公开(公告)号：KR1020080029370A

公开(公告)日：2008-04-03

申请号：KR1020060095383

申请日：2006-09-29

Applicant: 한국과학기술연구원

Inventor： 진창배 ,  이용섭 ,  김형자 ,  정서윤 ,  조정숙

IPC: A61K36/33 ,  A61P25/28

Abstract: A butanol extract of Opuntia ficus-indica is provided to show distinctive neuroprotective effect in a cerebral ischemic animal model, thereby preventing and treating neurological brain diseases such as stroke, concussion of the brain, Alzheimer's disease and Parkinson's disease and ischemic diseases such as myocardial infarction and cerebral infarction. A pharmaceutical composition for preventing neurological brain diseases, cerebrovascular diseases and cardiovascular diseases comprises a butanol extract of Opuntia ficus-indica as an effective ingredient, wherein the extract is obtained by extracting stems or fruits of the Opuntia ficus-indica with C1-4 lower alcohol solvent at a temperature of 20-90 deg.C, filtering the extract, evaporating the filtrate under reduced pressure to obtain an alcohol extract, adding water to the alcohol extract and extracting the aqueous extract with butanol. Further, the lower alcohol solvent is selected from a group consisting of anhydrous alcohol and alcohol water solution of 50% or more.

Abstract translation: 提供了仙人掌榕的丁醇提取物，以在脑缺血动物模型中显示出显着的神经保护作用，从而预防和治疗神经性脑疾病如脑卒中，脑震荡，阿尔茨海默病和帕金森病以及缺血性疾病如心肌梗死 和脑梗塞。 一种用于预防神经性脑病，脑血管疾病和心血管疾病的药物组合物，其特征在于，含有作为有效成分的仙茅樟脑的丁醇提取物，其中，所述提取物是通过用C 1-4低级醇提取榕树仙人掌的茎或果实而得到的 溶剂，温度为20-90℃，过滤提取物，减压蒸发滤液，得到醇提取液，向醇提取液中加入水，并用丁醇萃取水提液。 此外，低级醇溶剂选自无水醇和50％以上的醇水溶液。