公开(公告)号：WO2006086634A2

公开(公告)日：2006-08-17

申请号：PCT/US2006/004737

申请日：2006-02-10

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  DELLARIA, Joseph, F., Jr. ,  RADMER, Matthew, R. ,  ZIMMERMANN, Bernhard, M.

Inventor： KSHIRSAGAR, Tushar, A. ,  LUNDQUIST, Gregory, D., Jr. ,  DELLARIA, Joseph, F., Jr. ,  RADMER, Matthew, R. ,  ZIMMERMANN, Bernhard, M.

IPC: A61K31/4745

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo[4,5- c ] ring compounds, (e.g. imidazo[4,5- c ]pyridines, imidazo[4,5- c ]quinolines, 6,7,8,9-tetrahydro imidazo[4,5- c ]quinolines, imidazo[4,5- c ]naphthyridine, and 6,7,8,9-tetrahydro imidazo[4,5- c ]naphthyridine compounds) having an oxime or hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]吡啶，咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c] 喹啉，咪唑并[4,5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶化合物），其中2-位具有肟或羟胺取代基，药物组合物含有化合物 ，中间体和制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO0246192A2

公开(公告)日：2002-06-13

申请号：PCT/US0146697

申请日：2001-12-06

Applicant: 3M INNOVATIVE PROPERTIES CO ,  DELLARIA JOSEPH F ,  MERRILL BRYON A ,  RADMER MATTHEW R

Inventor： DELLARIA JOSEPH F ,  MERRILL BRYON A ,  RADMER MATTHEW R

IPC: C12P21/02 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/655 ,  A61P1/16 ,  A61P7/00 ,  A61P11/06 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P17/04 ,  A61P17/14 ,  A61P25/00 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/06 ,  A61P31/08 ,  A61P31/10 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P33/00 ,  A61P33/02 ,  A61P33/08 ,  A61P35/00 ,  A61P35/02 ,  A61P37/00 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D471/02 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/4745

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1-位含有硫醚官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：WO2006121528A2

公开(公告)日：2006-11-16

申请号：PCT/US2006/012022

申请日：2006-03-31

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  HAYS, David S., ,  MACKEY, Sonja S., ,  MOSER, William H., ,  STOERMER, Doris ,  RADMER, Matthew R., ,  NIWAS, Shri

Inventor： HAYS, David S., ,  MACKEY, Sonja S., ,  MOSER, William H., ,  STOERMER, Doris ,  RADMER, Matthew R., ,  NIWAS, Shri

IPC: G06Q50/00

CPC classification number: C07D471/04 ,  C07D233/90 ,  C07D471/14

Abstract: Methods and intermediates useful for making compounds of the formula: and the preparation of compounds of Formula I, preferably including the formation of intermediate compounds of the formula:

Abstract translation: 可用于制备下式化合物的方法和中间体：和式I化合物的制备，优选包括形成下式的中间体化合物：

公开(公告)号：WO2006028545A2

公开(公告)日：2006-03-16

申请号：PCT/US2005/021445

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  STOERMER, Doris ,  DELLARIA, Joseph, F., Jr. ,  AMOS, David, T. ,  ZIMMERMANN, Bernhard, M. ,  DRESSEL, Luke, T. ,  BONK, Jason, D. ,  RADMER, Matthew, R.

Inventor： STOERMER, Doris ,  DELLARIA, Joseph, F., Jr. ,  AMOS, David, T. ,  ZIMMERMANN, Bernhard, M. ,  DRESSEL, Luke, T. ,  BONK, Jason, D. ,  RADMER, Matthew, R.

IPC: A61K31/4745

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是在1位被环状取代基取代的喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘啶），含有化合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005079195A2

公开(公告)日：2005-09-01

申请号：PCT/US2004032480

申请日：2004-10-01

Applicant: 3M INNOVATIVE PROPERTIES CO ,  HAYS DAVID S ,  DANIELSON MICHAEL E ,  GERSTER JOHN F ,  NIWAS SHRI ,  PRINCE RYAN B ,  KSHIRSAGAR TUSHAR A ,  HEPPNER PHILIP D ,  MOSER WILLIAM H ,  MOSEMAN JOAN T ,  RADMER MATTHEW R ,  KAVANAGH MAUREEN A ,  STRONG SARAH A ,  BONK JASON D

Inventor： HAYS DAVID S ,  DANIELSON MICHAEL E ,  GERSTER JOHN F ,  NIWAS SHRI ,  PRINCE RYAN B ,  KSHIRSAGAR TUSHAR A ,  HEPPNER PHILIP D ,  MOSER WILLIAM H ,  MOSEMAN JOAN T ,  RADMER MATTHEW R ,  KAVANAGH MAUREEN A ,  STRONG SARAH A ,  BONK JASON D

IPC: C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D401/14 ,  C07D471/14 ,  C07D495/14

Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 吡唑并吡啶-4-胺，吡唑啉-4-胺和6,7,8,9-四氢吡唑并喹啉-4-胺，含有这些化合物的化合物，中间体和使用方法作为免疫调节剂的药物组合物 ，用于诱导或抑制动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2003050121A1

公开(公告)日：2003-06-19

申请号：PCT/US2002/018290

申请日：2002-06-07

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  BONK, Jason, D. ,  DELLARIA, Joseph, F. ,  MERRILL, Byron, A. ,  RADMER, Matthew, R.

Inventor： BONK, Jason, D. ,  DELLARIA, Joseph, F. ,  MERRILL, Byron, A. ,  RADMER, Matthew, R.

IPC: C07D487/04

CPC classification number: C07D471/04 ,  A61K31/4745 ,  Y02A50/409

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1-位含有硫醚官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：WO2007143526A3

公开(公告)日：2008-02-07

申请号：PCT/US2007070181

申请日：2007-06-01

Applicant: COLEY PHARM GROUP INC ,  DELLARIA JOSEPH F JR ,  MOSER WILLIAM H ,  RADMER MATTHEW R ,  KSHIRSAGAR TUSHAR A ,  HEPPNER PHILIP D

Inventor： DELLARIA JOSEPH F JR ,  MOSER WILLIAM H ,  RADMER MATTHEW R ,  KSHIRSAGAR TUSHAR A ,  HEPPNER PHILIP D

IPC: A01N47/10 ,  A61K31/27

CPC classification number: C07D471/14

Abstract: 6,7,8,9-Tetrahydro-1H-imidazo[4,5-c]naphthyridines with a substituent at the 6-, 7-, 8-, or 9-position nitrogen atom, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 在6-，7-，8-或9-位氮原子上具有取代基的6,7,8,9-四氢-1H-咪唑并[4,5-c]萘啶，含有这些化合物的药物组合物， 公开了这些化合物的化合物，中间体和使用方法作为免疫调节剂，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病。

公开(公告)号：WO2007143526A2

公开(公告)日：2007-12-13

申请号：PCT/US2007/070181

申请日：2007-06-01

Applicant: COLEY PHARMACEUTICAL GROUP, INC. ,  DELLARIA, Joseph F. Jr. ,  MOSER, William H. ,  RADMER, Matthew R. ,  KSHIRSAGAR, Tushar A. ,  HEPPNER, Philip D.

Inventor： DELLARIA, Joseph F. Jr. ,  MOSER, William H. ,  RADMER, Matthew R. ,  KSHIRSAGAR, Tushar A. ,  HEPPNER, Philip D.

IPC: A61K31/4745

CPC classification number: C07D471/14

Abstract: 6,7,8,9-Tetrahydro-1 H -imidazo[4,5- c ]naphthyridines with a substituent at the 6-, 7-, 8-, or 9-position nitrogen atom, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 在6-，7-，8-或9-位氮原子上具有取代基的6,7,8,9-四氢-1H-咪唑并[4,5-c]萘啶，含有这些化合物的药物组合物， 公开了这些化合物的化合物，中间体和使用方法作为免疫调节剂，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病。

公开(公告)号：WO2006086634A3

公开(公告)日：2007-08-09

申请号：PCT/US2006004737

申请日：2006-02-10

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  DELLARIA JOSEPH F JR ,  RADMER MATTHEW R ,  ZIMMERMANN BERNHARD M

Inventor： KSHIRSAGAR TUSHAR A ,  LUNDQUIST GREGORY D JR ,  DELLARIA JOSEPH F JR ,  RADMER MATTHEW R ,  ZIMMERMANN BERNHARD M

IPC: C07D471/04 ,  A61K31/15 ,  A61K31/437 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo[4,5-c] ring compounds, (e.g. imidazo[4,5-c]pyridines, imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydro imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridine, and 6,7,8,9-tetrahydro imidazo[4,5-c]naphthyridine compounds) having an oxime or hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并[4,5-c]环化合物（例如咪唑并[4,5-c]吡啶，咪唑并[4,5-c]喹啉，6,7,8,9-四氢咪唑并[4,5-c] 喹啉，咪唑并[4,5-c]萘啶和6,7,8,9-四氢咪唑并[4,5-c]萘啶化合物），其中2-位具有肟或羟胺取代基，药物组合物含有化合物 ，中间体和制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2005076783A3

公开(公告)日：2005-12-29

申请号：PCT/US2004040383

申请日：2004-12-03

Applicant: 3M INNOVATIVE PROPERTIES CO ,  RADMER MATTHEW R ,  MOSER WILLIAM H ,  MOSEMAN JOAN T ,  DELLARIA JOSEPH F JR

Inventor： RADMER MATTHEW R ,  MOSER WILLIAM H ,  MOSEMAN JOAN T ,  DELLARIA JOSEPH F JR

IPC: C07D471/02 ,  C07D471/06

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and 6,7,8,9-tetrahydroimidazonaphthyridines) with a sulfide-, sulfinyl-, or sulfonyl-containing ether substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 咪唑环化合物（例如，咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并吡啶和6,7,8,9-四氢咪唑并萘啶）与1-位硫醚基，亚磺酰基或磺酰基醚取代基 公开了含有化合物的药物组合物，中间体，制备化合物的方法以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。