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公开(公告)号：WO2009064752A3
公开(公告)日：2009-08-27
申请号：PCT/US2008083173
申请日：2008-11-12
Applicant: VERTEX PHARMA , STAMOS DEAN , MARTINBOROUGH ESTHER , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , WHITNEY TARA , ZIMMERMANN NICOLE , HAMPTON TARA LEANNE
Inventor： STAMOS DEAN , MARTINBOROUGH ESTHER , NEUBERT TIMOTHY , NUMA MEHDI MICHEL DJAMEL , WHITNEY TARA , ZIMMERMANN NICOLE , HAMPTON TARA LEANNE
IPC: C07D417/14 , A61K31/427 , A61K31/4427
CPC classification number: C07D417/14
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2009064752A2
公开(公告)日：2009-05-22
申请号：PCT/US2008/083173
申请日：2008-11-12
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , STAMOS, Dean , MARTINBOROUGH, Esther , NEUBERT, Timothy , NUMA, Mehdi Michel, Djamel , WHITNEY, Tara , ZIMMERMANN, Nicole , HAMPTON, Tara, Leanne
Inventor： STAMOS, Dean , MARTINBOROUGH, Esther , NEUBERT, Timothy , NUMA, Mehdi Michel, Djamel , WHITNEY, Tara , ZIMMERMANN, Nicole , HAMPTON, Tara, Leanne
IPC: C07D417/14 , A61K31/4427 , A61K31/427
CPC classification number: C07D417/14
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供了包含本发明化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2007111904A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/007016
申请日：2007-03-21
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , LAUFFER, David, J. , DAVIES, Robert, J. , STAMOS, Dean , ARONOV, Alexander , DEININGER, David, D. , GREY, Ronald, Jr. , XU, Jinwang , LI, Pan , LEDFORD, Brian , FARMER, Luc , BETHIEL, Randy, Scott , JACOBS, Dylan , MCGINTY, Kira
Inventor： LAUFFER, David, J. , DAVIES, Robert, J. , STAMOS, Dean , ARONOV, Alexander , DEININGER, David, D. , GREY, Ronald, Jr. , XU, Jinwang , LI, Pan , LEDFORD, Brian , FARMER, Luc , BETHIEL, Randy, Scott , JACOBS, Dylan , MCGINTY, Kira
CPC classification number: C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供了制备本发明化合物的方法，包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2007015923A2
公开(公告)日：2007-02-08
申请号：PCT/US2006028149
申请日：2006-07-21
Applicant: VERTEX PHARMA , BINCH HAYLEY , MORTIMORE MICHAEL , ROBINSON DANIEL , STAMOS DEAN
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , ROBINSON DANIEL , STAMOS DEAN
CPC classification number: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D487/08
Abstract: The present invention relates to compounds useful as inhibitors of Aurora, FLT-3, or PDKl protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作Aurora，FLT-3或PDK1蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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15.发明申请PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES 审中-公开PYRAZOLO [1,5-a] PYRIMIDINES有用作为蛋白激酶的抑制剂
公开(公告)号：WO2006052913A1
公开(公告)日：2006-05-18
申请号：PCT/US2005/040344
申请日：2005-11-04
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , JIMENEZ, Juan-Miguel , KNEGTEL, Ronald , CHARRIER, Jean-Damien , STAMOS, Dean , LI, Pan , COME, Jon, R. , ARONOV, Alex
Inventor： JIMENEZ, Juan-Miguel , KNEGTEL, Ronald , CHARRIER, Jean-Damien , STAMOS, Dean , LI, Pan , COME, Jon, R. , ARONOV, Alex
IPC: C07D487/04 , A61K31/519 , A61P35/00 , C07D239/00 , C07D231/00
CPC classification number: C07D487/04 , C07F9/6561
Abstract: The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的式（I）化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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Patent Agency Ranking16.发明申请C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开用于治疗增殖性疾病的C-MET蛋白激酶抑制剂
公开(公告)号：WO2007111904A3
公开(公告)日：2007-12-13
申请号：PCT/US2007007016
申请日：2007-03-21
Applicant: VERTEX PHARMA , LAUFFER DAVID J , DAVIES ROBERT J , STAMOS DEAN , ARONOV ALEXANDER , DEININGER DAVID D , GREY RONALD JR , XU JINWANG , LI PAN , LEDFORD BRIAN , FARMER LUC , BETHIEL RANDY SCOTT , JACOBS DYLAN , MCGINTY KIRA
Inventor： LAUFFER DAVID J , DAVIES ROBERT J , STAMOS DEAN , ARONOV ALEXANDER , DEININGER DAVID D , GREY RONALD JR , XU JINWANG , LI PAN , LEDFORD BRIAN , FARMER LUC , BETHIEL RANDY SCOTT , JACOBS DYLAN , MCGINTY KIRA
IPC: C07D401/04 , A61K31/4439 , A61K31/497 , A61K35/00 , A61P35/04 , C07D403/04 , C07D417/04 , C07D471/04
CPC classification number: C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供了制备本发明化合物的方法，包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2007064797A3
公开(公告)日：2007-12-13
申请号：PCT/US2006045847
申请日：2006-11-30
Applicant: VERTEX PHARMA , LAUFFER DAVID , ARONOV ALEXANDER , LI PAN , DEININGER DAVID , MCGINTY KIRA , STAMOS DEAN , COME JON , STEWART MICHELLE
Inventor： LAUFFER DAVID , ARONOV ALEXANDER , LI PAN , DEININGER DAVID , MCGINTY KIRA , STAMOS DEAN , COME JON , STEWART MICHELLE
IPC: C07D487/04 , A61K31/433 , A61P35/00 , C07D513/04 , C07D519/00
CPC classification number: C07D498/04 , C07D487/04 , C07D513/04
Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
Abstract translation: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号：WO2007064797A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/045847
申请日：2006-11-30
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , LAUFFER, David , ARONOV, Alexander , LI, Pan , DEININGER, David , MCGINTY, Kira , STAMOS, Dean , COME, Jon , STEWART, Michelle
Inventor： LAUFFER, David , ARONOV, Alexander , LI, Pan , DEININGER, David , MCGINTY, Kira , STAMOS, Dean , COME, Jon , STEWART, Michelle
IPC: C07D513/04 , C07D487/04 , C07D519/00 , A61K31/433 , A61P35/00
CPC classification number: C07D498/04 , C07D487/04 , C07D513/04
Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
Abstract translation: 本发明提供了用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供了包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号：WO2007056330A1
公开(公告)日：2007-05-18
申请号：PCT/US2006/043269
申请日：2006-11-06
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , CHARIFSON, Paul , DEININGER, David , DRUMM, Joseph , GRILLOT, Anne-Laure , LeTIRAN, Arnaud , LIAO, Yusheng , PEROLA, Emanuele , RONKIN, Steven , STAMOS, Dean , WANG, Tiansheng
Inventor： CHARIFSON, Paul , DEININGER, David , DRUMM, Joseph , GRILLOT, Anne-Laure , LeTIRAN, Arnaud , LIAO, Yusheng , PEROLA, Emanuele , RONKIN, Steven , STAMOS, Dean , WANG, Tiansheng
IPC: C07D401/04 , C07D403/04 , C07D403/14 , A61K31/4184 , A61P31/04
CPC classification number: C07D403/04 , C07D401/04 , C07D403/14
Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
Abstract translation: 本发明涉及抑制细菌促旋酶和/或Topo IV的式（I）化合物或其药学上可接受的盐以及包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此，本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号：WO2007015923A3
公开(公告)日：2007-02-08
申请号：PCT/US2006/028149
申请日：2006-07-21
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , BINCH, Hayley , MORTIMORE, Michael , ROBINSON, Daniel , STAMOS, Dean
Inventor： BINCH, Hayley , MORTIMORE, Michael , ROBINSON, Daniel , STAMOS, Dean
IPC: C07D403/04 , C07D401/14 , C07D403/14 , A61K31/506 , A61K31/4439 , A61K31/55 , A61K31/551 , A61P35/00
Abstract: The present invention relates to compounds useful as inhibitors of Aurora, FLT-3, or PDKl protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the invention.
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