公开(公告)号：CA2173200C

公开(公告)日：2003-12-30

申请号：CA2173200

申请日：1994-09-26

Applicant: OPTIX LP

Inventor： SODICKSON LESTER ,  BLOCK MYRON J

IPC: G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/64 ,  G01N33/487 ,  A61B5/14 ,  G01J3/50

Abstract: Improvements in non-invasive detection methods for glucose and other constituents of interest in a sample have been developed. The apparatus and methods of the invention provide an analog of color perception of human vision, preferably in the near infrared region, replacing spectrophotometers and narrow band sources used in other non-invasive near infrared detection methods. A plurality of detector units are used, each covering a broad and overlapping region of the detected spectrum, paralleling color perception and colorimetry. The improvements are primarily concerned with improving the signal-to- background (or noise) ratio such that the data stream is improved. These improvements use congruent sampling, comparison of different data streams from different sample portions or filter sets, using an interrogation system with sufficient speed to allow testing of arterial blood, and using a filter with a spectral structure. In some circumstances, a neural net is used for analysis, allowing the system to learn. A novel method for background discrimination is also described.

公开(公告)号：ES2146232T3

公开(公告)日：2000-08-01

申请号：ES93917056

申请日：1993-07-08

Applicant: OPTIX LP

Inventor： BLOCK MYRON J

IPC: G01N33/49 ,  A61B5/00 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N33/487 ,  G01N21/59

公开(公告)号：AU7842894A

公开(公告)日：1995-05-01

申请号：AU7842894

申请日：1994-09-26

Applicant: OPTIX LP

Inventor： BLOCK MYRON J ,  SODICKSON LESTER

IPC: G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/64 ,  G01N33/487 ,  G01J3/50

公开(公告)号：CA2173200A1

公开(公告)日：1995-04-13

申请号：CA2173200

申请日：1994-09-26

Applicant: OPTIX LP

Inventor： SODICKSON LESTER ,  BLOCK MYRON J

IPC: G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/64 ,  G01N33/487 ,  A61B5/14 ,  G01J3/50

Abstract: Improvements in non-invasive detection methods for glucose and other constituents of interest in a sample have been developed. The apparatus and methods of the invention provide an analog of color perception of human vision, preferably in the near infrared region, replacing spectrophotometers and narrow band sources used in other non-invasive near infrared detection methods. A plurality of detector units are used, each covering a broad and overlapping region of the detected spectrum, paralleling color perception and colorimetry. The improvements are primarily concerned with improving the signal-to-background (or noise) ratio such that the data stream is improved. These improvements use congruent sampling, comparison of different data streams from different sample portions or filter sets, using an interrogation system with sufficient speed to allow testing of arterial blood, and using a filter with a spectral structure. In some circumstances, a neural net is used for analysis, allowing the system to learn. A novel method for background discrimination is also described.

公开(公告)号：AU2003238843A1

公开(公告)日：2004-02-09

申请号：AU2003238843

申请日：2003-05-30

Applicant: OPTIX LP

Inventor： GUTHERMANN HOWARD E

IPC: A61B5/00 ,  G01N21/35 ,  G01N21/49 ,  G01N33/48

公开(公告)号：AU744758B2

公开(公告)日：2002-03-07

申请号：AU3968499

申请日：1999-04-28

Applicant: OPTIX LP

Inventor： BLOCK MYRON J

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455

Abstract: The invention provides non-invasive methods and apparati for measurement of the concentration of a selected constituent of a subject's blood. The invention cools a segment of the subject's tympanic membrane and employs the thermal radiation that the subject's inner ear emits and is transmitted through this cold segment to directly obtain absorption information related to the concentration of various constituents of blood flowing through the membrane. In particular the invention utilizes optical devices inserted into the external ear cavity to direct a portion of the transmitted radiation onto an infrared detection and analysis device. The signal from the detection device is analyzed to obtain the concentration of the constituent of interest. The invention can employ both traditional spectrophotometric techniques and also non-spectrophotometric techniques to derive the concentration of a particular constituent.

公开(公告)号：ES2145843T3

公开(公告)日：2000-07-16

申请号：ES94929335

申请日：1994-09-26

Applicant: OPTIX LP

Inventor： BLOCK MYRON J ,  SODICKSON LESTER

IPC: G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/64 ,  G01N33/487 ,  G01J3/50

公开(公告)号：AU3968499A

公开(公告)日：1999-11-23

申请号：AU3968499

申请日：1999-04-28

Applicant: OPTIX LP

Inventor： BLOCK MYRON J

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455

Abstract: The invention provides non-invasive methods and apparati for measurement of the concentration of a selected constituent of a subject's blood. The invention cools a segment of the subject's tympanic membrane and employs the thermal radiation that the subject's inner ear emits and is transmitted through this cold segment to directly obtain absorption information related to the concentration of various constituents of blood flowing through the membrane. In particular the invention utilizes optical devices inserted into the external ear cavity to direct a portion of the transmitted radiation onto an infrared detection and analysis device. The signal from the detection device is analyzed to obtain the concentration of the constituent of interest. The invention can employ both traditional spectrophotometric techniques and also non-spectrophotometric techniques to derive the concentration of a particular constituent.

公开(公告)号：CA2331697A1

公开(公告)日：1999-11-11

申请号：CA2331697

申请日：1999-04-28

Applicant: OPTIX LP

Inventor： BLOCK MYRON J

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455

Abstract: The invention provides non-invasive methods and apparati for measurement of the concentration of a selected constituent of a subject's blood. The invention cools a segment of the subject's tympanic membrane (10) and employs the thermal radiation that the subject's inner ear emits and is transmitted through this cold segment to directly obtain absorption information related to the concentration of various constituents of blood flowing through the membrane. In particular, the invention utilizes optical devices (16, 18, 22) inserted into the external ear cavity to direct a portion of the transmitted radiation onto an infrared detection and analysis device (24, 36). The signal from the detection device (24) is analyzed to obtain the concentration of the constituent of interest. The invention can employ both traditional spectrophotometric techniques and also non-spectrophotometric techniques to derive the concentration of a particular constituent.

公开(公告)号：CA2180128A1

公开(公告)日：1995-07-20

申请号：CA2180128

申请日：1995-01-09

Applicant: OPTIX LP

Inventor： BLOCK MYRON J ,  SODICKSON LESTER

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of analytes such as glucose has been developed. A plurality of broad spectrum filters (30A-30D) transmit distinguishably coded by choppers (20A-20D) beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interferometer cam be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by analogy to colorimetry and visual processing and can be converted into concentration measurements.