公开(公告)号：KR1020030080736A

公开(公告)日：2003-10-17

申请号：KR1020020019520

申请日：2002-04-10

Applicant: 재단법인서울대학교산학협력재단

Inventor： 유현승 ,  홍국선 ,  이춘기 ,  이동호 ,  이상림 ,  장봉순 ,  김수진 ,  임창균

IPC: A61L27/12

CPC classification number: A61L27/12 ,  A61F2/4644 ,  A61F2002/2835 ,  A61F2310/00293 ,  A61L27/56 ,  A61L2430/02

Abstract: PURPOSE: An artificial bone filler using calcium phosphate based compounds and a preparation method are provided to have not only the high bone fusion rate and tensile strength, but also the relatively high bio-absorbency. CONSTITUTION: The artificial bone filler is prepared by: formulating at least one selected from the group consisting of magnesium oxide(MgO), calcium pyrophosphate substituted by Mg(Ca2-XMgXP2O7), magnesium pyrophosphate(Mg2P2O7) and calcium magnesium pyrophosphate(CaMg2P2O7), and calcium pyrophosphate powders selected from the group consisting of calcium pyrophosphate(Ca2P2O7) or not more than 10 wt.% of tricalcium phosphate(Ca3(PO4)2); press-forming the compounds to a porous body; and sintering it at the temperature of 1000 to 1200 deg.C.

Abstract translation: 目的：提供一种使用磷酸钙基化合物的人造骨填料和制备方法，不仅具有高骨融合率和拉伸强度，而且具有较高的生物吸收性。 构成：通过以下方法制备人造骨填料：配制选自由Mg（Ca2-XMgXP2O7），焦磷酸镁（Mg2P2O7）和焦磷酸钙镁（CaMg2P2O7）取代的氧化镁（MgO），焦磷酸钙的至少一种， 和选自焦磷酸钙（Ca2P2O7）或不超过10重量％的磷酸三钙（Ca 3（PO 4）2））的焦磷酸钙粉末; 将化合物压制成多孔体; 并在1000〜1200℃的温度下烧结。

公开(公告)号：KR1020020096521A

公开(公告)日：2002-12-31

申请号：KR1020010035081

申请日：2001-06-20

Applicant: 재단법인서울대학교산학협력재단

Inventor： 홍국선 ,  유현승 ,  이동호 ,  이춘기 ,  장봉순 ,  김진호 ,  정성수 ,  윤혁준

IPC: A61L27/10

Abstract: PURPOSE: A process of preparing a ceramic composite for easy control of biosolubility by improving sinterability of a hydroxyapatite and tricalcium phosphate complex is provided which increases strength of the ceramic composite by 3 times while obtaining high density ceramic. Thus obtained ceramic composite can be applied to an artificial tooth and bone-graft material. CONSTITUTION: About 0.2 to 10% by weight of a magnesium salt is added to a complex of hydroxyapatite and tricalcium phosphate in a ratio of 5:95 to 80:20. The magnesium salt comprises one or more selected from the group consisting of magnesium nitrate, magnesium chloride, magnesium oxide, magnesium hydroxide and magnesium carbonate. In a case of synthesizing the hydroxyapatite and tricalcium phosphate, a magnesium is added instead of a calcium salt and then sintered.

Abstract translation: 目的：提供一种通过提高羟基磷灰石和磷酸三钙复合物的烧结性来控制生物溶解性的陶瓷复合材料的制备方法，其在获得高密度陶瓷的同时提高陶瓷复合材料的强度3倍。 这样获得的陶瓷复合材料可以应用于人造牙和骨移植材料。 构成：将约0.2〜10重量％的镁盐以5:95〜80:20的比例加入到羟基磷灰石和磷酸三钙的配合物中。 镁盐包括选自硝酸镁，氯化镁，氧化镁，氢氧化镁和碳酸镁的一种或多种。 在合成羟基磷灰石和磷酸三钙的情况下，加入镁代替钙盐，然后烧结。

公开(公告)号：KR1020080007801A

公开(公告)日：2008-01-23

申请号：KR1020060066911

申请日：2006-07-18

Applicant: 재단법인서울대학교산학협력재단

Inventor： 홍국선 ,  정성수 ,  이동호 ,  유현승

IPC: A61B17/70 ,  A61B17/72 ,  A61B17/56

CPC classification number: A61B17/7071 ,  A61B17/683 ,  A61F2/4465 ,  A61L27/10

Abstract: A spacer for a laminoplasty operation is provided to couple the spacer with a cross-section of a laminoplasty surface by increasing a contact area between the spacer and the laminoplasty surface. Upper and lower surfaces(12,11) are arranged to be apart from each other. Front and rear surfaces(13,14) couple the upper and lower surfaces. First and second coupling surfaces(15,16) are coupled with the upper, lower, front, and rear surfaces and formed in a multi-sectional structure. A main body(10) is made of a bio-active ceramic and directly connected to bones. The main body is coupled with a cut laminoplasty surface of a spine. At least one through-hole(18) is arranged to penetrate the first and second coupling surfaces. A weaving thread passes through at least one concave groove(17) along a length direction of the lower surface.

Abstract translation: 提供了用于椎板成形术操作的间隔件，以通过增加间隔件和椎板成形术表面之间的接触面积来将间隔件与椎板成形术表面的横截面联接。 上表面和下表面（12,11）被布置成彼此分开。 前表面和后表面（13,14）连接上表面和下表面。 第一和第二联接表面（15,16）与上表面，下表面，后表面和后表面联接并且形成为多截面结构。 主体（10）由生物活性陶瓷制成并直接连接到骨头上。 主体与脊柱的切割椎板成形术表面联接。 至少一个通孔（18）布置成穿透第一和第二联接表面。 编织线沿着下表面的长度方向穿过至少一个凹槽（17）。

公开(公告)号：KR1020040021111A

公开(公告)日：2004-03-10

申请号：KR1020020052566

申请日：2002-09-02

Applicant: 재단법인서울대학교산학협력재단

Inventor： 유현승 ,  홍국선 ,  김환 ,  이동호 ,  이춘기 ,  장봉순 ,  김득중 ,  서준혁 ,  이재협 ,  박기수

IPC: A61L27/10

CPC classification number: C03C4/0007 ,  A61L27/10 ,  A61L27/58 ,  C03C3/064 ,  C03C3/112 ,  C03C4/0014 ,  C03C8/22 ,  C03C10/00 ,  C03C11/00 ,  C03C12/00

Abstract: PURPOSE: A bioabsorbable type bioactive glass-ceramic and a preparation method thereof are provided to control the biodegradable speed according to the formulation ratio of glass-ceramics while maintaining the bioactivity. CONSTITUTION: The bioabsorbable type bioactive glass-ceramic comprises 41.4 to 45.75 wt.% of CaO, 35.0 to 47.62 wt.% of SiO2, 1.62 to 14.58 wt.% of P2O5, 0.5 to 14.58 wt.% of B2O3, 0.46 to 4.14 wt.% of MgO, and 0.05 to 0.45 wt.% of CaF2. The bioabsorbable type bioactive glass-ceramic is composed of the first glass and the second glass in a weight ratio of 90:10 to 10:90. The first glass comprises 41.03 to 45.86 wt.% of CaO, 43.97 to 49.14 wt.% of SiO2, and 5 to 15 wt.% of B2O3. The second glass comprises 44.7 wt.% of CaO, 44.7 wt.% of MgO, 34.0 wt.% of SiO2, 16.2 wt.% of P2O5, and 0.5 wt.% of CaF2.

Abstract translation: 目的：提供生物可吸收型生物活性玻璃陶瓷及其制备方法，以在保持生物活性的同时，根据玻璃陶瓷配方比例控制生物降解速度。 构成：生物可吸收型生物活性玻璃 - 陶瓷包含41.4〜45.75重量％的CaO，35.0〜47.62重量％的SiO 2，1.62〜14.58重量％的P 2 O 5，0.5〜14.58重量％的B 2 O 3，0.46〜4.14重量％ 的MgO，0.05〜0.45重量％的CaF 2。 生物可吸收型生物活性玻璃陶瓷由第一玻璃和第二玻璃组成，重量比为90:10至10:90。 第一玻璃包含CaO的41.03〜45.86重量％，SiO 2为43.97〜49.14重量％，B 2 O 3为5〜15重量％。 第二种玻璃包括44.7wt％的CaO，44.7wt％的MgO，34.0wt。％的SiO 2，16.2wt。％的P 2 O 5和0.5wt％的CaF 2。

公开(公告)号：KR1020040011885A

公开(公告)日：2004-02-11

申请号：KR1020020045175

申请日：2002-07-31

Applicant: 재단법인서울대학교산학협력재단

Inventor： 유현승 ,  홍국선 ,  이춘기 ,  이동호 ,  이재협 ,  장봉순 ,  김수진 ,  정성수

IPC: A61L27/10

Abstract: PURPOSE: Provided are a bio-active ceramics and a metallic implant used in surgical and dental applications coated with the ceramics in order to increase bio-affinity to a subject having the implant. CONSTITUTION: The bio-active ceramics comprises 40-49 wt.% of CaO, 40-49 wt.% of silica(SiO2) and 2-20 wt.% of B2O3. The process for producing the metallic implant comprises steps of preparing the bio-active ceramic by fusing raw material consisting of CaO, SiO2, B2O3 and quenching the fused material; grinding the frozen material into powders having less than 10 micrometer size; preparing slurry by adding aqueous or organic solvents and a binder; applying the slurry to a metallic implant by means of brush; and sintering the coated implant at 700-950 deg.C.

Abstract translation: 目的：提供一种生物活性陶瓷和用于外科和牙科应用的金属植入物，其涂覆有陶瓷，以增加对具有植入物的受试者的生物亲和力。 构成：生物活性陶瓷包含40-49重量％的CaO，40-49重量％的二氧化硅（SiO 2）和2-20重量％的B 2 O 3。 制造金属植入体的方法包括以下步骤：通过熔融由CaO，SiO 2，B 2 O 3组成的原料和淬火熔融材料来制备生物活性陶瓷; 将冷冻材料研磨成具有小于10微米尺寸的粉末; 通过加入水或有机溶剂和粘合剂制备浆料; 通过刷子将浆料施加到金属植入物; 并在700-950℃烧结涂覆的植入物。