公开(公告)号：WO2006038923A3

公开(公告)日：2006-06-01

申请号：PCT/US2005021436

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES CO ,  NIWAS SHRI ,  MERRILL BRYON A ,  HEPPNER PHILIP D ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  AMOS DAVID T ,  LINDSTROM KYLE J

Inventor： NIWAS SHRI ,  MERRILL BRYON A ,  HEPPNER PHILIP D ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  AMOS DAVID T ,  LINDSTROM KYLE J

IPC: A61K31/44 ,  C07D471/04 ,  C07D471/06

CPC classification number: C07D471/14

Abstract: Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 公开了用芳基取代基取代的咪唑并萘啶环系统，含有该化合物的药物组合物，以及将这些化合物用作免疫调节剂的方法，用于在动物中诱导细胞因子生物合成以及治疗疾病，包括病毒和肿瘤疾病。

公开(公告)号：WO2006038923A2

公开(公告)日：2006-04-13

申请号：PCT/US2005/021436

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  NIWAS, Shri ,  MERRILL, Bryon, A. ,  HEPPNER, Philip, D. ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  LINDSTROM, Kyle, J.

Inventor： NIWAS, Shri ,  MERRILL, Bryon, A. ,  HEPPNER, Philip, D. ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  LINDSTROM, Kyle, J.

IPC: A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/14

Abstract: Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 公开了用芳基取代基取代的咪唑并萘啶环体系，含有这些化合物的药物组合物，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005048945A2

公开(公告)日：2005-06-02

申请号：PCT/US2004/038033

申请日：2004-11-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  DELLARIA, Joseph, F., Jr. ,  ZIMMERMANN, Bernhard, M. ,  HEPPNER, Philip, D.

Inventor： KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  DELLARIA, Joseph, F., Jr. ,  ZIMMERMANN, Bernhard, M. ,  HEPPNER, Philip, D.

IPC: A61K

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6, 7, 8, 9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在2-位具有羟胺取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有化合物的药物组合物，中间体以及这些化合物作为免疫调节剂的使用方法 ，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2006107771A3

公开(公告)日：2007-10-04

申请号：PCT/US2006012031

申请日：2006-03-31

Applicant: COLEY PHARM GROUP INC ,  MERRILL BRYON A ,  DANIELSON MICHAEL E ,  HAYS DAVID S ,  AMOS DAVID T ,  HEPPNER PHILIP D ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  MOSER WILLIAM H

Inventor： MERRILL BRYON A ,  DANIELSON MICHAEL E ,  HAYS DAVID S ,  AMOS DAVID T ,  HEPPNER PHILIP D ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  MOSER WILLIAM H

IPC: C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Pyrazolo[3,4-c]quinolines, pyrazolo[4,5-c]naphthyridines, and analogs thereof, eg., 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inhibiting cytokine biosynthesis in animals and in the therapeutic or prophylactic treatment of diseases by inhibiting cytokine biosynthesis are disclosed.

Abstract translation: 吡唑并[3,4-c]喹啉，吡唑并[4,5-c]萘啶及其类似物，例如6,7,8,9-四氢吡唑并[3,4-c]喹啉，以及药物组合物 公开了含有化合物，中间体，制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于抑制动物中的细胞因子生物合成以及通过抑制细胞因子生物合成来治疗或预防性治疗疾病。

公开(公告)号：WO2006086634A3

公开(公告)日：2007-08-09

申请号：PCT/US2006004737

申请日：2006-02-10

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  DELLARIA JOSEPH F JR ,  RADMER MATTHEW R ,  ZIMMERMANN BERNHARD M

Inventor： KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  DELLARIA JOSEPH F JR ,  RADMER MATTHEW R ,  ZIMMERMANN BERNHARD M

IPC: C07D471/04 ,  A61K31/15 ,  A61K31/437 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo[4,5-c] ring compounds, (e.g. imidazo[4,5-c]pyridines, imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydro imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridine, and 6,7,8,9-tetrahydro imidazo[4,5-c]naphthyridine compounds) having an oxime or hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]吡啶，咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c] 喹啉，咪唑并[4,5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶化合物），其中2-位具有肟或羟胺取代基，药物组合物含有化合物 ，中间体和制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2006107853A3

公开(公告)日：2006-10-12

申请号：PCT/US2006/012265

申请日：2006-03-31

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  HAYS, David, S. ,  NIWAS, Shri ,  LUNDQUIST, Gregory, D., Jr.

Inventor： HAYS, David, S. ,  NIWAS, Shri ,  LUNDQUIST, Gregory, D., Jr.

IPC: C07D471/04 ,  C07D487/04 ,  A61K31/437

Abstract: Pyrazolopyridine-1,4-diamines and analogs thereof, e.g., pyrazolo[3,4- c ]pyridine-1,4-diamines, pyrazolo[3,4- c ]quinoline-1,4-diamines, 6,7,8,9-tetrahydro pyrazolo[3,4- c ]quinoline-1,4-diamines, and pyrazolo[3,4- c ]naphthyridine-1,4-diamines, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

公开(公告)号：WO2006107853A2

公开(公告)日：2006-10-12

申请号：PCT/US2006012265

申请日：2006-03-31

Applicant: 3M INNOVATIVE PROPERTIES CO ,  HAYS DAVID S ,  NIWAS SHRI ,  LUNDQUIST GREGORY D JR

Inventor： HAYS DAVID S ,  NIWAS SHRI ,  LUNDQUIST GREGORY D JR

IPC: A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: Pyrazolopyridine-1,4-diamines and analogs thereof, e.g., pyrazolo[3,4-c]pyridine-1,4-diamines, pyrazolo[3,4-c]quinoline-1,4-diamines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinoline-1,4-diamines, and pyrazolo[3,4-c]naphthyridine-1,4-diamines, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 吡唑并吡喃-1,4-二胺及其类似物，例如吡唑并[3,4-c]吡啶-1,4-二胺，吡唑并[3,4-c]喹啉-1,4-二胺，6,7,8 ，9-四氢吡唑并[3,4-c]喹啉-1,4-二胺和吡唑并[3,4-c]萘啶-1,4-二胺，含有这些化合物的药物组合物，中间体，制备这些化合物的方法 以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病的方法。

公开(公告)号：WO2006093514A2

公开(公告)日：2006-09-08

申请号：PCT/US2005/021334

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  PRINCE, Ryan B., ,  MERRILL, Bryon A., ,  KSHIRSAGAR, Tushar A., ,  HEPPNER, Philip D., ,  LUNDQUIST, Gregory D., Jr.

Inventor： PRINCE, Ryan B., ,  MERRILL, Bryon A., ,  KSHIRSAGAR, Tushar A., ,  HEPPNER, Philip D., ,  LUNDQUIST, Gregory D., Jr.

IPC: A61K31/4745 ,  C07D498/02

CPC classification number: C07D513/04

Abstract: Thiazoloquinoline and thiazolonaphthyridine compounds having an aryl or arylalkylenyl substituent at the 6-, 7-, 8-, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals 10 and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在6-，7-，8-或9-位具有芳基或芳基亚烷基取代基的噻唑并喹啉和噻唑并吡啶化合物，其含有化合物，中间体和制备方法以及这些化合物作为免疫调节剂的使用方法，用于调节 公开了动物10中的细胞因子生物合成和包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：WO2005048945A3

公开(公告)日：2006-03-23

申请号：PCT/US2004038033

申请日：2004-11-12

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  ZIMMERMANN BERNHARD M ,  HEPPNER PHILIP D

Inventor： KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  AMOS DAVID T ,  DELLARIA JOSEPH F JR ,  ZIMMERMANN BERNHARD M ,  HEPPNER PHILIP D

IPC: C07D471/00 ,  A61K20060101 ,  A61K31/44 ,  C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6, 7, 8, 9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在2-位具有羟胺取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有化合物的药物组合物，中间体以及这些化合物作为免疫调节剂的使用方法 ，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005048933A2

公开(公告)日：2005-06-02

申请号：PCT/US2004/037854

申请日：2004-11-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  DELLARIA, Joseph, F., Jr. ,  ZIMMERMANN, Bernhard, M. ,  HEPPNER, Philip, D.

Inventor： KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  AMOS, David, T. ,  DELLARIA, Joseph, F., Jr. ,  ZIMMERMANN, Bernhard, M. ,  HEPPNER, Philip, D.

IPC: A61K

CPC classification number: C07D471/04 ,  C07D471/14 ,  C07D519/00

Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在2-位具有肟取代基的咪唑环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和咪唑并吡啶），含有化合物的药物组合物，中间体以及这些化合物作为免疫调节剂的使用方法 ，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。