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    Solid state microscope
    11.
    发明公开
    Solid state microscope 失效
    Halbleiter Mikroskop。

    公开(公告)号：EP0380904A1

    公开(公告)日：1990-08-08

    申请号：EP89850028.5

    申请日：1989-02-01

    Applicant: XILLIX TECHNOLOGIES CORPORATION

    Inventor： Jaggi, Bruno ,  Deen, Mohamed J. ,  Palcic, Branko

    IPC: G02B21/00

    CPC classification number: G02B21/002 ,  G01N21/5911 ,  G01N2021/5938 ,  G01N2021/5957 ,  G01N2201/103

    Abstract: A quantitative light microscope for viewing and scanning microscopic objects that uses a solid state detector (7) in the primary image plane. The microscope has a light source (1) with a condensor (2) and diffusion filter (3). A moveable stage (5) is provided to allow X, Y, Z plane displacements in order to scan objects under the microscope. There is an objective (6) to magnify the image of the object and project this image onto a two dimensional solid state image sensor (7) positioned in the primary image plane of the objective. The solid state image sensor (7) sends signals to an analog-to-­digital converter (8) where the signals are digitized and sent to a frame memory (9). A monitor (10) is used to display the image of the object as stored in frame memory. The present invention can be interfaced with a computer (12) to allow for automatic focusing and scanning of an image. The computer also houses storage means to store images. Methods of scanning an object are also described. A prism element can be used to obtain spectral scans of an object. In another scanning method, a first edge row of pixels is used to detect an object of interest in the scanned image. This first detection row activates an area of the sensor array at a later time to capture the entire image. In this way, only relevant information is collected and processed.

    Abstract translation: 用于观察和扫描在主像平面中使用固态检测器（7）的微观物体的定量光学显微镜。 显微镜具有带有冷凝器（2）和扩散过滤器（3）的光源（1）。 提供可移动台（5）以允许X，Y，Z平面位移，以便在显微镜下扫描物体。 有一个目标（6）放大对象的图像并将该图像投影到位于物镜的主像平面中的二维固态图像传感器（7）上。 固态图像传感器（7）向模数转换器（8）发送信号，信号被数字化并发送到帧存储器（9）。 监视器（10）用于显示存储在帧存储器中的对象的图像。 本发明可以与计算机（12）接口以允许图像的自动聚焦和扫描。 计算机还容纳存储图像的存储装置。 还描述了扫描对象的方法。 可以使用棱镜元件来获得物体的光谱扫描。 在另一扫描方法中，使用第一边缘行像素来检测扫描图像中的感兴趣对象。 该第一检测行在稍后时间激活传感器阵列的区域以捕获整个图像。 以这种方式，只收集和处理相关信息。

    Apparatus and method for imaging diseased tissue using integrated autofluorescence
    13.
    发明公开
    Apparatus and method for imaging diseased tissue using integrated autofluorescence 失效
    使用集成的自发荧光的方法和装置用于成像患病组织

    公开(公告)号：EP1472972A1

    公开(公告)日：2004-11-03

    申请号：EP04018813.8

    申请日：1995-03-24

    Applicant: XILLIX TECHNOLOGIES CORPORATION

    Inventor： Palcic, Branko ,  Lam, Stephen ,  Macaulay, Calum ,  Jaggi, Bruno

    IPC: A61B5/00 ,  A61B1/05

    CPC classification number: A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

    Abstract: An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the one end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

    Abstract translation: 用于成像组织的疾病的装置和方法被呈现。 该装置采用一个光源，用于产生激发光来激发组织，以产生自体荧光光以及用于产生照明光，以产生反射并返回来自所述组织的散射光（汇款光）。 光学传感器用于接收所述自体荧光光以及汇款光收集自发荧光光图像和一个汇款光图像。 的过滤器的作用是自发荧光图像在波长范围内的，其中用于正常组织自体荧光强度是从自体荧光强度基本上不同的用于患病组织对组织的自体荧光的集成图像建立集成。 汇款光提供的背景图像以标准化的自发荧光图像，以考虑图像不均匀由于在距离，角度和照明强度的变化。 监视器显示集成自身荧光图像和汇款光图像，以产生归一化的图像，其中病变组织是从正常组织区分开来。 该光学传感器可被安装为邻近插入到体腔内的内窥镜探头的一端。 一种用于成像使用积分荧光图像和正火汇款图像患病组织的方法因此是游离缺失盘。

    Imaging system for detecting diseased tissue using native fluorescence in the gastrointestinal or respiratory tract
    16.
    发明公开
    Imaging system for detecting diseased tissue using native fluorescence in the gastrointestinal or respiratory tract 失效
    在消化道和呼吸道检测与天然荧光患病组织的成像系统

    公开(公告)号：EP1369077A3

    公开(公告)日：2004-11-17

    申请号：EP03010552.2

    申请日：1997-01-31

    Applicant: XILLIX TECHNOLOGIES CORPORATION

    Inventor： Haishan, Zeng ,  Cline, Richard, W. ,  MacAulay, Calum, E. ,  Jaggi, Bruno, W.

    IPC: A61B1/04 ,  A61B5/00

    CPC classification number: A61B5/42 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/043 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4255

    Abstract: A system for detecting cancerous or precancerous lesions directs light produced from a mercury arc lamp (100) into an illumination guide (106) of an endoscope. Autofluorescence light produced by the tissue under examination is divided into red and green spectral bands by a beam splitter (120). Light in the red and green spectral band is applied to a pair of image intensified CCD cameras (126, 130). The output of the camera that receives light in the red spectral band is coupled to a red video input of a color video monitor (150). Light produced by the camera that receives light in the green spectral band is coupled to the blue and green video inputs of the video monitor. The system produces a false color display, whereby healthy tissue appears cyan in color and cancerous or precancerous lesions appear reddish in color. The image displayed allows the operator to see the lesions within the context of the underlying tissue structures. The color contrast is adjustable to account for the autofluorescence property changes from patient to patient and from location to location.

    Imaging system for detecting diseased tissue using native fluorescence in the gastrointestinal or respiratory tract
    17.
    发明公开
    Imaging system for detecting diseased tissue using native fluorescence in the gastrointestinal or respiratory tract 失效
    在消化道和呼吸道检测与天然荧光患病组织的成像系统

    公开(公告)号：EP1369077A2

    公开(公告)日：2003-12-10

    申请号：EP03010552.2

    申请日：1997-01-31

    Applicant: XILLIX TECHNOLOGIES CORPORATION

    Inventor： Haishan, Zeng ,  Cline, Richard, W. ,  MacAulay, Calum, E. ,  Jaggi, Bruno, W.

    IPC: A61B1/04 ,  A61B5/00

    CPC classification number: A61B5/42 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/043 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4255

    Abstract: A system for detecting cancerous or precancerous lesions directs light produced from a mercury arc lamp (100) into an illumination guide (106) of an endoscope. Autofluorescence light produced by the tissue under examination is divided into red and green spectral bands by a beam splitter (120). Light in the red and green spectral band is applied to a pair of image intensified CCD cameras (126, 130). The output of the camera that receives light in the red spectral band is coupled to a red video input of a color video monitor (150). Light produced by the camera that receives light in the green spectral band is coupled to the blue and green video inputs of the video monitor. The system produces a false color display, whereby healthy tissue appears cyan in color and cancerous or precancerous lesions appear reddish in color. The image displayed allows the operator to see the lesions within the context of the underlying tissue structures. The color contrast is adjustable to account for the autofluorescence property changes from patient to patient and from location to location.

    Abstract translation: 一种用于检测癌症或癌前病变从汞弧灯（100）插入在内窥镜的照明引导件（106）产生的光ausrichtet系统。 由所检查的组织中产生的自发荧光的光被分成由分束器（120）的红色和绿色光谱带。 在红色和绿色光谱带的光被施加到对图像放大的CCD照相机（126，130）。 相机的输出那样接收光在红色光谱带被耦合到彩色视频监视器（150）的红色视频输入​​。 由摄像机产生的光没有接收光在绿色光谱带被耦合到视频显示器的蓝色和绿色的视频输入。 该系统产生伪色显示，由此健康组织显示于颜色和癌性或癌前病变青色颜色偏红。 显示的图像允许操作员看到下层组织结构的上下文中的病变。 颜色对比是可调节的，以考虑从患者自发荧光性质的变化对患者和从位置到位置。

    APPARATUS AND METHOD FOR IMAGING DISEASED TISSUE USING INTEGRATED AUTOFLUORESCENCE
    19.
    发明公开
    APPARATUS AND METHOD FOR IMAGING DISEASED TISSUE USING INTEGRATED AUTOFLUORESCENCE 失效
    方法和设备成像病变组织使用集成的自动荧光

    公开(公告)号：EP0752825A1

    公开(公告)日：1997-01-15

    申请号：EP95912989.0

    申请日：1995-03-24

    Applicant: XILLIX TECHNOLOGIES CORPORATION

    Inventor： PALCIC, Branko ,  MACAULAY, Calum ,  LAM, Stephen ,  JAGGI, Bruno

    IPC: A61B10 ,  A61B1 ,  A61B5 ,  G01N21

    CPC classification number: A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

    Abstract: An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light image provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

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