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公开(公告)号：KR1020120122709A
公开(公告)日：2012-11-07
申请号：KR1020110041035
申请日：2011-04-29
Applicant: 한국식품연구원 , 경기대학교 산학협력단
IPC: A61K36/888 , A61P35/00 , A23L33/00
CPC classification number: A61K36/888 , A23V2200/324 , Y10S514/885
Abstract: PURPOSE: A pharmaceutical composition and a health functional food containing taro extract for enhancing immune system are provided to be used as a therapeutic agent for anticancer and anti-metastasis. CONSTITUTION: A pharmaceutical composition for enhancing immune system contains polymer saccharides of chemical formula 1 as an active ingredient. A health functional food for enhancing immune system contains the polymer saccharides as an active ingredient. A pharmaceutical composition for anti-metastasis contains the polymer polysaccharides of chemical formula 1 as an active ingredient. A pharmaceutical composition for enhancing immune system contains taro exract as an active ingredient. The taro extract contains galactose and mannose. A health functional food for enhancing immune system contains the taro extract as an active ingredient.
Abstract translation: 目的：提供用于增强免疫系统的药物组合物和含芋头提取物的保健功能食品，用作抗癌和抗转移的治疗剂。 构成：用于增强免疫系统的药物组合物含有化学式1的聚合物糖作为活性成分。 用于增强免疫系统的健康功能食品含有聚合物糖作为活性成分。 用于抗转移的药物组合物含有化学式1的聚合物多糖作为活性成分。 用于增强免疫系统的药物组合物含有芋头作为活性成分。 芋头提取物含有半乳糖和甘露糖。 用于增强免疫系统的保健功能食品含有芋头提取物作为活性成分。
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12.发明公开
公开(公告)号：KR1020140120808A
公开(公告)日：2014-10-14
申请号：KR1020130167856
申请日：2013-12-30
Applicant: 한국식품연구원 , 경기대학교 산학협력단
CPC classification number: A61K39/39 , A23L33/10 , A23L33/105 , A23L33/22 , A23V2002/00 , A61K2039/55583
Abstract: 본 발명은 면역 증강 활성 및 항종양 활성이 있는 감잎 유래 다당 분획물 및 이의 제조방법에 관한 것으로, 더 상세하게는전체 다당 분획물 대비 중성 다당(neutral sugar)은 60 내지 80 중량%, 우론산(uronic acid)은 18 내지 39 중량%, KDO(3-deoxy-D-manno-2- octulosonic acid) 유사 물질은 0.5 내지 10 중량% 인 것을 특징으로 하는 감잎 유래 다당 분획물인 것을 특징으로 하는 감잎 유래 다당 분획물, 이의 제조방법 및 이의 용도에 관한 것이다.
본 발명의 감잎 유래 다당 분획물은 인터루킨-6, 12 및 TNF-α의 생성을 촉진하여 면역 기능을 증진시키고, 대식세포에 대해 뚜렷한 독성이 없으며, 자연살해세포의 활성을 증가시키며, 암세포의 전이를 억제하는 효능을 나타내는 바, 면역 증강용 또는 암 개선용 식품용 조성물, 면역력 저하로 인한 질환의 예방 또는 치료용 약학적 조성물 및 암 예방 또는 치료용 약학적 조성물의 제조에 효과적이다.Abstract translation: 本发明涉及具有免疫增强活性和抗肿瘤活性的柿叶衍生多糖级分及其制备方法，更具体地涉及具有免疫增强活性和抗肿瘤活性的柿叶衍生多糖级分及其制备方法， 使用它。 柿叶多糖馏分含有60-80重量％的中性糖，18-39重量％的糖醛酸和0.5-10重量％的类似于3-脱氧-D-壬酰基-2-辛氧酸的物质（ KDO）。 根据本发明，柿叶衍生的多糖部分促进白细胞介素-6和TNF-α的产生以提高免疫功能，对巨噬细胞没有明显的毒性，增加了自然杀伤细胞的活性，并且显示出 抑制癌细胞的扩散，从而有效地用于产生免疫增强或控癌食物的组合物，用于预防或治疗由免疫力下降引起的疾病的药物组合物，或用于预防或治疗癌症的药物组合物。
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公开(公告)号：KR1020130121783A
公开(公告)日：2013-11-06
申请号：KR1020130118568
申请日：2013-10-04
Applicant: 한국식품연구원 , 경기대학교 산학협력단
IPC: A61K31/702 , A61K31/70 , A61K36/888 , A61P35/00
CPC classification number: A61K31/715 , A23L29/30 , A23V2200/308 , A61K36/888
Abstract: The present invention relates to a pharmaceutical composition and health functional food comprising taro extract as an active ingredient, and the pharmaceutical composition and health functional food comprising taro extract by the present invention can be used as an anticancer medicine and an anti-metastasis treating agent by having an anti-complement activity function, a macrophage or a natural killer cell activity funftion, and thereby activating immune system and having effectively reduing spread of cancel cell.
Abstract translation: 本发明涉及包含芋头提取物作为活性成分的药物组合物和保健功能食品，含有本发明的芋头提取物的药物组合物和保健功能食品可以用作抗癌药和抗转移治疗剂 具有抗补体活性功能，巨噬细胞或天然杀伤细胞活性功能，从而激活免疫系统并有效减少消除细胞的扩散。
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公开(公告)号：KR1020130070396A
公开(公告)日：2013-06-27
申请号：KR1020110137702
申请日：2011-12-19
Applicant: 한국식품연구원
IPC: A23L1/30 , A23L19/00 , A61K36/752
CPC classification number: A23L19/00 , A23L5/25 , A23V2002/00 , A23V2200/324 , A23V2250/21 , A23V2250/51 , A61K36/752
Abstract: PURPOSE: A manufacturing method of a citrus peel originated polysaccharide fraction is provided to improve an immune function of strengthening the activity of a complement system to the citrus peel originated polysaccharide fraction. CONSTITUTION: Citrus peel is bleached. The bleached citrus peel is extracted with alcohol with 1-4 carbons. A polysaccharide is precipitated by adding the alcohol with 1-4 carbons to the extract. The precipitated polysaccharide is collected and is treated with a pectin hydrolysis enzyme. A polysaccharide fraction is manufactured by collecting the fractions in the molecular weight of 100-200kDa in the polysaccharide fraction treated with the enzyme. The citrus peel originated polysaccharide fraction has the carbohydrate content consisting of 2-6mole% of rhamnose, 20-25mole% of arabinose, 1-5mole% of mannose, 1-5mole% of xylose, 15-20mole% of glucose, 10-17mole% of galactose, and 40-50mole% of galacturonic acid.
Abstract translation: 目的：提供柑橘皮起源的多糖级分的制造方法，以提高增强柑橘皮起源多糖级分的补体系统的活性的免疫功能。 构成：柑橘皮被漂白。 漂白的柑橘皮由具有1-4个碳原子的醇萃取。 通过向提取物中加入具有1-4个碳的醇而沉淀多糖。 收集沉淀的多糖并用果胶水解酶处理。 通过在用酶处理的多糖级分中收集分子量为100-200kDa的级分来制备多糖级分。 柑橘皮起源的多糖级分的碳水化合物含量为2-6毫摩尔％的鼠李糖，20-25摩尔％的阿拉伯糖，1-5摩尔％的甘露糖，1-5摩尔％的木糖，15-20摩尔％的葡萄糖，10-17摩尔 ％的半乳糖和40-50摩尔％的半乳糖醛酸。
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