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    항염증 활성이 우수한 섬쑥부쟁이 분획물 및 이로부터 분리된 활성화합물
    4.
    发明授权
    항염증 활성이 우수한 섬쑥부쟁이 분획물 및 이로부터 분리된 활성화합물 有权
    Aster glehni级分或其分离的化合物具有抗炎活性

    公开(公告)号：KR101611851B1

    公开(公告)日：2016-04-14

    申请号：KR1020140121177

    申请日：2014-09-12

    Applicant: 한국과학기술연구원

    Inventor： 김형자 ,  진창배 ,  손민정 ,  이용섭 ,  육창수 ,  이경태 ,  이재열

    IPC: A61K31/7034 ,  A61K36/28 ,  A61P29/00

    Abstract: 본발명은항염증활성이우수한섬쑥부쟁이 () 분획물및 이로부터분리된화합물에관한것이다. 본발명의섬쑥부쟁이의에틸아세테이트분획물과상기분획물로부터분리된활성화합물로서 6'--카페오일로세오사이드 (6'--caffeoylroseoside), 6'--카페오일디히드로시린진 (6'--caffeoyldihydrosyringin), 글레노사이드 (glehnoside)는강력한자유라디칼소거능에의한항산화을가지며, 동시에리포폴리사카라이드 (LPS)에의해유도되는염증성대사산물인 NO (Nitric oxide)과프로스타글란딘 E(PGE), TNF-α (tumour necrosis factor alpha), IL-6 (interleukin-6) 및 IL-1β (interleukin-1beta) 등과같은염증유발성사이토카인 (cytokine)의생성을억제하므로, 염증질환의치료, 예방및 개선이필요한의약품, 화장품, 건강식품등의활성성분으로유용하게사용될수 있다.

    층꽃풀로부터 분리된 페놀계 화합물을 함유하는 간보호용 조성물
    7.
    发明公开
    층꽃풀로부터 분리된 페놀계 화합물을 함유하는 간보호용 조성물 有权
    包含从CARYOPTERIS INCANA分离的酚化合物的保护性药物组合物

    公开(公告)号：KR1020130086580A

    公开(公告)日：2013-08-02

    申请号：KR1020130069884

    申请日：2013-06-18

    Applicant: 한국과학기술연구원

    Inventor： 진창배 ,  김형자 ,  이용섭 ,  정서윤

    IPC: C07D493/00 ,  A61K31/7016 ,  A61K31/7028 ,  A61K36/85

    Abstract: PURPOSE: A Caryopteris incana extract, a fraction thereof, and a compound isolated from the extract or the fraction, and a composition containing the same for protecting liver are provided to protect liver cells from hepatotoxicity caused by toxic materials and to prevent and treat liver diseases. CONSTITUTION: A pharmaceutical composition for a liver protective agent contains one or more kinds of compounds selected among compounds of chemical formulas 1-3, 5, and 8-10. The compounds protect liver cells from toxicity induced by tertiary-butyl hydroperoxide (t-BHP). A food composition for protecting liver contains one or more kinds of compounds selected among the compounds of chemical formulas 1-3, 5, and 8-10. The compound of chemical formula 1 or 2 is isolated from Caryopteris incana.

    Abstract translation: 目的：提供Caryopteris incana提取物及其一部分，从提取物或级分分离的化合物和含有该化合物的组合物用于保护肝脏，以保护肝细胞免受有毒物质引起的肝毒性并预防和治疗肝脏疾病 。 构成：用于肝保护剂的药物组合物含有选自化学式1-3,5和8-10的化合物中的一种或多种化合物。 该化合物可保护肝细胞免受叔丁基过氧化氢（t-BHP）诱导的毒性。 用于保护肝的食品组合物含有选自化学式1-3,5和8-10的化合物中的一种或多种化合物。 化学式1或2的化合物从ary is分离。

    신규한 플라본 유도체, 그의 제조 방법 및 이를 포함하는뇌신경계 질환의 예방 및 치료용 조성물
    8.
    发明公开
    신규한 플라본 유도체, 그의 제조 방법 및 이를 포함하는뇌신경계 질환의 예방 및 치료용 조성물 失效
    新型FLAVONE衍生物，其制备方法及其含有预防和治疗脑神经系统疾病的组合物

    公开(公告)号：KR1020070056601A

    公开(公告)日：2007-06-04

    申请号：KR1020050115501

    申请日：2005-11-30

    Applicant: 한국과학기술연구원

    Inventor： 이용섭 ,  진창배 ,  김형자 ,  김승환

    IPC: C07D311/30

    Abstract: A novel flavone derivative is provided to show excellent antioxidative effect, neuron protecting effect and neuroethological effect, thereby being usefully used for preventing and treating various neurodegenerative diseases such as stroke, chronic degenerative disease, Parkinson's disease and Alzheimer's disease. The flavone derivative is represented by the formula(1), wherein R1 is H or C1-4 alkoxy, R2 is H or hydroxy, each R3 and R4 is independently H or R5, R5 is glucose or -(CH2)mR6(m is from 0 to 3), and R6 is tetrahydrobenzopyran, tetrahydrobenzopyranylalkylacetate or tetrahydrobenzopyranylalkoxyalkyl substituted by at least one substituent selected from the group consisting of C3-7 heterocyclic compound including at least one of N and O; amino which is substituted or unsubstituted by at least one C1-4 alkyl; hydroxy; and hydroxyalkyl. The method for preparing the flavone derivative according to the reaction formula(1) comprises the steps of: (a) synthesizing a compound represented by the formula(VI) from a compound of the formula(I); and (b) after introducing at least one amine or glucose into the compound of the formula(VI) to prepare a compound represented by the formula(VII), deprotecting the compound of the formula(VII) to synthesize the compound of the formula(1). In the reaction formula(1), each R1 to R6 is same as defined above, X is halogen or alkyl halogen, MOM is methoxymethyl, and Bn is benzyl.

    Abstract translation: 提供了一种新型的黄酮衍生物，以显示优异的抗氧化作用，神经元保护作用和神经听觉效果，从而有效地用于预防和治疗各种神经变性疾病如中风，慢性退行性疾病，帕金森病和阿尔茨海默病。 黄酮衍生物由式（1）表示，其中R1是H或C1-4烷氧基，R2是H或羟基，R3和R4独立地是H或R5，R5是葡萄糖或 - （CH2）mR6（m是 0至3），R6为四氢苯并吡喃基烷基乙酸酯或四氢苯并吡喃基烷氧基烷基，其被至少一个选自由以下组成的组的C3-7杂环化合物所取代：包括N和O中至少一个的杂环化合物; 被至少一个C 1-4烷基取代或未取代的氨基; 羟基; 和羟烷基。 根据反应式（1）制备黄酮衍生物的方法包括以下步骤：（a）由式（I）化合物合成由式（VI）表示的化合物; 和（b）在将至少一种胺或葡萄糖引入式（VI）化合物中以制备式（Ⅶ）表示的化合物之后，将式（Ⅶ）化合物脱保护，合成式 1）。 在反应式（1）中，每个R 1至R 6与上述定义相同，X为卤素或烷基卤素，MOM为甲氧基甲基，Bn为苄基。

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