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公开(公告)号：KR101372325B1
公开(公告)日：2014-03-13
申请号：KR1020110021514
申请日：2011-03-10
Applicant: 한국과학기술연구원
IPC: C07D311/36 , C07D493/04 , A61K36/60 , A61K31/352
Abstract: 본 발명은 상기한 문제점을 해결하기 위한 꾸지뽕으로부터 주요 프레닐레이티드 플라보노이드를 분리하는 방법으로서, 원심분리 분배 크로마토그래피( centrifugal partition chromatography)를 사용하여 적은양의 용매와 보다 적은 노동력으로 꾸지뽕으로부터 주요 프레닐레이티드 플라보노이드를 분리하는 방법을 제공한다.
CPC는 분리하고자 하는 물질이 다양한 용매의 조성으로 이루어진 섞이지 않는 두층의 용매에 대한 친화력을 이용하여 물질을 분리하는 방법으로, 물질을 분리하는데 있어 고체의 고정상을 사용하지 않기 때문에 시료의 손실이 없고, 고가의 용매를 다량사용하지 않아도 되기 때문에 경제적이다. 따라서, 본 발명은 꾸지뽕의 주요 물질인 6,8-디프레닐오로볼(6,8-diprenylorobol), 6,8-디프레닐게니스테인(6,8-diprenylgenistein) 또는 4´-
O -메틸알피눔이소플라본(4´-
O -methylalpinumisoflavone)와 같은 프레닐레이티드 플라보노이드의 대량생산을 가능하게 하여, 식품분야, 의학분야, 산업분야에서의 활용 가능성을 넓힐 수 있다.-
公开(公告)号：KR1020130037110A
公开(公告)日：2013-04-15
申请号：KR1020110101488
申请日：2011-10-05
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A Crepidiastrum denticulatum extract is provided to protect degeneration of retinal neuronal cells induced by oxidative stress and to be used as a therapeutic agent, a functional food, and a pharmaceutical material for retinal diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating retinal diseases contains a Crepidiastrum denticulatum extract. The retinal diseases include age-related macular degeneration. The extract is prepared using water, C1-C4 alcohol, acetone, or a mixture solvent thereof.
Abstract translation: 目的：提供一种Crepidiastrum denticulatum提取物，以保护由氧化应激诱导的视网膜神经元细胞的变性，并用作治疗剂，功能性食品和视网膜疾病的药物。 构成：用于预防和治疗视网膜疾病的药物组合物含有Crepidiastrum denticulatum提取物。 视网膜疾病包括年龄相关性黄斑变性。 萃取液用水，C 1 -C 4醇，丙酮或其混合溶剂制备。
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13.发明公开
公开(公告)号：KR1020110103102A
公开(公告)日：2011-09-20
申请号：KR1020100022255
申请日：2010-03-12
Applicant: 한국과학기술연구원
IPC: A61K36/899 , A61P27/06
Abstract: 본 발명은 오죽 추출물, 이의 분획물 또는 이로부터 분리된 하기 [화학식 1]로 기재되는 화합물을 유효성분으로 함유하는 녹내장 예방 및 치료용 조성물에 관한 것으로, 구체적으로 오죽을 유기용매로 추출하여 제조되는 추출물, 이의 분획물 및 상기 분획물에서 분리한 화합물인 루테오린 6-C-(6''-
O -트랜스-카페오일클루코사이드)[Luteolin 6-C-(6''-
O -trans-caffeoylglucoside)]을 포함하는 녹내장 예방 및 치료용 조성물에 관한 것이다. 본 발명의 조성물은 녹내장의 원인인 망막 신경 세포의 퇴화를 보호해 주는 작용을 나타냄으로써, 녹내장의 예방 또는 치료용 조성물로 유용하게 사용될 수 있다:
[화학식 1]
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公开(公告)号：KR1020090041533A
公开(公告)日：2009-04-29
申请号：KR1020070107087
申请日：2007-10-24
Applicant: 한국과학기술연구원
IPC: A61K36/185 , A61K8/97 , A61P17/18 , A61Q19/08
CPC classification number: A61K36/185
Abstract: A composition containing Chamaenerion angustifolium extract with anti-wrinkle and antioxidant activities is provided to show wrinkle and elasticity improvement by the Chamaenerion angustifolium extracts having effects of inhibiting type I collagenase and AP-1. A composition containing Chamaenerion angustifolium extract with anti-wrinkle and antioxidant activities comprises Chamaenerion angustifolium extract obtained by adding water and alcohol or a mixed solvent thereof. The Chamaenerion angustifolium extract inhibits inflammation and improves skin elasticity. The composition has a formulation of external skin application. The composition represents cosmetics or health foods. The Chamaenerion angustifolium extract is an active ingredient in the composition.
Abstract translation: 提供了具有抗皱和抗氧化活性的含有Chamaenerion angustifolium提取物的组合物，以显示具有抑制I型胶原酶和AP-1的作用的Chamaenerion angustifolium提取物的皱纹和弹性改善。 具有抗皱和抗氧化活性的含有尖角鳗提取物的组合物包括通过加入水和醇或其混合溶剂获得的Challenerion angustifolium提取物。 Chamaenerion angustifolium提取物抑制炎症并改善皮肤弹性。 该组合物具有外用皮肤应用的配方。 组合物代表化妆品或保健食品。 Chamaenerion angustifolium提取物是组合物中的活性成分。
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公开(公告)号：KR1020090041531A
公开(公告)日：2009-04-29
申请号：KR1020070107085
申请日：2007-10-24
Applicant: 한국과학기술연구원
IPC: A61K36/185 , A61K8/97 , A61P39/06 , A61Q19/08
CPC classification number: A61K36/45 , A23L2/02 , A23L2/52 , A23L33/105 , A61K8/97 , A61K9/0095 , A61K9/1617 , A61K9/1623 , A61K9/2018 , A61K9/2059 , A61K2800/522 , A61K2800/782 , A61Q19/08
Abstract: A composition containing Ortilia secunda extracts is provided to show wrinkle and elasticity improvement by the Ortilia secunda extracts having effects of inhibiting type I collagenase and AP-1 and increasing generation of collagen while suppressing decomposition of the collagen. A composition for wrinkle improvement comprises Ortilia secunda extracts obtained by adding water and C1-C4 low alcohol such as ethanol and methanol or mixed solvents thereof. The Ortilia secunda extracts are active ingredients in the composition for wrinkle improvement. The Ortilia secunda extracts eliminate radicals. The composition has a formulation of external skin application. The composition for wrinkle improvement represents antioxidant.
Abstract translation: 提供含有Ortilia secunda提取物的组合物，以显示具有抑制I型胶原酶和AP-1的作用的Ortilia secunda提取物的皱纹和弹性改善，并增加胶原蛋白的产生，同时抑制胶原蛋白的分解。 用于皱纹改良的组合物包括通过加入水和C1-C4低级醇如乙醇和甲醇或其混合溶剂获得的Ortilia secunda提取物。 Ortilia secunda提取物是用于皱纹改善的组合物中的活性成分。 Ortilia secunda提取物消除自由基。 该组合物具有外用皮肤应用的配方。 用于皱纹改善的组合物表示抗氧化剂。
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Patent Agency Ranking16.发明公开고삼 추출물 또는 이로부터 분리한 5-메틸소포라플라바논Ｂ를 유효성분으로 함유하는 당뇨병 합병증 또는 비만의예방 및 치료용 약학적 조성물 失效用于预防和治疗糖尿病合并症或含有SOPHORA FLAVASCENS提取物的药物的药物组合物或其作为活性成分的分离的5-甲基磺酰丙酮B
公开(公告)号：KR1020080090710A
公开(公告)日：2008-10-09
申请号：KR1020070033872
申请日：2007-04-05
Applicant: 한국과학기술연구원
IPC: A61K31/352 , A61K36/48 , A61P3/10
Abstract: A 5-methylsophoraflavanone B isolated from an extract of Sophora flavascens is provided to show inhibitory effect on the activity of aldose reductase causing diabetic complications and prevent obesity by inhibiting differentiation of fat cells, thereby being usefully used for preventing or treating the diabetic complications or the obesity. A pharmaceutical composition for preventing and treating diabetic complications or obesity comprises an extract of Sophora flavascens or 5-methylsophoraflavanone B isolated therefrom and represented by a formula(1) as an effective ingredient, wherein the extract of Sophora flavascens or the 5-methylsophoraflavanone B is prepared by extracting dried materials of Sophora flavascens roots with C1-4 alcohol to obtain the extract of Sophora flavascens, subjecting the extract to high speed liquid chromatography to isolate the 5-methylsophoraflavanone B and purifying the isolated 5-methylsophoraflavanone B. Further, the C1-4 alcohol is ethanol.
Abstract translation: 提供从苦参中提取物中分离出的5-甲基异佛唑酮B，以显示对糖尿病并发症的醛糖还原酶的活性的抑制作用，并通过抑制脂肪细胞的分化来预防肥胖，从而有效地用于预防或治疗糖尿病并发症或 肥胖。 用于预防和治疗糖尿病并发症或肥胖症的药物组合物包含由其分离并由式（1）代表的作为有效成分的苦参皂甙或5-甲基异佛唑酮乙酸酯B的提取物，其中苦参中的苦参提取物或5-甲基异佛唑酮B为 通过用C 1-4醇提取苦参皂甙干燥物质，得到苦参皂甙提取物，高效液相色谱法分离5-甲基异佛唑酮B，纯化分离出的5-甲基异佛唑酮B.制备C1， -4酒精是乙醇。
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公开(公告)号：KR1020130071918A
公开(公告)日：2013-07-01
申请号：KR1020110139401
申请日：2011-12-21
Applicant: 한국과학기술연구원
IPC: A61K36/899 , A61K31/192 , A61K31/352 , A61K31/35
CPC classification number: A61K31/192 , A61K31/05 , A61K31/352 , A61K36/899 , A61K2236/333 , A61K2236/37
Abstract: PURPOSE: A method for preparing a bamboo leaf extract is provided to quickly extract and to selectively obtain useful substances according to an extraction condition. CONSTITUTION: A method for preparing a bamboo leaf extract comprises a step of treating bamboo leaves with a subcritical solvent. The subcritical solvent is prepared by treating with a mixture of water and ethanol at 120-220 deg. C and 100-2500 PSI. The volume ratio of water and ethanol is 0.1-10:1. The extract contains one or more compounds selected from the group consisting of coumaric acid, tricin, p-coumaryl alcohol, 3- (4-hydroxyphenyl)-2-propenoic acid ethyl ester, and ferulic acid ethyl ester.
Abstract translation: 目的：提供竹叶提取物的制备方法，以提取条件快速提取和选择性地获得有用物质。 构成：竹叶提取物的制备方法包括用亚临界溶剂处理竹叶的步骤。 通过用水和乙醇的混合物在120-220度处理制备亚临界溶剂。 C和100-2500 PSI。 水和乙醇的体积比为0.1-10:1。 提取物含有一种或多种选自香豆酸，tricin，对香豆醇，3-（4-羟基苯基）-2-丙烯酸乙酯和阿魏酸乙酯的化合物。
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公开(公告)号：KR1020120103324A
公开(公告)日：2012-09-19
申请号：KR1020110021514
申请日：2011-03-10
Applicant: 한국과학기술연구원
IPC: C07D311/36 , C07D493/04 , A61K36/60 , A61K31/352
Abstract: PURPOSE: A method for isolating prenylated flavonoid from Cudrania tricuspidata (Call.) Bureau is provided to prevent sample loss. CONSTITUTION: A method for isolating prenylated flavonoid from Cudrania tricuspidata (Call.) Bureau comprises: a step of extracting Cudrania tricuspidata (Call.) Bureau with an organic solvent to prepare an extract; a step of concentrating the extract by centrifugal partition chromatography(CPC). The CPC comprises a step of filling upper phase solvent in a rotor; a step of dropping the upper phase solvent and stabilizing two phases; a step of injecting the extract to prepare a fraction.
Abstract translation: 目的：提供一种从三头螨（Call。）局分离异戊烯酮化黄酮的方法，以防止样品损失。 构成：用于从三趾甲（Call。）局分离异戊烯酮化黄酮的方法包括：用有机溶剂萃取葫芦科（Call。）局以制备提取物的步骤; 通过离心分离色谱（CPC）浓缩提取物的步骤。 CPC包括在转子中填充上相溶剂的步骤; 滴入上相溶剂并稳定两相的步骤; 注射提取物以制备级分的步骤。
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公开(公告)号：KR1020110093513A
公开(公告)日：2011-08-18
申请号：KR1020100013614
申请日：2010-02-12
Applicant: 한국과학기술연구원
IPC: A61K36/896 , A61K36/80 , A61P15/12
Abstract: PURPOSE: A composition containing wild edible greens extract or fraction for preventing and treating postmenopause syndrome is provided to promote expression of a promoter containing ERE(Estrogen Responsive Element) and improve estrogen activity. CONSTITUTION: A composition for preventing and treating postmenopause syndrome contains Disporum uniflorum extract, Humulus japonicus extract or fraction thereof as an active ingredient. The extract is isolated using water, low alcohol of C1-C4, or mixture thereof. The fraction is n-hexane, ethyl acetate, or n-butanol fraction. A health food for preventing and treating postmenopause syndrome contains the extract or fraction as an active ingredient.
Abstract translation: 目的：提供含有野生食用果蔬提取物或预防和治疗绝经后综合征的组分的组合物，以促进含有ERE（雌激素反应元件）的启动子的表达并改善雌激素活性。 构成：用于预防和治疗绝经后综合征的组合物含有单孢菌提取物，葎草提取物或其分数作为活性成分。 使用水，C1-C4的低级醇或其混合物分离提取物。 该级分为正己烷，乙酸乙酯或正丁醇级分。 用于预防和治疗绝经后综合征的保健食品含有提取物或级分作为活性成分。
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公开(公告)号：KR100991398B1
公开(公告)日：2010-11-02
申请号：KR1020080061614
申请日：2008-06-27
Applicant: 한국과학기술연구원
Abstract: 본 발명은 해조류인 쇠꼬리산말(
Desmarestia
viridis ) 추출물을 유효성분으로 함유하는 항염증 조성물에 관한 것으로, 본 발명의 쇠꼬리산말 추출물은 질소산화물(NO) 생성 억제, 프로스타글란딘 E
2 (PGE
2 ) 생성 억제, 유도성 질소산화물 합성효소(iNOS) 발현 억제 및 전염증성 사이토카인인 인터루킨-1β(IL-1β) 발현 억제 활성을 통하여 항염증 효과를 나타내며 세포독성은 없으므로, 염증관련 질환의 예방 및 치료를 위한 의약품, 건강기능식품 또는 기능성 사료에 유용하게 사용될 수 있다.
쇠꼬리산말, 항염증, 질소산화물, 프로스타글란딘, 질소산화물 합성효소, 인터루킨-1β
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