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公开(公告)号：KR101919002B1
公开(公告)日：2018-11-20
申请号：KR1020160164441
申请日：2016-12-05
Applicant: 대한민국(농림축산식품부 농림축산검역본부장) , 충남대학교산학협력단
IPC: C07K14/005 , C12N15/70 , A61K39/135
Abstract: 본발명은혈청형이서로다른구제역바이러스의 VP1 단백질내 주요항원성에피토프들을코돈최적화하여연결한후 특이미생물발현시스템을이용하여융합단백질항원 (Multi-VP1 epitopes)을가용성의단백질 (Soluble protein)로발현시키는벡터, 이에의해형질전환된 미생물, 상기미생물로부터발현·정제된가용성 Multi-VP1 epitope 단백질및 상기단백질의백신목적으로의이용에대한것으로, 더욱자세하게는대장균의코돈에최적화되게유전자서열을변환한 O, A, Asia1 type 구제역바이러스혹은각각의동일혈청형내 서로다른지역형구제역바이러스의 VP1 단백질내 주요항원에피토프들을연결한유전자를포함하는대장균발현벡터, 상기의벡터로형질전환된 특이재조합대장균및, 상기의대장균으로부터발현및 정제된가용성의 Multi-VP1 epitope 단백질을유효성분으로하는구제역바이러스감염예방을위한백신에관한것이다.
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公开(公告)号：KR20180064158A
公开(公告)日：2018-06-14
申请号：KR20160164441
申请日：2016-12-05
Applicant: 대한민국(농림축산식품부 농림축산검역본부장) , 충남대학교산학협력단
IPC: C07K14/005 , A61K39/135 , C12N15/70
Abstract: 본발명은혈청형이서로다른구제역바이러스의 VP1 단백질내 주요항원성에피토프들을코돈최적화하여연결한후 특이미생물발현시스템을이용하여융합단백질항원 (Multi-VP1 epitopes)을가용성의단백질 (Soluble protein)로발현시키는벡터, 이에의해형질전환된 미생물, 상기미생물로부터발현·정제된가용성 Multi-VP1 epitope 단백질및 상기단백질의백신목적으로의이용에대한것으로, 더욱자세하게는대장균의코돈에최적화되게유전자서열을변환한 O, A, Asia1 type 구제역바이러스혹은각각의동일혈청형내 서로다른지역형구제역바이러스의 VP1 단백질내 주요항원에피토프들을연결한유전자를포함하는대장균발현벡터, 상기의벡터로형질전환된 특이재조합대장균및, 상기의대장균으로부터발현및 정제된가용성의 Multi-VP1 epitope 단백질을유효성분으로하는구제역바이러스감염예방을위한백신에관한것이다.
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公开(公告)号：KR100457791B1
公开(公告)日：2004-11-18
申请号：KR1020010008201
申请日：2001-02-19
Applicant: 충남대학교산학협력단
IPC: C12N15/86
Abstract: PURPOSE: An Alphavirus expression vector capable of expressing a cancer-inhibiting protein, its producing method and its use are provided, thereby effectively inhibiting and preventing the growth of a cancer cell. CONSTITUTION: The Alphavirus expression vector capable of expressing a cancer-inhibiting protein contains a first cancer-inhibiting gene which is operably linked under operation of a first subgenomic promoter, a second cancer-inhibiting gene which is operably linked under operation of a second subgenomic promoter, and a third cancer-inhibiting gene which is operably linked under operation of a third subgenomic promoter, in which the cancer-inhibiting gene is selected from pRb/p110 or its homologue p107 and p120, p53 protein, p21 protein, p21 protein(WAF-1), bak, BRCA1, BRCA2, PTEN, APC, DCC, NF-1, NF-2, WT-1, MEN-I, MEN-II, zac1, p73, VHL, FCC and MCC; and the Alphavirus is Sindbis virus or Semliki Forest virus(SFV).
Abstract translation: 目的：提供一种能够表达癌症抑制蛋白的甲病毒表达载体，其生产方法及其用途，由此有效地抑制和预防癌细胞的生长。 构成：能够表达癌症抑制蛋白的甲病毒表达载体含有第一种癌症抑制基因，该基因在第一亚基因组启动子的操作下可操作地连接，第二癌基因是在第二亚基因组启动子操作下可操作地连接的 和在第三亚基因组启动子的操作下可操作连接的第三癌抑制基因，其中所述癌抑制基因选自pRb / p110或其同源物p107和p120，p53蛋白，p21蛋白，p21蛋白（WAF -1），bak，BRCA1，BRCA2，PTEN，APC，DCC，NF-1，NF-2，WT-1，MEN-1，MEN-II，zac1，p73，VHL，FCC和MCC; 而α病毒是辛德毕斯病毒或塞姆利基森林病毒（SFV）。
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14.发明公开암억제 단백질을 발현하는 알파바이러스계 발현 벡터,이의 제조 방법 및 용도 有权基于ALPHAVIRUS的表达载体表达肿瘤抑制蛋白，其制备方法及其用途同时显示各种肿瘤抑制蛋白和有效抑制肿瘤的作用
公开(公告)号：KR1020040077600A
公开(公告)日：2004-09-04
申请号：KR1020040060593
申请日：2004-07-30
Applicant: 충남대학교산학협력단
CPC classification number: A61K48/00 , A61K2039/585 , C12N15/85
Abstract: PURPOSE: Alphavirus-based expression vectors expressing tumor suppressor proteins, a method for preparing the same and the use thereof are provided, thereby simultaneously expressing various tumor suppressor proteins, and consequently suppressing tumor effectively. CONSTITUTION: The alphavirus-based expression vector expressing tumor suppressor proteins comprises a first tumor suppressing gene or angiogenesis suppressing gene which is operably linked to a first subgenomic promoter; a second tumor suppressing gene or angiogenesis suppressing gene which is operably linked to a second subgenomic promoter; and a third tumor suppressing gene or angiogenesis suppressing gene which is operably linked to a third subgenomic promoter, wherein the first, second and third tumor suppressing genes or angiogenesis suppressing genes are the same or different; the tumor suppressing gene is p53 gene or PTEN gene; the antigiogenesis suppressing gene is angiostatin gene; and the alphavirus-based expression vector expresses tumor suppressor proteins Semliki forest virus(SFV) and Sindbis virus.
Abstract translation: 目的：提供表达肿瘤抑制蛋白的基于甲病毒的表达载体，其制备方法及其用途，同时表达各种肿瘤抑制蛋白，从而有效抑制肿瘤。 构成：表达肿瘤抑制蛋白的基于甲病毒的表达载体包含与第一亚基因组启动子有效连接的第一肿瘤抑制基因或血管发生抑制基因; 与第二亚基因组启动子可操作地连接的第二肿瘤抑制基因或血管发生抑制基因; 和与第三亚基因组启动子可操作地连接的第三肿瘤抑制基因或血管发生抑制基因，其中第一，第二和第三肿瘤抑制基因或血管发生抑制基因相同或不同; 肿瘤抑制基因是p53基因或PTEN基因; 抗血管生成抑制基因是血管抑素基因; 并且基于甲病毒的表达载体表达肿瘤抑制蛋白Semliki森林病毒（SFV）和辛德毕斯病毒。
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公开(公告)号：KR101987775B1
公开(公告)日：2019-06-12
申请号：KR1020180067917
申请日：2018-06-14
Applicant: 대한민국(농림축산식품부 농림축산검역본부장) , 충남대학교산학협력단
IPC: C07K14/005 , C12N15/70 , A61K39/135
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Patent Agency Ranking
公开(公告)号：KR101886415B1
公开(公告)日：2018-08-08
申请号：KR1020170118709
申请日：2017-09-15
Applicant: 충남대학교산학협력단
IPC: C12N15/63 , C12N9/00 , C07K14/245 , C07K14/25 , C07K14/33 , A61K39/08 , A61K39/108 , A61K39/112
CPC classification number: C12N15/63 , A61K39/0258 , A61K39/0283 , A61K39/08 , C07K14/245 , C07K14/25 , C07K14/33 , C07K2319/21 , C12N9/93 , C12Y601/01002
Abstract: 본발명은돼지유래의트립토파닐-tRNA 합성효소유전자를포함하는재조합벡터및 이의용도에관한것으로, 본발명의재조합벡터는트립토파닐-tRNA 합성효소단백질을융합파트너(fusion partner)로사용하여숙주세포내에서목적단백질의수용성을증가시켜, 재조합단백질생산에유용하게이용될수 있을것이다.
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公开(公告)号：KR101773059B1
公开(公告)日：2017-08-31
申请号：KR1020150042407
申请日：2015-03-26
Applicant: 한국생명공학연구원 , 충남대학교산학협력단
IPC: C12N1/20 , A61K35/742 , C12R1/145 , A23L33/135 , A23K10/16 , C12P7/40 , C12P7/54
CPC classification number: A61K35/742 , C12N1/20 , C12P7/40 , C12P7/54 , C12R1/145
Abstract: 본발명은면역증진및 항바이러스활성을가지는클로스트리디움부티리쿰(균주, 상기균주또는이의배양액을유효성분으로함유하는면역증진및 항바이러스용조성물, 프로바이오틱조성물, 항균용조성물, 부티르산(butyric acid) 또는아세트산(acetic acid) 생산용조성물및 상기균주를배양하는단계를포함하는부티르산또는아세트산을생산하는방법을제공한다.
Abstract translation: 本发明免疫增强和抗克劳斯具有抗病毒活性树体育场丁炔基rikum（菌株，免疫增强和抗病毒组合物，包括上述菌株或本培养基中，作为活性成分，所述的益生菌组合物，抗微生物组合物，酸（ 丁酸或乙酸，以及生产丁酸或乙酸的方法，其包括培养菌株。
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公开(公告)号：KR1020170079932A
公开(公告)日：2017-07-10
申请号：KR1020150191006
申请日：2015-12-31
Applicant: 충남대학교산학협력단
IPC: A23L1/30 , A23L33/155 , A23L1/09
Abstract: 피부미용효과를증진하고, 정장작용과배변활동에도움이되는피부미용및 정장작용의딸기스틱제형제품및 그의제조방법에관한것으로, (a) 딸기농축액, 올리고당, 정제수, 히알루론산과비타민 C를준비하는단계, (b) 교반용기에상기히알루론산과상기정제수를투입하고교반하여제1 혼합액을마련하는단계, (c) 상기제1 혼합액에상기올리고당을투입하고교반하여제2 혼합액을마련하는단계, (d) 상기제2 혼합액에상기딸기농축액을투입하고교반하여제3 혼합액을마련하는단계, (e) 상기제3 혼합액에비타민 C를투입하고교반하여피부미용및 정장작용의딸기용액을마련하고, 이딸기용액을봉지형스틱에투입하여봉합하는단계, (f) 상기단계 (e)에서봉합된스틱을가온살균하는단계를포함하는구성을마련하여, 항산화활성을하면서정장작용과배변활동에도움에되어피부미용효과를달성할수 있다.
Abstract translation: （A）草莓浓缩液，寡糖，精制水，透明质酸和维生素C及其制造方法， 制备的步骤，（b）中的步骤把透明质酸和其中在搅拌容器中的纯化水并搅拌以通过将寡糖提供第一混合物，（c）提供第二混合物，并将该混合物在第一混合物搅拌 （D）将草莓浓缩物加入到第二混合物中并搅拌以制备第三混合物，（e）将维生素C加入到第三混合物中，搅拌混合物，并且施加皮肤 - （E）通过加热杀菌对密封的棒进行杀菌，通过抗氧化活性和排便的作用，草莓溶液的抗氧化活性得到改善 为了帮助活动，皮肤美丽 它能够达到的效果。
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公开(公告)号：KR1020020067833A
公开(公告)日：2002-08-24
申请号：KR1020010008201
申请日：2001-02-19
Applicant: 충남대학교산학협력단
IPC: C12N15/86
CPC classification number: C12N15/86 , C07K14/4703 , C07K14/4746 , C12N5/0693
Abstract: PURPOSE: An Alphavirus expression vector capable of expressing a cancer-inhibiting protein, its producing method and its use are provided, thereby effectively inhibiting and preventing the growth of a cancer cell. CONSTITUTION: The Alphavirus expression vector capable of expressing a cancer-inhibiting protein contains a first cancer-inhibiting gene which is operably linked under operation of a first subgenomic promoter, a second cancer-inhibiting gene which is operably linked under operation of a second subgenomic promoter, and a third cancer-inhibiting gene which is operably linked under operation of a third subgenomic promoter, in which the cancer-inhibiting gene is selected from pRb/p110 or its homologue p107 and p120, p53 protein, p21 protein, p21 protein(WAF-1), bak, BRCA1, BRCA2, PTEN, APC, DCC, NF-1, NF-2, WT-1, MEN-I, MEN-II, zac1, p73, VHL, FCC and MCC; and the Alphavirus is Sindbis virus or Semliki Forest virus(SFV).
Abstract translation: 目的：提供能够表达癌抑制蛋白的甲病毒表达载体及其制备方法及其用途，从而有效抑制和预防癌细胞的生长。 构成：能够表达癌症抑制蛋白的甲病毒载体表达载体含有第一癌抑制基因，其在第一亚基因组启动子的操作下可操作地连接，第二癌抑制基因在第二亚基因组启动子的操作下可操作地连接 ，以及第三癌抑制基因，其在第三亚基因组启动子的操作下可操作地连接，其中所述癌抑制基因选自pRb / p110或其同源物p107和p120，p53蛋白，p21蛋白，p21蛋白（WAF -1），bak，BRCA1，BRCA2，PTEN，APC，DCC，NF-1，NF-2，WT-1，MEN-1，MEN-II，zac1，p73，VHL，FCC和MCC; 甲病毒属于辛德毕斯病毒或辛格利奇森林病毒（SFV）。
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