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公开(公告)号：KR101713143B1
公开(公告)日：2017-03-08
申请号：KR1020150130341
申请日：2015-09-15
Applicant: 조선대학교산학협력단
IPC: A23L1/305 , A61K38/16 , C07K14/435
CPC classification number: A61K38/16 , C07K14/435
Abstract: 본발명은클라바스피린펩타이드유사체를유효성분으로함유하는항염증용조성물에관한것으로, 본발명에서미더덕유래클라바스피린(Clavaspirin) 펩타이드중 9번과 12번에양이온을띠는라이신(Lysine, K) 아미노산으로치환시켜제조한합성펩타이드인 CSP-4 펩타이드가항생제내성균에의해유발된염증반응동물모델에대한항균효과가우수하고, 세포독성을거의나타내지않으므로, 본발명의클라바스피린펩타이드유사체인 CSP-4는염증질환의예방또는치료용약학조성물, 화장료조성물, 식품첨가제등의유효성분으로유용하게사용될수 있다.
Abstract translation: 本发明涉及含有巴拉曲林肽类似物作为活性成分的抗炎组合物。 作为本发明中的CSP-4肽，其是通过用带正电荷的赖氨酸（K）氨基酸取代Styela clava来源的巴伐他汀肽的9和12位制备的合成肽，对动物模型展示具有优异的抗微生物作用 由抗生素抗性细菌引起的并且显示出很少细胞毒性的炎性反应，因此本发明的作为克拉司亭肽类似物的CSP-4可用作预防或治疗炎性疾病的药物组合物的活性成分， 化妆品组合物，食品添加剂等。
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12.发明公开헬리코박터 파일로리균의 리보좀 단백질 L1으로부터 유래된 신규한 항생 펩타이드 및 이의 용도 有权衍生自HELICOBACTER PYLORI的RIBOSOMAL蛋白L1的新型抗微生物肽及其用途
公开(公告)号：KR1020140089664A
公开(公告)日：2014-07-16
申请号：KR1020130001074
申请日：2013-01-04
Applicant: 조선대학교산학협력단
CPC classification number: A61K38/10 , C07K7/08 , C07K14/205 , Y02A50/473
Abstract: The present invention relates to a novel antibiotic peptide derived from ribosomal protein L1 of Helicobacter pylori and a use thereof. Specifically, a novel peptide of SEQ ID NO: 4 was synthesized by substituting proline for phenylalanine, which is the 12th amino acid of a peptide consisting of an amino acid sequence of SEQ ID NO: 3. The novel peptide was confirmed to exhibit significant antibiotic activity and have no cytotoxicity, and thus the novel peptide can be used as an active ingredient of a natural antibiotic agent.
Abstract translation: 本发明涉及一种衍生自幽门螺杆菌的核糖体蛋白L1的新型抗生素肽及其用途。 具体地，通过用脯氨酸取代作为由SEQ ID NO：3的氨基酸序列组成的肽的第12个氨基酸的苯丙氨酸来合成SEQ ID NO：4的新肽。证实新肽显示出显着的抗生素 活性并且没有细胞毒性，因此新型肽可以用作天然抗生素的活性成分。
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公开(公告)号：KR101379318B1
公开(公告)日：2014-03-28
申请号：KR1020120026472
申请日：2012-03-15
Applicant: 조선대학교산학협력단
IPC: C07K14/435 , A61K38/17 , A61P31/04
CPC classification number: Y02A50/473 , Y02P20/55
Abstract: 본 발명은 항균 활성을 가지는 항균 펩타이드 및 이의 용도에 관한 것으로, 더욱 상세하게는 기존에 알려진 서열번호 1의 아미노산 서열에서 N-말단으로부터 9번 및 12번째 아미노산에 위치한 이소루신(Isoleucine, I)을 라이신(Lysine, K)으로 치환된 항균 펩타이드 및 그의 용도에 관한 것이다. 본 발명에 따른 항균 펩타이드는 이를 유효성분으로 함유하는 항균 또는 방부용 조성물, 항생용 약학적 조성물, 병원성 세균감염의 예방 및 치료용 약학적 조성물, 항생용 식품첨가제로 제공될 수 있다.
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公开(公告)号：KR1020130104718A
公开(公告)日：2013-09-25
申请号：KR1020120026472
申请日：2012-03-15
Applicant: 조선대학교산학협력단
IPC: C07K14/435 , A61K38/17 , A61P31/04
CPC classification number: Y02A50/473 , Y02P20/55 , C07K14/43504 , A23L3/34635 , A61K38/00
Abstract: PURPOSE: An antibacterial peptide is provided to be used as an antibacterial or antiseptic composition, an antibiotic pharmaceutical composition, a pharmaceutical composition for preventing and treating pathogenic bacterial infection, and an antibiotic food additive. CONSTITUTION: An antibacterial peptide is prepared by substituting 9th and 12th amino acids (isoleucine) from N-terminal in an amino acid sequence of sequence number 1 with lysine. The peptide has an amino acid sequence of sequence number 2 and has an antibacterial activity against gram-positive bacteria or gram-negative bacteria. The gram-negative bacteria are Escherichia coli or Proteus vulgaris. The gram-positive bacteria are Listeria monocytogenes or Staphylococcus epidermidis.
Abstract translation: 目的：提供用作抗菌或防腐组合物的抗菌肽，抗生素药物组合物，用于预防和治疗病原菌感染的药物组合物和抗生素食品添加剂。 构成：通过用赖氨酸用序列号1的氨基酸序列的N末端取代第9位和第12位氨基酸（异亮氨酸）制备抗菌肽。 肽具有序列号2的氨基酸序列，对革兰氏阳性菌或革兰氏阴性细菌具有抗菌活性。 革兰氏阴性细菌是大肠杆菌或普通变种。 革兰氏阳性菌是单核细胞增多性李斯特菌或表皮葡萄球菌。
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公开(公告)号：KR101077180B1
公开(公告)日：2011-10-27
申请号：KR1020080117335
申请日：2008-11-25
Applicant: 조선대학교산학협력단
Abstract: 본발명은헬리코박터파일로리균()의리보좀단백질 L1(ribosomal protein L1, RPL1) 유래의새로운항생펩타이드및 그의용도에관한것으로, 구체적으로헬리코박터파일로리균의리보좀단백질 L1 유래의서열번호 1로기재되는아미노산서열을가지는항생펩타이드로부터 1번과 8번위치의페닐아라닌을알라닌으로치환하거나, 이에추가적으로 13번위치의아스파라긴을리신으로치환함으로써제조된펩타이드들은기존의항생펩타이드에비해세포독성은낮게유지하면서항균활성은더 높게나타냄으로써인체에안전한항생제로유용하게사용될수 있다.
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Patent Agency Ranking16.发明公开
公开(公告)号：KR1020100058794A
公开(公告)日：2010-06-04
申请号：KR1020080117335
申请日：2008-11-25
Applicant: 조선대학교산학협력단
Abstract: PURPOSE: A ribosomal protein L1(RPL1)-derived novel antibiotics peptide of helicobacter pylori is provided to ensure high antibacterial activity to gram positive bacterial and gram negative bacteria. CONSTITUTION: An antibiotics peptide with reduced citotoxicity is obtained by substituting phenylalanine of site 1 and 8 in an antibiotics peptide of sequence number 1 with alanine. The antibiotics peptide is denoted by sequence number 2. An antibiotics having antibacterial activity to gram-positive bacteria or gram-negative bacteria contains the antibiotics peptide as an active ingredient. A food additive or food supplement contains the antibiotic peptide as an active ingredient.
Abstract translation: 目的：提供核糖体蛋白L1（RPL1）衍生自幽门螺杆菌的新型抗生素肽，以确保革兰氏阳性细菌和革兰氏阴性菌的高抗菌活性。 构成：通过用1号丙氨酸取代序列号1的抗生素肽中的位点1和8的苯丙氨酸来获得具有降低的宿性毒性的抗生素肽。 抗生素肽由序列号2表示。对革兰氏阳性菌或革兰氏阴性菌具有抗菌活性的抗生素含有抗生素肽作为活性成分。 食品添加剂或食品添加剂含有抗生素肽作为活性成分。
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公开(公告)号：KR1020080114008A
公开(公告)日：2008-12-31
申请号：KR1020070063140
申请日：2007-06-26
Applicant: 조선대학교산학협력단
IPC: H01B1/22
Abstract: A manufacturing method of paste for plasticized electrode, using nano silver particles is provided to save the fuel by lowering a temperature necessary for plasticizing due to sinterability at the temperature lower than the melting point of the inherent metal. A manufacturing method of paste for plasticized electrode, using nano silver particles comprises a step for synthesizing the silver particle of nano-size consisting of silver powder of nano-size 5~20wt%, silver powder 50~65 wt%, lead-free Bi-based frit glass 3~9wt%, and a vehicle 21~27 wt% which is an organic solvent; and a step for mixing the synthesized silver particle of nano-size with the silver powder.
Abstract translation: 提供使用纳米银颗粒的塑化电极用糊料的制造方法，通过降低在比固有金属的熔点低的温度下由于烧结性而使塑化所需的温度来降低燃料。 使用纳米银粒子的增塑电极糊的制造方法包括：将纳米尺寸为5〜20wt％的银粉，银粉50〜65wt％，无铅Bi 3〜9重量％的玻璃料玻璃，21〜27重量％的有机溶剂; 以及将合成的纳米尺寸银粒子与银粉末混合的步骤。
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公开(公告)号：KR1020080096204A
公开(公告)日：2008-10-30
申请号：KR1020070041361
申请日：2007-04-27
Applicant: 조선대학교산학협력단
IPC: H01B1/02
Abstract: A low temperature cofired paste composition containing nanosilver particles and a manufacturing method of the conductive thick film using the same are provided to manufacture the low temperature cofired paste using silver particles of nano size, to reduce the waste of material and to solve the disadvantage that the precision of the electrode morphology is decreased. A low temperature cofired paste composition containing nanosilver particles comprises silver powder of nano-size, glass powder, and vehicle as a solvent in a mass rate of 80:1:19. A manufacturing method of the conductive thick film using the low temperature cofired paste composition comprises a step for screen-printing the paste composition on an alumina substrate with the screen mask; a step for drying the paste composition at 120deg.C for 20 minutes to remove the vehicle so as to form a thick film; and a step for heat-treating the thick film at 250~450deg.C for 15 minutes.
Abstract translation: 提供含有纳米银粒子的低温共烧糊剂组合物和使用其的导电性厚膜的制造方法，以制造使用纳米尺寸的银粒子的低温共烧糊剂，以减少材料的浪费，并解决以下缺点： 电极形态的精度降低。 含有纳米银粒子的低温共烧糊剂组合物包含纳米尺寸的银粉，玻璃粉末和作为溶剂的载体，质量比为80:1:19。 使用低温共烧糊组合物的导电性厚膜的制造方法包括用丝网掩模将糊料组合物丝网印刷在氧化铝基板上的工序; 在120℃下干燥糊剂组合物20分钟以除去载体以形成厚膜的步骤; 以及在250〜450℃下对厚膜进行15分钟的热处理的工序。
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公开(公告)号：KR101111721B1
公开(公告)日：2012-03-13
申请号：KR1020090057051
申请日：2009-06-25
Applicant: 조선대학교산학협력단
Abstract: 본 발명은 패각 분말이 부착된 친환경 코팅 콘크리트에 관한 것으로, 보다 상세하게는 포틀랜드 콘크리트의 표면에 무기 결합재를 이용하여 입자 크기가 5~5000㎛인 패각 분말을 부착함으로써 제조되는 것을 특징으로 하며, 이때, 상기 무기 결합재는 지오폴리머이며, 상기 지오폴리머는 플라이 애쉬, 메타카올린, 슬래그 및 고로 슬래그를 포함하는 그룹에서 선택된 하나 이상의 무기물이 알칼리성 액체에 의해 중합반응이 일어나 얻어지는 것을 특징으로 하는 패각 분말이 부착된 친환경 코팅 콘크리트에 관한 것이다.
지오폴리머, 패각 분말, 코팅 콘크리트, 포틀랜드 콘크리트-
公开(公告)号：KR1020090027870A
公开(公告)日：2009-03-18
申请号：KR1020070093031
申请日：2007-09-13
Applicant: 조선대학교산학협력단
CPC classification number: A61L27/3608 , A61L27/02 , A61L27/12 , C01B25/32
Abstract: A method for producing sintered body of hydroxyapatite is provided, which makes the high valuation of the waste resources possible. A method for producing sintered body of hydroxyapatite comprises: a step for injecting the natural bone ash in the NaOH aqueous solution of 0.1% which is heated to 80 deg.C and agitating it for 4 hours; a step for removing the sodium ion by washing the natural bone ash in the flowing water for 24 hours; a step for drying the washed natural bone ash at 80 deg.C; a step for calcining at 800 deg.C for 1 hour; a step for drying the calcined powder at 80 deg.C after ball-milling for 24 hours; and a step for sintering the powder obtained in the drying step.
Abstract translation: 提供了一种生产羟基磷灰石烧结体的方法，可以使废弃物资源的高估值成为可能。 一种生产羟基磷灰石烧结体的方法包括：将天然骨灰在0.1％的NaOH水溶液中注入加热至80℃并搅拌4小时的步骤; 通过洗涤流水中的天然骨灰24小时除去钠离子的步骤; 在80摄氏度下干燥天然骨灰的步骤; 在800℃下煅烧1小时的步骤; 在球磨后在80℃干燥煅烧粉末24小时的步骤; 以及烧结在干燥工序中得到的粉末的工序。
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