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公开(公告)号：KR1020110089108A
公开(公告)日：2011-08-04
申请号：KR1020110009687
申请日：2011-01-31
Applicant: 한미사이언스 주식회사 , 한국과학기술연구원 , 가톨릭대학교 산학협력단
Inventor： 손정범 , 정승현 , 최화일 , 정영희 , 최재율 , 송지연 , 이규항 , 이재철 , 김은영 , 안영길 , 김맹섭 , 최환근 , 심태보 , 함영진 , 박동식 , 김환 , 김동욱
IPC: C07D495/04 , A61K31/519 , A61P35/00
CPC classification number: C07D495/04
Abstract: PURPOSE: A thieno[3,2-d]pyrimidine derivative having an activity of suppressing protein kinase is provided to prevent abnormal cell growth diseases. CONSTITUTION: A thieno[3,2-d]pyrimidine derivative has a structure of chemical formula 1. A pharmaceutical composition for preventing or treating abnormal cell growth caused by excessive activation of protein kinase contains the compound. The protein kinase includes Bcr-Ab1, FGFR, Flt, KDR, PDGFR, Fms, Kit, Raf, Tie2, Src, or Ret.
Abstract translation: 目的：提供具有抑制蛋白激酶活性的噻吩并[3,2-d]嘧啶衍生物，以防止异常细胞生长疾病。 构成：噻吩并[3,2-d]嘧啶衍生物具有化学式1的结构。用于预防或治疗由蛋白激酶的过度活化引起的异常细胞生长的药物组合物含有该化合物。 蛋白激酶包括Bcr-Ab1，FGFR，Flt，KDR，PDGFR，Fms，Kit，Raf，Tie2，Src或Ret。
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公开(公告)号：KR101598327B1
公开(公告)日：2016-02-26
申请号：KR1020160006107
申请日：2016-01-18
Applicant: 가톨릭대학교 산학협력단
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
Abstract: 본발명은 DNA 복제수변이(DNA copy number variants)를이용하는강직성척추염발병위험도예측방법에관한것이다. 본발명의 DNA 복제수변이검출용프라이머를이용하여, 강직성척추염발병위험도를효과적으로예측할수 있으며, 단일염기다형성(SNP) 측정결과를접목시킴으로써상기예측의민감도와특이도를증진시킬수 있음을확인하였는바, 강직성척추염의예방및 치료에있어서보다근본적으로접근할수 있을것으로기대된다.
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公开(公告)号：KR1020160014083A
公开(公告)日：2016-02-05
申请号：KR1020160006107
申请日：2016-01-18
Applicant: 가톨릭대학교 산학협력단
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
Abstract: 본발명은 DNA 복제수변이(DNA copy number variants)를이용하는강직성척추염발병위험도예측방법에관한것이다. 본발명의 DNA 복제수변이검출용프라이머를이용하여, 강직성척추염발병위험도를효과적으로예측할수 있으며, 단일염기다형성(SNP) 측정결과를접목시킴으로써상기예측의민감도와특이도를증진시킬수 있음을확인하였는바, 강직성척추염의예방및 치료에있어서보다근본적으로접근할수 있을것으로기대된다.
Abstract translation: 本发明涉及通过使用DNA拷贝数变体来预测强直性脊柱炎的发病风险的方法。 通过使用用于检测本发明的DNA拷贝数变体的引物可以有效地预测强直性脊柱炎的发病风险。 通过嫁接单核苷酸多态性（SNP）的测量结果可以提高对预测的敏感性和特异性。 因此，预防和治疗强直性脊柱炎的基本方法是预期的。 该组合物包含在1q32.2位，2q31.2位，6p21.32位，13q13.1位和16p13.3位的染色体上的遗传标记的组合。 该方法包括以下步骤：（a）进行PCR; （b）对PCR产物进行测序; 和（c）确定样品是否具有来自测序结果的DNA拷贝数变体。
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公开(公告)号：KR1020130135414A
公开(公告)日：2013-12-11
申请号：KR1020120058639
申请日：2012-05-31
Applicant: 가톨릭대학교 산학협력단
CPC classification number: C12Q1/6883 , C12Q1/6811 , C12Q1/6862
Abstract: The present invention relates to a multiple detection method of a copy number variation using the mobile phase difference by a cubical structure of a probe regardless of the length difference of the probe, and a kit for embodying the method. The multiple detection method of a copy number variation is obtained by changing conventional MLPA (multiplex ligation-dependent probe amplification) technology for analyzing the copy number based on the length difference of the probe.
Abstract translation: 本发明涉及使用探针的立方体结构的移动相位差的多重检测方法，而不管探针的长度差如何，以及用于体现该方法的试剂盒。 通过改变用于基于探针的长度差分析拷贝数的常规MLPA（多重连接依赖性探针扩增）技术来获得拷贝数变异的多重检测方法。
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公开(公告)号：KR1020110096385A
公开(公告)日：2011-08-30
申请号：KR1020100015806
申请日：2010-02-22
Applicant: 삼성전자주식회사 , 가톨릭대학교 산학협력단
CPC classification number: C12Q1/6888 , C12Q1/6837
Abstract: 아시아 인종을 구별하는 마커, 조성물, 키트 및 마이크로어레이, 및 아시아 인종을 구별하는 방법을 제공한다.
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Patent Agency Ranking
公开(公告)号：KR101967100B1
公开(公告)日：2019-08-13
申请号：KR1020180080660
申请日：2018-07-11
Applicant: 가톨릭대학교 산학협력단
IPC: C12Q1/6886 , G01N33/574
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18.发明公开１ｑ２５．１(RABGAP1L) 위치, 6p21.32 (C4) 위치 및 １０ｑ２１．３위치의 ＤＮＡ 복제 수 변이 검출용 프라이머를 포함하는 전신성 홍반성 루푸스 발병 위험도 예측용 조성물 有权用于检测1Q25.1，C4和10Q21.3复制编号变量的系统性LUPUS ERYTHEMATOSUS风险预测组合
公开(公告)号：KR1020140046362A
公开(公告)日：2014-04-18
申请号：KR1020120144720
申请日：2012-12-12
Applicant: 가톨릭대학교 산학협력단
CPC classification number: C12Q1/6851 , A61K48/00 , C12Q1/6827
Abstract: The present invention relates to a composition for a systemic lupus erythematosus risk prediction. In detail, in case where copy number variants of 1q25.1, C4 and 10q21.3 loci occur, the variants are regarded as high-risk groups for a systemic lupus erythematosus through the composition. The composition of the present invention enables prediction for the risk of systemic lupus erythematosus as the copy number variants of the three loci have a synergy effect for a development of systemic lupus erythematosus. Furthermore, the present invention is a test-friendly method which reduces analytical errors which may be created due to a new equipment purchased or technological limitations as a PCR generally implemented in a inspection room of majority of hospitals is used. In addition, the present invention is able to apply a non-invasive method to a person to be tested. Ultimately, the present invention predicts the risk of systemic lupus erythematosus which will essentially contribute to delaying development of the disease or to preventing an aggravation of state.
Abstract translation: 本发明涉及一种用于系统性红斑狼疮风险预测的组合物。 详细地，如果发生1q25.1，C4和10q21.3位点的拷贝数变体，则该变体被认为是通过该组合物的系统性红斑狼疮的高风险组。 本发明的组合物能够预测系统性红斑狼疮的风险，因为三个位点的拷贝数变体对系统性红斑狼疮的发展具有协同作用。 此外，本发明是一种测试友好的方法，其减少了由于购买的新设备而产生的分析错误或技术限制，因为通常在多数医院的检查室中实施PCR。 此外，本发明能够将非侵入性方法应用于被测试者。 最终，本发明预测系统性红斑狼疮的风险，其将基本上有助于延缓疾病的发展或防止状态恶化。
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公开(公告)号：KR102072562B1
公开(公告)日：2020-02-03
申请号：KR1020180074326
申请日：2018-06-27
Applicant: 가톨릭대학교 산학협력단
IPC: C12Q1/6883
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20.发明授权
公开(公告)号：KR101598328B1
公开(公告)日：2016-02-26
申请号：KR1020160006113
申请日：2016-01-18
Applicant: 가톨릭대학교 산학협력단
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158
Abstract: 본발명은 DNA 복제수변이(DNA copy number variants)를이용하는강직성척추염발병위험도예측방법에관한것이다. 본발명의 DNA 복제수변이검출용프라이머를이용하여, 강직성척추염발병위험도를효과적으로예측할수 있으며, 단일염기다형성(SNP) 측정결과를접목시킴으로써상기예측의민감도와특이도를증진시킬수 있음을확인하였는바, 강직성척추염의예방및 치료에있어서보다근본적으로접근할수 있을것으로기대된다.
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