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公开(公告)号：KR101283398B1
公开(公告)日：2013-07-08
申请号：KR1020110012395
申请日：2011-02-11
Applicant: 건국대학교 산학협력단
Abstract: 본 발명은 췌장상피세포를 이용한 효율적인 역분화 만능유도세포 개발방법 및 그 조성물에 관한 것으로, 더욱 상세하게는 비만이 없는 당뇨병 (Nonobese diabetic, NOD) 생쥐 유래 췌장상피세포를 이용한 효율적인 역분화 만능유도세포 개발 및 그 조성물에 관한 것이다.
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13.发明公开
公开(公告)号：KR1020090132236A
公开(公告)日：2009-12-30
申请号：KR1020080058406
申请日：2008-06-20
Applicant: 건국대학교 산학협력단
CPC classification number: C12N5/0696 , C12N5/0018 , C12N15/63 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606
Abstract: PURPOSE: A method for establishing induced pluripotent stem cells through non-viral transformation is provided to induce induced pluripotent stem cells without virus and introduce gene with high efficiency. CONSTITUTION: A method for producing induced pluripotent stem cells comprises: a step of preparing gene vector relating to induced pluripotency; a step of introducing the induced pluripotent relating gene to a cell using a nanoparticle; a step of culturing stem cells containing LIF(leukemia inhibitory factor) in a culture device; and a step of replating the cells on a dish having a support cell. The cell is fibroblast. The support cell is STO embryonic fibroblast cell line of rat.
Abstract translation: 目的：提供通过非病毒转化建立诱导性多能干细胞的方法，以诱导无病毒诱导的多能干细胞，并以高效率引入基因。 构成：产生诱导多能干细胞的方法包括：制备与诱导多能性相关的基因载体的步骤; 使用纳米颗粒将诱导的多能相关基因导入细胞的步骤; 在培养装置中培养含有LIF（白血病抑制因子）的干细胞的步骤; 以及将细胞置于具有支持细胞的盘上的步骤。 细胞是成纤维细胞。 支持细胞是大鼠的STO胚胎成纤维细胞系。
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公开(公告)号：KR100729731B1
公开(公告)日：2007-06-20
申请号：KR1020050065393
申请日：2005-07-19
Applicant: 건국대학교 산학협력단
IPC: A61K31/352
Abstract: 본 발명은 사람 피부 세포의 세포사멸을 억제하는 활성을 갖는 플라보노이드에 관한 것으로, 더욱 구체적으로 식물 유래 플라보노이드인 3,4'-디하이드록시플라본(3,4'-dihydroxyflavone)을 유효성분으로 함유하는 사람 피부세포의 세포사멸(apoptosis) 억제용 조성물에 관한 것이다.
본 발명에 따르면, 3,4'-디하이드록시플라본(3,4'-dihydroxyflavone)의 사람 피부세포의 세포사멸(apoptosis) 억제 기능을 이용함으로써 사람 피부세포의 세포사멸을 예방 또는 치료할 수 있는 기능성 화장료 조성물 또는 약학적 조성물의 개발에 유용하게 이용될 수 있다.
3,4'-디하이드록시플라본, 사람피부세포-
公开(公告)号：KR1020150001519A
公开(公告)日：2015-01-06
申请号：KR1020130074884
申请日：2013-06-27
Applicant: 건국대학교 산학협력단
IPC: A61K31/352 , A61K31/353 , A61K31/35 , A61P3/04
Abstract: 본 발명은 3,4`-다이하이드록시플라본을 유효성분으로 포함하는 지방세포형성 저해용 조성물에 관한 것이다.
Abstract translation: 在本发明中，提供了抑制形成作为活性成分的3,4'-二羟基黄酮（DHF）的脂肪细胞的组合物。 此外，本发明涉及通过在前体脂肪细胞中处理3,4'-二羟基黄酮而制造的细胞的过氧化物酶体增殖物激活受体（PPAR）γ的表达抑制方法。 在本发明中，3,4'-二羟基黄酮具有降低MEK / ERK的活性并因此抑制脂肪细胞形成的作用。 因此，3,4'-二羟基黄酮可作为治疗超重或肥胖症的新选择。
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Patent Agency Ranking16.发明公开
公开(公告)号：KR1020120092382A
公开(公告)日：2012-08-21
申请号：KR1020110012399
申请日：2011-02-11
Applicant: 건국대학교 산학협력단
IPC: C12N5/0735 , C12N5/079 , C12N5/10 , C12N15/12
Abstract: PURPOSE: A method for promoting differentiation of embryonic stem cells into neuronal precursor cells is provided to enhance cell survival rate and differentiation efficiency. CONSTITUTION: A method for promoting differentiatioin of embryonic stem cells into neuronal precursor cells comprise a step of introducing Bax inhibitor-1 gene to embryonic stem cells and expressing the Bax inhibitor-1 in the embryonic stem cells. The Bax inhibitor-1 has an amino acid sequence of sequence number 1. The Bax inhibitor-1 gene has a base of sequence number 2. A composition for promoting differentiation of the embryonic stem cells into neuronal precursor cells contains the Bax inhibitor-1 as an active ingredient.
Abstract translation: 目的：提供一种促进胚胎干细胞分化为神经元前体细胞的方法，以增强细胞存活率和分化效率。 构成：促进胚胎干细胞分化为神经元前体细胞的方法包括将Bax抑制剂-1基因引入胚胎干细胞并在胚胎干细胞中表达Bax抑制剂-1的步骤。 Bax抑制剂-1具有序列号1的氨基酸序列.Bax抑制剂-1基因具有序列号2的碱基。用于促进胚胎干细胞分化为神经元前体细胞的组合物含有Bax抑制剂-1作为 活性成分。
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公开(公告)号：KR101114438B1
公开(公告)日：2012-03-13
申请号：KR1020090112092
申请日：2009-11-19
Applicant: 건국대학교 산학협력단
IPC: A61K31/085 , A61K36/708 , A61P35/00
Abstract: 본 발명은 라폰티게닌(3,3',5-trihydroxy-4'-methoxystilbene) 화합물 및 제약상 허용가능한 담체, 보조제, 또는 비히클을 포함하는 암 예방 또는 치료용 약학 조성물에 관한 것으로 더욱 바람직하게는 상기 화합물을 유효성분으로 포함하는 유방암 예방 또는 치료용 조성물에 관한 것이다.
라폰티게닌, 암, 유방암, 치료-
公开(公告)号：KR1020110055852A
公开(公告)日：2011-05-26
申请号：KR1020090112453
申请日：2009-11-20
Applicant: 건국대학교 산학협력단
Abstract: PURPOSE: A composition containing plant-derived flavonoid is provided to suppress influenza virus and to treat and prevent viral diseases. CONSTITUTION: A composition for preventing or treating viral diseases contains isorhamnetin compounds as an active ingredient. The isorhamnetin compound is an analog or homolog of isorhamnetin compounds. The virus is influenza virus. The composition suppresses hemagglutinin protein and neuraminidase protein activities. A viral gene is hemagglutinin or neuraminidase gene. A composition for preventing or treating viral diseases contains 3,4'-dihydroxyflavone compounds as an active ingredient.
Abstract translation: 目的：提供含有植物来源的类黄酮的组合物以抑制流感病毒并治疗和预防病毒性疾病。 构成：用于预防或治疗病毒性疾病的组合物含有异鼠李素类化合物作为活性成分。 异鼠除虫素化合物是异鼠李素类化合物的类似物或同系物。 病毒是流感病毒。 该组合物抑制血凝素蛋白和神经氨酸酶蛋白活性。 病毒基因是血凝素或神经氨酸酶基因。 用于预防或治疗病毒性疾病的组合物含有3,4'-二羟基黄酮化合物作为活性成分。
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公开(公告)号：KR1020110055176A
公开(公告)日：2011-05-25
申请号：KR1020090112092
申请日：2009-11-19
Applicant: 건국대학교 산학협력단
IPC: A61K31/085 , A61K36/708 , A61P35/00
Abstract: PURPOSE: A composition containing rhapontigenin compounds is provided to induce specific apoptosis of breast cancer cell line and to prevent or treat breast cancer. CONSTITUTION: A composition for preventing or treating breast cancer contains rhapontigenin compounds(3,3',5-trihydroxy-4'-methoxystilbene), pharmaceutically acceptable carrier, additive, vehicle, autophagy inhibitor, and ERK pathway inhibitor. The compound is isolated from Rheum. The compound contains an analogue or homologue of rhapontigenin compounds.
Abstract translation: 目的：提供含有rhampontigenin化合物的组合物以诱导乳腺癌细胞系的特异性凋亡并预防或治疗乳腺癌。 构成：用于预防或治疗乳腺癌的组合物含有rhapontigenin化合物（3,3'，5-三羟基-4'-甲氧基茋），药学上可接受的载体，添加剂，载体，自噬抑制剂和ERK途径抑制剂。 该化合物与Rheum分离。 该化合物含有rhampontigenin化合物的类似物或同系物。
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公开(公告)号：KR1020100101764A
公开(公告)日：2010-09-20
申请号：KR1020090020115
申请日：2009-03-10
Applicant: 건국대학교 산학협력단
Abstract: PURPOSE: A composition containing specific flavoid derivative is provided to ensure efficiency of maintaining and growing dedifferentiation pluripotent stem cell. CONSTITUTION: A composition for improving prolifation and differentiation of dedifferentiation pluripotent stem cells contains 3,2'-dihydroxyflavone(DHF) as an active ingredient. The effective amount is 1-10uM. The composition has an effect of maintaining undifferentiation of the stem cells. The dedifferentiation pluripotent stem cells are derived from mammal. The composition contains flavoid with dihydroxyflavone(DHF) and 3,4'-dihydroxyflavone(DHF).
Abstract translation: 目的：提供含有特定黄体衍生物的组合物，以确保维持和增殖去分化多能干细胞的效率。 构成：用于改善去分化多能干细胞的增殖和分化的组合物含有3,2'-二羟基黄酮（DHF）作为活性成分。 有效量为1-10uM。 该组合物具有维持干细胞未分化的作用。 去分化多能干细胞来源于哺乳动物。 该组合物含有黄素与二羟基黄酮（DHF）和3,4'-二羟基黄酮（DHF）。
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