公开(公告)号：KR1020080106779A

公开(公告)日：2008-12-09

申请号：KR1020070054628

申请日：2007-06-04

Applicant: 삼성전자주식회사

Inventor： 이범석 ,  조윤경 ,  박종면 ,  이정건

IPC: G01N35/10 ,  G01N33/53 ,  G01N35/00 ,  G01N33/48

CPC classification number: B01L3/502738 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N35/00069

Abstract: A disk-shaped microfluidic apparatus is provided to allow both immune serum test and biochemical test to be carried out simultaneously, thereby reducing the time and effort required for the pathological examination. A disk type microfluidic apparatus(200) comprises a rotatable disk-shaped platform(100); an immune serum test unit which is arranged at the one part of the platform, comprises a plurality of chambers, a plurality of channels connecting the chambers and a plurality of valves controlling the flow of fluid through the channels, and detects the target material from the sample by using a microparticle having a capture probe on surface; and a biochemical test unit(230, 240) which is arranged at the other part of the platform and detects the target material from the sample by the biochemical reaction of the flown sample and the pre-stored reaction solution, wherein the plurality of valves comprises at least one phase transfer valve which comprises a valve material of a heat radiating particle dispersed in a phase transfer material which is solid at a room temperature and is liquid in a high temperature and whose valve material moves in the state molten by the electromagnetic wave irradiated from the external energy source so as to open or close the channels.

Abstract translation: 提供盘状微流体装置，以同时进行免疫血清检测和生物化学检测，从而减少病理检查所需的时间和精力。 盘式微流体装置（200）包括可旋转的盘形平台（100）; 布置在平台一部分的免疫血清测试单元包括多个腔室，连接腔室的多个通道和多个控制通过通道的流体流动的阀门，并从 通过使用表面上具有捕获探针的微粒进行样品测定; 和生化测试单元（230,240），其布置在所述平台的另一部分并且通过所述流动样品和所述预先存储的反应溶液的生化反应从所述样品检测所述目标材料，其中所述多个阀包括 至少一个相转移阀，其包括分散在室温下为固体且在高温下为液体并且其阀材料以电磁波辐射熔化的状态移动的相转移材料中的散热粒子的阀材料 从外部能源开启或关闭通道。

公开(公告)号：KR1020080103232A

公开(公告)日：2008-11-27

申请号：KR1020070050266

申请日：2007-05-23

Applicant: 삼성전자주식회사

Inventor： 이범석 ,  이정건 ,  박종면 ,  조윤경

IPC: G01N35/10 ,  G01N35/00

CPC classification number: B01L3/502738 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/04 ,  B01L2300/0636 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  Y10T436/15

Abstract: A disk type microfluidic device using a microfluidic chip is provided to automatically perform the work using various microfluidic chips within a disk type platform, and to reduce the manual work required in experiment or diagnosis using a microarray chip. A disk type microfluidic device using a biomolecule microarray chip includes a rotatable disk-type platform(100); a microfluidic structure which are arranged within the disk-type platform, includes a plurality of chambers(120,130,140), a plurality of channels(183) connecting a plurality of chambers and a plurality of valves controlling the flow of the fluid through the chambers, and manipulates the fluid sample with the rotation of the disk-shape platform and the valve; and a biomolecule microarray chip(190) mounted on the disk-type platform to contact the biomass capture probe with the sample of the microflow structure.

Abstract translation: 提供使用微流控芯片的盘式微流体装置，以使用盘式平台内的各种微流控芯片自动执行工作，并减少使用微阵列芯片进行实验或诊断所需的手动工作。 使用生物分子微阵列芯片的盘式微流体装置包括可旋转的盘式平台（100）; 布置在盘式平台内的微流体结构包括多个室（120,130,140），连接多个室的多个通道（183）和控制流经该室的流体的多个阀，以及 通过盘形平台和阀门的旋转来操纵流体样品; 和安装在盘型平台上的生物分子微阵列芯片（190），以将生物量捕获探针与微流结构的样品接触。

公开(公告)号：KR1020080098287A

公开(公告)日：2008-11-07

申请号：KR1020070043809

申请日：2007-05-04

Applicant: 삼성전자주식회사

Inventor： 이정건 ,  이정남 ,  조윤경 ,  유정석

IPC: G01N21/03 ,  G01N21/29 ,  G11B7/00

CPC classification number: G01N35/00069 ,  G01N21/07 ,  G01N21/253 ,  G01N21/64 ,  G01N21/6452 ,  G01N2201/0415 ,  G01N2201/0696 ,  G01N21/03 ,  G01N21/29 ,  G11B7/00

Abstract: An optical detection device and method for disk-type microfluidic apparatus use phase-sensitive detection method in order to provide precise information about the optical characteristic of reactant even at the state the darkroom condition is not prepared. An optical detection device using phase-sensitive detection method for disk-type microfluidic apparatus comprisesa rotation driving part(140), a light source, an optical sensor(153), a filter, and a signal processing unit. The rotation driving part stops the detection area of the disk-type microfluidic apparatus in the predetermined location. The light source irradiates the light to the detection area stopped in the predetermined location while flickering at the fixed frequency. The optical sensor is arranged toward the detection area and generates electric signal according to the intensity of the incident light. The filter is arranged on the optical path between the detection area and the optical sensor, and passes the light of the specific band. The signal processing unit receives the signal generated in the optical sensor and outputs only the signal of the same frequency component as the flickering frequency of the light source.

Abstract translation: 盘式微流体装置的光学检测装置和方法使用相敏检测方法，以便即使在未制备暗室条件的状态下也提供关于反应物的光学特性的精确信息。 使用盘式微流体装置的相敏检测方法的光学检测装置包括旋转驱动部分（140），光源，光学传感器（153），滤波器和信号处理单元。 旋转驱动部在预定位置停止盘型微流体装置的检测区域。 在以固定频率闪烁的同时，光源将光照射到在预定位置停止的检测区域。 光学传感器朝向检测区域布置，并根据入射光的强度产生电信号。 滤光器被布置在检测区域和光学传感器之间的光路上，并且通过特定波段的光。 信号处理单元接收在光学传感器中产生的信号，并且仅输出与光源的闪烁频率相同的频率分量的信号。

公开(公告)号：KR1020080090667A

公开(公告)日：2008-10-09

申请号：KR1020070033769

申请日：2007-04-05

Applicant: 삼성전자주식회사

Inventor： 이범석 ,  이정건 ,  조윤경 ,  김기은 ,  이정남

IPC: G01N35/00 ,  G01N35/10 ,  G01N33/48

Abstract: A centrifugal force-based microfluidic system is provided to prevent a waste of resources by scraping only a bio cartridge used in an examination when a biochemical examination is performed. A centrifugal force-based microfluidic system(10) includes: a spindle motor(12); a frame(15) which has a plurality of cells(20) divided by barrier ribs(18), is detachably fitted in the spindle motor, and rotates; and a bio cartridge(30) which is detachably mounted on at least one of the plurality of cells. The bio cartridge has a chamber(35) for storing fluid, a channel(36) for transferring the fluid, and a valve(33) for controlling a flow of the fluid.

Abstract translation: 提供了一种离心力微流体系统，以便在进行生物化学检查时仅刮擦检查中使用的生物药筒来防止资源的浪费。 离心力微流体系统（10）包括：主轴电机（12）; 具有由障壁（18）分割的多个单元（20）的框架（15）可拆卸地装配在主轴电机中并旋转; 以及可拆卸地安装在所述多个单元中的至少一个单元上的生物滤芯（30）。 生物药筒具有用于储存流体的腔室（35），用于输送流体的通道（36）和用于控制流体流动的阀门（33）。

公开(公告)号：KR100763923B1

公开(公告)日：2007-10-05

申请号：KR1020060092925

申请日：2006-09-25

Applicant: 삼성전자주식회사

Inventor： 박종면 ,  조윤경 ,  이정건 ,  이범석

IPC: G01N33/48 ,  G01N33/00 ,  B81B7/00

Abstract: A closing valve unit is provided to close the channel of a biochip rapidly by using an electromagnetic wave, and remove an air pump or a heating plate from the substrate which is required for dissolving and transporting paraffin wax into the channel, so that the substrate is miniaturized and integrated. A closing valve unit(110A) comprises: valve chambers(120A, 125A) which contain a valve filler containing a phase transition material which is solid state at room temperature and a plurality of micro heating particles which are dispersed to the phase transition material, absorb the external electromagnetic energy and emit heat; connection pathways(122A, 127A) for connecting the valve chambers to the channel; and external energy sources(150) for irradiating the electromagnetic wave to the valve filler, wherein the micro heating particles which are irradiated by the external electromagnetic wave dissolve and expand the phase transition material, so that the valve filler enters the channel through the connection pathways and close the channel. The reaction apparatus(100A) contains a fluid channel(111), a substrate(101) having a reaction chamber on the fluid channel, and the closing valve unit(110A).

Abstract translation: 提供关闭阀单元，通过使用电磁波快速关闭生物芯片的通道，并将石蜡溶解和输送到通道中所需的基板上移除空气泵或加热板，使基板为 小型化和集成化。 关闭阀单元（110A）包括：阀室（120A，125A），其包含含有在室温下为固态的相变材料的阀填料和分散到相变材料中的多个微加热颗粒吸收 外部电磁能发出热量; 用于将阀室连接到通道的连接通路（122A，127A） 以及用于将电磁波照射到阀填料的外部能量源（150），其中由外部电磁波照射的微加热颗粒溶解并膨胀相变材料，使得阀填料通过连接路径进入通道 并关闭频道。 反应装置（100A）包含流体通道（111），在流体通道上具有反应室的基板（101）和封闭阀单元（110A）。

公开(公告)号：KR100763922B1

公开(公告)日：2007-10-05

申请号：KR1020060092924

申请日：2006-09-25

Applicant: 삼성전자주식회사

Inventor： 박종면 ,  이정건 ,  조윤경

IPC: G01N33/48 ,  G01N33/00

Abstract: A valve unit is provided to control the channel opening precisely in the biochip by increasing speed of channel opening compared to the conventional valve unit with plugs consisting of wax, minimize the substrate by containing no heating tool of wax, and reduce the manufacturing costs of the valve unit and apparatus by containing smaller number of energy source than number of plugs. A valve unit(50A) comprises: a plurality of plugs(60) which contains a phase transition material which is a solid phase at room temperature and a plurality of micro heating particles which are dispersed to the phase transition material, absorb the external electromagnetic energy and emit heat, and block fluid flow formed by the channel(55); and external energy sources(70) for irradiating the electromagnetic wave to the plugs, wherein the micro heating particles emit heat and phase transition material is dissolved when the external electromagnetic wave are irradiated to the plugs. The valve unit further comprises a phase transition material chamber(65) for receiving the dissolved phase transition material and micro heating particles mixed thereto.

Abstract translation: 提供一个阀单元，通过提高通道开口的速度来控制通道开口，与传统的具有由蜡构成的塞子的阀门单元相比，通过不含蜡的加热工具使基板最小化，并降低了生产成本 阀单元和装置通过包含比插头数量少的能量源。 阀单元（50A）包括：多个塞子（60），其包含在室温下为固相的相变材料和分散到相变材料中的多个微加热颗粒，吸收外部电磁能量 并发出热量，阻止由通道（55）形成的流体流动; 以及用于将电磁波照射到插头的外部能量源（70），其中当外部电磁波照射到插头时，微加热颗粒发射热和相变材料溶解。 阀单元还包括用于接收溶解的相变材料和与其混合的微加热颗粒的相变材料室（65）。

公开(公告)号：KR100754409B1

公开(公告)日：2007-08-31

申请号：KR1020060082941

申请日：2006-08-30

Applicant: 삼성전자주식회사

Inventor： 조윤경 ,  이범석 ,  이정건

IPC: G01N33/53

Abstract: A magnetic bead packing unit by using centrifugal force, a microfluidic device comprising the same unit and a method for immunoassay by using the same microfluidic device are provided to pack the magnetic beads in the microfluidic device effectively by using centrifugal and magnetic forces, minimize the size of microfluidic device, and reduce operation power of the device. The magnetic bead packing unit by using centrifugal force comprises: a controllable rotation plate(100); a microfluidic channel(130) which is located on the rotation plate and contains an inlet(31) disposed near the rotation center, an outlet(32) disposed far away the rotation center and a channel from the inlet and outlet through which fluid flows from the inlet to outlet by the centrifugal force; a curved part(135) which is a part of the microfluidic channel and is curved; and a magnet(40) which is disposed corresponding to the curved part and influencing magnetic force to fluid flowing the channel. The microfluidic device comprises a rotation body having a sample fluid chamber(110) disposed near the rotation center and a waste chamber(150) disposed far away the rotation center, a microfluidic channel, a curved part and a magnet.

Abstract translation: 提供了通过使用离心力的磁珠包装单元，包括相同单元的微流体装置以及通过使用相同的微流体装置进行免疫测定的方法，以通过使用离心力和磁力有效地将磁珠包装在微流体装置中， 的微流体装置，并降低装置的操作功率。 利用离心力的磁珠包装单元包括：可控旋转板（100）; 位于旋转板上并且包含设置在旋转中心附近的入口（31）的微流体通道（130），远离旋转中心设置的出口（32）以及来自流体从其流动的入口和出口的通道 通过离心力进入出口; 弯曲部分（135），其是微流体通道的一部分并且是弯曲的; 以及磁体（40），其对应于所述弯曲部分设置并影响流过所述通道的流体的磁力。 微流体装置包括具有设置在旋转中心附近的样品流体室（110）和远离旋转中心设置的废物室（150）的旋转体，微流体通道，弯曲部分和磁体。

公开(公告)号：KR1020070031696A

公开(公告)日：2007-03-20

申请号：KR1020050086420

申请日：2005-09-15

Applicant: 삼성전자주식회사

Inventor： 최수형 ,  한정임 ,  조윤경

IPC: C12Q1/00

CPC classification number: C12Q1/18

Abstract: 본 발명은 원핵 세포를 이용하여 독성물질의 유해성을 전기적으로 측정하는 방법 및 장치에 관한 것으로, 보다 구체적으로는 독성물질 존재 시 초래되는 세포 내 변화를 원핵 세포의 세포막의 전기적 신호 변화로서 측정함으로써, 독성물질의 유해성을 분석하는 방법 및 장치에 관한 것이다.
본 발명에 따르면, 독성여부 및 유해성 정도를 매우 손쉽게 빠른 시간 내에 전기적으로 측정 가능하고, 유해물질의 특정 종류와 상관없이 유해성을 측정할 수 있어 범용의 응용예를 가질 뿐만 아니라, 랩-온-어-칩(lab-on- a-chip)에 적용하여 구현하는 것 또한 용이하다.

公开(公告)号：KR100647320B1

公开(公告)日：2006-11-23

申请号：KR1020050010988

申请日：2005-02-05

Applicant: 삼성전자주식회사

Inventor： 조윤경 ,  김태곤 ,  황승용 ,  오광욱 ,  박진구 ,  지원호

IPC: A61M1/36

CPC classification number: B01L3/502715 ,  B01L3/5021 ,  B01L3/502723 ,  B01L3/502753 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409

Abstract: 본 발명은 원심분리기를 이용하여 혈액 중의 혈청을 분리하기 위한 혈청 분리용 마이크로 장치에 관한 것으로서, 마이크로 장치 내에 소정의 챔버 및 채널이 구비되어 있어, 혈액을 마이크로 장치 내에 형성되어 있는 채널에 주입시키고 원심분리를 수행하면 그 주입된 혈액 중의 혈청과 혈구가 서로 다른 챔버에 분포되어 혈액으로부터 혈청을 분리할 수 있는 혈청 분리용 마이크로 장치를 제공한다.

公开(公告)号：KR1020060058523A

公开(公告)日：2006-05-30

申请号：KR1020040097595

申请日：2004-11-25

Applicant: 삼성전자주식회사

Inventor： 조윤경 ,  이규상 ,  김숙영 ,  김진태

IPC: C12N15/10

CPC classification number: C12N15/1006 ,  C12Q1/6806 ,  C12Q1/70 ,  Y10S977/924 ,  C12Q2563/155 ,  C12Q2523/308

Abstract: 본 발명은 (a) 티올기를 갖는 분자가 포함된 시료와 은 나노입자를 혼합하여 상기 분자와 은 나노입자 복합체를 형성하는 단계; 및 (b) 상기 혼합물로부터 상기 복합체를 분리하여 제거하는 단계를 포함하는 은 나노입자 (silver nanoparticle)를 이용하여 표적 물질을 정제하는 방법에 관한 것이다. 본 발명에 따르면, 기존의 핵산 정제 방법에 비해 3 단계 작업으로 신속하게 PCR 증폭이 가능한 DNA 를 정제할 수 있으므로, 랩온어칩에 매우 유용하게 이용될 수 있다.