公开(公告)号：KR1020140086213A

公开(公告)日：2014-07-08

申请号：KR1020120156419

申请日：2012-12-28

Applicant: 한국식품연구원

Inventor： 권대영 ,  김명선 ,  김현진 ,  허행전 ,  박수진 ,  한안나

IPC: A61K31/519 ,  A61K31/407 ,  A61P3/04

CPC classification number: A61K31/519 ,  A23L33/10 ,  A61K31/407 ,  Y10S514/866 ,  Y10S514/886

Abstract: The present invention relates to a composition for treating obesity-induced inflammation, wherein the composition contains evodiamine as an active ingredient. The composition of the present invention induces the expression of adiponectin and decreases the expression of IL-6 and MCP-1 which are involved in obesity-mediated inflammation reaction so that obesity-induced inflammation can be prevented and treated.

Abstract translation: 本发明涉及一种用于治疗肥胖症的炎症的组合物，其中该组合物含有作为活性成分的吴茱萸碱。 本发明的组合物诱导脂联素的表达并降低参与肥胖介导的炎症反应的IL-6和MCP-1的表达，从而可以预防和治疗肥胖诱发的炎症。

公开(公告)号：KR1020140086210A

公开(公告)日：2014-07-08

申请号：KR1020120156408

申请日：2012-12-28

Applicant: 한국식품연구원

Inventor： 권대영 ,  김명선 ,  김현진 ,  허행전 ,  박수진 ,  한안나

IPC: A61K31/47 ,  A61K31/435 ,  A61P3/04 ,  A61P29/00

CPC classification number: A61K31/4741 ,  A23L33/10 ,  A61K31/4748 ,  Y10S514/866 ,  Y10S514/886 ,  Y10S514/909

Abstract: The present invention relates to a composition for treating obesity-induced inflammation, wherein the composition contains tetrandrine as an active ingredient. The composition of the present invention induces the expression of adiponectin and decreases the expression of IL-6 and MCP-1 which are involved in obesity-mediated inflammation reaction so that obesity-induced inflammation can be prevented and treated.

Abstract translation: 本发明涉及一种用于治疗肥胖症引起的炎症的组合物，其中该组合物含有四片丹宁作为活性成分。 本发明的组合物诱导脂联素的表达并降低参与肥胖介导的炎症反应的IL-6和MCP-1的表达，从而可以预防和治疗肥胖诱发的炎症。

公开(公告)号：KR1020140006376A

公开(公告)日：2014-01-16

申请号：KR1020120073081

申请日：2012-07-04

Applicant: 한국식품연구원

Inventor： 성미정 ,  성기승 ,  황진택 ,  박재호 ,  김명선 ,  김병목 ,  이경원 ,  김성희 ,  다와세렌,뭉크투스 ,  신은주 ,  박수진

IPC: A61K31/404 ,  A61K31/4025 ,  A61P35/00 ,  A61P25/28

CPC classification number: A61K31/404 ,  A23L29/045 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  Y10S514/886

Abstract: The present invention relates to a pharmaceutical composition containing 3,3'-Diindolymethane as an active ingredient for preventing and treating inflammatory diseases and angiogenesis inhibitory activity. According to the present invention, the 3,3'-Diindolymethane has an excellent effect in inhibiting angiogenesis and inflammation, thereby being used as the active ingredient in the pharmaceutical composition and health functional food for preventing and treating inflammatory diseases. [Reference numerals] (AA,EE,II,MM) Normal group; (BB,FF,JJ,NN) Control group; (CC,GG,KK,OO) Experimental group 1; (DD,HH,LL,PP) Experimental group 2

Abstract translation: 本发明涉及含有3,3'-二取代甲烷作为预防和治疗炎性疾病和血管生成抑制活性的活性成分的药物组合物。 根据本发明，3,3'-二聚甲烷在抑制血管发生和炎症中具有优异的效果，因此用作用于预防和治疗炎性疾病的药物组合物和保健功能食品中的活性成分。 （标号）（AA，EE，II，MM）正常组; （BB，FF，JJ，NN）对照组; （CC，GG，KK，OO）实验组1; （DD，HH，LL，PP）实验组2

公开(公告)号：KR101349089B1

公开(公告)日：2014-01-10

申请号：KR1020120021489

申请日：2012-02-29

Applicant: 한국식품연구원

Inventor： 허행전 ,  양혜정 ,  이경원 ,  박수진 ,  한안나

IPC: A61K31/357 ,  A61K31/35 ,  A61K31/352 ,  A61P3/04

Abstract: 본 발명은 바바치닌 A를 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 예방 및 치료용 약학적 조성물과 건강기능식품에 관한 것으로 본 발명에 따른 바바치닌 A는 지방세포분화 저해 효과가 우수하므로, 이를 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 예방 및 치료용 약학적 조성물과 건강기능식품으로 사용할 수 있다.

公开(公告)号：KR1020130099754A

公开(公告)日：2013-09-06

申请号：KR1020120021490

申请日：2012-02-29

Applicant: 한국식품연구원

Inventor： 허행전 ,  양혜정 ,  이경원 ,  박수진 ,  한안나

IPC: A61K31/122 ,  A61K9/16 ,  A61K9/20 ,  A61P3/04

Abstract: PURPOSE: A composition containing deoxyshikonin for preventing and treating obesity or lipid metabolic disorders is provided to effectively suppress adipocyte differentiation. CONSTITUTION: A pharmaceutical composition for preventing and treating obesity or lipid metabolic disorders contains deoxyshikonin as an active ingredient. The metabolic disorders are selected among diabetes, hyperlipidemia, fatty liver, arteriosclerosis, hypertension, cardiovascular disease, and metabolic syndrome. Deoxyshikonin suppresses adipocyte differentiation. A health food for preventing obesity or lipid-related metabolic disorders or alleviating symptoms thereof contains deoxyshikonin as an active ingredient. [Reference numerals] (AA) Neutral lipid (absorbance); (BB) Normal; (CC) Control group; (DD) Deoxyshikonin

Abstract translation: 目的：提供含有去氧喜草素预防和治疗肥胖症或脂质代谢紊乱的组合物，以有效抑制脂肪细胞分化。 构成：用于预防和治疗肥胖或脂质代谢紊乱的药物组合物含有脱氧喜树碱作为活性成分。 代谢紊乱选自糖尿病，高脂血症，脂肪肝，动脉硬化，高血压，心血管疾病和代谢综合征。 去氧喜树碱抑制脂肪细胞分化。 用于预防肥胖或与脂质有关的代谢紊乱或减轻其症状的保健食品含有脱氧喜树碱作为活性成分。 （AA）中性脂质（吸光度）; （BB）正常; （CC）对照组; （DD）Deoxyshikonin

公开(公告)号：KR1020130099753A

公开(公告)日：2013-09-06

申请号：KR1020120021489

申请日：2012-02-29

Applicant: 한국식품연구원

Inventor： 허행전 ,  양혜정 ,  이경원 ,  박수진 ,  한안나

IPC: A61K31/357 ,  A61K31/35 ,  A61K31/352 ,  A61P3/04

Abstract: PURPOSE: A composition containing bavachinin A for preventing and treating obesity or lipid metabolic disorders is provided to effectively suppress adipocyte differentiation. CONSTITUTION: A pharmaceutical composition for preventing and treating obesity or lipid metabolic disorders contains bavachinin A as an active ingredient. The lipid metabolic disorder is selected among diabetes, hyperlipidemia, fatty liver, arteriosclerosis, hypertension, cardiovascular disease, and metabolic syndrome. Bavachinin A suppresses adipocyte differentiation. A health food for preventing obesity or lipid metabolic disorders contains bavachinin A as an active ingredient. [Reference numerals] (AA) Neutral lipid (absorbance); (BB) Normal; (CC) Control group; (DD) Bavachinin A

Abstract translation: 目的：提供含有巴伐他丁A用于预防和治疗肥胖症或脂质代谢紊乱的组合物以有效抑制脂肪细胞分化。 构成：用于预防和治疗肥胖或脂质代谢紊乱的药物组合物含有巴伐他丁作为活性成分。 脂代谢紊乱选自糖尿病，高脂血症，脂肪肝，动脉硬化，高血压，心血管疾病和代谢综合征。 巴伐他汀A抑制脂肪细胞分化。 用于预防肥胖或脂质代谢紊乱的保健食品含有巴伐他丁A作为活性成分。 （AA）中性脂质（吸光度）; （BB）正常; （CC）对照组; （DD）巴伐他汀A

公开(公告)号：KR1020140086186A

公开(公告)日：2014-07-08

申请号：KR1020120156374

申请日：2012-12-28

Applicant: 한국식품연구원

Inventor： 허행전 ,  양혜정 ,  이경원 ,  박수진 ,  한안나

IPC: A61K31/195 ,  A61K31/198 ,  A61P29/00 ,  A61P3/04

Abstract: The present invention relates to a composition for treating obesity-induced inflammation, wherein the composition contains S-aryl cysteine as an active ingredient. The composition of the present invention induces the expression of adiponectin and decreases the expression of IL-6 and MCP-1 which are involved in obesity-mediated inflammation reaction so that obesity-induced inflammation can be prevented and treated.

Abstract translation: 本发明涉及一种用于治疗肥胖症引起的炎症的组合物，其中该组合物含有S-芳基半胱氨酸作为活性成分。 本发明的组合物诱导脂联素的表达并降低参与肥胖介导的炎症反应的IL-6和MCP-1的表达，从而可以预防和治疗肥胖诱发的炎症。