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公开(公告)号：WO2010104237A1
公开(公告)日：2010-09-16
申请号：PCT/KR2009/002252
申请日：2009-04-29
IPC: C12N15/10
CPC classification number: C12N15/1136 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/51
Abstract: 본 발명은 에스아이알엔에이(small interfering RNA; siRNA) 다중 접합체 및 이의 제조방법에 관한 것으로, 보다 상세하게는 이중가닥 센스/안티센스(sense/antisense) siRNA 단량체를 직접 또는 가교제나 고분자를 매개로 한 공유결합을 통해 연결시킨 (-X-A-)n의 구조식(여기서, X는 이중가닥 siRNA 단량체; A는 있거나 없을 수 있으며, 가교제 또는 고분자를 의미함; 및 n은 이중가닥 siRNA 단량체의 개수)을 가지는 siRNA 다중 접합체, 및 이의 제조방법에 관한 것이다. 본 발명의 siRNA 다중 접합체 제조방법은 그 반응이 간단하고 효율이 높으며, 상기의 방법으로 제조된 siRNA 다중 접합체는 기존 siRNA 비해 분자량이 수배 이상으로 크기 때문에 음이온 전하 밀도가 높아 양이온성 유전자 전달체와의 이온성 결합력이 우수하여 유전자 전달 효율을 현저히 높일 수 있다.
Abstract translation: 本发明涉及多聚体小干扰RNA（siRNA）及其制备方法。 更具体地说，本发明涉及具有结构式（-XA-）n的多聚体siRNA（其中X是双链siRNA单体，A可以存在或不存在，代表交联剂或聚合物，n是 通过双链正义/反义siRNA单体通过直接，交联或聚合物介导的共价键连接的双链siRNA单体及其制备方法。 在本发明的多聚体siRNA的制备方法中，反应简单且高效。 由于通过所述方法制备的多聚体siRNA的分子量大于现有siRNA的分子量几倍或更多，因为阴离子电荷密度高，因此与阳离子基因载体的离子键合力显示出极好的性能，因此能显着改善 基因传递的效率。
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公开(公告)号：KR1020100103206A
公开(公告)日：2010-09-27
申请号：KR1020090021705
申请日：2009-03-13
Applicant: 한국과학기술원
CPC classification number: C12N15/1136 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/51
Abstract: PURPOSE: A siRNA multi-conjugate and a method for preparing the same are provided to ensure simple reaction and high efficiency and to enhance gene transfer effieciency. CONSTITUTION: A siRNA multi-conjugate is connected by covalent bond mediated by cross-linking agent or polymer or directly by double stranded sense/antisense siRNA monomer. The siRNA multi-conjugate has a structural formula 1((-X-)n). A method for preparing the siRNA multi-conjugate comprises: a step of preparing yXy by complementary hydrogen bond of single stranded sense/antisense siRNA monomer(yx + x'y); and a step of performing covalent bond of yXy by cross-linking agent or polymer.
Abstract translation: 目的：提供siRNA多偶联物及其制备方法，以确保简单的反应和高效率，并提高基因转移效率。 构成：通过由交联剂或聚合物介导的共价键或直接由双链有义/反义siRNA单体连接siRNA多偶联物。 siRNA多偶联物具有结构式1（（ - X-）n）。 制备siRNA多偶联物的方法包括：通过单链有义/反义siRNA单体（yx + x'y）的互补氢键制备yXy的步骤; 以及通过交联剂或聚合物进行yXy的共价键的步骤。
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公开(公告)号：KR101113007B1
公开(公告)日：2012-03-13
申请号：KR1020100015204
申请日：2010-02-19
IPC: H01L51/42
CPC classification number: Y02E10/549 , Y02P70/521
Abstract: 본 발명의 태양 전지는 투광성을 지닌 기판부의 양측에 위치하는 제1 광전변환유닛과 제2 광전변환유닛을 포함하며, 상기 제1 광전변환유닛은 투광성을 지닌 제1 전극부, 투광성을 지닌 제2 전극부, 및 상기 제1 전극부와 상기 제2 전극부 사이에 위치하는 제1 광전변환층을 포함하고, 제2 광전변환유닛은 투광성을 지닌 제3 전극부, 제4 전극부 및 상기 제1 전극부와 상기 제2 전극부 사이에 위치하는 제2 광전변환층을 포함한다.
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公开(公告)号：KR1020100111994A
公开(公告)日：2010-10-18
申请号：KR1020090030509
申请日：2009-04-08
Applicant: 한국과학기술원
CPC classification number: G06Q50/2053 , G06Q50/10
Abstract: PURPOSE: A method for enrolling in classes using geographic information is provided to use mapped school geographic information and enables a user to visually perform enrollment in classes, thereby user can recognize accurate location information about the lectures. CONSTITUTION: A first lecture is selected when enrolling in classes by using online(S220). By using geographic information mapped with the selected first lecture, whether the selected first lecture is relevant to constraint condition of geographic information(S230). If the geographic information does not satisfies the first lecture, an announcement is outputted(S250). A finial selecting signal is received as considering the selected first lecture as a lecture of enrollment of classes. Signal selecting other lecture is received.
Abstract translation: 目的：提供使用地理信息登记课程的方法，以使用映射的学校地理信息，并使用户能够在视觉上执行课堂注册，从而用户可以识别有关讲座的准确位置信息。 规定：在网上注册上课时，选择第一次讲座（S220）。 通过使用与所选择的第一讲座映射的地理信息，所选择的第一讲座是否与地理信息的约束条件相关（S230）。 如果地理信息不满足第一讲义，则输出通知（S250）。 考虑到所选择的第一个讲座作为课程的入学讲座，收到了一个完整的选择信号。 收到信号选择其他讲座。
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公开(公告)号：KR1020100109770A
公开(公告)日：2010-10-11
申请号：KR1020090028196
申请日：2009-04-01
Applicant: 한국과학기술원
IPC: G06Q50/20
CPC classification number: G06Q50/2053
Abstract: PURPOSE: A method for registering for courses by point allocation is provided to supply a change for enabling users to register for courses that the users want under fair conditions. CONSTITUTION: A lecture for course registration is selected(S220). Points are allocated within the limit of previously provided points for the selected lecture(S230). The same amount of points is assigned to all people who want to register for courses online. The points that the people hold are displayed. If points are allocated to the selected lecture, the points that the people hold are deducted.
Abstract translation: 目的：提供一种通过点分配进行课程注册的方法，以提供更改，使用户能够在公平条件下注册用户想要的课程。 规定：选择课程注册讲座（S220）。 积分在先前提供的选定讲座的限制内分配（S230）。 所有想要在线注册课程的人都分配相同数量的积分。 显示了人们所持有的观点。 如果点数分配给选定的讲座，则扣除人员所持有的积分。
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Patent Agency Ranking6.发明公开아자인돌 유도체 화합물, 이를 포함하는 c-KIT 저해제 조성물 및 c-KIT와 관련된 질환의 치료용 약학 조성물 有权酰胺衍生物，C-kit抑制组合物和药物组合物，用于治疗与包含其的C-kit连接的疾病
公开(公告)号：KR1020150114673A
公开(公告)日：2015-10-13
申请号：KR1020140039115
申请日：2014-04-02
Applicant: 한국과학기술원
IPC: A61K31/437 , A61K31/4427 , A61P35/02 , A61P35/00
CPC classification number: A61K31/437 , A61K31/4427
Abstract: 본발명은하기 [화학식 1]로표시되는아자인돌유도체, 이를유효성분으로포함하는 c-KIT D816V 돌연변이및 c-KIT 야생형(WT) 저해용조성물에관한것으로서, 본발명에따른조성물은 c-KIT WT뿐만아니라 c-KIT D816V 돌연변이의발현을유효하게저해할수 있고, 이에따라서 c-KIT D816V 돌연변이및 c-KIT 야생형(WT)과관련된질환, 특히암 치료용으로사용할수 있다. [화학식 1]
Abstract translation: 本发明涉及由化学式1表示的氮杂吲哚衍生物化合物，其包含与活性成分相同的c-kit D816V突变体和c-kit野生型（WT）抑制剂组合物。 根据本发明的组合物可以有效地抑制c-kit D816V突变体以及c-kit WT的表达，因此可用于治疗c-kit D816V突变体和c-kit WT相关疾病，特别是 ，癌症。
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公开(公告)号：KR1020110083919A
公开(公告)日：2011-07-21
申请号：KR1020100003901
申请日：2010-01-15
Applicant: 한국과학기술원
IPC: C12N15/11 , C07H21/02 , A61K31/7105 , A61K47/48
CPC classification number: C12N15/11 , A61K31/7105 , C07H21/02
Abstract: PURPOSE: A siRNA multi-conjugate which targets multiple genes and a method for preparing the same are provided to improve gene delivery efficiency and to deliver siRNA of various sequences to cells. CONSTITUTION: A siRNA multi-conjugate which targets multiple genes has a structure formula 1(-(X1-A)n1 - (X2-A)n2 - (X3-A)n3 - (X3-A)n3 - ... - (Xi-A)ni-) or 2(x - A-(X1-A)n1 - (X2-A)n2 - (X3-A)n3 - (X3-A)n3 -...- (Xi-A)ni - x') which is connected through covalent bond of two or more kinds of double strand sense/antisense siRNA monomer with a crosslinking agent or polymers. The double strand sense/antisense siRNA monomer has 15-29 bases. The siRNA multi-conjugate targets surviving and Bcl-2. The multi-conjugate further contains a cell selective ligand at the end.
Abstract translation: 目的：提供靶向多种基因的siRNA多偶联物及其制备方法，以改善基因传递效率，并将各种序列的siRNA递送至细胞。 构成：靶向多个基因的siRNA多偶联物具有结构式1（ - （X1-A）n1 - （X2-A）n2 - （X3-A）n3 - （X3-A）n3 - （X-A）ni-）或2（x-A-（X1-A）n1 - （X2-A）n2 - （X3-A）n3 - （X3-A）n3 -...-（Xi- A）ni-x'），其通过两种或更多种双链有义/反义siRNA单体的共价键与交联剂或聚合物连接。 双链有义/反义siRNA单体具有15-29个碱基。 siRNA多重共轭靶向存活和Bcl-2。 多结合物在末端还含有细胞选择性配体。
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8.发明授权아자인돌 유도체 화합물, 이를 포함하는 c-KIT 저해제 조성물 및 c-KIT와 관련된 질환의 치료용 약학 조성물 有权c-KIT c-Kit靛蓝衍生物c-KIT抑制剂组合物和用于治疗与包含其的c-KIT相关的疾病的药物组合物
公开(公告)号：KR101662597B1
公开(公告)日：2016-10-05
申请号：KR1020140039115
申请日：2014-04-02
Applicant: 한국과학기술원
IPC: A61K31/437 , A61K31/4427 , A61P35/02 , A61P35/00
Abstract: 본발명은하기 [화학식 1]로표시되는아자인돌유도체, 이를유효성분으로포함하는 c-KIT D816V 돌연변이및 c-KIT 야생형(WT) 저해용조성물에관한것으로서, 본발명에따른조성물은 c-KIT WT뿐만아니라 c-KIT D816V 돌연변이의발현을유효하게저해할수 있고, 이에따라서 c-KIT D816V 돌연변이및 c-KIT 야생형(WT)과관련된질환, 특히암 치료용으로사용할수 있다. [화학식 1]
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9.发明公开친수성 핵산 유전자를 유기용매에 가용화시키고, 이를 소수성 미립자에 봉입한 제어방출형 유전자 전달용 복합체와 이의 제조방법 有权通过将有机溶剂溶解在有机溶剂中，通过将其渗透到疏水性纳米微粒和微粒中而制备的受控释放的基因输送组合物及其方法
公开(公告)号：KR1020140091133A
公开(公告)日：2014-07-21
申请号：KR1020130002031
申请日：2013-01-08
Applicant: 한국과학기술원
CPC classification number: A61K9/127 , A61K47/56 , A61K48/005
Abstract: Disclosed are a controlled release gene delivery composition produced by solubilizing hydrophilic nucleic acid genes in an organic solvent and encapsulating the same in hydrophobic particles and a method for producing the same. The controlled release gene delivery composition according to an embodiment of the present invention comprises: a cationic and hydrophilic polymer grafted with hydrophobic molecules; and a gene composite which is produced by the bonding of genes on an organic solvent mixture. The cationic and hydrophilic polymer and gene composite are dispersed on the organic solvent so as to be easily encapsulated in nano particles.
Abstract translation: 公开了通过将亲水性核酸基因溶解在有机溶剂中并将其包封在疏水性颗粒中而产生的控释基因递送组合物及其制造方法。 根据本发明实施方案的控释基因递送组合物包含：用疏水性分子接枝的阳离子和亲水性聚合物; 以及通过在有机溶剂混合物上键合基因而产生的基因复合物。 将阳离子和亲水性聚合物和基因复合物分散在有机溶剂上以便容易地包封在纳米颗粒中。
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公开(公告)号：KR1020110095630A
公开(公告)日：2011-08-25
申请号：KR1020100015204
申请日：2010-02-19
IPC: H01L51/42
CPC classification number: Y02E10/549 , Y02P70/521 , H01L51/42
Abstract: PURPOSE: A tandem type solar cell including organic photoelectric conversion materials is provided to improve photoelectric conversion efficiency by reducing a refractive index between a first substrate and a second substrate through a transmissive combination unit including a pressure sensitive adhesive film. CONSTITUTION: A first photoelectric conversion unit(200) includes a first electrode unit(210), a first photoelectric conversion layer(230), and a second electrode unit(250). A second photoelectric conversion unit(300) includes a third electrode unit(310), a second photoelectric conversion layer(330), and a fourth electrode unit(350). The first photoelectric conversion unit and the second photoelectric conversion unit are located on both sides of a substrate unit(100). The substrate unit includes a first substrate and a second substrate.
Abstract translation: 目的：提供包括有机光电转换材料的串联型太阳能电池，以通过包括压敏粘合剂膜的透射组合单元降低第一基板和第二基板之间的折射率来提高光电转换效率。 构成：第一光电转换单元（200）包括第一电极单元（210），第一光电转换层（230）和第二电极单元（250）。 第二光电转换单元（300）包括第三电极单元（310），第二光电转换层（330）和第四电极单元（350）。 第一光电转换单元和第二光电转换单元位于基板单元（100）的两侧。 基板单元包括第一基板和第二基板。
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