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公开(公告)号：KR1020170105756A
公开(公告)日：2017-09-20
申请号：KR1020160028763
申请日：2016-03-10
Applicant: 서울대학교산학협력단
IPC: A61B6/14
Abstract: 본발명은 CT촬영방법에관한것으로, 보다구체적으로는 3축스캔원리를이용하여잇몸및 잇몸뼈를타겟으로촬영된잇몸조직 CT 영상을정확하게해석할수 있는 3축스캔원리를이용한 CT 영상해석방법에관한것이다.
Abstract translation: CT成像方法技术领域本发明涉及一种CT成像方法，更具体地说，涉及一种使用3轴扫描原理的CT成像方法，该方法能够使用3轴扫描原理来精确地解释用牙龈和牙龈靶成像的牙龈组织CT图像 它涉及。
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公开(公告)号：KR1020170081783A
公开(公告)日：2017-07-13
申请号：KR1020160000371
申请日：2016-01-04
Applicant: 중앙대학교 산학협력단 , 서울대학교산학협력단
IPC: C07D277/66 , C12N5/079
Abstract: 본발명은신경줄기세포의분화조절을위한신규벤조티아졸유도체및 이의용도에관한것이다. 본발명에서, 유기합성적인방법으로제조한신규한벤조티아졸유도체를신경줄기세포에처리함으로써, 신경세포로의분화를촉진시킬수 있음을확인하였는바, 신경세포손상질환의치료제로유용하게이용할수 있으며, 상기신경세포로의분화촉진과정에서, LIF IL-6, 및 CNTF 등의사이토카인의분비의현격한증가를확인하였는바, 이들을생산하기위한시약등으로도활용될수 있을것으로기대된다.
Abstract translation: 本发明涉及新的苯并噻唑衍生物及其用于调节神经干细胞分化的用途。 在本发明中，通过处理在hansingyu苯并噻唑衍生物的神经干细胞中制备的有机合成法，棒hayeotneun确认sikilsu促进分化成神经细胞，并且可以有利地用于神经元损伤的疾病的治疗中， 预计在促进向神经元分化的过程中，细胞因子如LIF IL-6和CNTF的分泌显着增加，并且其可用作生产它们的试剂。
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公开(公告)号：KR1020170035576A
公开(公告)日：2017-03-31
申请号：KR1020150134596
申请日：2015-09-23
Applicant: 서울대학교산학협력단
Abstract: 본발명은세포간결합이취약한치은접합상피의세포간결합발달을유도하여접합상피의상피방어막기능을증진시키는기술에관한것이다. 치은접합상피는세포간결합이밀착되어있지않고간격이벌어져있기때문에외부에서세균이나독성물질이침투해들어올수 있는통로가될 수있다. 따라서접합상피의상피방어막기능을증진시키기위해서는치은접합상피의세포간결합을강화할필요가있다. 치은접합상피의상피간 E-cadherin 결합은 c-Jun N-terminal kinases에의해발달이억제된다. 이에본 발명은 c-Jun N-terminal kinases 활성을억제하므로서치은접합상피내세포막에 E-cadherin 결합의발달을유도하므로서접합상피의세포간결합을증진시킬수 있다.
Abstract translation: 本发明涉及通过诱导细胞间连接弱的牙龈连接上皮的细胞间连接发育来增强连接上皮的上皮屏障功能的技术。 牙龈连接处上皮细胞没有紧密连接，并且间隙间隔开，这可以是细菌和毒素从外部穿过的通道。 因此，为了增强连接上皮的上皮屏障功能，有必要加强牙龈连接上皮的细胞内结合。 上皮E-钙粘蛋白与牙龈上皮的结合受到c-Jun N端激酶的抑制。 因此，本发明可以抑制c-Jun N-末端激酶活性，因此，通过诱导结合上皮细胞膜上E-钙粘着蛋白结合的发展，可以促进结合上皮细胞的细胞间连接。
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公开(公告)号：KR101341889B1
公开(公告)日：2013-12-16
申请号：KR1020120058086
申请日：2012-05-31
Applicant: 서울대학교산학협력단
IPC: C07C227/44 , C07C227/26 , C07C229/08
Abstract: 본발명은천연물유래의폴리아미드-12 단량체인 12-아미노도데카논산의제조방법에관한것이다. 보다구체적으로는천연물인피마자유로부터얻을수 있는운데실렌산또는그 에스터로부터폴리아미드계열가소성탄성체(TPE)의원료가되는 12-아미노도데카논산또는그의에스터유도체를제조하는방법에관한것이다. 또한본 발명에따른제조방법에따라제조되는 12-아미노도데카논산은폴리아미드-12의단량체로사용되며, 본발명에따른제조방법은천연유래의피마자유로부터제조될수 있는운데실렌산또는그 에스터로부터제조할수 있는바, 12-아미노도데카논산의새로운친환경적이면서도효율적인제조방법으로이용될수 있다.
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15.发明授权히알루론산―도파민 컨쥬게이트로 표면이 개질된 하이드록시아파타이트 나노입자를 포함하는 실크피브로인 나노섬유 및 이를 이용한 지지체 有权包含用羟丙酸/多巴胺结合物修饰的羟基磷酸酯的纳米纤维素和使用其的SCAFFOLD
公开(公告)号：KR101313898B1
公开(公告)日：2013-09-30
申请号：KR1020120044954
申请日：2012-04-27
Applicant: 대한민국(농촌진흥청장) , 서울대학교산학협력단
CPC classification number: D01F4/02 , A61F2/2846 , A61L24/00 , A61L27/3604 , D01D5/0015 , D01D10/06 , D01F1/10
Abstract: PURPOSE: The complex nanofiber of hydroxyapatite and silk fibroin, a two dimensional structure and a three dimensional structure supporter using the same is provided to easily facilitate the uniformity and guarantee of reappearance, is able to electrospinning for a long time, and useful for cell formation, bond tissue regeneration and supporter as its mechanical property is satisfied. CONSTITUTION: The complex nanofiber uniformly disperses the hydroxyapatite nano particle which surface is reformed with the hyaluronic acid-dopamine conjugate inside the silk fibroin nanofiber. Conjugate of the hyaluronic acid-dopamine is the formation of amide bond by combining the carboxyl group of hyaluronic acid and amine group of dopamine. The hydroxyapatite which surface is reformed with the hyaluronic acid-dopamine conjugate is the combination of two hydroxyl radicals of dopamine to the surface of the hydroxyapatite. The diameter of the complex nanofiber is 100-1000 nm.
Abstract translation: 目的：提供复合纳米纤维的羟基磷灰石和丝素蛋白，二维结构和三维结构支持体，使其易于均匀，保证再现，能长时间静电纺丝，可用于细胞形成 ，粘合组织再生和支持体作为其机械性能得到满足。 构成：复合纳米纤维将丝氨蛋白纳米纤维内透明质酸 - 多巴胺缀合物表面的羟基磷灰石纳米粒子均匀分散。 透明质酸 - 多巴胺的结合物是通过将透明质酸的羧基和多巴胺的胺基组合而形成酰胺键。 表面用透明质酸 - 多巴胺缀合物重整的羟基磷灰石是多巴胺的两个羟基自由基与羟基磷灰石表面的组合。 复合纳米纤维的直径为100-1000nm。
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Patent Agency Ranking
公开(公告)号：KR1020120128449A
公开(公告)日：2012-11-27
申请号：KR1020110046401
申请日：2011-05-17
Applicant: 서울대학교산학협력단
IPC: C07C227/04 , C07C229/08 , C07C51/097 , C07C55/02
Abstract: PURPOSE: A manufacturing method of 10-aminodecanoic acid or ester derivatives is provided to easily manufacture effectively and environmentally manufacture decanedioic acid through two reactions form a medium compound. CONSTITUTION: A manufacturing method of 10-aminodecanoic acid or ester derivatives comprises: a step of manufacturing a compound indicated in chemical formula 2 through a pre-ozonolysis of an oleic acid indicated in chemical formula 1 or ester thereof; a step of manufacturing a compound indicated in chemical formula 3 through a Henry reaction by putting base into a mixture of compound indicated in chemical formula 2 and nitromethane; a step of manufacturing a compound thorough a removal reaction accepting a leaving group into a hydroxy group of a compound indicated in chemical formula 3 and removing the same; and a step of manufacturing a compound indicated in chemical formula 7 through a reduction reaction of a compound in chemical formula 4 under the presence of a transition metal catalyst. [Reference numerals] (AA) Catalyst, H_2
Abstract translation: 目的：提供10-氨基十一烷酸或酯衍生物的制造方法，通过两种反应形成中等化合物，有效地制造和环境化生产癸二酸。 构成：10-氨基十一烷酸或酯衍生物的制造方法包括：通过化学式1表示的油酸的前臭氧分解或其酯制造化学式2所示的化合物的工序; 将化学式2表示的化合物与硝基甲烷的混合物中的碱进行亨利反应，制造化学式3所示化合物的工序; 将通过化学式3表示的化合物的羟基取代离去基团的除去反应的化合物的制造步骤，并除去该化合物; 以及通过化学式4中的化合物在过渡金属催化剂的存在下的还原反应制造化学式7所示化合物的步骤。 （AA）催化剂，H_2
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公开(公告)号：KR102255066B1
公开(公告)日：2021-05-24
申请号：KR1020200019414
申请日：2020-02-18
Applicant: 중앙대학교 산학협력단 , 서울대학교산학협력단
Abstract: 본발명은 3’-메톡시플라본을유효성분으로포함하는줄기세포의성상세포로의분화유도용조성물등에관한것으로, 본발명의조성물을사용하면기존의줄기세포분화촉진제를사용하지않고성상세포로분화를유도할수 있을뿐만아니라, 분화된성상세포를이용하여신경퇴행성질환을효과적으로치료할수 있을것으로기대된다.
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公开(公告)号：KR101716325B1
公开(公告)日：2017-03-15
申请号：KR1020110017894
申请日：2011-02-28
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: 열차단지수의생성방법은, 열차단물질이도포된제1 영역및 상기열 차단물질이도포되지않은제2 영역에각각열을가하는단계; 상기제1 영역및 제2 영역각각의포화온도를측정하는단계; 상기제1 영역에가해진열에대응되는에너지를상기제1 영역의포화온도로나누어제1 에너지를산출하는단계; 상기제2 영역에가해진열에대응되는에너지를상기제2 영역의포화온도로나누어제2 에너지를산출하는단계; 및상기제1 에너지를상기제2 에너지로나누거나, 또는상기제1 에너지및 상기제2 에너지의차를상기제1 에너지로나누어상기열 차단물질의열 차단지수를산출하는단계를포함할수 있다.
Abstract translation: 本发明涉及一种计算热保护因子的方法，其中该方法包括以下步骤：将热量施加到涂覆有热保护材料的第一区域和未涂覆有热保护材料的第二区域; 测量第一区域和第二区域的各自的饱和温度; 通过将对应于第一区域的热量的能量除以第一区域的饱和温度来计算第一能量; 通过将对应于第二区域的热量的能量除以第二区域的饱和温度来计算第二能量; 以及通过将第一能量除以第二能量或将第一能量与第二能量之间的差除以第一能量来计算热保护材料的热保护因子。
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公开(公告)号：KR101341888B1
公开(公告)日：2013-12-16
申请号：KR1020120058082
申请日：2012-05-31
Applicant: 서울대학교산학협력단
IPC: C07C227/44 , C07C227/26 , C07C229/08
Abstract: 본발명은천연물유래의폴리아미드-11 단량체인 11-아미노운데카논산의제조방법에관한것이다. 보다구체적으로는천연물인올리브유로부터얻을수 있는올레산또는그 에스터로부터폴리아미드계열가소성탄성체(TPE)의원료가되는 11-아미노운데카논산또는그의에스터유도체를제조하는방법에관한것이다. 본발명에따른제조방법에따라제조되는 11-아미노운데카논산은폴리아미드-12의단량체로사용되며, 천연유래의올리브유로부터제조될수 있는올레산또는그 에스터로부터제조할수 있는바, 11-아미노운데카논산의새로운친환경적이면서도효율적인제조방법으로이용될수 있다.
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公开(公告)号：KR1020120128466A
公开(公告)日：2012-11-27
申请号：KR1020110046438
申请日：2011-05-17
Applicant: 서울대학교산학협력단
IPC: C07C227/04 , C07C229/08 , C07C51/097 , C07C55/02
Abstract: PURPOSE: A manufacturing method 11-aminoundecanoic acid or ester derivatives thereof is provided to effectively manufacture 11-aminoundecanoic acid and undecanedioic acid which are monomers of polyamide-11 from undesileic acid or ester thereof which can be easily obtain from undesileic acid or ester thereof. CONSTITUTION: A manufacturing method 11-aminoundecanoic acid or ester derivatives thereof comprises: a step of manufacturing a compound indicated in chemical formula 2 through a reductive pre-ozonolysis of undesileic acid indicated in chemical formula 1 or ester thereof; a step of manufacturing a compound indicated in chemical formula 3 by putting base into a mixture of a compound indicated in chemical formula 2 and nitromethane; a step of manufacturing a compound indicated in chemical formula 4 through a removal reaction of a compound indicated in chemical formula 3; a step of manufacturing a chemical formula 7 through reduction of a compound indicated in chemical formula 4 under the presence of a transition metal catalyst. [Reference numerals] (AA) Catalyst, H_2
Abstract translation: 目的：提供制备方法11-氨基十一烷酸或其酯衍生物，以有效地制备作为不溶性酸或其酯的聚酰胺-11单体的11-氨基十一烷酸和十一烷二酸，其可以容易地从不适当的酸或其酯获得。 构成：制备方法11-氨基十一烷酸或其酯衍生物包括：通过化学式1所示的不寻常的酸的还原性预臭氧分解或其酯制备化学式2所示化合物的步骤; 将化学式3所示的化合物与硝基甲烷的化合物混合，制成化学式3表示的化合物的工序; 通过化学式3表示的化合物的去除反应制造化学式4所示化合物的步骤; 通过在过渡金属催化剂的存在下还原化学式4所示的化合物来制造化学式7的步骤。 （AA）催化剂，H_2
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