公开(公告)号：KR101725281B1

公开(公告)日：2017-04-10

申请号：KR1020150158405

申请日：2015-11-11

Applicant: 한국과학기술원

Inventor： 남윤성 ,  김지선 ,  사육능

IPC: A61K47/48 ,  G01N33/574 ,  A61K31/337 ,  A61K41/00 ,  A61K51/04

Abstract: 본발명은, 특정화학구조의반복단위를포함하고말단에친수성고분자결합되거나, 상기특정화학구조의반복단위가친수성고분자를연결기로하여결합되어있는양친매성고분자및 광감작제를포함하는고분자복합체와상기고분자복합체를포함한광역학적화학요법치료제에관한것이다.

公开(公告)号：KR1020140100640A

公开(公告)日：2014-08-18

申请号：KR1020130013354

申请日：2013-02-06

Applicant: 한국과학기술원

Inventor： 남윤성 ,  김지선 ,  박재윤

IPC: C08F28/00 ,  C08F297/00 ,  A61K47/48 ,  A61K9/127

CPC classification number: C08F273/00 ,  A61K9/10 ,  A61K47/34 ,  A61K47/50

Abstract: The present invention relates to an amphiphilic polymer which comprises a repeat unit of a specific chemical structure and is linked through amphiphilic polymers at the terminal end or comprises the repeat units of the specific chemical structure linked by the medium of amphiphilic polymers, and to a polymeric micelle composition including the amphiphilic polymer.

Abstract translation: 本发明涉及两亲性聚合物，其包含具有特定化学结构的重复单元，并且通过两末端聚合物在末端连接或包含通过两亲聚合物介质连接的特定化学结构的重复单元，以及聚合物 胶束组合物包括两亲性聚合物。

公开(公告)号：KR1020140091133A

公开(公告)日：2014-07-21

申请号：KR1020130002031

申请日：2013-01-08

Applicant: 한국과학기술원

Inventor： 남윤성 ,  이정유 ,  오미화 ,  김지선 ,  이수현

IPC: A61K47/48 ,  A61K9/127 ,  A61K48/00

CPC classification number: A61K9/127 ,  A61K47/56 ,  A61K48/005

Abstract: Disclosed are a controlled release gene delivery composition produced by solubilizing hydrophilic nucleic acid genes in an organic solvent and encapsulating the same in hydrophobic particles and a method for producing the same. The controlled release gene delivery composition according to an embodiment of the present invention comprises: a cationic and hydrophilic polymer grafted with hydrophobic molecules; and a gene composite which is produced by the bonding of genes on an organic solvent mixture. The cationic and hydrophilic polymer and gene composite are dispersed on the organic solvent so as to be easily encapsulated in nano particles.

Abstract translation: 公开了通过将亲水性核酸基因溶解在有机溶剂中并将其包封在疏水性颗粒中而产生的控释基因递送组合物及其制造方法。 根据本发明实施方案的控释基因递送组合物包含：用疏水性分子接枝的阳离子和亲水性聚合物; 以及通过在有机溶剂混合物上键合基因而产生的基因复合物。 将阳离子和亲水性聚合物和基因复合物分散在有机溶剂上以便容易地包封在纳米颗粒中。