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公开(公告)号：KR100949011B1
公开(公告)日：2010-03-23
申请号：KR1020090080306
申请日：2009-08-28
Applicant: 강화군
IPC: A61K31/34 , A61K36/282 , A61P3/06 , A61P9/10
Abstract: 본 발명은 사자발쑥 추출물을 포함하는 약학 조성물에 관한 것으로, 특히 사자발쑥 추출물 중 3β,4β-에폭시-8α-이소부티릴옥시구아이아-1(10),11(13)-디엔-12,6α-올라이드를 유효성분으로 포함하여 심장순환계 질환의 예방 및 치료에 효과적인 약학 조성물에 관한 것이다.
3β,4β-에폭시-8α-이소부티릴옥시구아이아-1(10),11(13)-디엔-12,6α-올라이드, 사자발쑥, 동맥경화, 고지혈증Abstract translation: 本发明涉及药物组合物，特别是3β，4β-环氧-8α-异丁氧基sajabal艾蒿提取物AH-1岁儿童（10），其包括sajabal艾蒿提取物，11（13） - 二烯-12， 6α-内酯为有效成分，对心血管疾病的预防和治疗有效。
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公开(公告)号：KR1020090064692A
公开(公告)日：2009-06-22
申请号：KR1020070131982
申请日：2007-12-17
Applicant: 강화군
IPC: A61K31/352 , A61K36/282 , A61P35/00
Abstract: A pharmaceutical composition containing an Artemisia princeps extract is provided to prevent and treat cancer and cardiac circulation disease by the effects of strong cytotoxicity and antioxidation activity. A composition for preventing and treating cancer comprises a 3beta,4beta-epoxy-8a-isobutyryloxyguaia-1(10),11(13)-diene-12.6a-olide as an active ingredient. The 3beta,4beta-epoxy-8a-isobutyryloxyguaia-1(10),11(13)-diene-12.6a-olide is isolated from an Artemisia princeps. The 3beta,4beta-epoxy-8a-isobutyryloxyguaia-1(10),11(13)-diene-12.6a-olide is contained in a ratio of 0.01-94 weight%. The cancer is ovarian cancer or leukemia.
Abstract translation: 提供含有青蒿提取物的药物组合物，以通过强的细胞毒性和抗氧化活性的作用预防和治疗癌症和心脏循环疾病。 用于预防和治疗癌症的组合物包含作为活性成分的3β，4β-环氧-8a-异丁酰氧基瓜亚-1（10），11（13） - 二烯-12.6a-olide。 从艾蒿中分离出3β，4β-环氧-8a-异丁酰氧基瓜亚-1（10），11（13） - 二烯-12.6a-olide。 3β，4β-环氧-8a-异丁酰氧基瓜亚-1（10），11（13） - 二烯-12.6a-olide的含量为0.01-94重量％。 癌症是卵巢癌或白血病。
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公开(公告)号：KR100865513B1
公开(公告)日：2008-10-29
申请号：KR1020070025560
申请日：2007-03-15
Applicant: 강화군
IPC: A61K36/282 , A61P3/04
Abstract: A composition for preventing and treating obesity is provided to show an effect for improving a liver function and an anti-obesity effect and not to have a side effect when users take the composition for preventing and treating obesity because the composition for preventing and treating obesity is natural food material. A composition for preventing and treating obesity has the alcoholic extract of 1 - 3 carbon number of the Artemisia princeps as an active ingredient. The gang-hwa mugwort extract is manufactured by adding the ethanol in the gang-hwa mugwort powder 2~10 times, and extracts at the room temperature for 12 ~24 hours. The extract is filtered into a centrifuge or the filter paper, precipitates are removed, and a supernatant is collected. The gang-hwa mugwort extract is manufactured into the powder form by drying the concentrated supernatant after the collected supernatant is concentrated.
Abstract translation: 提供了用于预防和治疗肥胖症的组合物，以显示用于改善肝功能和抗肥胖效果的效果，并且当用户采取预防和治疗肥胖症的组合物时不具有副作用，因为用于预防和治疗肥胖症的组合物是 天然食材。 用于预防和治疗肥胖症的组合物具有作为活性成分的艾蒿的1-3个碳数的醇提取物。 通过将乙炔加入组合艾蒿粉2〜10次，制成江阴艾蒿提取物，室温萃取12〜24小时。 将提取物过滤到离心机或滤纸中，除去沉淀物，并收集上清液。 将收集的上清液浓缩后，将干燥浓缩的上清液制成粉状的粉末状提取物。
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公开(公告)号：KR100933738B1
公开(公告)日：2009-12-24
申请号：KR1020070131988
申请日：2007-12-17
Applicant: 강화군
IPC: A61K31/352 , A61K36/282 , A61P35/00
Abstract: 본 발명은 사자발쑥 추출물을 포함하는 약학 조성물에 관한 것으로, 특히 사자발쑥으로부터 추출한 3-(2-메틸-부티릴옥시)-코스투-1(10),4(5)-디엔-12,6-올라이드(3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide)를 유효성분으로 포함하여 암 질환 뿐 아니라 심장순환계 질환의 예방 및 치료에 효과적인 약학 조성물에 관한 것이다.
3-(2-메틸-부티릴옥시)-코스투-1(10),4(5)-디엔-12,6-올라이드, 사자발쑥, 난소암, 백혈병, 심장순환계 질환Abstract translation: 提供含有艾蒿的药物组合物以诱导卵巢癌和白血病细胞的凋亡并抑制胆固醇酰基转移酶的活化。 用于预防和治疗癌症的药物组合物包含作为活性成分的（3-（2-甲基丁酰氧基） - 缩水甘油-1（10），4（5） - 二烯-12,6-内酯）。 从蒿属植物中分离出（3-（2-甲基丁酰氧基） - 羰基-1（10），4（5） - 二烯-12,6-内酯），其含量为0.01-99重量％。 癌症是卵巢癌和白血病。 用于预防和治疗心脏循环疾病的药物组合物包含作为活性成分的（3-（2-甲基丁酰氧基） - 缩水甘油-1（10），4（5） - 二烯-12,6-内酯）。 心脏循环疾病是高脂血症，冠心病，动脉硬化或心肌梗塞。
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公开(公告)号：KR100929098B1
公开(公告)日：2009-11-30
申请号：KR1020090069668
申请日：2009-07-29
Applicant: 강화군
IPC: C07D307/77 , A61K31/352 , A61K36/282 , A61P35/00
Abstract: 본 발명은 사자발쑥 추출물에 관한 것으로, 특히 사자발쑥으로부터 추출한 3-(2-메틸-부티릴옥시)-코스투-1(10),4(5)-디엔-12,6-올라이드(3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide)에 관한 것이다.
3-(2-메틸-부티릴옥시)-코스투-1(10),4(5)-디엔-12,6-올라이드, 사자발쑥, 난소암, 백혈병, 심장순환계 질환Abstract translation: 提供含有从提取物中分离的艾蒿提取物或倍半萜烯化合物的药物组合物具有强烈的细胞毒性，例如抑制癌细胞增殖或诱导细胞凋亡。 用于治疗癌症或心脏循环系统疾病的药物组合物包含从提取物中分离的化学式1的艾蒿提取物或倍半萜烯化合物。 化学式1的倍半萜烯化合物是3-（2-甲基丁酰氧基） - 羰基-1（10），4（5） - 二烯-12,6-内酯。 生产化学式1的倍半萜化合物的方法包括：将干燥的蒿属植物在C1-C4的低级醇中浸渍24小时的步骤; 以及过滤，压缩和分离的步骤。
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Patent Agency Ranking
公开(公告)号：KR1020090064705A
公开(公告)日：2009-06-22
申请号：KR1020070132002
申请日：2007-12-17
Applicant: 강화군
IPC: A61K31/7034 , A61K31/35 , A61K36/31 , A61P13/12
CPC classification number: A61K31/7034 , A61K36/31
Abstract: A pharmaceutical composition for preventing and treating disease of nephrotoxicity caused by anticancer drug is provided to reduce the nephrotoxicity and enhance anticancer activity. A pharmaceutical composition for preventing and treating diseases of nephrotoxicity caused by an anticancer drug comprises a zingerone-4-O-beta-D-glucopyranoside as an active ingredient. The zingerone-4-O-beta-D-glucopyranoside is isolated from a Brassica rapa. The zingerone-4-O-beta-D-glucopyranoside is contained in a ratio of 0.01-98 weight%. An anticancer adjuvant having inhibition activity to nephrotoxicity caused by anticancer drug comprises the zingerone-4-O-beta-D-glucopyranoside as an active ingredient.
Abstract translation: 提供了用于预防和治疗由抗癌药物引起的肾毒性疾病的药物组合物，以减少肾毒性并增强抗癌活性。 用于预防和治疗由抗癌药引起的肾毒性疾病的药物组合物包含作为有效成分的姜油酮-4-O-β-D-吡喃葡萄糖苷。 从芸苔属油菜籽中分离出了姜黄酮-4-O-β-D-吡喃葡萄糖苷。 姜黄酮-4-O-β-D-吡喃葡萄糖苷的含量为0.01-98重量％。 由抗癌药物引起的对肾毒性具有抑制活性的抗癌佐剂，以姜黄酮-4-O-β-D-吡喃葡萄糖苷为活性成分。
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公开(公告)号：KR1020090064702A
公开(公告)日：2009-06-22
申请号：KR1020070131999
申请日：2007-12-17
Applicant: 강화군
IPC: A61K31/4045 , A61K31/404 , A61K36/31 , A61P9/02
CPC classification number: A61K31/404 , A61K36/31
Abstract: A pharmaceutical composition containing Brassica rapa extracts is provided to prevent and treat kidney toxicity diseases by cisplatin and cardiac circulation disease by LDL oxidation. A pharmaceutical composition for preventing and treating kidney toxicity diseases which is caused by an anticancer drug comprises 0.01-98 weight% of 4-methoxyindole-3-acetonitrile as an active ingredient. The 4-methoxyindole-3-acetonitrile is isolated from a Brassica rapa. An anticancer adjuvant having suppression activity to kidney toxicity comprises the 4-methoxyindole-3-acetonitrile. A pharmaceutical composition for preventing and treating cardiac circulation diseases comprises the 4-methoxyindole-3-acetonitrile as an active ingredient. The cardiac circulation diseases are hyperlipidemia, cerebral artery, coronary heart disease, arteriosclerosis or myocardial infarction.
Abstract translation: 提供含有芸苔属提取物的药物组合物，通过LDL氧化预防和治疗顺铂和心脏循环疾病的肾脏毒性疾病。 用于预防和治疗由抗癌药物引起的肾毒性疾病的药物组合物包含0.01-98重量％的4-甲氧基吲哚-3-乙腈作为活性成分。 从芸苔属油菜中分离4-甲氧基吲哚-3-乙腈。 对肾毒性具有抑制活性的抗癌佐剂包括4-甲氧基吲哚-3-乙腈。 用于预防和治疗心脏循环疾病的药物组合物包含4-甲氧基吲哚-3-乙腈作为活性成分。 心脏循环疾病是高脂血症，脑动脉，冠心病，动脉硬化或心肌梗死。
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公开(公告)号：KR100933737B1
公开(公告)日：2009-12-24
申请号：KR1020070131982
申请日：2007-12-17
Applicant: 강화군
IPC: A61K31/352 , A61K36/282 , A61P35/00
Abstract: 본 발명은 사자발쑥 추출물을 포함하는 약학 조성물에 관한 것으로, 특히 사자발쑥 추출물 중 3β,4β-에폭시-8α-이소부티릴옥시구아이아-1(10),11(13)-디엔-12,6α-올라이드를 유효성분으로 포함하여 암 질환 뿐 아니라 심장순환계 질환의 예방 및 치료에 효과적인 약학 조성물에 관한 것이다.
3β,4β-에폭시-8α-이소부티릴옥시구아이아-1(10),11(13)-디엔-12,6α-올라이드, 사자발쑥, 난소암, 백혈병, 동맥경화, 고지혈증Abstract translation: 本发明提供一种含有艾蒿提取物的药物组合物，其通过强细胞毒性和抗氧化活性的作用来预防和治疗癌症和心脏循环疾病。 用于预防和治疗癌症的组合物包含作为活性成分的3β，4β-环氧-8α-异丁酰氧基瓜氨酸-1（10），11（13） - 二烯-12.6a-内酯。 从Artemisia princeps中分离出3beta，4beta-环氧-8a-异丁酰氧基guiaia-1（10），11（13） - 二烯-12.6a-内酯。 以0.01-94重量％的比例包含3β，4β-环氧-8α-异丁酰氧基瓜氨酸-1（10），11（13） - 二烯-12.6a-内酯。 癌症是卵巢癌或白血病。
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公开(公告)号：KR1020090064700A
公开(公告)日：2009-06-22
申请号：KR1020070131992
申请日：2007-12-17
Applicant: 강화군
IPC: A61K31/352 , A61K36/282 , A61P35/00
Abstract: A pharmaceutical composition containing an Artemisia princeps is provided to suppress the proliferation of cervical tumor cell, lung cancer cell, and brain tumor cell and prevent and treat cardiac circulation diseases. A pharmaceutical composition for preventing and treating cancer comprises 0.01-96 weight% of eupafolin as an active ingredient. The eupafolin is isolated from an Artemisia princeps. The cancer is ovarian cancer, lung cancer or brain tumor. A pharmaceutical composition for preventing and treating cardiac circulation diseases comprises the eupafolin as an active ingredient. The cardiac circulation diseases are arteriosclerosis, hyperlipidemia, cerebral artery or coronary artery.
Abstract translation: 提供含有青蒿的药物组合物，以抑制宫颈肿瘤细胞，肺癌细胞和脑肿瘤细胞的增殖，并预防和治疗心脏循环疾病。 用于预防和治疗癌症的药物组合物包含0.01-96重量％的作为活性成分的儿茶酚素。 紫花苜蓿从艾蒿中分离出来。 癌症是卵巢癌，肺癌或脑肿瘤。 用于预防和治疗心脏循环疾病的药物组合物包括作为活性成分的欧蓬芬。 心脏循环疾病是动脉硬化，高脂血症，脑动脉或冠状动脉。
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公开(公告)号：KR100949001B1
公开(公告)日：2010-03-23
申请号：KR1020070131999
申请日：2007-12-17
Applicant: 강화군
IPC: A61K31/4045 , A61K31/404 , A61K36/31 , A61P9/02
Abstract: 본 발명은 순무 추출물을 포함하는 약학 조성물에 관한 것으로, 특히 순무로부터 추출한 4-메톡시인돌-3-아세토니트릴(4-methoxyindole-3-acetonitrile)을 유효성분으로 포함하여 항암제에 의해 유발되는 신장 독성 질환뿐 아니라 심장순환계 질환의 예방 및 치료용 약학 조성물에 관한 것이다.
4-메톡시인돌-3-아세토니트릴, 순무, 시스플라틴, 신장 독성, 항암제, 심장순환계 질환
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