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1.发明授权지방 줄기세포 유래 단백질 추출물을 안정화시킨 프로리포솜을 유효성분으로 포함하는 아토피성 피부염 치료 또는 예방용 조성물 有权用于治疗或预防特应性皮炎的组合物，其包含用前体脂质体稳定的高级脂肪干细胞衍生的蛋白质提取物
公开(公告)号：KR101211828B1
公开(公告)日：2012-12-12
申请号：KR1020100116211
申请日：2010-11-22
Applicant: 서울대학교산학협력단
Abstract: 본발명은지방줄기세포유래단백질추출물을안정화시킨프로리포솜을유효성분으로포함하는아토피성피부염치료또는예방용조성물에관한것으로, 상기프로리포솜은지방줄기세포유래단백질추출물의안정성을증진시킬뿐 아니라, 아토피성피부염치료효과를향상시키므로아토피성피부염치료용약제또는아토피성피부염개선용화장품으로유용하게사용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020120086948A
公开(公告)日：2012-08-06
申请号：KR1020110008315
申请日：2011-01-27
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A manufacturing method of interpenetrating polymer network scaffold for cell delivery which includes hyaluronic acid and alginate are provided to provide porous hyaluronic acid-alginate supporter which recycles chondrocyte and enoughly delivers nutrients. CONSTITUTION: A manufacturing method of interpenetrating polymer network scaffold for cell delivery which includes hyaluronic acid and alginate comprises the following steps: melting hyaluronic acid and alginate into a sodium hydroxide aqueous solution; adding an epoxy-based cross linking agent and homogenizing the hyaluronic acid-alginate solution; hydrogelizing the homogenized hyaluronic acid-alginate solutions; washing the hydrogel with a calcium chloride aqueous solution; obtaining porosity by expanding the washed hyaluronic acid-alginate in a calcium chloride aqueous solution; eliminating calcium chloride remaining in the hyaluronic acid - alginate supporter using distilled water; and obtaining a porous hyaluronic acid supporter by freeze-drying the hydrogel.
Abstract translation: 目的：提供包含透明质酸和藻酸盐的细胞递送的互穿聚合物网络支架的制造方法，以提供多孔透明质酸藻酸盐载体，其回收软骨细胞并足够输送营养物质。 构成：包含透明质酸和藻酸盐的细胞递送的互穿聚合物网络支架的制造方法包括以下步骤：将透明质酸和藻酸盐溶解成氢氧化钠水溶液; 加入环氧基交联剂并均化透明质酸 - 藻酸盐溶液; 水化均匀的透明质酸 - 藻酸盐溶液; 用氯化钙水溶液洗涤水凝胶; 通过在氯化钙水溶液中膨胀洗涤的透明质酸藻酸盐来获得孔隙度; 使用蒸馏水去除透明质酸 - 藻酸盐载体中残留的氯化钙; 并通过冷冻干燥水凝胶得到多孔透明质酸载体。
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公开(公告)号：KR101240133B1
公开(公告)日：2013-03-11
申请号：KR1020110008315
申请日：2011-01-27
Applicant: 서울대학교산학협력단
Abstract: 본 발명은 히알루론산과 알지네이트를 포함하는 상호관입고분자망목 구조의 세포전달용 지지체의 제조방법에 관한 것으로, 상기 세포전달용 지지체는 히알루론산과 알지네이트를 상호관입고분자망목 구조로 결합시킨 것으로서, 세포 재생에 적합하고 영양분이 충분히 전달될 수 있는 물리적 성질이 뛰어난 구조를 지니기 때문에 특정 세포로의 분화 및 증식을 향상시킬 수 있어 연골세포 등 다양한 세포의 재생에 기여할 수 있는 생체적합성 3차원 지지체를 제공할 수 있다.
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4.发明公开지방 줄기세포 유래 단백질 추출물을 안정화시킨 프로리포솜을 유효성분으로 포함하는 아토피성 피부염 치료 또는 예방용 조성물 有权用于治疗或预防包含高级ADIPOSE干细胞的原发性成分的组合物衍生的蛋白质提取物稳定化
公开(公告)号：KR1020120054862A
公开(公告)日：2012-05-31
申请号：KR1020100116211
申请日：2010-11-22
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A composition containing proliposome which stabilizes adipose stem cell-derived protein extract is provided to enhance extract stability and to treat atopic dermatitis. CONSTITUTION: A pharmaceutical composition for preventing or treating atopic dermatitis contains proliposome which stabilizes adipose stem cell-derived protein extract as an active ingredient. The proliposome contains 0.1-5 wt% of adipose stem cells-derived protein extract, 1-20 wt% of lipid, 0.1-10 wt% of stabilizing agent, and remaining amount of sugars. The stabilizing agent includes non-ionic surfactant of poloxamer, polyol derivative, polyoxyethylene ester, or polyoxyethylene ether.
Abstract translation: 目的：提供含有稳定脂肪干细胞衍生蛋白质提取物的脱脂体的组合物，以提高提取物的稳定性和治疗特应性皮炎。 构成：用于预防或治疗特应性皮炎的药物组合物含有使脂肪干细胞衍生的蛋白质提取物稳定的活性成分的脱脂体。 前体脂质体含有0.1-5重量％的脂肪干细胞衍生的蛋白质提取物，1-20重量％的脂质，0.1-10重量％的稳定剂和剩余量的糖。 稳定剂包括泊洛沙姆的非离子表面活性剂，多元醇衍生物，聚氧乙烯酯或聚氧乙烯醚。
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公开(公告)号：KR1020140110329A
公开(公告)日：2014-09-17
申请号：KR1020130024483
申请日：2013-03-07
Applicant: 서울대학교산학협력단
CPC classification number: A61K47/30 , A61K9/1277 , A61K47/24 , A61K47/26
Abstract: The present invention relates to multi-layered proliposome and a method for preparing the same. The multi-layered prolipsome can significantly increase the content of a bioactive ingredient in a lipid layer when compared with existing proliposome; maintain the stability of the bioactive ingredient; promote the absorption into the intestinal tract; and control the release rate, the release amount, and the release site of the bioactive ingredient. Particularly, a multi-layered coating is performed while the amount of sugar used in the preparation of the proloposome is reduced, thereby producing the multi-layered proliposome capable of increasing the release rate and the release amount of a poorly water-soluble drug and significantly reducing the amount of vehicle. The multi-layered proliposome can be useful to develop medicines for treatment or prevention, cosmetics, or food additives.
Abstract translation: 本发明涉及多层哺乳动物体及其制备方法。 与现有的脂质体相比，多层脱脂体可显着增加脂质层中生物活性成分的含量; 保持生物活性成分的稳定性; 促进吸收进入肠道; 并控制生物活性成分的释放速率，释放量和释放位置。 特别是，在制备前列腺素的糖的量降低的同时进行多层包衣，从而制备能够提高水难溶性药物的释放速度和释放量的多层脱脂体，显着地 减少车辆的数量。 多层脱脂素可用于开发用于治疗或预防的药物，化妆品或食品添加剂。
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公开(公告)号：KR101468796B1
公开(公告)日：2014-12-08
申请号：KR1020130024483
申请日：2013-03-07
Applicant: 서울대학교산학협력단
Abstract: 본발명은다층프로리포솜및 이의제조방법에관한것으로, 상기다층프로리포솜은기존의프로리포솜에비해지질층중 생리활성성분의함유량을크게증가시킬뿐 아니라, 생리활성성분의안정성을유지시켜주며, 장관내흡수를증진시키며, 사용된고분자특성에따라생리활성성분의방출속도, 방출량및 방출장소를조절할수 있다. 특히프로리포솜의제조에사용되는당류의양을줄여서다층코팅을함으로써난용성약물의방출속도와방출량을높이면서도부형제의양을획기적으로줄일수 있는다층프로리포솜을제조할수 있다. 상기다층프로리포솜은치료또는예방용약제, 화장품또는식품첨가제의개발에유용하게사용될수 있다.
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