公开(公告)号：KR1020130078309A

公开(公告)日：2013-07-10

申请号：KR1020110147176

申请日：2011-12-30

Applicant: 한국식품연구원

Inventor： 황진택 ,  성미정 ,  박재호 ,  왕수옥 ,  다와세렌,뭉크투스 ,  윤여초 ,  김종찬 ,  허진영 ,  박수진 ,  손희진

IPC: A61K31/35 ,  A61K31/352 ,  A61P11/02

Abstract: PURPOSE: A pharmaceutical composition containing luteolin as an active ingredient for preventing and treating hyperosmia is provided to suppress recognition of disgusting smell from various olfactory stimulants by suppressing or reducing cyclic AMP (cAMP) generation, thereby effectively preventing and treating hyperosmia. CONSTITUTION: A pharmaceutical composition for preventing and treating hyperosmia contains luteolin as an active ingredient. Luteolin reduces cAMP concentration. The pharmaceutical composition is manufactured in a formulation selected from a group consisted of an oral formulation, an external use formulation, a suppository, a sterilized injection solution, and a spray. A health functional food for preventing and alleviating hyperosmia contains luteolin as an active ingredient. An aroma composition contains luteolin as an active ingredient.

Abstract translation: 目的：提供含有木犀草素作为预防和治疗高血压的有效成分的药物组合物，通过抑制或减少环AMP（cAMP）的产生来抑制各种嗅觉兴奋剂对恶心呕吐的认识，从而有效预防和治疗高血糖。 构成：用于预防和治疗高血糖的药物组合物含有木犀草素作为活性成分。 木犀草素降低cAMP浓度。 药物组合物以选自口服制剂，外用制剂，栓剂，灭菌注射液和喷雾剂的组合物制成。 用于预防和缓解高血糖症的健康功能食品含有木犀草素作为活性成分。 芳香组合物含有木犀草素作为活性成分。

公开(公告)号：KR1020140006376A

公开(公告)日：2014-01-16

申请号：KR1020120073081

申请日：2012-07-04

Applicant: 한국식품연구원

Inventor： 성미정 ,  성기승 ,  황진택 ,  박재호 ,  김명선 ,  김병목 ,  이경원 ,  김성희 ,  다와세렌,뭉크투스 ,  신은주 ,  박수진

IPC: A61K31/404 ,  A61K31/4025 ,  A61P35/00 ,  A61P25/28

CPC classification number: A61K31/404 ,  A23L29/045 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  Y10S514/886

Abstract: The present invention relates to a pharmaceutical composition containing 3,3'-Diindolymethane as an active ingredient for preventing and treating inflammatory diseases and angiogenesis inhibitory activity. According to the present invention, the 3,3'-Diindolymethane has an excellent effect in inhibiting angiogenesis and inflammation, thereby being used as the active ingredient in the pharmaceutical composition and health functional food for preventing and treating inflammatory diseases. [Reference numerals] (AA,EE,II,MM) Normal group; (BB,FF,JJ,NN) Control group; (CC,GG,KK,OO) Experimental group 1; (DD,HH,LL,PP) Experimental group 2

Abstract translation: 本发明涉及含有3,3'-二取代甲烷作为预防和治疗炎性疾病和血管生成抑制活性的活性成分的药物组合物。 根据本发明，3,3'-二聚甲烷在抑制血管发生和炎症中具有优异的效果，因此用作用于预防和治疗炎性疾病的药物组合物和保健功能食品中的活性成分。 （标号）（AA，EE，II，MM）正常组; （BB，FF，JJ，NN）对照组; （CC，GG，KK，OO）实验组1; （DD，HH，LL，PP）实验组2

公开(公告)号：KR1020130078326A

公开(公告)日：2013-07-10

申请号：KR1020110147201

申请日：2011-12-30

Applicant: 한국식품연구원

Inventor： 권대영 ,  성미정 ,  황진택 ,  박재호 ,  양혜정 ,  김명선 ,  김현진 ,  허행전 ,  왕수옥 ,  다와세렌,뭉크투스 ,  윤석후

IPC: A61K31/353 ,  A61K9/08 ,  A61P17/00

Abstract: PURPOSE: A pharmaceutical composition containing auraptene as an active ingredient for promoting angiogenesis is provided to promote angiogenesis by auraptene, and to effectively regenerate tissues through skin flap regeneration, wound and burn healing, and artificial skin transplantation. CONSTITUTION: A pharmaceutical composition for promoting angiogenesis contains 1-10 micromole of auraptene as an active ingredient. Auraptene promotes tissue regeneration. The pharmaceutical composition is used for skin flap regeneration, wound and burn healing, artificial skin transplantation, or preparation of blood vessels for transplantation. A food composition for promoting angiogenesis contains auraptene as an active ingredient. Auraptene promotes angiogenesis. [Reference numerals] (AA) Control group; (BB) Auraptene 1μM; (CC) Auraptene 5μM; (DD) Auraptene 10μM; (EE) Auraptene 40μM

Abstract translation: 目的：提供含有紫罗烯作为促进血管发生的活性成分的药物组合物，用于促进紫罗烯烯的血管生成，并通过皮瓣再生，伤口和烧伤愈合以及人造皮肤移植有效地再生组织。 构成：用于促进血管发生的药物组合物含有1-10微摩尔的奥来哌啶作为活性成分。 Auraptene促进组织再生。 药物组合物用于皮瓣再生，伤口和烧伤愈合，人造皮肤移植或用于移植的血管制备。 用于促进血管生成的食品组合物含有作为活性成分的紫罗烯。 Auraptene促进血管生成。 （附图标记）（AA）对照组; （BB）Auraptene1μM; （CC）Auraptene5μM; （DD）Auraptene10μM; （EE）Auraptene40μM

公开(公告)号：KR1020140006375A

公开(公告)日：2014-01-16

申请号：KR1020120073079

申请日：2012-07-04

Applicant: 한국식품연구원

Inventor： 성미정 ,  성기승 ,  황진택 ,  박재호 ,  김명선 ,  김병목 ,  이경원 ,  김성희 ,  다와세렌,뭉크투스 ,  신은주 ,  박수진

IPC: A61K31/26 ,  A61K9/20 ,  A61K9/48 ,  A61P35/00

Abstract: The present invention relates to a composition containing Allyl isothiocyanate as an active ingredient for preventing and treating angiogenesis. According to the present invention, the Allyl isothiocyanate has an excellent effect in inhibiting angiogenesis, thereby being used as the active ingredient in a pharmaceutical composition and health functional food for preventing and treating angiogenesis. [Reference numerals] (AA,CC,GG,KK) Normal group; (BB,DD,HH,LL) Control group; (EE,II,MM) Experimental group 1; (FF,JJ,NN) Experimental group 2

Abstract translation: 本发明涉及含有异硫氰酸烯丙酯作为预防和治疗血管发生的活性成分的组合物。 根据本发明，异硫氰酸烯丙酯在抑制血管发生中具有极好的效果，因此用作用于预防和治疗血管发生的药物组合物和保健功能食品中的活性成分。 （标号）（AA，CC，GG，KK）正常组; （BB，DD，HH，LL）对照组; （EE，II，MM）实验组1; （FF，JJ，NN）实验组2

公开(公告)号：KR101322937B1

公开(公告)日：2013-10-28

申请号：KR1020110147201

申请日：2011-12-30

Applicant: 한국식품연구원

Inventor： 권대영 ,  성미정 ,  황진택 ,  박재호 ,  양혜정 ,  김명선 ,  김현진 ,  허행전 ,  왕수옥 ,  다와세렌,뭉크투스 ,  윤석후

IPC: A61K31/353 ,  A61K9/08 ,  A61P17/00

Abstract: 본 발명은 어랩틴(Auraptene)을 유효성분으로 함유하는 신생혈관 촉진용 약학조성물에 관한 것으로, 본 발명에 의한 신생혈관 촉진용 약학조성물은 유효성분인 어랩틴에 의해 혈관 신생을 촉진시켜 피부판 재생, 상처 및 화상치유, 인공피부이식 및 이식용 혈관 제조 등의 조직 재생에 효과적이다.