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公开(公告)号：KR1020130133593A
公开(公告)日：2013-12-09
申请号：KR1020120056977
申请日：2012-05-29
Applicant: 한국과학기술연구원
IPC: G01N33/68 , G01N33/574
CPC classification number: G01N33/6893 , G01N33/57446
Abstract: The present invention relates to a biomarker composition for diagnosing stomach cancer and a method for diagnosing stomach cancer using the same. According to an embodiment of the present invention, the biomarker composition for diagnosing stomach cancer and the method using the biomarker composition for diagnosing stomach cancer are usefully used for diagnosing a suspected stomach cancer patient.
Abstract translation: 本发明涉及用于诊断胃癌的生物标志物组合物和使用其的胃癌诊断方法。 根据本发明的实施方案，用于诊断胃癌的生物标志物组合物和使用该生物标志物组合物诊断胃癌的方法可用于诊断疑似胃癌患者。
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公开(公告)号：KR101188714B1
公开(公告)日：2012-10-09
申请号：KR1020110039268
申请日：2011-04-27
Applicant: 한국과학기술연구원
CPC classification number: G01N30/72 , G01N30/64 , G01N2030/8813 , G01N2030/8822 , G01N2030/8827
Abstract: PURPOSE: A method for simultaneously detecting nucleotides in blood plasma using a capillary electrophoresis-mass spectrometer is provided to effectively separate nine kinds of nucleotides from a blood plasma specimen by securing optimal analyzing conditions of the capillary electrophoresis-mass spectrometer. CONSTITUTION: A method for simultaneously detecting nucleotides in blood plasma includes the following: protein is removed from the blood plasma; the blood plasma without the protein passes through a micelle electrokinetically capillary chromatography column which is adjusted with a surfactant containing developing solvent; and the treated blood plasma is analyzed by a capillary electrophoresis-mass spectrometer. The protein is removed using 50-70% of an ethanol solution containing ethylene diamine tetraacetic acid(EDTA). The concentration of the EDTA is in a range between 1 and 5 mM. The surfactant is a cationic surfactant. The developing solvent is an ammonium acetate buffer solution. The concentration of the ammonium acetate buffer solution is in a range between 10 and 60 nM.
Abstract translation: 目的：提供使用毛细管电泳 - 质谱仪同时检测血浆中核苷酸的方法，通过确保毛细管电泳 - 质谱仪的最佳分析条件，有效地将9种核苷酸与血浆标本分离。 构成：同时检测血浆中核苷酸的方法包括：从血浆中除去蛋白质; 没有蛋白质的血浆通过胶束电动毛细管色谱柱，其用含显影溶剂的表面活性剂调节; 并通过毛细管电泳 - 质谱仪分析处理过的血浆。 使用含有乙二胺四乙酸（EDTA）的50-70％的乙醇溶液除去蛋白质。 EDTA的浓度在1至5mM的范围内。 表面活性剂是阳离子表面活性剂。 显影溶剂为乙酸铵缓冲溶液。 乙酸铵缓冲溶液的浓度在10至60nM的范围内。
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公开(公告)号：KR1020110130071A
公开(公告)日：2011-12-05
申请号：KR1020100049515
申请日：2010-05-27
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A method for simultaneously analyzing cholesterol, oxysterol, and bile acid in urine is provided to treat diseases and to prevent side effect. CONSTITUTION: A method for simultaneously detecting cholesterol, oxysterol, and bile acid in urine comprises a step of TMS(trimethylsilylation) derivatization of cholesterol, oxysterol, and bile acid contained in a urine sample. The simultaneous detection comprises: a process of treating enzyme to the urine sample for hydrolyzation; and a process of solvent extraction. The enzyme is beta-glucuronidase or arylsulfatase. They used solvent is a mixture solution of ethyl acetate and n-hexane, ethyl ether, or t-butyl methyl ether.
Abstract translation: 目的：同时分析尿中胆固醇，胆固醇和胆汁酸的方法，用于治疗疾病和预防副作用。 构成：同时检测尿液中胆固醇，氧固醇和胆汁酸的方法包括在尿样中含有胆固醇，氧固醇和胆汁酸的TMS（三甲基甲硅烷基化）衍生化步骤。 同时检测包括：将酶处理至尿样进行水解的过程; 和溶剂萃取过程。 酶是β-葡糖苷酸酶或芳基硫酸酯酶。 使用溶剂是乙酸乙酯和正己烷，乙醚或叔丁基甲基醚的混合溶液。
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14.发明公开임산부의 뇨 중의 에스트리올 3-글루쿠로나이드 및에스트리올 16-글루쿠로나이드의 검출 방법 및 그 장치 失效基于具有高灵敏度的高性能液相色谱法检测孕激素孕激素尿激酶3-GLUCURONIDE和ESTRIOL 16-GLUCURONIDE的方法及其设备
公开(公告)号：KR1020040107775A
公开(公告)日：2004-12-23
申请号：KR1020030038199
申请日：2003-06-13
Applicant: 한국과학기술연구원
IPC: G01N30/72
Abstract: PURPOSE: Provided is a method for detecting estriol 3-glucuronide and estriol 16-glucuronide, which has no need of pretreating urine samples, ensures high analytical sensitivity even with a small amount of sample and gives excellent operation property. CONSTITUTION: The method for detecting estriol 3-glucuronide and estriol 16-glucuronide in urine by using HPLC comprises the steps of: introducing a urine sample into a concentration column(5) in which proteins and analytically undesirable materials are removed from the sample and the sample is concentrated in the presence of buffered triethylamine solution as an eluting solvent; and terminating the introduction of the buffered triethylamine solution after the completion of the concentration step, introducing acetonitrile as an eluting solvent to elute the concentrated estriol 3-glucuronide and estriol 16-glucuronide out of the concentration column, and then introducing the eluted materials into an analytic column(6) to perform analysis for concentration. In the method, the kind of eluting solvent is determined by a switching valve(3). Additionally, injection of the sample into the concentration column(5) and ejection of the concentrated sample from the concentration column(5) are determined by another switching valve(4).
Abstract translation: 目的：提供一种检测雌三醇3-葡萄糖醛酸苷和雌三醇16葡萄糖醛酸苷的方法，无需预处理尿液样品，即使使用少量样品也能保证高分析灵敏度，并具有优异的操作性能。 构成：使用HPLC检测尿中三醇3-葡萄糖醛酸苷和雌三醇16-葡糖苷酸的方法包括以下步骤：将尿液样品引入浓缩柱（5），其中从样品中除去蛋白质和分析不需要的物质， 将样品浓缩在缓冲三乙胺溶液存在下作为洗脱溶剂; 在浓缩步骤完成后终止引入缓冲的三乙胺溶液，引入乙腈作为洗脱溶剂，将浓缩的三醇3-葡糖苷酸和雌三醇16-葡萄糖醛酸苷从浓缩柱中洗脱出来，然后将洗脱的物质引入 分析柱（6）进行浓缩分析。 在该方法中，洗脱溶剂的种类由切换阀（3）确定。 此外，通过另一个切换阀（4）确定样品注入浓缩塔（5）和浓缩样品从浓缩塔（5）的喷射。
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公开(公告)号：KR1020030073428A
公开(公告)日：2003-09-19
申请号：KR1020020012980
申请日：2002-03-11
Applicant: 한국과학기술연구원
IPC: G01N33/82
Abstract: PURPOSE: Provided is a method of detecting vitamin E in the serum which extracts the vitamin E from the serum, and provides optimum analyzing conditions with selective and excellent sensitivity to the high performance liquid chromatography and ultraviolet ray absorber. CONSTITUTION: A method of detecting the vitamin E in the serum comprises the steps of: treating the serum by a buffer solution containing 0.075-0.2M of salt with pH4.0-5.5; extracting the vitamin E from the treated serum by diethyl ether; and analyzing the concentration of the extracted vitamin E by a high performance liquid chromatography with a ultraviolet ray absorber. The serum is derived from livestock, the buffer solution from phosphoric acid or acetic acid, and the salt from NaCl.
Abstract translation: 目的：提供一种检测血清中维生素E的方法，从血清中提取维生素E，为高效液相色谱和紫外线吸收剂提供了选择性和极好敏感性的最佳分析条件。 构成：检测血清中维生素E的方法包括以下步骤：用含有0.075-0.2M盐的pH4.0-5.5的缓冲溶液处理血清; 用乙醚从处理过的血清中提取维生素E; 并用紫外线吸收剂通过高效液相色谱分析提取的维生素E的浓度。 血清来自家畜，来自磷酸或乙酸的缓冲溶液，以及来自NaCl的盐。
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Patent Agency Ranking
公开(公告)号：KR101758354B1
公开(公告)日：2017-07-17
申请号：KR1020150042566
申请日：2015-03-26
Applicant: 한국과학기술연구원
CPC classification number: C07K7/56 , C07K14/4713 , G01N33/564 , G01N33/577 , G01N33/6803 , G01N2440/18 , G01N2800/102
Abstract: CCP를포함하는류마티스관절염진단용조성물및 키트, 이를이용한류마티스관절염진단방법및 류마티스관절염진단에필요한정보를얻는방법, 새로운류마티스관절염진단마커스크리닝방법을이용하면류마티스관절염을효율적으로진단하고, 환자의편의성을향상시킬수 있다.
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公开(公告)号：KR1020160139781A
公开(公告)日：2016-12-07
申请号：KR1020150075295
申请日：2015-05-28
Applicant: 한국과학기술연구원
IPC: G01N30/72 , G01N33/573
Abstract: 본발명은시토크롬 P450 이소효소에특이적으로반응하는기질을포함하는가스크로마토그래피를이용한시토크롬 P450(Cytochrome P450) 이소효소활성분석용조성물을제공함으로써, 가스크로마토그래피질량분석을통해다양한시토크롬 P450 이소효소들의활성을동시에측정할수 있다. 따라서, 본발명은한약탕재와같은다성분을포함하는복합물에서의약물의상호작용을효율적으로측정할수 있는시스템을제공할수 있다.
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公开(公告)号：KR1020160136645A
公开(公告)日：2016-11-30
申请号：KR1020150070447
申请日：2015-05-20
Applicant: 한국과학기술연구원
Abstract: 본발명은섬쑥부쟁이의에틸아세테이트용매분획물(AGE)을에스터화학반응시켜얻은섬쑥부쟁이에스터잔사(AGEM), 또는상기섬쑥부쟁이에스터잔사(AGEM)를농도구배컬럼크로마토그래피로분획하여얻은섬쑥부쟁이에스터분획물(AGEM-M) 각각이 HMG-CoA 환원효소에대한저해활성이탁월하므로, 상기섬쑥부쟁이에스터잔사(AGEM) 또는섬쑥부쟁이에스터분획물(AGEM-M)을활성성분으로포함하여혈중콜레스테롤의농도저하를목적으로이용되는약제조성물또는건강식품조성물에관한것이다.
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公开(公告)号：KR1020160123859A
公开(公告)日：2016-10-26
申请号：KR1020150054597
申请日：2015-04-17
Applicant: 한국과학기술연구원
CPC classification number: G01N33/492 , G01N33/6893 , G01N2405/02 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/324
Abstract: 본발명은트립토판(tryptophan), 호모세린(homoserine), 지방산(fatty acid)(16:1), 지방산(18:0), 지방산(18:1), 지방산(18:2), 지방산(22:6), 포스파티딜콜린(phosphatidylcholine, PC)(34:2), PC(34:3), 라이소PC(lysophosphatidylcholine)(16:0), 라이소PC(18:0), 라이소PC(20:3), 라이소PC(20:4), 라이소PC(22:6), 모노글리세라이드(monoglyceride)(18:1/0:0/0:0) 및스핑고마이엘린(sphingomyelin)(d18:2/16:0)으로이루어진군에서선택된 1종이상의생체대사체를바이오마커로이용한멀티-생체대사체플랫폼을제공함으로써체내레벨분석을통해급성관상동맥질환및 그발명이전징후까지단계별로간단하고정확하게진단할수 있다.
Abstract translation: 本公开提供了使用一种或多种选自色氨酸，高丝氨酸，脂肪酸（16:1），脂肪酸（18：0），脂肪酸（18：1），脂肪酸 （18:2），脂肪酸（22:6），磷脂酰胆碱（PC）（34:2），PC（34:3），溶血磷脂酰胆碱（溶血卵磷脂）（16：0），溶血卵磷脂（18：0） 20：3），lysoPC（20：4），溶血卵磷脂（22：6），单甘油酯（18：1：0：0/0：0）和鞘磷脂（d18：2/16：0） 通过体内水平分析简单准确地诊断急性冠状动脉综合征以及发病前的症状。
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20.发明公开신규한 시클릭 시트룰리네이티드 펩티드, 이를 포함하는 류마티스 관절염 진단용 조성물 및 이를 이용한 진단 방법, 및 류마티스 관절염 마커 스크리닝 방법 有权用于诊断类风湿性关节炎的新型环状瓜氨酸肽组合物，包括新型环瓜氨酸肽及其用于诊断类风湿性关节炎的方法和用于筛选类风湿性关节炎标志物的方法
公开(公告)号：KR1020160115265A
公开(公告)日：2016-10-06
申请号：KR1020150042566
申请日：2015-03-26
Applicant: 한국과학기술연구원
CPC classification number: C07K7/56 , C07K14/4713 , G01N33/564 , G01N33/577 , G01N33/6803 , G01N2440/18 , G01N2800/102 , G01N33/68 , G01N33/53
Abstract: CCP를포함하는류마티스관절염진단용조성물및 키트, 이를이용한류마티스관절염진단방법및 류마티스관절염진단에필요한정보를얻는방법, 새로운류마티스관절염진단마커스크리닝방법을이용하면류마티스관절염을효율적으로진단하고, 환자의편의성을향상시킬수 있다.
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