公开(公告)号：KR100465984B1

公开(公告)日：2005-01-17

申请号：KR1020020045175

申请日：2002-07-31

Applicant: 재단법인서울대학교산학협력재단

Inventor： 유현승 ,  홍국선 ,  이춘기 ,  이동호 ,  이재협 ,  장봉순 ,  김수진 ,  정성수

IPC: A61L27/10

Abstract: PURPOSE: Provided are a bio-active ceramics and a metallic implant used in surgical and dental applications coated with the ceramics in order to increase bio-affinity to a subject having the implant. CONSTITUTION: The bio-active ceramics comprises 40-49 wt.% of CaO, 40-49 wt.% of silica(SiO2) and 2-20 wt.% of B2O3. The process for producing the metallic implant comprises steps of preparing the bio-active ceramic by fusing raw material consisting of CaO, SiO2, B2O3 and quenching the fused material; grinding the frozen material into powders having less than 10 micrometer size; preparing slurry by adding aqueous or organic solvents and a binder; applying the slurry to a metallic implant by means of brush; and sintering the coated implant at 700-950 deg.C.

Abstract translation: 目的：提供一种生物活性陶瓷和金属植入物，其用于外科和牙科应用中涂覆有陶瓷以增加具有植入物的对象的生物亲和力。 构成：生物活性陶瓷包含40-49重量％的CaO，40-49重量％的二氧化硅（SiO2）和2-20重量％的B2O3。 生产金属植入物的方法包括以下步骤：通过熔化由CaO，SiO2，B2O3组成的原材料并淬火熔融材料来制备生物活性陶瓷; 将冷冻材料研磨成小于10微米大小的粉末; 通过加入水溶液或有机溶剂和粘合剂制备浆液; 通过刷子将浆料施加到金属植入物上; 并在700-950℃下烧结涂覆的植入物。

公开(公告)号：KR100460685B1

公开(公告)日：2004-12-09

申请号：KR1020020019520

申请日：2002-04-10

Applicant: 재단법인서울대학교산학협력재단

Inventor： 유현승 ,  홍국선 ,  이춘기 ,  이동호 ,  이상림 ,  장봉순 ,  김수진 ,  임창균

IPC: A61L27/12

CPC classification number: A61L27/12 ,  A61F2/4644 ,  A61F2002/2835 ,  A61F2310/00293 ,  A61L27/56 ,  A61L2430/02

Abstract: A bone graft substitute using magnesium substituted calcium phosphate compounds and a method of manufacturing the same is provided in which the bone graft substitute is used for recovering bones damaged due to a bone fracture. The method of manufacturing a bone graft substitute includes the steps of mixing powdered calcium pyrophosphate and a magnesium included compound to thereby obtain a composition, pressure-forming the compositions to obtain a plastic body; and sintering the plastic body.

Abstract translation: 提供了使用镁取代磷酸钙化合物的骨移植替代物及其制造方法，其中骨移植替代物用于恢复由于骨折而损坏的骨。 制造骨移植替代品的方法包括以下步骤：将粉状焦磷酸钙和含镁化合物混合，从而获得组合物，将组合物加压成形以获得塑性体; 并烧结塑料体。

公开(公告)号：KR100465985B1

公开(公告)日：2005-01-15

申请号：KR1020020044845

申请日：2002-07-30

Applicant: 재단법인서울대학교산학협력재단

Inventor： 유현승 ,  홍국선 ,  이춘기 ,  이동호 ,  이재협 ,  장봉순 ,  김수진 ,  정성수

IPC: A61L27/10

CPC classification number: C04B35/447 ,  A61F2/28 ,  A61F2002/30968 ,  A61F2310/00293 ,  C04B35/22 ,  C04B2235/3212 ,  C04B2235/3454 ,  C04B2235/44 ,  C04B2235/442 ,  C04B2235/444 ,  C04B2235/445 ,  C04B2235/77 ,  C04B2235/9615

Abstract: A bioactive biphasic ceramic composition combining apatite and wollastonite is disclosed, in order to solve the defect of apatite ceramic that has poor bioactivity though it is excellent in biocompatibility, which has improved bioactivity, as compared to monophasic ceramics of apatite or wollastonite. The ceramic composition is produced by steps of: providing a composition including powders of apatite of formula Ca10(PO4)6X, in which X is any one of O, (OH)2, CO3, F2 and Cl2, and wollastonite (CaSiO3) in a weight ratio of 5:95 to 90:10, forming the composition into a desired body by press or forming the composition into a porous body, and sintering the formed body.

Abstract translation: 本发明公开了一种磷灰石与硅灰石组合的生物活性双相陶瓷组合物，用于解决与磷灰石或硅灰石单相陶瓷相比生物相容性优异，生物活性提高的生物活性差的磷灰石陶瓷的缺点。 所述陶瓷组合物通过以下步骤制备：提供包含式Ca 10（PO 4）6 X的磷灰石粉末的组合物，其中X为O，（OH）2，CO 3，F 2和Cl 2中的任一种以及硅灰石（CaSiO 3） 5:95至90:10的重量比，通过压制或将该组合物成形为多孔体而将该组合物成形为所需的主体，并烧结成形体。

公开(公告)号：KR1020040011744A

公开(公告)日：2004-02-11

申请号：KR1020020044845

申请日：2002-07-30

Applicant: 재단법인서울대학교산학협력재단

Inventor： 유현승 ,  홍국선 ,  이춘기 ,  이동호 ,  이재협 ,  장봉순 ,  김수진 ,  정성수

IPC: A61L27/10

CPC classification number: C04B35/447 ,  A61F2/28 ,  A61F2002/30968 ,  A61F2310/00293 ,  C04B35/22 ,  C04B2235/3212 ,  C04B2235/3454 ,  C04B2235/44 ,  C04B2235/442 ,  C04B2235/444 ,  C04B2235/445 ,  C04B2235/77 ,  C04B2235/9615

Abstract: PURPOSE: A bio-active combined ceramics composition is provided to eliminate problems of conventional apatite ceramics and improve bio-activity by combining the apatite with wollastonite. CONSTITUTION: The composition is produced by combining the apatite(Ca10(PO4)6)X (wherein X is any one selected from O, (OH)2, CO3, F2, Cl2) and the wollastonite(CaSiO3) in weight ratio of 5:95 to 90:10; pressing the composition or conducting a molding process of the composition to obtain a porous form; and sintering the molded form at 1200-1400 deg.C. The wollastonite is generally synthesized by blending calcium oxide and silica in 1:1 mole ratio.

Abstract translation: 目的：提供一种生物活性组合陶瓷组合物，以消除常规磷灰石陶瓷的问题，并通过将磷灰石与硅灰石组合来改善生物活性。 构成：通过将磷灰石（Ca 10（PO 4）6）X（其中X是选自O，（OH）2，CO 3，F 2，Cl 2）和硅灰石（CaSiO 3）中的任何一种）的重量比5 ：95〜90:10; 压制组合物或进行组合物的模塑过程以获得多孔形式; 并在1200-1400℃烧结成型。 硅灰石通常通过以1:1摩尔比混合氧化钙和二氧化硅来合成。

公开(公告)号：KR1020030080736A

公开(公告)日：2003-10-17

申请号：KR1020020019520

申请日：2002-04-10

Applicant: 재단법인서울대학교산학협력재단

Inventor： 유현승 ,  홍국선 ,  이춘기 ,  이동호 ,  이상림 ,  장봉순 ,  김수진 ,  임창균

IPC: A61L27/12

CPC classification number: A61L27/12 ,  A61F2/4644 ,  A61F2002/2835 ,  A61F2310/00293 ,  A61L27/56 ,  A61L2430/02

Abstract: PURPOSE: An artificial bone filler using calcium phosphate based compounds and a preparation method are provided to have not only the high bone fusion rate and tensile strength, but also the relatively high bio-absorbency. CONSTITUTION: The artificial bone filler is prepared by: formulating at least one selected from the group consisting of magnesium oxide(MgO), calcium pyrophosphate substituted by Mg(Ca2-XMgXP2O7), magnesium pyrophosphate(Mg2P2O7) and calcium magnesium pyrophosphate(CaMg2P2O7), and calcium pyrophosphate powders selected from the group consisting of calcium pyrophosphate(Ca2P2O7) or not more than 10 wt.% of tricalcium phosphate(Ca3(PO4)2); press-forming the compounds to a porous body; and sintering it at the temperature of 1000 to 1200 deg.C.

Abstract translation: 目的：提供一种使用磷酸钙基化合物的人造骨填料和制备方法，不仅具有高骨融合率和拉伸强度，而且具有较高的生物吸收性。 构成：通过以下方法制备人造骨填料：配制选自由Mg（Ca2-XMgXP2O7），焦磷酸镁（Mg2P2O7）和焦磷酸钙镁（CaMg2P2O7）取代的氧化镁（MgO），焦磷酸钙的至少一种， 和选自焦磷酸钙（Ca2P2O7）或不超过10重量％的磷酸三钙（Ca 3（PO 4）2））的焦磷酸钙粉末; 将化合物压制成多孔体; 并在1000〜1200℃的温度下烧结。

公开(公告)号：KR1020040011885A

公开(公告)日：2004-02-11

申请号：KR1020020045175

申请日：2002-07-31

Applicant: 재단법인서울대학교산학협력재단

Inventor： 유현승 ,  홍국선 ,  이춘기 ,  이동호 ,  이재협 ,  장봉순 ,  김수진 ,  정성수

IPC: A61L27/10

Abstract: PURPOSE: Provided are a bio-active ceramics and a metallic implant used in surgical and dental applications coated with the ceramics in order to increase bio-affinity to a subject having the implant. CONSTITUTION: The bio-active ceramics comprises 40-49 wt.% of CaO, 40-49 wt.% of silica(SiO2) and 2-20 wt.% of B2O3. The process for producing the metallic implant comprises steps of preparing the bio-active ceramic by fusing raw material consisting of CaO, SiO2, B2O3 and quenching the fused material; grinding the frozen material into powders having less than 10 micrometer size; preparing slurry by adding aqueous or organic solvents and a binder; applying the slurry to a metallic implant by means of brush; and sintering the coated implant at 700-950 deg.C.

Abstract translation: 目的：提供一种生物活性陶瓷和用于外科和牙科应用的金属植入物，其涂覆有陶瓷，以增加对具有植入物的受试者的生物亲和力。 构成：生物活性陶瓷包含40-49重量％的CaO，40-49重量％的二氧化硅（SiO 2）和2-20重量％的B 2 O 3。 制造金属植入体的方法包括以下步骤：通过熔融由CaO，SiO 2，B 2 O 3组成的原料和淬火熔融材料来制备生物活性陶瓷; 将冷冻材料研磨成具有小于10微米尺寸的粉末; 通过加入水或有机溶剂和粘合剂制备浆料; 通过刷子将浆料施加到金属植入物; 并在700-950℃烧结涂覆的植入物。