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公开(公告)号：KR1020160115202A
公开(公告)日：2016-10-06
申请号：KR1020150042407
申请日：2015-03-26
Applicant: 한국생명공학연구원 , 충남대학교산학협력단
IPC: C12N1/20 , A61K35/742 , C12R1/145 , A23L33/135 , A23K10/16 , C12P7/40 , C12P7/54
CPC classification number: A61K35/742 , C12N1/20 , C12P7/40 , C12P7/54 , C12R1/145 , A23K10/16 , A23L33/135 , A23V2200/3204
Abstract: 본발명은면역증진및 항바이러스활성을가지는클로스트리디움부티리쿰(균주, 상기균주또는이의배양액을유효성분으로함유하는면역증진및 항바이러스용조성물, 프로바이오틱조성물, 항균용조성물, 부티르산(butyric acid) 또는아세트산(acetic acid) 생산용조성물및 상기균주를배양하는단계를포함하는부티르산또는아세트산을생산하는방법을제공한다.
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公开(公告)号：WO2016153247A1
公开(公告)日：2016-09-29
申请号：PCT/KR2016/002839
申请日：2016-03-22
Applicant: 한국생명공학연구원
CPC classification number: A61K35/742 , C12N1/20 , C12P7/40 , C12P7/54 , C12R1/145
Abstract: 본 발명은 면역 증진 및 항바이러스 활성을 가지는 클로스트리디움 부티리쿰( Clostridium butyricum) 균주, 상기 균주 또는 이의 배양액을 유효성분으로 함유하는 면역 증진 및 항바이러스용 조성물, 프로바이오틱 조성물, 항균용 조성물, 부티르산(butyric acid) 또는 아세트산(acetic acid) 생산용 조성물 및 상기 균주를 배양하는 단계를 포함하는 부티르산 또는 아세트산을 생산하는 방법을 제공한다.
Abstract translation: 本发明提供：具有免疫增强和抗病毒活性的丁酸梭菌菌株; 免疫增强和抗病毒组合物，益生菌组合物，抗菌组合物和用于生产丁酸或乙酸的组合物，其中所有组合物含有作为活性成分的菌株或其培养溶液; 以及生产丁酸或乙酸的方法，包括培养菌株的步骤。
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公开(公告)号：KR101773059B1
公开(公告)日：2017-08-31
申请号：KR1020150042407
申请日：2015-03-26
Applicant: 한국생명공학연구원 , 충남대학교산학협력단
IPC: C12N1/20 , A61K35/742 , C12R1/145 , A23L33/135 , A23K10/16 , C12P7/40 , C12P7/54
CPC classification number: A61K35/742 , C12N1/20 , C12P7/40 , C12P7/54 , C12R1/145
Abstract: 본발명은면역증진및 항바이러스활성을가지는클로스트리디움부티리쿰(균주, 상기균주또는이의배양액을유효성분으로함유하는면역증진및 항바이러스용조성물, 프로바이오틱조성물, 항균용조성물, 부티르산(butyric acid) 또는아세트산(acetic acid) 생산용조성물및 상기균주를배양하는단계를포함하는부티르산또는아세트산을생산하는방법을제공한다.
Abstract translation: 本发明免疫增强和抗克劳斯具有抗病毒活性树体育场丁炔基rikum（菌株，免疫增强和抗病毒组合物，包括上述菌株或本培养基中，作为活性成分，所述的益生菌组合物，抗微生物组合物，酸（ 丁酸或乙酸，以及生产丁酸或乙酸的方法，其包括培养菌株。
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公开(公告)号：KR1020120119904A
公开(公告)日：2012-10-31
申请号：KR1020120117208
申请日：2012-10-22
Applicant: 한국생명공학연구원
Abstract: PURPOSE: An oral composition for preventing and treating dental caries due to breeding of the oral bacteria and periodontal diseases is provided to enhance antibacterial activity for Streptococcus mutants and/or Fusobacterium nucleatum. CONSTITUTION: An oral composition for preventing and treating dental caries due to breeding of the oral bacteria and periodontal diseases contains Bilberry, Vaccinium myrtillus L. which are uniformly dispersed inside an aqueous film substrate. The composition is manufactured into film, dentifrice, oral cavity cleaning solution, ointment, spray, dressing solution, coating material, dental floss, or preodontal pack. The Bilberry is uniformly dispersed inside the aqueous-soluble film material at the concentration of 0.2-0.5 mg / ml. The composition displays the antibacterial activity for Streptococcus mutans and/or Fusobacterium nucleatum.
Abstract translation: 目的：提供口腔用组合物，用于预防和治疗由于口腔细菌和牙周疾病的滋生导致的龋齿，以增强对链球菌突变体和/或核细小芽孢杆菌的抗菌活性。 构成：由口腔细菌和牙周病的滋生预防和治疗龋齿的口腔用组合物含有均匀分散在水性膜基质内的越桔，牛痘苗。 该组合物制成薄膜，洁牙剂，口腔清洁溶液，软膏，喷雾剂，敷料溶液，涂料，牙线或预牙膏包装。 越桔以0.2-0.5mg / ml的浓度均匀地分散在水溶性薄膜材料的内部。 该组合物显示出变形链球菌和/或核细胞核杆菌的抗菌活性。
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公开(公告)号：KR1020110000241A
公开(公告)日：2011-01-03
申请号：KR1020090057649
申请日：2009-06-26
Applicant: 한국생명공학연구원
IPC: A61K31/74 , A61P1/02 , A61K36/539 , A61K36/45
CPC classification number: A61K9/0063 , A61K31/21 , A61K31/77 , A61K36/45 , A61K36/54 , Y10S514/90
Abstract: PURPOSE: An oral composition for preventing and treating periodontal diseases by bacterial proliferation in the oral cavity is provided to ensure antibacterial activity against Porphyromonas gingivalis and/or Prevotella intermedia. CONSTITUTION: A composition for preventing and treating periodontal diseases by proliferation of Prevotella gingivalis contains polysorbate, sorbitan esters of fatty acids, or extract of Biberry or Scutellariae radix inside a soluble film substrate. The polysorbate is evenly dispersed in a concentration of 0.7x10^-4 -0.04 mg/ml inside the soluble film substrate. The sorbitan fatty acid ester is evenly dispersed in a concentration of 0.15-0.03 mg/ml inside a soluble film substrate.
Abstract translation: 目的：提供口腔用组合物，用于通过口腔内细菌增殖来预防和治疗牙周病，以确保对牙龈卟啉单胞菌和/或间叶球菌的抗菌活性。 组成：牙龈卟啉单胞菌增生预防和治疗牙周病的组合物含有聚山梨醇酯，脂肪酸的脱水山梨糖醇酯，或可溶性薄膜底物中的Biberry或黄芩提取物。 聚山梨酯在可溶性薄膜基材内以0.7×10 -4 -4.04mg / ml的浓度均匀分散。 脱水山梨醇脂肪酸酯在可溶性薄膜基材内以0.15-0.03mg / ml的浓度均匀分散。
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Patent Agency Ranking
公开(公告)号：KR1020100107591A
公开(公告)日：2010-10-06
申请号：KR1020090025728
申请日：2009-03-26
Applicant: 한국생명공학연구원
Abstract: PURPOSE: A Leuconostoc Lactis EG001-derived novel glucansucrase which are isolated from Kimchi lactobacillus is provided to use in foods and medicinal and pharmaceutical industries. CONSTITUTION: A glucansucrase is denoted by amino acid of sequence number 1. The optimal pH concentration and temperature are pH 4.5-6 and 25-35°C, respectively. A gene encoding the glucansucrase is denoted by base sequence of sequence number 2. The gene is derived from Leuconostoc Lactis EG001. A recombinant microorganism which is able to produce glucansucrase is obtained by transforming a host microorganism with a recombinant vector having the gene. The recombinant microorganism is E.coli BL21(DE3)/pET22b(+).
Abstract translation: 目的：提供从泡菜乳杆菌中分离出来的出自明串珠菌乳杆菌EG001的新型葡聚糖蔗糖酶用于食品和药用和制药行业。 构成：葡聚糖蔗糖酶由序列号1的氨基酸表示。最佳pH浓度和温度分别为pH 4.5-6和25-35℃。 编码葡聚糖蔗糖酶的基因由序列号2的碱基序列表示。该基因衍生自乳酸杆菌（Leuconostoc Lactis EG001）。 通过用具有该基因的重组载体转化宿主微生物获得能够产生葡聚糖蔗糖酶的重组微生物。 重组微生物是大肠杆菌BL21（DE3）/ pET22b（+）。
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7.发明公开Ｐａｅｎｉｂａｃｉｌｌｕｓ ｓｐ． ＥＡ００１ 균주 유래의 신규 2-디옥시리보오스 5-포스페이트 알돌라아제 有权来自PAENIBACILLUS SP的新型2-脱氧-5-磷酸酯脱氢酶。 EA001
公开(公告)号：KR1020100051930A
公开(公告)日：2010-05-19
申请号：KR1020080110749
申请日：2008-11-10
Applicant: 한국생명공학연구원
CPC classification number: C12N9/88 , C12N15/52 , C12Y401/02004
Abstract: PURPOSE: A Paenibacillus sp. EA001 strain-derived novel-2-dioxyribose 5-phosphate aldolase(DERA) is provided to manufacture various physiologically active ingredients through enzymetic method. CONSTITUTION: A 2-dioxyribose-5-phosphate aldolase has an amino acid sequence of sequence number 1. The aldolase is obtained from Paenibacillus sp. EA001 strain. A 2- deoxyribose 5- phosphate aldolase gene has a nucleotide gene of sequence number 2. A recombinant vector contains the 2- deoxyribose 5- phosphate aldolase gene.
Abstract translation: 目的：一种Paenibacillus sp。 提供EA001菌株衍生的新型2-二核糖5-磷酸醛缩酶（DERA），通过酶法制备各种生理活性成分。 构成：2-二核糖-5-磷酸醛缩酶具有序列号1的氨基酸序列。醛缩酶得自Paenibacillus sp。 EA001菌株。 2-脱氧核糖5-磷酸醛缩酶基因具有序列号2的核苷酸基因。重组载体含有2-脱氧核糖5-磷酸醛缩酶基因。
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8.发明公开헤모필루스 인플루엔자 Rd KW20 균주 유래의 재조합 2-디옥시리보오스 5-포스페이트 알돌라아제의 제조방법 无效从HAEMOPHILUS INFLUENZAE RD KW20制备重组体2-脱氧-5-磷酸酯脱氢酶的方法
公开(公告)号：KR1020150007934A
公开(公告)日：2015-01-21
申请号：KR1020140049418
申请日：2014-04-24
Applicant: 한국생명공학연구원
Abstract: The present invention relates to a method for producing recombinant 2-deoxyribose 5-phosphate aldolase (DERA) derived from Haemophilus influenzae Rd KW20. More specifically, the present invention relates to a method for producing recombinant DERA and a method for producing lactol using the recombinant DERA, wherein a recombinant microorganism having a recombinant DERA productivity is cultured, and a gene coding the recombinant DERA having a base sequence of sequence number 1 or a recombinant vector containing the gene is induced in a host cell. The recombinant DERA of the present invention has lower substrate inhibition and more excellent activities for acete aldehyde than existing enzymes. A functional group (2-carbon unit), such as an acetaldehyde derivative, having two carbons is continuously condensed in an acceptor molecule so that lactol which is an intermediate product during a statin synthesizing process can be synthesized. Accordingly, the recombinant DERA can be variously applied to chemical processes requiring carbon polymerization.
Abstract translation: 本发明涉及一种衍生自流感嗜血杆菌KW20的重组2-脱氧核糖5-磷酸醛缩酶（DERA）的方法。 更具体地说，本发明涉及使用重组DERA制备重组DERA的方法和使用该重组DERA制备乳糖的方法，其中培养具有重组DERA生产力的重组微生物，以及编码具有序列的碱基序列的重组DERA的基因 在宿主细胞中诱导1号或含有该基因的重组载体。 本发明的重组DERA具有比现有酶更低的底物抑制和更优异的乙醛活性。 具有两个碳的官能团（2-碳单元）如乙醛衍生物在受体分子中连续缩合，从而可以合成在他汀类合成过程中作为中间产物的内酰醇。 因此，重组DERA可以各种应用于需要碳聚合的化学方法。
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公开(公告)号：KR101217715B1
公开(公告)日：2012-12-31
申请号：KR1020090057646
申请日：2009-06-26
Applicant: 한국생명공학연구원
IPC: A61K36/539 , A61P1/02 , A61K31/215 , A61K36/45
Abstract: 본발명은구강세균의증식에의한치아우식증및 치주질환예방및 치료를위한경구용조성물에관한것으로, 글리세린지방산에스테르(Glycerin Esters of Fatty Acids), 차카테킨(tea catechin), 소르비탄지방산에스테르(Sorbitan Esters of Fatty Acids), 빌베리(Bilberry) 및황금추출물로이루어진군으로부터선택된단일또는 2종이상이수용성필름기재내부에균일하게분산된경구용조성물에관한것이다. 본발명의경구용조성물은치아우식증의원인균인스트렙토코커스뮤탄스() 및/또는치주질환의대표원인균인푸조박테리움뉴클레아툼()에대해뛰어난항균활성을나타내므로상기균의증식에의한치아우식증및 치주질환예방및 치료에유용하게이용될수 있다.
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公开(公告)号：KR101073990B1
公开(公告)日：2011-10-17
申请号：KR1020090076848
申请日：2009-08-19
Applicant: 한국생명공학연구원
Abstract: 본발명은아스코르브산 2-글루코시드의생산방법에관한것으로, 보다상세하게는글루칸수크라제를이용하여 L-아스코르브산의글리코실화를통하여증가된안정성을가지는아스코르브산 2-글루코시드를생산하는방법에관한것이다. 본발명에따른방법은다양한산업분야에사용되고있는 L-아스코르브산유도체인아스코르브산 2-글루코시드를수크로스와같은풍부한탄수화물자원을이용하여합성할수 있어경제적이며, 또한우수한효율로아스코르브산 2-글루코시드를생산하는바유용하다.
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