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11.发明公开
公开(公告)号：KR1020120086948A
公开(公告)日：2012-08-06
申请号：KR1020110008315
申请日：2011-01-27
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A manufacturing method of interpenetrating polymer network scaffold for cell delivery which includes hyaluronic acid and alginate are provided to provide porous hyaluronic acid-alginate supporter which recycles chondrocyte and enoughly delivers nutrients. CONSTITUTION: A manufacturing method of interpenetrating polymer network scaffold for cell delivery which includes hyaluronic acid and alginate comprises the following steps: melting hyaluronic acid and alginate into a sodium hydroxide aqueous solution; adding an epoxy-based cross linking agent and homogenizing the hyaluronic acid-alginate solution; hydrogelizing the homogenized hyaluronic acid-alginate solutions; washing the hydrogel with a calcium chloride aqueous solution; obtaining porosity by expanding the washed hyaluronic acid-alginate in a calcium chloride aqueous solution; eliminating calcium chloride remaining in the hyaluronic acid - alginate supporter using distilled water; and obtaining a porous hyaluronic acid supporter by freeze-drying the hydrogel.
Abstract translation: 目的：提供包含透明质酸和藻酸盐的细胞递送的互穿聚合物网络支架的制造方法，以提供多孔透明质酸藻酸盐载体，其回收软骨细胞并足够输送营养物质。 构成：包含透明质酸和藻酸盐的细胞递送的互穿聚合物网络支架的制造方法包括以下步骤：将透明质酸和藻酸盐溶解成氢氧化钠水溶液; 加入环氧基交联剂并均化透明质酸 - 藻酸盐溶液; 水化均匀的透明质酸 - 藻酸盐溶液; 用氯化钙水溶液洗涤水凝胶; 通过在氯化钙水溶液中膨胀洗涤的透明质酸藻酸盐来获得孔隙度; 使用蒸馏水去除透明质酸 - 藻酸盐载体中残留的氯化钙; 并通过冷冻干燥水凝胶得到多孔透明质酸载体。
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公开(公告)号：KR101810540B1
公开(公告)日：2017-12-19
申请号：KR1020170039312
申请日：2017-03-28
Applicant: (주) 씨유스킨 , 서울대학교산학협력단
CPC classification number: A61K9/1075 , A61K8/066 , A61K8/11 , A61K8/67 , A61K9/113 , A61K9/19 , A61K2800/65
Abstract: 본발명은비타민 U를 W/O 에멀젼형태로제조한후, 이를다중유화를통해복합코아세르베이트입자로제조함으로써, 2개의쉘 구조, 즉오일로구성된 1차쉘 및복합코아세르베이트쉘을갖는비타민 U가봉입된복합코아세르베이트입자의제조방법을제공한다. 본발명의제조방법은비타민 U의냄새를효과적으로차폐할수 있으며, 높은봉입효율로비타민 U를봉입할수 있고또한얻어지는복합코아세르베이트입자는우수한안정성을갖는다.
Abstract translation: 本发明是与维生素U制备为W / O乳液，通过使作为通过多乳液的复合凝聚颗粒，这两个壳结构，即，具有第一chaswel和复合凝聚层壳与油维生素U的加蓬嘴配置 提供了一种制备复合核碳酸酯颗粒的方法。 本发明的生产方法能够有效地屏蔽维生素U的气味，并且能够以高包封率封装维生素U，得到的复合凝聚颗粒具有优异的稳定性。
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公开(公告)号：KR101682821B1
公开(公告)日：2016-12-06
申请号：KR1020150103192
申请日：2015-07-21
Applicant: 서울대학교산학협력단
Abstract: 본발명은물에당류지지체를용해시켜제 1 용액을제조하는단계; 유기용매에생리활성성분, 안정화제및 지질을용해시켜제 2 용액을제조하는단계; 상기제 1 용액과제 2 용액을혼합하여균일하게하는단계; 상기혼합용액을응축교반하는단계; 및상기응축교반된혼합용액을동결건조하는단계를포함하는프로리포솜제조방법에관한것으로, 본발명에따른프로리포솜제조방법은응축교반을이용하여기존의프로리포솜보다부형제의양을획기적으로감소시켜생리활성성분의함유량이증가된약제학적조성물의제조가가능하며, 생리활성성분으로난용성약물을봉입하여장관내용출및 흡수를증진시킴으로써생체이용률을향상시킬수 있는프로리포솜을제조할수 있다.
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公开(公告)号：KR1020140110329A
公开(公告)日：2014-09-17
申请号：KR1020130024483
申请日：2013-03-07
Applicant: 서울대학교산학협력단
CPC classification number: A61K47/30 , A61K9/1277 , A61K47/24 , A61K47/26
Abstract: The present invention relates to multi-layered proliposome and a method for preparing the same. The multi-layered prolipsome can significantly increase the content of a bioactive ingredient in a lipid layer when compared with existing proliposome; maintain the stability of the bioactive ingredient; promote the absorption into the intestinal tract; and control the release rate, the release amount, and the release site of the bioactive ingredient. Particularly, a multi-layered coating is performed while the amount of sugar used in the preparation of the proloposome is reduced, thereby producing the multi-layered proliposome capable of increasing the release rate and the release amount of a poorly water-soluble drug and significantly reducing the amount of vehicle. The multi-layered proliposome can be useful to develop medicines for treatment or prevention, cosmetics, or food additives.
Abstract translation: 本发明涉及多层哺乳动物体及其制备方法。 与现有的脂质体相比，多层脱脂体可显着增加脂质层中生物活性成分的含量; 保持生物活性成分的稳定性; 促进吸收进入肠道; 并控制生物活性成分的释放速率，释放量和释放位置。 特别是，在制备前列腺素的糖的量降低的同时进行多层包衣，从而制备能够提高水难溶性药物的释放速度和释放量的多层脱脂体，显着地 减少车辆的数量。 多层脱脂素可用于开发用于治疗或预防的药物，化妆品或食品添加剂。
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公开(公告)号：KR1020100093428A
公开(公告)日：2010-08-25
申请号：KR1020090012608
申请日：2009-02-16
Applicant: 서울대학교산학협력단
CPC classification number: A61K9/0043 , A61K9/08 , A61K9/1075 , A61K31/445 , Y10S514/885
Abstract: PURPOSE: A liquid phase formulation for nasal administration containing antiallergic A drug is provided to easily administrate and to minimize side effects. CONSTITUTION: A liquid phase formulation for nasal administration contains 0.1-5 weight% of antiallergic drug, 2-10 weight% of oil, 20-70 weight aprts of% surfactant. The antiallergic drug is anti-histamin agent, steroid drug. The liquid phase formulation is microemulsion.
Abstract translation: 目的：提供含有抗过敏药物的用于鼻内给药的液相制剂以容易地施用并尽量减少副作用。 构成：用于鼻内给药的液相制剂含有0.1-5重量％的抗过敏药物，2-10重量％的油，20-70重量％的表面活性剂。 抗过敏药物是抗组胺药，类固醇药物。 液相制剂是微乳液。
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Patent Agency Ranking
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公开(公告)号：KR101811048B1
公开(公告)日：2017-12-20
申请号：KR1020160117089
申请日：2016-09-12
Applicant: 서울대학교산학협력단 , 한국생명공학연구원
IPC: A61K36/42 , A61K31/704 , A23L33/105 , A23K20/105 , C07J17/00
CPC classification number: A61K36/42 , A23K20/105 , A23L33/105 , A23V2002/00 , A23V2200/322 , A23V2250/21 , A23V2250/60 , A61K31/704 , C07J17/005
Abstract: 본발명은지노스테마론기페스 VK1(VK1) 추출물또는이로부터분리한론기페노사이드 A(longipenoside A) 화합물을유효성분으로포함하는인지기능장애예방또는치료용조성물에관한것으로, 지노스테마론기페스 VK1 추출물또는이로부터분리한론기페노사이드 A 화합물을기억력감퇴및 인지장애동물모델에투여한결과, 인지능력및 기억력증진효과가있음을확인하였다.
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公开(公告)号：KR101468796B1
公开(公告)日：2014-12-08
申请号：KR1020130024483
申请日：2013-03-07
Applicant: 서울대학교산학협력단
Abstract: 본발명은다층프로리포솜및 이의제조방법에관한것으로, 상기다층프로리포솜은기존의프로리포솜에비해지질층중 생리활성성분의함유량을크게증가시킬뿐 아니라, 생리활성성분의안정성을유지시켜주며, 장관내흡수를증진시키며, 사용된고분자특성에따라생리활성성분의방출속도, 방출량및 방출장소를조절할수 있다. 특히프로리포솜의제조에사용되는당류의양을줄여서다층코팅을함으로써난용성약물의방출속도와방출량을높이면서도부형제의양을획기적으로줄일수 있는다층프로리포솜을제조할수 있다. 상기다층프로리포솜은치료또는예방용약제, 화장품또는식품첨가제의개발에유용하게사용될수 있다.
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公开(公告)号：KR101327595B1
公开(公告)日：2013-11-13
申请号：KR1020110101301
申请日：2011-10-05
Applicant: 서울대학교산학협력단
IPC: A61K9/10 , A61K9/06 , A61K36/258 , A61P35/00
Abstract: 본 발명은 가공인삼 성분을 국소 피부에 적용할 수 있는 마이크로이멀젼계 하이드로겔에 관한 것으로, 가공인삼, 이소프로필 미리스테이트, 라브라솔, 프로필렌 글리콜 및 인지질을 유효성분으로 함유하는 100nm 이하의 마이크로이멀젼을 제조하고 상기 마이크로이멀젼에 겔화제를 첨가하여 얻어진 마이크로이멀젼계 하이드로겔은 피부 미백, 재생 및 항주름 효과 등 피부개선 효과가 기대되지만 난용성이고 분자량이 500Da 이상으로 피부흡수가 어려운 가공인삼을 피부내로 잘 투과시키고 국재시킬 수 있을 수 있기 때문에 가공인삼을 유효성분으로 함유하는 피부개선용 피부외용제로 유용하게 사용할 수 있다.
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公开(公告)号：KR1020130036997A
公开(公告)日：2013-04-15
申请号：KR1020110101301
申请日：2011-10-05
Applicant: 서울대학교산학협력단
IPC: A61K9/10 , A61K9/06 , A61K36/258 , A61P35/00
Abstract: PURPOSE: A micro emulsion hydro gel which contains processed ginseng as an active ingredient is provided to be used as external preparation of skin for skin improvement by penetrating and localizing processed ginseng within skin. CONSTITUTION: A micro emulsion hydro gel comprises 0.02-3.0 wt% of processed ginseng, 5.0-15.0 wt% of Isopropyl myristate, 15.0-60.0 wt% of surfactant, 0.5-5.0 wt% of gelling agent, and residual water. Processed ginseng is steamed and is dried at 110 to 130>= for two to four hours.
Abstract translation: 目的：提供含有加工人参作为活性成分的微乳液水凝胶，用于通过渗透和定位皮肤中加工的人参，用作皮肤改善皮肤的外用剂。 构成：微乳液水凝胶含有0.02-3.0重量％的加工人参，5.0-15.0重量％的肉豆蔻酸异丙酯，15.0-60.0重量％的表面活性剂，0.5-5.0重量％的胶凝剂和残余水。 将人参蒸干，并在110〜130℃下干燥2〜4小时。
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