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11.发明公开헬리코박터 파일로리균의 리보좀 단백질 Ｌ１유래의 유사체펩타이드로부터 풀림구조를 절단한 양이온 증가 항생펩타이드 및 항균 및 항진균용 조성물 有权没有随机线圈区域的新型合成抗微生物肽和由HELICOBACTER PYLORI的RIBOSOMAL蛋白L1衍生的阳离子阳离子和用于抗真菌和抗真菌剂的组合物
公开(公告)号：KR1020090022608A
公开(公告)日：2009-03-04
申请号：KR1020070088127
申请日：2007-08-31
Applicant: 조선대학교산학협력단
IPC: C07K14/195 , C07K14/205
Abstract: A cationic increment antibiotic peptide produced by cleaving a non-native structure of an analogs peptide derived from ribosomal protein l1 of helicobacter pylori is provided to improve cationic properties while leaving a helical structure of an analogs peptide derived from ribosomal protein l1 of helicobacter pylori. A method for producing a cationic increment antibiotic peptide comprises the following steps of: cleaving 1st~4th amino acids of HPA3(Helicobacter pylori Analogue 3) having an amino acid sequence indicated as sequence number 2; and substituting a positive charge amino acid for the 9th amino acid of glutamic acid and the 13th amino acid of serine. The positive charge amino acid is selected from the group consisting of lysine, arginine, and histidine.
Abstract translation: 提供通过切割衍生自幽门螺杆菌的核糖体蛋白质11的类似物肽的非天然结构产生的阳离子增量抗生素肽，以改善阳离子性质，同时留下衍生自幽门螺杆菌的核糖体蛋白质11的类似物肽的螺旋结构。 制备阳离子增量抗生素肽的方法包括以下步骤：切割具有序列号2表示的氨基酸序列的HPA3（幽门螺杆菌模拟物3）的第1-4位氨基酸; 用正电荷氨基酸取代谷氨酸的第9个氨基酸和丝氨酸的第13个氨基酸。 正电荷氨基酸选自赖氨酸，精氨酸和组氨酸。
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12.发明公开
公开(公告)号：KR1020080044689A
公开(公告)日：2008-05-21
申请号：KR1020060114038
申请日：2006-11-17
Applicant: 조선대학교산학협력단
IPC: C12N1/20
Abstract: A novel peptide isolated from a novel Bacillus subtilis S1 is provided to show excellent antibiotic effect on harmful fungi and bacteria, thereby being usefully used as an antibacterial and anti-fungal pharmaceutical composition, a pesticide, or a preservative of food, cosmetics or medicines. A Bacillus subtilis S1 having the antibiotics activity is deposited as a deposition no. KCTC 10888BP. A method for purifying a peptide from the Bacillus subtilis comprises the steps of: (a) culturing the Bacillus subtilis S1; (b) after filtering a culture solution obtained from the step(a), loading the filtrate into RP-HPLC(reverse phase-high performance liquid chromatography); (c) eluting proteins to a column of the step(b) using an eluent with gradually increased acetonitrile concentration; and (d) recovering a peak fraction from the eluent and investigating the antibacterial activity thereof. A peptide purified by the method and showing anti-bacterial and anti-fungal activities is characterized in that it is secreted from the Bacillus subtilis S1, has a molecular weight of 1.4-1.6 KDa, and shows antibacterial activity on Rhizoctonia solani and Colletotrichum coccodes. An anti-bacterial and anti-fungal pharmaceutical composition, a biological pesticide or a preservative of foods, cosmetics, or medicines comprises the peptide as an effective ingredient. Further, the concentration of the acetonitrile increases from 5% to 65%.
Abstract translation: 提供从新型枯草芽孢杆菌S1分离的新肽，以显示对有害真菌和细菌的优异的抗生素效果，从而有效地用作食品，化妆品或药物的抗菌和抗真菌药物组合物，农药或防腐剂。 将具有抗生素活性的枯草芽孢杆菌S1沉积为沉积物。 KCTC 10888BP。 从枯草芽孢杆菌纯化肽的方法包括以下步骤：（a）培养枯草芽孢杆菌S1; （b）过滤由步骤（a）得到的培养液后，将滤液装入RP-HPLC（反相高效液相色谱法）中; （c）使用具有逐渐增加的乙腈浓度的洗脱液将蛋白质洗脱到步骤（b）的柱中; 和（d）从洗脱液中回收峰分数并研究其抗菌活性。 通过该方法纯化并显示抗菌和抗真菌活性的肽的特征在于其从枯草芽孢杆菌S1分泌，分子量为1.4-1.6KDa，并且对丝核菌（Rhizoctonia solani）和Colletotrichum coccodes显示出抗菌活性。 抗菌和抗真菌药物组合物，生物杀虫剂或食品，化妆品或药物的防腐剂包括该肽作为有效成分。 此外，乙腈的浓度从5％增加至65％。
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公开(公告)号：KR1020130101755A
公开(公告)日：2013-09-16
申请号：KR1020120022744
申请日：2012-03-06
Applicant: 조선대학교산학협력단
CPC classification number: Y02A50/473
Abstract: PURPOSE: An antibiotic peptide is provided to have excellent antibacterial activity against Escherichia coli or Staphylococcus aureus and to show thermal stability, thereby being used as an active ingredient of an antibacterial and antiseptic composition. CONSTITUTION: An antibiotic peptide has an amino acid sequence of sequence number 1 or 2. The antibiotic peptide is isolated from Nordotis discus discus and has thermal stability. An antibacterial or antiseptic composition contains the antibiotic peptide as an active ingredient. An antibacterial pharmaceutical composition contains the antibiotic peptide as an active ingredient. An antibacterial cosmetic composition contains the antibiotic peptide as an active ingredient.
Abstract translation: 目的：提供抗生素肽以对大肠杆菌或金黄色葡萄球菌具有优异的抗菌活性并显示出热稳定性，从而用作抗菌和防腐组合物的活性成分。 构成：抗生素肽具有序列号1或2的氨基酸序列。抗生素肽分离自诺德铁杆菌铁饼，具有热稳定性。 抗菌或防腐组合物含有抗生素肽作为活性成分。 抗菌药物组合物含有抗生素肽作为活性成分。 抗菌化妆品组合物含有抗生素肽作为活性成分。
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公开(公告)号：KR101263452B1
公开(公告)日：2013-05-10
申请号：KR1020110053429
申请日：2011-06-02
Applicant: 조선대학교산학협력단
IPC: C07K14/435 , A61K38/17 , A61K8/64 , A61P31/04
CPC classification number: Y02A50/473
Abstract: 본발명은키조개(Korean pen shell,)에서추출한신규한열 안정성펩타이드에관한것으로, 보다구체적으로본 발명의키조개에서추출한신규한열 안정성펩타이드는그람음성균에대한강력한항균활성을나타내고독성이없으므로본 발명의펩타이드를유효성분으로함유하는항균제, 화장품보존제, 의약품보존제및 생물농약으로유용하게사용될수 있다.
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公开(公告)号：KR101249771B1
公开(公告)日：2013-04-01
申请号：KR1020100080018
申请日：2010-08-18
Applicant: 조선대학교산학협력단
Abstract: 본 발명은 생물체 유래의 천연 항적조 펩타이드에 관한 것으로서, 보다 구체적으로 본 발명에 따른 HPA3NT3 펩타이드는 탁월한 항적조 활성을 나타내며, 이러한 항적조 활성은 적조유발 생물에만 선택적으로 나타나며, 자연 분해가 가능하며, 세포 독성이 없으므로 해양 생태계에 안전하고 유용한 항적조제로써 사용될 수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020120021826A
公开(公告)日：2012-03-09
申请号：KR1020100080012
申请日：2010-08-18
Applicant: 조선대학교산학협력단
IPC: C07K7/08 , C07K14/435 , A01N63/02
Abstract: PURPOSE: An anti-red tide peptide P5 with anti-red tidal activity is provided to ensure excellent red tidal activity without toxicity. CONSTITUTION: A P5 peptide has an amino acid sequence of sequence number 2. The P5 peptide is a peptide or derivative with enhanced positive charge and hydrophobic region by substituting one or more amino acids of CA-MA(crecropinA-magainin 2) peptide of sequence number 1. The P5 peptide has an anti-red tidal activity to C. polykrikoides, C. marina, or H. akashiwo. An anti-red tidal composition contains P5 peptides as an active ingredient.
Abstract translation: 目的：提供抗红潮汐活性的抗红潮肽P5，以确保无毒性的极好的红潮活性。 构成：P5肽具有序列号2的氨基酸序列.P5肽是具有增强的正电荷和疏水区域的肽或衍生物，其通过用序列的CA-MA（crecropinA-magainin 2）肽取代一个或多个氨基酸 P5肽对C. polykrikoides，C. marina或H. akashiwo具有抗红潮汐活动。 抗红潮组合物含有P5肽作为活性成分。
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公开(公告)号：KR101077180B1
公开(公告)日：2011-10-27
申请号：KR1020080117335
申请日：2008-11-25
Applicant: 조선대학교산학협력단
Abstract: 본발명은헬리코박터파일로리균()의리보좀단백질 L1(ribosomal protein L1, RPL1) 유래의새로운항생펩타이드및 그의용도에관한것으로, 구체적으로헬리코박터파일로리균의리보좀단백질 L1 유래의서열번호 1로기재되는아미노산서열을가지는항생펩타이드로부터 1번과 8번위치의페닐아라닌을알라닌으로치환하거나, 이에추가적으로 13번위치의아스파라긴을리신으로치환함으로써제조된펩타이드들은기존의항생펩타이드에비해세포독성은낮게유지하면서항균활성은더 높게나타냄으로써인체에안전한항생제로유용하게사용될수 있다.
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18.发明公开
公开(公告)号：KR1020100058794A
公开(公告)日：2010-06-04
申请号：KR1020080117335
申请日：2008-11-25
Applicant: 조선대학교산학협력단
Abstract: PURPOSE: A ribosomal protein L1(RPL1)-derived novel antibiotics peptide of helicobacter pylori is provided to ensure high antibacterial activity to gram positive bacterial and gram negative bacteria. CONSTITUTION: An antibiotics peptide with reduced citotoxicity is obtained by substituting phenylalanine of site 1 and 8 in an antibiotics peptide of sequence number 1 with alanine. The antibiotics peptide is denoted by sequence number 2. An antibiotics having antibacterial activity to gram-positive bacteria or gram-negative bacteria contains the antibiotics peptide as an active ingredient. A food additive or food supplement contains the antibiotic peptide as an active ingredient.
Abstract translation: 目的：提供核糖体蛋白L1（RPL1）衍生自幽门螺杆菌的新型抗生素肽，以确保革兰氏阳性细菌和革兰氏阴性菌的高抗菌活性。 构成：通过用1号丙氨酸取代序列号1的抗生素肽中的位点1和8的苯丙氨酸来获得具有降低的宿性毒性的抗生素肽。 抗生素肽由序列号2表示。对革兰氏阳性菌或革兰氏阴性菌具有抗菌活性的抗生素含有抗生素肽作为活性成分。 食品添加剂或食品添加剂含有抗生素肽作为活性成分。
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公开(公告)号：KR101131563B1
公开(公告)日：2012-04-04
申请号：KR1020060114038
申请日：2006-11-17
Applicant: 조선대학교산학협력단
IPC: C12N1/20
Abstract: 본 발명은 신규 분리, 동정한 바실러스 서브틸리스 에스원(
Bacillus subtilis S1 ), 이로부터 분리한 신규 펩타이드 및 이의 용도에 관한 것으로서, 구체적으로는 토양으로부터 분리, 동정한 신균주인 바실러스 서브틸리스 에스원(
Bacillus subtilis S1 ), 이로부터 분리 정제한 항진균용 신규 펩타이드인 S1-14, S1-19, S1-23 및 이의 용도에 관한 것이다. 본 발명의 신규 펩타이드인 S1-14, S1-19 및 S1-23은 항진균 활성이 우수하고 독성이 없으므로 항균제, 항진균제 뿐 아니라 생물농약, 기능성 화장품, 화장품 보존제, 식품 또는 의약품 보존제로 유용하게 사용될 수 있다.
항생제, 농약, 기능성 화장품-
公开(公告)号：KR1020120021827A
公开(公告)日：2012-03-09
申请号：KR1020100080018
申请日：2010-08-18
Applicant: 조선대학교산학협력단
Abstract: PURPOSE: An organism-derived natural anti-red tidal peptide HPA3NT3 is provided to ensure selective anti-red tidal activity without cytotoxicity. CONSTITUTION: An HPA3NT3 peptide has an amino acid sequence of sequence number 3. The HPA3NT3 peptide has a sequence in which 9th amino acid, glutamic acid(Glu) and 13th amino acid, serine of HPA3 peptide of sequence number 2 are substituted. The HPA3NT3 peptide has an anti-red tidal activity to C. polykrikoides, C. marina, or H. akashiwo. An anti-red tidal composition contains the HPA3NT3 peptide as an active ingredient.
Abstract translation: 目的：提供一种有机体衍生的天然抗红潮汐肽HPA3NT3，以确保选择性抗红潮汐活动而无细胞毒性。 构成：HPA3NT3肽具有序列号3的氨基酸序列。HPA3NT3肽具有序列号为2的HPA3肽的第9位氨基酸，谷氨酸（Glu）和第13位氨基酸的丝氨酸被取代的序列。 HPA3NT3肽对C. polykrikoides，C. marina或H. akashiwo具有抗红潮汐活动。 抗红潮汐组合物含有HPA3NT3肽作为活性成分。
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