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公开(公告)号：KR1020090107005A
公开(公告)日：2009-10-12
申请号：KR1020090080306
申请日：2009-08-28
Applicant: 강화군
IPC: A61K31/34 , A61K36/282 , A61P3/06 , A61P9/10
Abstract: PURPOSE: A pharmaceutical composition containing Artemisia princeps pampanini extract is provided to ensure anti-oxidative activity and prevent and treat heart circulatory diseases such as hyperlipidemia, coronary artery, arteriosclerosis, and myocardial infarction. CONSTITUTION: A pharmaceutical composition for preventing and treating heart circulatory diseases contains 3β,4β-epoxy-8α-isobutyryloxyguaia-1(10),11(13)-diene-12,6α-olide of the chemical formula 1 as an active ingredient. The 3β,4β-epoxy-8α-isobutyryloxyguaia-1(10),11(13)-diene-12,6α-olide is obtained by extracting Artemisia princeps pampanini using low alcohol of C1-C4, desirably methanol solution, and performing fraction.
Abstract translation: 目的：提供含有青蒿提取物的药物组合物，以确保抗氧化活性，预防和治疗心脏循环系统疾病如高脂血症，冠状动脉，动脉硬化和心肌梗塞。 构成：用于预防和治疗心脏循环系统疾病的药物组合物含有化学式1的3β，4β-环氧-8α-异丁酰氧基瓜亚-1（10），11（13） - 二烯-12,6α-二醇作为活性成分。 通过使用C1-C4的低醇，优选甲醇溶液提取青蒿提取青蒿素获得3β，4β-环氧-8α-异丁酰氧基瓜亚胺（10），11（13） - 二烯-12,6α- 。
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公开(公告)号：KR1020090064697A
公开(公告)日：2009-06-22
申请号：KR1020070131988
申请日：2007-12-17
Applicant: 강화군
IPC: A61K31/352 , A61K36/282 , A61P35/00
Abstract: A pharmaceutical composition containing an Artemisia princeps is provided to induce apoptosis of cells of ovarian cancer and leukemia and suppress the activation of cholesterol acyltransferase. A pharmaceutical composition for preventing and treating cancer comprises (3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide) as an active ingredient. The (3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide) is isolated from an Artemisia princeps and contained in a ratio of 0.01-99 weight%. The cancer is ovarian cancer and leukemia. A pharmaceutical composition for preventing and treating cardiac circulation diseases comprises the (3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide) as an active ingredient. The cardiac circulation diseases are hyperlipidemia, coronary heart disease, arteriosclerosis or myocardial infarction.
Abstract translation: 提供含有青蒿的药物组合物以诱导卵巢癌和白血病细胞的凋亡并抑制胆固醇酰基转移酶的活化。 用于预防和治疗癌症的药物组合物包含作为活性成分的（3-（2-甲基 - 丁酰氧基）-costu-1（10），4（5） - 二 - 12,6-二醇）。 （3-（2-甲基 - 丁酰氧基）-costu-1（10），4（5）-ien-12,6-olide）从艾蒿中分离，其含量为0.01-99重量％。 癌症是卵巢癌和白血病。 用于预防和治疗心脏循环疾病的药物组合物包含作为活性成分的（3-（2-甲基 - 丁酰氧基）-costu-1（10），4（5）-ien-12,6-olide）。 心脏循环疾病是高脂血症，冠心病，动脉硬化或心肌梗死。
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公开(公告)号：KR100900875B1
公开(公告)日：2009-06-04
申请号：KR1020060029316
申请日：2006-03-31
Applicant: 강화군
IPC: A61K36/282 , A61P3/10
Abstract: 본 발명은 강화약쑥 추출물을 포함하는 당뇨병의 예방 및 치료용 조성물에 관한 것이다. 보다 구체적으로, 본 발명은 강화약쑥 추출물을 유효성분으로 함유하는 당뇨병의 예방 또는 치료용 약학적 조성물 및 식품 조성물에 관한 것이다.
본 발명에 따른 강화약쑥 추출물은 당뇨병으로 인한 당대사 및 지질대사 이상을 정상화하고 당뇨로 인해 비정상적으로 증가된 항산화 효소의 활성을 정상화함으로써 당뇨병의 예방 및 치료에 유용하게 사용될 수 있다.
강화약쑥 추출물, 당뇨병, 당대사, 지질대사, 항산화 효소-
Patent Agency Ranking
公开(公告)号：KR100865514B1
公开(公告)日：2008-10-29
申请号：KR1020070031249
申请日：2007-03-30
Applicant: 강화군
IPC: A61K36/282 , A61P9/10
Abstract: Gang-Hwa Mugwart is provided to have the excellent antioxidant activity to the low density lipoprotein, to suppress effectively an activity of an acyl coA: an cholesterol transferase, suppress effectively an activity of the cholesteryl ester transfer protein and suppress a synthesis and an accumulation of the cholesteryl ester which is the storage-shaped cholesterol. A composition for preventing or treating vascular disease has Artemisia princeps extracts which are extracted by an alcohol as the active ingredient. The alcohol is selected from the group consisting of methanol, the ethanol propanol and butanol. A concentration of the alcohol is 0 - 100%.
Abstract translation: Gang-Hwa Mugwart具有对低密度脂蛋白的优异的抗氧化活性，有效抑制酰基辅酶A的活性：胆固醇转移酶，有效抑制胆固醇酯转移蛋白的活性，抑制合成和积累 胆固醇酯是存储形状的胆固醇。 用于预防或治疗血管疾病的组合物具有以醇作为活性成分提取的青蒿提取物。 醇选自甲醇，乙醇丙醇和丁醇。 醇的浓度为0-100％。
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公开(公告)号：KR100949012B1
公开(公告)日：2010-03-23
申请号：KR1020070131992
申请日：2007-12-17
Applicant: 강화군
IPC: A61K31/352 , A61K36/282 , A61P35/00
Abstract: 본 발명은 사자발쑥 추출물을 포함하는 약학 조성물에 관한 것으로, 특히 사자발쑥 추출물 중 유파폴린(Eupafolin)을 유효성분으로 포함하여 암 질환 뿐 아니라 심장순환계 질환의 예방 및 치료에 효과적인 약학 조성물에 관한 것이다.
유파폴린, 사자발쑥, 난소암, 폐암, 뇌종양, 동맥경화, 고지혈증-
公开(公告)号：KR100926413B1
公开(公告)日：2009-11-12
申请号：KR1020070132002
申请日：2007-12-17
Applicant: 강화군
IPC: A61K31/7034 , A61K31/35 , A61K36/31 , A61P13/12
Abstract: 본 발명은 항암제에 의해 유발되는 신장 독성 질환 예방 및 치료용 약학 조성물에 관한 것으로, 특히 순무로부터 추출한 진저론-4-
O -
β -
D -글루코피라노사이드(Zingerone-4-
O -
β -
D -glucopyranoside)를 유효성분으로 포함함으로써 기존 항암제로 사용되는 시스플라틴(cisplatin)과 같이 투여할 경우 시스플라틴의 부작용인 신장 독성을 감소시키면서 항암 효능을 증진시킬 수 있는 항암제에 의해 유발되는 신장 독성 질환 예방 및 치료용 약학 조성물에 관한 것이다.
진저론-글루코피라노사이드, 시스플라틴, 신장 독성, 항암제-
公开(公告)号：KR1020090086506A
公开(公告)日：2009-08-13
申请号：KR1020090069668
申请日：2009-07-29
Applicant: 강화군
IPC: C07D307/77 , A61K31/352 , A61K36/282 , A61P35/00
Abstract: A pharmaceutical composition containing Artemisia princeps PAMPANINI extract or sesquiterpene compound isolated from the extract is provided to have strong cytotoxicity such as suppression of cancer cell proliferation or induction of apoptosis. A pharmaceutical composition for treating cancer or heart circulatory diseases comprises Artemisia princeps PAMPANINI extract or sesquiterpene compound of the chemical formula 1 isolated from the extract. The sesquiterpene compound of the chemical formula 1 is 3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide. A method for producing the sesquiterpene compound of the chemical formula 1 comprises: a step of dipping dried Artemisia princeps in low alcohol of C1-C4 for 24 hours; and a step of filtering, compressing and fractioning.
Abstract translation: 提供含有从提取物中分离的青蒿提取物或倍半萜烯化合物的药物组合物以具有强的细胞毒性，例如抑制癌细胞增殖或诱导细胞凋亡。 用于治疗癌症或心脏循环系统疾病的药物组合物包括从提取物中分离的化学式1的青蒿提取物或倍半萜烯化合物。 化学式1的倍半萜化合物是3-（2-甲基 - 丁酰氧基） - 硬脂酸-1（10），4（5） - 二 - 12,6-二醇。 制备化学式1的倍半萜烯化合物的方法包括：将干燥的青蒿干燥在C1-C4的低醇中浸渍24小时的步骤; 以及过滤，压缩和分馏的步骤。
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公开(公告)号：KR1020070098092A
公开(公告)日：2007-10-05
申请号：KR1020060029316
申请日：2006-03-31
Applicant: 강화군
IPC: A61K36/282 , A61P3/10
Abstract: A composition for preventing and treating diabetes mellitus comprising the extract of gang-hwa mugwort(Artemisia) is provided to normalize sugar metabolism and lipid metabolism disorders caused by diabetes mellitus and activity of anti-oxidizing enzyme which is abnormally increased. A composition for preventing and treating diabetes mellitus comprises the extract of gang-hwa mugwort which is prepared by extracting gang-hwa mugwort with water or C1-C5 alcohol including methanol, ethanol, butanol, propanol and pentanol, wherein the diabetes mellitus is non-insulin dependent diabetes mellitus; and the composition is a pharmaceutical or food composition.
Abstract translation: 提供一种用于预防和治疗糖尿病的组合物，其包含由江蒿（艾蒿）提取物提供的糖代谢和由糖尿病引起的脂质代谢紊乱和异常升高的抗氧化酶的活性。 用于预防和治疗糖尿病的组合物包括通过用水或包括甲醇，乙醇，丁醇，丙醇和戊醇的C1-C5醇提取组合艾草而制备的组织提取物，其中糖尿病是非 - 胰岛素依赖性糖尿病; 并且组合物是药物或食物组合物。
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