, such as a human being is obtained.

Abstract translation: 提供了一种基本上没有合成可生物降解的脚手架结构的分离的，无细胞的生物合成软骨基质。 通过以下步骤的方法：a）将体细胞群体的软骨细胞与合成的可生物降解的支架接触; b）在体外培养所述合成可生物降解的支架内所述软骨形成细胞的一段时间，使得软骨形成细胞产生生物合成软骨基质; c）基本上除去源自所述软骨形成细胞的任何抗原，获得适合植入活体个体哺乳动物（例如人）的基质。

公开(公告)号：EP1924146A2

公开(公告)日：2008-05-28

申请号：EP06824898.8

申请日：2006-09-05

Applicant: Interface Biotech A/S

Inventor： EVERLAND, Hanne ,  CLAUSEN, Christian ,  OSTHER, Kurt

IPC: A01N63/00 ,  A61F2/00 ,  A61F2/02 ,  A61K45/00

CPC classification number: A61K38/4833 ,  A61K35/32 ,  A61K38/363 ,  A61L27/3843 ,  A61K2300/00

Abstract: The present invention provides for a method for tissue engineering by cell implantation that involves the use of a scaffold in situ at the site of a defect, where the therapeutic cells are fixed in place into the scaffold only once the scaffold is inserted at the site of the tissue defect, thereby locking not only the cells to the scaffold, but also the scaffold to the tissue defect. The invention also provides a kit of parts suitable for performing the method of the invention.