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公开(公告)号：KR1020130077953A
公开(公告)日：2013-07-10
申请号：KR1020110146636
申请日：2011-12-30
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: Carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is provided to suppress elastase activation or matrix metalloproteinase-9 (MMP) expression, and to basically inhibit vital reaction mediated by the suppression. CONSTITUTION: An elastase activation inhibitor contains carnosic acid of chemical formula 1, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The carnosic acid derivative is carnosic acid methyl ester or carnosic methyl alcohol. The carnosic acid, the derivative, or the pharmaceutically acceptable salt is derived from rosemary and/or sage. The inhibitor contains 0.0001-20 wt% of the active ingredient. An MMP expression inhibitor contains the carnosic acid, the derivative, or the pharmaceutically acceptable salt as an active ingredient. A composition for skin anti-aging contains the carnosic acid, the derivative, or the pharmaceutically acceptable salt as an active ingredient.
Abstract translation: 目的：为了抑制弹性蛋白酶活化或基质金属蛋白酶-9（MMP）的表达，基本上抑制由抑制介导的生物反应，提供鼠尾草衍生物或其药学上可接受的盐。 构成：弹性蛋白酶活化抑制剂含有化学式1的山梨酸，其衍生物或其药学上可接受的盐作为活性成分。 鼠尾草酸衍生物是鼠尾草酸甲酯或鼠尾草甲醇。 鼠尾草酸，衍生物或药学上可接受的盐衍生自迷迭香和/或鼠尾草。 抑制剂含有0.0001-20重量％的活性成分。 MMP表达抑制剂含有鼠尾草酸，衍生物或药学上可接受的盐作为活性成分。 用于皮肤抗衰老的组合物含有鼠尾草酸，衍生物或药学上可接受的盐作为活性成分。
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公开(公告)号：KR102224314B1
公开(公告)日：2021-03-09
申请号：KR1020170096881
申请日：2017-07-31
Applicant: (주)아모레퍼시픽
IPC: A61K8/02 , A61K8/04 , A61K8/34 , A61K8/60 , A61K8/68 , A61K8/9789 , A61Q19/00 , A61Q19/08 , A61Q19/02
Abstract: 외상으로서수상부; 및상기수상부에분산된구형입자들로이루어진유상부;를포함하고, 상기구형입자는탄소수 22 이하의알코올및 수크로스(sucrose)계계면활성제를포함하는것인분산제형화장료조성물에관한것으로, 상기구형입자를포함함으로써제형의안정성이우수하고, 피부에도포시이물감이없다.
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公开(公告)号：KR1020160116861A
公开(公告)日：2016-10-10
申请号：KR1020150045201
申请日：2015-03-31
Applicant: (주)아모레퍼시픽
IPC: C07C233/70 , A61K8/42 , A61K31/166 , A23L1/30 , A61Q19/00
CPC classification number: C07C233/70 , A61K8/42 , A61K31/166 , A61Q19/00 , A61Q19/02
Abstract: 본발명은신규벤조산아마이드유도체화합물, 이의이성질체, 이의약학적으로허용가능한염, 이의프로드럭, 이의수화물또는이의용매화물을개시한다. 상기신규화합물등은멜라닌생성을억제하고, 타이로시나제활성을저해하며, 뛰어난피부미백효과를가진다.
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公开(公告)号：KR1020170003163A
公开(公告)日：2017-01-09
申请号：KR1020150093463
申请日：2015-06-30
Applicant: (주)아모레퍼시픽
Abstract: 본발명은무계면활성제시스템의고형지질미립자를포함하는분산액및 이를이용한화장료조성물에관한것으로, 특정조합에서의고형지질미립자의열적거동이현저하게저하됨에따른향상된온도안정성및 우수한외관품질을가지는고형지질미립자를포함하는분산액및 이를이용한화장료조성물을제공한다.
Abstract translation: 本发明涉及含有不含表面活性剂的体系的固体脂质微粒的分散液和使用其的化妆品组合物，并且提供：含有固体脂质微粒的分散液，其具有改善的温度稳定性和优异的外观质量 固体脂质微粒在特定组合中的热行为显着恶化; 和使用其的化妆品组合物。
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Patent Agency Ranking
公开(公告)号：KR1020150062443A
公开(公告)日：2015-06-08
申请号：KR1020130147098
申请日：2013-11-29
Applicant: (주)아모레퍼시픽
IPC: C07C235/24 , A61K31/166 , A61P17/18
Abstract: 본발명은일측면에서아이오논유도체화합물, 이의이성질체, 이의약학적으로허용가능한염, 이의프로드럭, 이의수화물또는이의용매화물에관한것이다. 본발명은다른일측면에서아이오논유도체화합물, 이의이성질체, 이의약학적으로허용가능한염, 이의프로드럭, 이의수화물또는이의용매화물을포함하는피부노화방지용조성물에관한것이다.
Abstract translation: 本发明的一个方面涉及紫罗兰酮衍生物化合物，其异构体，其异构体，其药学上可接受的盐，其前体药物，其水合物或其溶剂合物。 本发明的另一方面涉及一种用于防止皮肤老化的组合物，其中紫罗兰酮衍生物化合物，其异构体，其药学上可接受的盐，其前药，其水合物或 包括其中的溶剂合物。
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公开(公告)号：KR1020140117842A
公开(公告)日：2014-10-08
申请号：KR1020130032634
申请日：2013-03-27
Applicant: (주)아모레퍼시픽
IPC: C07C233/05 , A61K31/165 , A61P17/16
Abstract: The present invention relates to a novel phenylacetic acid amide derivative compound, isomers thereof, pharmaceutically acceptable salt thereof, prodrug thereof, a hydrate or a solvate thereof, and a composition for skin whitening comprising the same. The novel compound or the like has excellent skin whitening effect.
Abstract translation: 本发明涉及一种新的苯乙酸酰胺衍生物化合物，其异构体，其药学上可接受的盐，其前体药物，其水合物或溶剂合物，以及包含其的皮肤美白组合物。 新颖的化合物等具有优异的皮肤美白效果。
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公开(公告)号：KR1020140069931A
公开(公告)日：2014-06-10
申请号：KR1020120137822
申请日：2012-11-30
Applicant: (주)아모레퍼시픽
IPC: C07C233/09 , C07C233/02
Abstract: The present invention provides a novel pseudo-ceramide compound represented by Chemical Formula 1, an isomer thereof, a pharmaceutically acceptable salt thereof, a pro-drug thereof, a hydrate thereof, and a solvate thereof. [Chemical Formula 1] (In Chemical Formula 1, R is a C9 to 17 saturated or unsaturated aliphatic chain, and R′ is an amino group or an alkoxy group having a C10 to 18 saturated aliphatic chain.) According to the present invention, the novel pseudo-ceramide compound has a skin protecting effect by having excellent stability, dissolubility, and skin moisturization, so that the novel pseudo-ceramide compound can be used as an active ingredient for protecting the skin from external stimuli without side effects, preventing the skin from damage, and recovering damaged skin. Accordingly, the novel pseudo-ceramide compound can be used as a skin-moisturizing composition for external application on skin, a cosmetic composition, or a pharmaceutical composition.
Abstract translation: 本发明提供由化学式1表示的新型假神经酰胺化合物，其异构体，药学上可接受的盐，其前体药物，其水合物及其溶剂合物。 [化学式1]（化学式1中，R为C 9〜17饱和或不饱和脂肪族链，R'为氨基或碳原子数为10〜18的饱和脂肪族链的烷氧基。）根据本发明， 新型伪神经酰胺化合物通过具有优异的稳定性，溶解性和皮肤保湿性而具有皮肤保护效果，因此新颖的假神经酰胺化合物可以用作保护皮肤免受外部刺激的活性成分而没有副作用，从而防止 皮肤受损，并恢复受损皮肤。 因此，新颖的假神经酰胺化合物可以用作皮肤外用的皮肤保湿组合物，化妆品组合物或药物组合物。
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公开(公告)号：KR1020130052243A
公开(公告)日：2013-05-22
申请号：KR1020110117591
申请日：2011-11-11
Applicant: (주)아모레퍼시픽
IPC: A61K31/192 , A61K31/185 , A61K31/047 , A61P17/00
Abstract: PURPOSE: A skin irritation relieving agent containing carnosic acid or a derivative thereof is provided to suppress release of IL-8(interleukin-8), MCP-1(monocyte chemotactic protein-1), and IL-6(interleukin-6), and to relieves skin irritation due to retinoid or surfactant. CONSTITUTION: A skin irritation relieving agent contains carnosic acid denoted by chemical formula 1, a derivative thereof, or pharmaceutically acceptable salt thereof as an active ingredient. The skin irritation relieving agent relieves inflammation, skin dryness, erythema, horny substance, itching, or burning sensation. The skin irritation is caused by retinoid or surfactant of an external use skin formulation. The retinoid is selected from the group consisting of retinol, retinal, and retinoic acid.
Abstract translation: 目的：提供含有肌痛酸或其衍生物的皮肤刺激缓解剂，以抑制IL-8（白细胞介素-8），MCP-1（单核细胞趋化蛋白-1）和IL-6（白细胞介素-6）的释放， 并减轻由类视黄醇或表面活性剂引起的皮肤刺激。 构成：皮肤刺激缓释剂含有以化学式1表示的棘皮酸，其衍生物或其药学上可接受的盐作为活性成分。 皮肤刺激缓解剂减轻炎症，皮肤干燥，红斑，角质，瘙痒或灼热感。 皮肤刺激是由外用皮肤制剂的类视色素或表面活性剂引起的。 类视黄醇选自视黄醇，视黄醛和视黄酸。
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公开(公告)号：KR1020130015954A
公开(公告)日：2013-02-14
申请号：KR1020110078309
申请日：2011-08-05
Applicant: (주)아모레퍼시픽
IPC: C07C235/46 , C07C235/48 , A61K8/42 , A61Q19/02
CPC classification number: A61K8/42 , A61Q19/00 , A61Q19/02 , C07C235/46 , C07C235/48 , C07C2603/74
Abstract: PURPOSE: A benzoic acid amide compound is provided to have excellent a skin-whitening effect without side effects by suppressing melanin generation and decreasing tyrosinase activity. CONSTITUTION: A benzoic acid amide compound, an isomer thereof, pharmaceutically-acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof is represented by chemical formula 1. In the chemical formula 1: each of R1, R3, and R4 is independently selected from hydrogen, hydroxy, C1-C5 alkoxy, C3-C6 cycloalkoxy, aryloxy, and C1-C15 haloalkoxy; R2 is selected from hydrogen, C1-C5 alkyl, C3-C6 cycloalkyl, aryl, and C1-C5 haloalkyl; and n is an integer from 1-5.
Abstract translation: 目的：提供苯甲酸酰胺化合物以通过抑制黑色素产生和降低酪氨酸酶活性而具有优异的美白效果而没有副作用。 构成：化学式1表示苯甲酸酰胺化合物，其异构体，药学上可接受的盐，其前药，其水合物或其溶剂合物。在化学式1中，R1，R3和 R 4独立地选自氢，羟基，C 1 -C 5烷氧基，C 3 -C 6环烷氧基，芳氧基和C 1 -C 15卤代烷氧基; R2选自氢，C1-C5烷基，C3-C6环烷基，芳基和C1-C5卤代烷基; n为1-5的整数。
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