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公开(公告)号：KR101164020B1
公开(公告)日：2012-07-18
申请号：KR1020060095383
申请日：2006-09-29
Applicant: 한국과학기술연구원
Abstract: 본 발명은 손바닥선인장 추출물을 함유하는 약학 조성물에 관한 것으로, 더욱 상세하게는 손바닥선인장의 부탄올 추출물 또는 이 추출물의 산 가수분해물이 유효성분으로 함유되어 있음으로써 뇌신경 질환, 뇌혈관 질환 또는 심혈관 질환 보다 구체적으로는 뇌졸중, 뇌진탕, 알쯔하이머병, 파킨슨병, 뇌경색, 심근경색 등의 치료 및 예방에 유효한 약학 조성물에 관한 것이다.
손바닥선인장, 부탄올 추출물, 뇌졸중, 허혈, 신경세포 보호, 뇌신경질환-
公开(公告)号：KR100523562B1
公开(公告)日：2005-10-25
申请号：KR1020020065744
申请日：2002-10-28
Applicant: 한국과학기술연구원
CPC classification number: A61K31/352 , A61K36/33
Abstract: 본 발명은 손바닥선인장을 에틸 아세테이트로 추출하여 얻은 신경세포 보호효과를 갖는 추출물 및, 이 추출물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 신경세포 보호용 약학 조성물에 관한 것으로, 본 발명의 약학 조성물은 알쯔하이머병, 뇌졸중, 파킨슨병과 같은 뇌신경질환에 의한 뇌신경세포 손상, 허혈로 인한 세포와 조직 손상 또는 심근경색과 같은 심혈관계 질환의 예방 및 치료에 유용하게 사용될 수 있다.
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公开(公告)号：KR1020080029370A
公开(公告)日：2008-04-03
申请号：KR1020060095383
申请日：2006-09-29
Applicant: 한국과학기술연구원
Abstract: A butanol extract of Opuntia ficus-indica is provided to show distinctive neuroprotective effect in a cerebral ischemic animal model, thereby preventing and treating neurological brain diseases such as stroke, concussion of the brain, Alzheimer's disease and Parkinson's disease and ischemic diseases such as myocardial infarction and cerebral infarction. A pharmaceutical composition for preventing neurological brain diseases, cerebrovascular diseases and cardiovascular diseases comprises a butanol extract of Opuntia ficus-indica as an effective ingredient, wherein the extract is obtained by extracting stems or fruits of the Opuntia ficus-indica with C1-4 lower alcohol solvent at a temperature of 20-90 deg.C, filtering the extract, evaporating the filtrate under reduced pressure to obtain an alcohol extract, adding water to the alcohol extract and extracting the aqueous extract with butanol. Further, the lower alcohol solvent is selected from a group consisting of anhydrous alcohol and alcohol water solution of 50% or more.
Abstract translation: 提供了仙人掌榕的丁醇提取物，以在脑缺血动物模型中显示出显着的神经保护作用，从而预防和治疗神经性脑疾病如脑卒中，脑震荡，阿尔茨海默病和帕金森病以及缺血性疾病如心肌梗死 和脑梗塞。 一种用于预防神经性脑病，脑血管疾病和心血管疾病的药物组合物，其特征在于，含有作为有效成分的仙茅樟脑的丁醇提取物，其中，所述提取物是通过用C 1-4低级醇提取榕树仙人掌的茎或果实而得到的 溶剂，温度为20-90℃，过滤提取物，减压蒸发滤液，得到醇提取液，向醇提取液中加入水，并用丁醇萃取水提液。 此外，低级醇溶剂选自无水醇和50％以上的醇水溶液。
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公开(公告)号：KR1020030035974A
公开(公告)日：2003-05-09
申请号：KR1020020065744
申请日：2002-10-28
Applicant: 한국과학기술연구원
CPC classification number: A61K31/352 , A61K36/33
Abstract: PURPOSE: A composition containing an extract of Opuntia ficus-indica var. Saboten Makino and a compound isolated therefrom which exhibit antioxidative action and nerve cell protecting activity is provided. The composition inhibits neurotoxicity caused by cell death and exhibits nerve cell protecting effect on animal models of brain ischemia and is thus expected to be useful for prevention and treatment of cerebral apoplexy, cerebral concussion, Alzheimer's disease, Parkinson's disease, myocardial infarction and brain infarction. CONSTITUTION: A composition for protecting nerve cells contains an ethyl acetate extract of Opuntia ficus-indica and a compound isolated from therefrom as an active ingredient. The ethyl acetate extract contains campherol, dihydroquercetin or quercetin-3-methyl ether as an active ingredient and is prepared by adding 0.1 to 10L of an alcohol solvent to stems, fruits or processed fruits of Opuntia ficus-indica, followed by leaving them at room temperature for 4 to 5 days, filtering, distilling under reduced pressure and then extracting with 0.5 to 2L of ethyl acetate.
Abstract translation: 目的：一种含有仙人掌提取物的组合物。 提供了Saboten Makino和从其分离的化合物，其显示出抗氧化作用和神经细胞保护活性。 该组合物抑制由细胞死亡引起的神经毒性，并且对脑缺血动物模型显示神经细胞保护作用，因此预期可用于预防和治疗脑中风，脑震荡，阿尔茨海默氏病，帕金森病，心肌梗死和脑梗死。 构成：用于保护神经细胞的组合物含有榕属仙茅的乙酸乙酯萃取物和从其分离的化合物作为活性成分。 乙酸乙酯提取物含有荆芥，二氢槲皮素或槲皮素-3-甲醚作为活性成分，并通过向榕树芸苔的茎，果实或加工水果中加入0.1至10L的醇溶剂，然后将其留在室内 温度4〜5天，过滤，减压蒸馏，然后用0.5〜2L乙酸乙酯萃取。
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