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公开(公告)号：KR1020080105766A
公开(公告)日：2008-12-04
申请号：KR1020070053777
申请日：2007-06-01
Applicant: 재단법인서울대학교산학협력재단
IPC: C07D263/57 , C07D277/66
CPC classification number: C07D307/87 , A61K51/0419 , A61K51/0431 , A61K51/0453 , C07D263/57 , C07D277/66 , C07D333/72
Abstract: A heterocyclic indene derivative, a radioactive isotope labeled compound of the derivative, a method for preparing the radioactive isotope labeled compound, and a composition for the beta-amyloid imaging containing the radioactive isotope labeled compound are provided to allow a radioactive isotope to be labeled easily, to improve the initial brain absorption and to enhance the disappearance at normal brain. A heterocyclic indene derivative is represented by the formula 1, wherein X is O, S or NH; Y is CH or N; Z is F, Cl, Br, I or a sulfonic acid derivative; and R1 to R8 are independently H, a C1-C4 alkyl group, F, Cl, Br, I, O-CH3, O-CH2-CH3, O-CH2=CH2-CH3 or OH.
Abstract translation: 提供杂环茚衍生物，衍生物的放射性同位素标记化合物，制备放射性同位素标记化合物的方法和含有放射性同位素标记化合物的β-淀粉样成像组合物，以允许放射性同位素易于标记 ，以改善初始脑吸收并增强正常大脑的消失。 杂环茚衍生物由式1表示，其中X是O，S或NH; Y是CH或N; Z是F，Cl，Br，I或磺酸衍生物; 且R 1至R 8独立地为H，C 1 -C 4烷基，F，Cl，Br，I，O-CH 3，O-CH 2 -CH 3，O-CH 2 = CH 2 -CH 3或OH。
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12.发明公开펩타이드 수용체 영상용 제제로 사용할 수 있는 Ｆ－１８－플로로벤질리덴하이드라존－니코틴아마이드－펩타이드 유도체 및 펩타이드에 방사성불소를 효율적으로 표지하기 위한 방법 有权用于肽吸收成像剂的F-18-氟代苄基赖氨酸 - 新戊酰胺肽和具有放射性荧光素的标签肽的有效方法
公开(公告)号：KR1020060134244A
公开(公告)日：2006-12-28
申请号：KR1020050053779
申请日：2005-06-22
Applicant: 재단법인서울대학교산학협력재단
Abstract: A F-18-fluorobenzylidenehydrazone-nicotineamide-peptide compound is provided to be coupled to various peptide receptors existing on various cancerous tissues and angiogenesis portion in human body so as to emit positron, thereby being used as an agent for positron emission tomography. The F-18-fluorobenzylidenehydrazone-nicotineamide-peptide compound is represented by the formula(1) and prepared by mixing a hydrazinonicotinamide-peptide represented by the formula(2) with an F-18-fluorobenzaldehyde represented by the formula(3) so as to form a hydrazone bond.
Abstract translation: 提供F-18-氟亚苄基腙 - 尼古丁酰胺 - 肽化合物偶联到存在于人体各种癌组织和血管生成部分上的各种肽受体，以便发射正电子，从而用作正电子发射断层摄影的试剂。 F-18-氟亚苄基腙 - 尼古丁酰胺 - 肽化合物由式（1）表示，通过将由式（2）表示的肼基烟酰胺 - 肽与由式（3）表示的F-18-氟代苯甲醛混合，由 以形成腙键。
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公开(公告)号：KR1020090072384A
公开(公告)日：2009-07-02
申请号：KR1020070140477
申请日：2007-12-28
Applicant: 재단법인서울대학교산학협력재단
IPC: C12Q1/68
CPC classification number: G01N33/53 , C12Q1/6883
Abstract: A method for identifying synovium cell which proliferative or chondrogenic potential is decreased is provided to easily and accurately identify the synovium cell. A kit for identifying or detecting a synovium which proliferative or chondrogenic potential is decreased comprises: an antibody which specifically binds to CD166, CD49a or CD106; and a probe or primer which specifically binds to the sequence of cyclin-dependent kinase suppressor 2A gene, v-Ki-ras 2 gene, thrombospondin 1 gene, mitogen activated protein kinase 9 gene, tumor necrosis factor receptor super family member 6 gene, tumor necrosis factor receptor super family member 10d gene or PRKC apoptosis WT1 regulator (PAWR) gene. A method for identifying or detecting the synovium cell comprises: a step of containing an antibody which specifically binds to a test cell to analyze in CD166, CD49a or CD106; and a step of determining the bind of the antibody on the surface of the cell.
Abstract translation: 提供用于鉴定滑膜细胞增殖或软骨形成潜力降低的方法以容易且准确地鉴定滑膜细胞。 用于鉴定或检测增殖或软骨形成潜力降低的滑膜的试剂盒包括：特异性结合CD166，CD49a或CD106的抗体; 和特异性结合细胞周期蛋白依赖性激酶抑制基因2A基因，v-Ki-ras 2基因，血小板反应蛋白1基因，丝裂原活化蛋白激酶9基因，肿瘤坏死因子受体超家族成员6基因，肿瘤的序列的探针或引物 坏死因子受体超家族成员10d基因或PRKC凋亡WT1调节因子（PAWR）基因。 用于鉴定或检测滑膜细胞的方法包括：含有特异性结合于测试细胞以在CD166，CD49a或CD106中分析的抗体的步骤; 以及测定抗体在细胞表面上的结合的步骤。
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Patent Agency Ranking14.发明公开
公开(公告)号：KR1020070056421A
公开(公告)日：2007-06-04
申请号：KR1020050115012
申请日：2005-11-29
Applicant: 재단법인서울대학교산학협력재단
IPC: C07C251/24
CPC classification number: A61K51/04 , C07C251/24
Abstract: Provided are a benzylideneaniline derivative for imaging beta-amyloid peptide plaques to diagnose or treat the disease derived from beta-amyloid peptide plaques such as Alzheimer's disease, a pharmaceutical composition for injection containing the derivative, and a method for preparing a 18F-labeled benzylideneaniline derivative. The benzylideneaniline derivative is represented by a formula 1, wherein R1 to R5 are independently H, a C1-C4 alkyl group or F, but at least one among R1 to R5 is F; and R6 to R10 are independently H, a C1-C4 alkyl group, OH, OCH3, NH2, NHCH3 or N(CH3)2, but at least one among R6 to R10 is OH, OCH3, NH2, NHCH3 or N(CH3)2.
Abstract translation: 提供了用于成像β-淀粉样蛋白肽斑块的亚苄基苯胺衍生物，用于诊断或治疗衍生自β-淀粉样蛋白肽斑块如阿尔茨海默氏病的疾病，含有该衍生物的注射用药物组合物和制备18F-标记的亚苄基苯胺衍生物的方法 。 亚苄基苯胺衍生物由式1表示，其中R 1至R 5独立地为H，C 1 -C 4烷基或F，但R 1至R 5中的至少一个为F; R 6至R 10独立地为H，C 1 -C 4烷基，OH，OCH 3，NH 2，NHCH 3或N（CH 3）2，但R 6至R 10中的至少一个为OH，OCH 3，NH 2，NHCH 3或N（CH 3） 2。
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公开(公告)号：KR101021853B1
公开(公告)日：2011-03-16
申请号：KR1020100101429
申请日：2010-10-18
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 (a) CD166, CD49a 또는 CD106에 특이적으로 결합하는 항체; 또는 (b) 사이클린-의존성 키나아제 억제자 2A 유전자, v-Ki-ras 2 유전자, 트롬보스폰딘 1 유전자, 마이토젠-활성 단백질 키나아제 9 유전자, 엑토뉴클레오타이드 파이로포스파타아제/포스포다이에스터라아제 1 유전자, 종양괴사인자 수용체 슈퍼패밀리 멤머 6 유전자, 종양괴사인자 수용체 슈퍼패밀리 멤버 10d 유전자, 종양괴사인자 수용체 슈퍼패밀리 멤머 10b 유전자, 종양괴사인자 수용체 슈퍼패밀리 11b 유전자, TNF 수용체-연관 인자 4 유전자 또는 PRKC 아폽토시스 WT1 조절자(PAWR) 유전자 서열에 특이적으로 결합하는 프라이머 또는 프로브를 포함하는 증식능 또는 연골생성능이 감소된 활액막 세포의 동정 또는 검출용 키트를 제공한다. 본 발명에 따르면, 증식능 및/또는 연골생성능이 감소된 활액막 세포를 용이하면서도 정확하게 동정할 수 있으며, 본 발명은 활액막 세포를 이용한 관절연골의 손상 치료에 새로운 단서를 제공한다.
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公开(公告)号：KR1020110000706A
公开(公告)日：2011-01-05
申请号：KR1020100101429
申请日：2010-10-18
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C12Q1/6876 , C12N5/0655 , G01N2800/105
Abstract: PURPOSE: A method for identifying synovial cells with reduced proliferation ability or chondrogenecity is provided to accurately and easily identify synobial cells. CONSTITUTION: A kit for identifying or detecting synovial cells with reduced proliferation ability or chondrogenecity contains a primer or probe which specifically binds to PRKC apoptosis WT1 regulator(PAWR) gene sequence. A method for identifying or detecting synovial cells comprises: a step of isolating total RNA from synobial cells; a step of synthesizing cDNA from the total RNA; a step of hybridizing the cDNA to the probe; and a step of confirming hybridization.
Abstract translation: 目的：提供用于鉴定具有降低的增殖能力或软骨形成的滑膜细胞的方法，以准确和容易地鉴定合成细胞。 构成：用于鉴定或检测具有降低的增殖能力或软骨形成的滑膜细胞的试剂盒含有特异性结合PRKC细胞凋亡WT1调节因子（PAWR）基因序列的引物或探针。 用于鉴定或检测滑膜细胞的方法包括：从synobial细胞分离总RNA的步骤; 从总RNA合成cDNA的步骤; 将cDNA与探针杂交的步骤; 和确认杂交的步骤。
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公开(公告)号：KR1020110000705A
公开(公告)日：2011-01-05
申请号：KR1020100101400
申请日：2010-10-18
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C12Q1/6876 , C12N5/0655 , G01N2800/105
Abstract: PURPOSE: A method for identifying synovial cells with reduced proliferation ability or chondrogenecity is provided to easily and accurately identify synovial cells. CONSTITUTION: A kit for identifying or detecting synovial cells with proliferation ability or chondrogenecity contains a primer or probe which specifically binds to TNF receptor super family 11n gene sequence. A method for identifying or detecting synovial cells with reduce proliferation ability or chondrogenecity comprises: a step of preparing total RNA from synovial cells; a step of synthesizing cDNA from the total RNA; a step of hybridizing the synovial cell-derived cDNA to the probe; and a step of confirming hybridization.
Abstract translation: 目的：提供用于鉴定具有降低的增殖能力或软骨形成的滑膜细胞的方法以容易且准确地鉴定滑膜细胞。 构成：用于鉴定或检测具有增殖能力或软骨形成的滑膜细胞的试剂盒含有特异性结合TNF受体超家族11n基因序列的引物或探针。 用于鉴定或检测具有降低增殖能力或软骨形成的滑膜细胞的方法包括：从滑膜细胞制备总RNA的步骤; 从总RNA合成cDNA的步骤; 将滑膜细胞衍生的cDNA杂交到探针的步骤; 和确认杂交的步骤。
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公开(公告)号：KR100975273B1
公开(公告)日：2010-08-11
申请号：KR1020070140477
申请日：2007-12-28
Applicant: 재단법인서울대학교산학협력재단
IPC: C12Q1/68
Abstract: 본 발명은 (a) CD166, CD49a 또는 CD106에 특이적으로 결합하는 항체; 또는 (b) 사이클린-의존성 키나아제 억제자 2A 유전자, v-Ki-ras 2 유전자, 트롬보스폰딘 1 유전자, 마이토젠-활성 단백질 키나아제 9 유전자, 엑토뉴클레오타이드 파이로포스파타아제/포스포다이에스터라아제 1 유전자, 종양괴사인자 수용체 슈퍼패밀리 멤머 6 유전자, 종양괴사인자 수용체 슈퍼패밀리 멤버 10d 유전자, 종양괴사인자 수용체 슈퍼패밀리 멤머 10b 유전자, 종양괴사인자 수용체 슈퍼패밀리 11b 유전자, TNF 수용체-연관 인자 4 유전자 또는 PRKC 아폽토시스 WT1 조절자(PAWR) 유전자 서열에 특이적으로 결합하는 프라이머 또는 프로브를 포함하는 증식능 또는 연골생성능이 감소된 활액막 세포의 동정 또는 검출용 키트를 제공한다. 본 발명에 따르면, 증식능 및/또는 연골생성능이 감소된 활액막 세포를 용이하면서도 정확하게 동정할 수 있으며, 본 발명은 활액막 세포를 이용한 관절연골의 손상 치료에 새로운 단서를 제공한다.
활액막 세포, 증식, 분화, 연골생성
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