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公开(公告)号:KR102157701B1
公开(公告)日:2020-09-21
申请号:KR1020187004954
申请日:2016-08-17
Applicant: 서울대학교산학협력단
IPC: C07K14/725 , C07K16/16 , C12N15/85 , A61K35/17 , A61K38/17 , A61K39/395
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公开(公告)号:KR1020120100629A
公开(公告)日:2012-09-12
申请号:KR1020110019648
申请日:2011-03-04
Applicant: 삼성전자주식회사 , 서울대학교산학협력단
CPC classification number: C07H21/00 , B82Y15/00 , C12P19/34 , Y10T428/2991 , C12Q1/6876 , C12Q2525/197
Abstract: PURPOSE: A nanoparticle-nucleic acid complex and a method for linearizing target nucleic acids using the same are provided to enable effectively sequencing and mapping of the target nucleic acids. CONSTITUTION: A nanoparticle-nucleic acid complex contains nanoparticles(100) in which two or more protection sequence parts(110) and a probe sequence part(120) are fixed. The protection sequence parts are fixed at the nanoparticfles at one end and have a single strand nucleic acid containing a random base sequence. The probe sequence part is fixed at the nanoparticles at one end and has a single strand nucleic acid containing a base sequenc ewhic complementarily binds to a first region(131) of connection sequence part(130). The protection sequence part further contains a spacer. The spacer binds on the surface of the nanoparticles at one end and binds the single stand nucleic acid of the production sequene at the other end.
Abstract translation: 目的:提供纳米颗粒 - 核酸复合物和使用其的靶核酸线性化的方法,以有效地测序和测定靶核酸。 构成:纳米颗粒 - 核酸复合物含有其中固定有两个或多个保护序列部分(110)和探针序列部分(120)的纳米颗粒(100)。 保护序列部分在一端固定在纳米颗粒上,并具有含有随机碱基序列的单链核酸。 探针序列部分在一端固定在纳米颗粒上,并且具有单链核酸,其含有与连接序列部分(130)的第一区域(131)互补结合的碱基序列。 保护序列部分还包含间隔物。 间隔物在一端在纳米颗粒的表面上结合,并且在另一端结合生产顺序的单一核酸。
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公开(公告)号:KR102199383B1
公开(公告)日:2021-01-06
申请号:KR1020190123866
申请日:2019-10-07
Applicant: 서울대학교산학협력단 , 이화여자대학교 산학협력단
Abstract: 본발명은 PDGF 수용체에대한항체, 상기 PDGF 수용체에대한항체에화학요법제를접합한항체-약물접합체및 이를이용한혈관신생성질환의예방또는치료용도에관한것이다.
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公开(公告)号:KR1020120079320A
公开(公告)日:2012-07-12
申请号:KR1020110000548
申请日:2011-01-04
Applicant: 삼성전자주식회사 , 서울대학교산학협력단
CPC classification number: G06F19/22 , C12Q1/6869
Abstract: PURPOSE: A method and an apparatus for repairing gene sequences using a probe map are provided to accurately repair target sequences. CONSTITUTION: A method for repairing gene sequences using a probe map comprises: a step of arranging a probe on a target sequence based on probe-hybridized result(1201); a step of determining representative value of each arranged site based on statistic distribution(1202); and a step of repairing target sequences using the probe map in which determined representative value and probe sequence information are mapped(1203).
Abstract translation: 目的:提供使用探针图修复基因序列的方法和装置,以准确地修复靶序列。 构成:使用探针图修复基因序列的方法包括:基于探针杂交结果在靶序列上排列探针的步骤(1201); 基于统计分布确定每个布置点的代表值的步骤(1202); 以及使用其中映射了确定的代表值和探针序列信息的探针图来修复靶序列的步骤(1203)。
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