Abstract:
The present invention provides a drug delivery agent for cancer tissues containing microbeads in which bacteria with biotin combined to the surface and streptavidin are coated on the surface of the microbeads and drugs are physically inserted, for providing bacterium based microbeads which is capable of specifically targeting the cancer tissues in a living body.
Abstract:
PURPOSE: A tumor-specific imageable therapeutic agent is provided to monitor/diagnose cancer through image photographing. CONSTITUTION: A tumor imageable therapeutic agent contains ppGpp-deleted Samonella containing a cytotoxic gene and luminescence gene which are operatively linked to a inducible or tumor-specific promoter. The cytotoxic gene and luminescence gene are inserted to a plasmid or Salmonella gene. The luminescence gene is luciferase gene. The cytotoxic gene is ClyA gene. The tumor-specific promoter is amsB(asparaginase coding), pflE(pyruvate-formate-lyase activating enzyme coding), or pepT(tripeptidase coding). The inducible promoter is pBAD or pTET.
Abstract:
본 발명은 이중영상 촬영장치에 관한 것으로, 보다 구체적으로는 살아있는 소 동물의 형광영상 및 감마선영상을 동시에 획득할 수 있는 형광영상 및 감마선영상 촬영을 위한 소 동물용 이중영상 촬영장치에 관한 것이다. 생체영상, 형광영상, 감마선영상, 분자영상, 리포터 유전자
Abstract:
PURPOSE: A multifunctional small animal operating table for the fluoroscopic image preprocessing is provided, which enables to perform preprocessing for the fluoroscopic image acquisition of the subject in the state that the subject is alive. CONSTITUTION: A multifunctional small animal operating table for the fluoroscopic image preprocessing includes a support frame, a settlement axis, a light source, and an optical filter. The support frame(100) forms the floor side and on which the subject is placed. The settlement axis(200) is built at a certain part of the support frame. The light source(300) rotates based on the axis and radiates light to the subject. The optical filter(400) passes the specific wavelength light which is reflected on the subject while rotating based on the axis.
Abstract:
본 발명은 생체 내에서 암 조직에 대하여 특이적으로 타겟팅 될 수 있는 박테리아 기반의 마이크로비드를 제공하기 위하여, 바이오틴(biotin)이 표면에 결합된 갖는 박테리아와 스트렙타비딘(streptavidin)이 표면에 코팅되고, 약물이 물리적으로 봉입된 마이크로비드를 포함하는 암 조직에 대한 약물운반체을 제공한다.
Abstract:
Provided in the present invention is a composition to prevent and treat cancer which comprises attenuated salmonella species strain and interleukin-1β (IL-1β) to increase an anticancer effect of attenuated anaerobic bacteria for treatment. According to an embodiment of the present invention formed like the same, a composition to prevent and treat cancer, and a treatment method using the same increasing the anticancer effect of the attenuated salmonella strain can be provided.