公开(公告)号：WO2005051317A2

公开(公告)日：2005-06-09

申请号：PCT/US2004/039512

申请日：2004-11-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  KREPSKI, Larry, R. ,  DELLARIA, Joseph, F., Jr. ,  DUFFY, Daniel, E. ,  RADMER, Matthew, R. ,  AMOS, David, T.

Inventor： KREPSKI, Larry, R. ,  DELLARIA, Joseph, F., Jr. ,  DUFFY, Daniel, E. ,  RADMER, Matthew, R. ,  AMOS, David, T.

IPC: A61K

CPC classification number: C07D471/04 ,  C07D213/74 ,  C07D255/02 ,  C07D471/14

Abstract: Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1位置取代的咪唑环体系，含有化合物的药物组合物，中间体，制备化合物的方法以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤的疾病 疾病被披露。

公开(公告)号：WO2005020999A1

公开(公告)日：2005-03-10

申请号：PCT/US2004/028021

申请日：2004-08-27

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  LINDSTROM, Kyle J., ,  MARTIN, Hugues ,  MERRILL, Bryon A., ,  RICE, Michael J., ,  WURST, Joshua R., ,  HARALDSON, Chad A., ,  KSHIRSAGAR, Tushar ,  HEPPNER, Philip D., ,  NIWAS, Shri ,  GRIESGRABER, George W., ,  RADMER, Matthew R.,

Inventor： LINDSTROM, Kyle J., ,  MARTIN, Hugues ,  MERRILL, Bryon A., ,  RICE, Michael J., ,  WURST, Joshua R., ,  HARALDSON, Chad A., ,  KSHIRSAGAR, Tushar ,  HEPPNER, Philip D., ,  NIWAS, Shri ,  GRIESGRABER, George W., ,  RADMER, Matthew R.,

IPC: A61K31/4745

CPC classification number: C07D471/04

Abstract: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 在6,7,8或9位含有芳氧基或芳基亚烷基氧基或羟基取代基的咪唑并喹啉化合物含有这些化合物作为免疫调节剂的化合物，中间体和使用方法，用于调节动物中的细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：WO2006121528A3

公开(公告)日：2007-09-13

申请号：PCT/US2006012022

申请日：2006-03-31

Applicant: COLEY PHARM GROUP INC ,  HAYS DAVID S ,  MACKEY SONJA S ,  MOSER WILLIAM H ,  STOERMER DORIS ,  RADMER MATTHEW R ,  NIWAS SHRI

Inventor： HAYS DAVID S ,  MACKEY SONJA S ,  MOSER WILLIAM H ,  STOERMER DORIS ,  RADMER MATTHEW R ,  NIWAS SHRI

IPC: C07D235/02 ,  C07D233/54 ,  C07D233/64 ,  C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D233/90 ,  C07D471/14

Abstract: Methods and intermediates useful for making compounds of the formula: and the preparation of compounds of Formula I, preferably including the formation of intermediate compounds of the formula:

Abstract translation: 可用于制备下式化合物的方法和中间体：和式I化合物的制备，优选包括形成下式的中间体化合物：

公开(公告)号：WO2006028545A3

公开(公告)日：2007-08-23

申请号：PCT/US2005021445

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES CO ,  STOERMER DORIS ,  DELLARIA JOSEPH F JR ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  DRESSEL LUKE T ,  BONK JASON D ,  RADMER MATTHEW R

Inventor： STOERMER DORIS ,  DELLARIA JOSEPH F JR ,  AMOS DAVID T ,  ZIMMERMANN BERNHARD M ,  DRESSEL LUKE T ,  BONK JASON D ,  RADMER MATTHEW R

IPC: C07D471/14 ,  A61K31/437

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘并噻嗪）在1位被环状取代基取代的药物组合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：WO2007028129A1

公开(公告)日：2007-03-08

申请号：PCT/US2006/034427

申请日：2006-09-01

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  DELLARIA, Joseph, F., Jr. ,  MOSER, William, H. ,  RADMER, Matthew, R. ,  GRIESGRABER, George, W.

Inventor： DELLARIA, Joseph, F., Jr. ,  MOSER, William, H. ,  RADMER, Matthew, R. ,  GRIESGRABER, George, W.

IPC: C07D471/04 ,  A61K31/437 ,  A61P37/02

CPC classification number: C07D471/04

Abstract: Hydroxy substituted 1 H -imidazo[4,5-c]pyridin-4-amines, with a hydroxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 在2-位羟基取代的1H-咪唑并[4,5-c]吡啶-4-胺，含有这些化合物的药物组合物，制备化合物的方法，中间体和这些化合物的使用方法如 公开了用于在动物中诱导细胞因子生物合成和用于治疗包括病毒和肿瘤疾病的疾病的免疫调节剂。

公开(公告)号：WO2005051317A3

公开(公告)日：2006-05-11

申请号：PCT/US2004039512

申请日：2004-11-24

Applicant: 3M INNOVATIVE PROPERTIES CO ,  KREPSKI LARRY R ,  DELLARIA JOSEPH F JR ,  DUFFY DANIEL E ,  RADMER MATTHEW R ,  AMOS DAVID T

Inventor： KREPSKI LARRY R ,  DELLARIA JOSEPH F JR ,  DUFFY DANIEL E ,  RADMER MATTHEW R ,  AMOS DAVID T

IPC: A61K20060101 ,  A61K31/4745 ,  A61P37/00 ,  C07D213/74 ,  C07D221/00 ,  C07D235/00 ,  C07D471/02 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D213/74 ,  C07D255/02 ,  C07D471/14

Abstract: Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 在1位置取代的咪唑环体系，含有化合物的药物组合物，中间体，制备化合物的方法以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤的疾病 疾病被披露。

公开(公告)号：WO2005079195A3

公开(公告)日：2005-09-01

申请号：PCT/US2004/032480

申请日：2004-10-01

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  HAYS, David, S. ,  DANIELSON, Michael, E. ,  GERSTER, John, F. ,  NIWAS, Shri, ,  PRINCE, Ryan, B. ,  KSHIRSAGAR, Tushar, A. ,  HEPPNER, Philip, D. ,  MOSER, William, H. ,  MOSEMAN, Joan, T. ,  RADMER, Matthew, R. ,  KAVANAGH, Maureen, A. ,  STRONG, Sarah, A. ,  BONK, Jason, D.

Inventor： HAYS, David, S. ,  DANIELSON, Michael, E. ,  GERSTER, John, F. ,  NIWAS, Shri, ,  PRINCE, Ryan, B. ,  KSHIRSAGAR, Tushar, A. ,  HEPPNER, Philip, D. ,  MOSER, William, H. ,  MOSEMAN, Joan, T. ,  RADMER, Matthew, R. ,  KAVANAGH, Maureen, A. ,  STRONG, Sarah, A. ,  BONK, Jason, D.

IPC: A61K31/437 ,  C07D471/04 ,  C07D471/14 ,  C07D487/02 ,  C07D487/12

Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

公开(公告)号：WO2005076783A2

公开(公告)日：2005-08-25

申请号：PCT/US2004/040383

申请日：2004-12-03

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  RADMER, Matthew R., ,  MOSER, William H., ,  MOSEMAN, Joan T., ,  DELLARIA, Joseph F., Jr.

Inventor： RADMER, Matthew R., ,  MOSER, William H., ,  MOSEMAN, Joan T., ,  DELLARIA, Joseph F., Jr.

IPC: C07D471/02 ,  C07D471/06

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and 6,7,8,9-tetrahydroimidazonaphthyridines) with a sulfide-, sulfinyl-, or sulfonyl-containing ether substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 咪唑啉环化合物（例如咪唑并喹啉，6,7,8,9-四氢咪唑并喹啉，咪唑并萘啶和6,7,8,9-四氢咪唑并萘啶）与硫化物 - ，亚磺酰 - 或磺酰基 - 含1-位含醚取代基的药物组合物，含有该化合物的药物组合物，中间体，制备该化合物的方法以及这些化合物作为免疫调节剂的用途，用于在动物中诱导细胞因子生物合成以及治疗疾病，包括病毒和肿瘤疾病 ，被披露。

公开(公告)号：WO2002046192A3

公开(公告)日：2002-06-13

申请号：PCT/US2001/046697

申请日：2001-12-06

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  DELLARIA, Joseph F. ,  MERRILL, Bryon A. ,  RADMER, Matthew R.

Inventor： DELLARIA, Joseph F. ,  MERRILL, Bryon A. ,  RADMER, Matthew R.

IPC: C07D471/04

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.