公开(公告)号：KR1020090064942A

公开(公告)日：2009-06-22

申请号：KR1020070132330

申请日：2007-12-17

Applicant: 한국전자통신연구원

Inventor： 김용준 ,  신동호 ,  정문연 ,  박선희

IPC: G01N33/533 ,  G01N33/53

Abstract: A multiplex detection method on a microfluid chip is provided to detect a plurality of antigens at once by controlling fluorescent molecules. A multiplex detection method on a microfluid chip(100) comprises: a step of providing fluorescence particles(125) containing fluorescence molecules; a step of reacting a plurality of antigens with fluorescence particles through the movement of fluid sample to form antigen-fluorescence particle complex; a step of reacting a fixed antibodies with antigen-fluorescence particle complex to form antibody-antigen-fluorescence particle complex; and a step of measuring wave length and fluorescence sensitivity.

Abstract translation: 提供微流体芯片上的多重检测方法，通过控制荧光分子一次性检测多种抗原。 微流体芯片（100）的多重检测方法包括：提供含有荧光分子的荧光粒子（125）的工序; 通过流体样品的运动使多种抗原与荧光颗粒反应以形成抗原 - 荧光颗粒复合物的步骤; 使固定抗体与抗原 - 荧光粒子复合物反应形成抗体 - 抗原 - 荧光粒子复合物的步骤; 以及测量波长和荧光灵敏度的步骤。

公开(公告)号：KR1020090039127A

公开(公告)日：2009-04-22

申请号：KR1020070104585

申请日：2007-10-17

Applicant: 한국전자통신연구원

Inventor： 정문연 ,  신동호 ,  김용준 ,  정민숙 ,  김상희 ,  박선희

IPC: C12Q1/68

CPC classification number: B01L7/52 ,  G01N35/026

Abstract: An automatic diagnosis system is provided to perform chemical analysis not depending on experimenter by using microrobot, prevent mistake by experimenter, shorten analyzing time. An automatic diagnosis system(100) comprises a pre-treatment part(120), a polymerase chain reaction chamber(130), and a hybridization chamber(140) equipped in a substrate, a microrobot(150) connected to the substrate, and a control part(160) for controlling the pre-treatment part and the microrobot. And the automatic diagnosis system additionally comprises light source providing upper side and lower side of the substrate in the area in which the hybridization chamber is equipped, and image pick-up device.

Abstract translation: 提供自动诊断系统，通过使用微型机器进行化学分析，不依赖于实验者，防止实验者错误，缩短分析时间。 自动诊断系统（100）包括预处理部分（120），聚合酶链式反应室（130）和装在基板中的杂交室（140），连接到基板的微型机器人（150）和 用于控制预处理部分和微型机器人的控制部分（160）。 并且，自动诊断系统还包括在设置有杂交室的区域中提供衬底的上侧和下侧的光源和图像拾取装置。

公开(公告)号：KR100772519B1

公开(公告)日：2007-11-01

申请号：KR1020060056532

申请日：2006-06-22

Applicant: 한국전자통신연구원

Inventor： 정문연 ,  박세호 ,  신동호 ,  표현봉

IPC: G01N33/53 ,  G01N33/68 ,  G01N33/50

Abstract: 본 발명은 생체분자 결합 영역을 구비하는 막대 모양의 제 1 전극; 및 생체분자 결합 영역을 구비하는 막대 모양의 제 2 전극을 포함하고, 상기 제 1 전극 및 제 2 전극은 동일 평면상에서 비평행하게 이격되어 있고 상기 생체분자 결합 영역들은 서로 대향 배치되는 것을 특징으로 하는 생체분자 검출용 센서, 그를 포함하는 생체분자 검출 장치, 및 그를 이용한 생체분자 검출 방법을 제공한다. 본 발명에 따르면, 무한개의 이격거리를 갖는 전극 사이의 적어도 한 지점에 임의의 길이 또는 크기를 갖는 생체분자가 결합할 수 있으므로 다양한 또는 미지의 길이를 갖는 모든 생체분자를 검출할 수 있고, 따라서 생체분자의 검출 센서 또는 장치를 용이하게 설계 및 제작할 수 있다.
생체분자, 단백질, 항원-항체 반응, 전극, 비평형

公开(公告)号：KR1020070061187A

公开(公告)日：2007-06-13

申请号：KR1020060056532

申请日：2006-06-22

Applicant: 한국전자통신연구원

Inventor： 정문연 ,  박세호 ,  신동호 ,  표현봉

IPC: G01N33/53 ,  G01N33/68 ,  G01N33/50

Abstract: A sensor for detecting biomolecules, a device for detecting biomolecules comprising the same sensor, and a method for detecting the biomolecules by using the same sensor are provided to detect various or all biomolecules having an unknown length, so that the sensor or device for detecting biomolecules is easily designed and manufactured. The sensor for detecting biomolecules comprises: a first electrode(101) having a rod shape and containing a biomolecule-binding site; and a second electrode(102) having a rod shape and containing the biomolecule-binding site, wherein the first and second electrodes are separated in non-parallel on the same plane and the biomolecule-binding sites are disposed oppositely each other; the angle and distance between the first and second electrodes are 1-30 degree and 1-100 nm, respectively; and the first and second electrodes are made of Si, Au, Ti, Pt, Pd or TiN.

Abstract translation: 用于检测生物分子的传感器，用于检测包含相同传感器的生物分子的装置以及通过使用相同的传感器检测生物分子的方法被提供以检测具有未知长度的各种或所有生物分子，从而用于检测生物分子的传感器或装置 易于设计和制造。 用于检测生物分子的传感器包括：具有棒状并且包含生物分子结合位点的第一电极（101） 和具有棒状并且包含生物分子结合位点的第二电极（102），其中所述第一和第二电极在同一平面上不平行地分离，并且所述生物分子结合位点彼此相对地设置; 第一和第二电极之间的角度和距离分别为1-30度和1-100nm; 并且第一和第二电极由Si，Au，Ti，Pt，Pd或TiN制成。

公开(公告)号：KR1020070061184A

公开(公告)日：2007-06-13

申请号：KR1020060056528

申请日：2006-06-22

Applicant: 한국전자통신연구원

Inventor： 정문연 ,  신동호 ,  박세호 ,  표현봉 ,  전치훈

IPC: C12Q1/68

CPC classification number: C12Q1/6837

Abstract: A programmable mask for fabricating a biomolecule or polymer array, an apparatus for fabricating the biomolecule or polymer array comprising the same mask, and a method for fabricating the biomolecule or polymer array by using the same programmable mask are provided to obtain the array immobilizing high density of biomolecules or polymers, and reduce the time for fabrication of the array. The programmable mask for fabricating a biomolecule or polymer array comprises: a first substrate(410) containing a black matrix(430) having opening parts and a first pixel electrodes; a second substrate(400) containing thin layer transistors for switching the pixel area corresponding to the opening parts according to the applied electric signal, and second pixel electrodes connected to the drain electrodes of the thin layer transistors; a liquid crystal layer(420) formed between the first and second substrate, and having a liquid crystal which is selectively penetrate a light by changing the arrangement status according to the electric signal of the thin layer transistor; a first polarizing plate(445) accumulated in one side of the first substrate; a second polarizing plate(440) accumulated in one side of the second substrate; and a hemispheric lens array layer(450) accumulated in one side of the second polarizing plate and containing hemispheric lenses in the pixel area.

Abstract translation: 提供用于制造生物分子或聚合物阵列的可编程掩模，用于制造包含相同掩模的生物分子或聚合物阵列的装置，以及通过使用相同的可编程掩模制造生物分子或聚合物阵列的方法，以获得固定高密度的阵列 的生物分子或聚合物，并且减少了制造阵列的时间。 用于制造生物分子或聚合物阵列的可编程掩模包括：包含具有开口部分的黑矩阵（430）和第一像素电极的第一基板（410） 第二基板（400），其包含薄层晶体管，用于根据施加的电信号切换对应于开口部分的像素区域;以及第二像素电极，连接到薄层晶体管的漏电极; 形成在第一和第二基板之间并具有通过根据薄层晶体管的电信号改变布置状态来选择性地穿透光的液晶的液晶层（420） 积聚在第一基板的一侧的第一偏振片（445） 第二偏振板（440），其累积在所述第二基板的一侧; 以及半球透镜阵列层（450），其累积在第二偏振片的一侧，并且在像素区域中包含半球透镜。

公开(公告)号：KR1020070061108A

公开(公告)日：2007-06-13

申请号：KR1020060046521

申请日：2006-05-24

Applicant: 한국전자통신연구원

Inventor： 신동호 ,  정문연 ,  박세호 ,  표현봉 ,  최창억

IPC: C12Q1/68 ,  B82B1/00 ,  B82B3/00

CPC classification number: C12Q1/6825 ,  B82B1/001 ,  C12Q1/6806 ,  B82B1/008 ,  B82B3/0014 ,  C12Q1/6841 ,  C12Q2565/133 ,  C12Q2563/137

Abstract: Nucleic acid nanostructures and a fabrication method thereof are provided to produce sensors for detecting gases, chemical substances or biological materials by using the nucleic acid having quadruplex structure, and be used in devices having local surface plasmon properties. The nucleic acid nanostructure comprises: a substrate; a nucleic acid having quadruplex structure fixed perpendicularly to the substrate; a metal ion present within a unit lattice consisting of 8 bases of the nucleic acid having quadruplex structure; and a nanoparticle located at the end of the nucleic acid having quadruplex structure, wherein the glass is made of metal, glass, semiconductor wafer, quartz or plastic; the nucleic acid having quadruplex structure consists of 4 nucleic acid strands comprising the nucleotide sequences of SEQ ID NO:1 to SEQ ID NO:3 aligned in parallel or reverse parallel each other; the metal ion is Na^+, K^+, Mg^2+, Ca^2+, Mn^2+, Ni^2+, Cd^2+, Co^2+ or Zn^2+; and the nanoparticle is composed of Au, Ag, ZnS, CdS, CdSe, SiO2, SnO2, TiO2, GaAs or InP. The fabrication method of the nucleic acid nanostructure comprises the steps of: introducing nucleic acids on the substrate; forming the nucleic acid having quadruplex structure from the introduced nucleic acids; and binding a nanoparticle to the nucleic acid having quadruplex structure.

Abstract translation: 提供了核酸纳米结构及其制造方法，以通过使用具有四重结构的核酸来产生用于检测气体，化学物质或生物材料的传感器，并用于具有局部表面等离子体性质的器件中。 核酸纳米结构包括：底物; 具有垂直于衬底固定的四重结构的核酸; 存在于由具有四重结构的核酸的8个碱基组成的单位晶格内的金属离子; 和位于具有四重结构的核酸末端的纳米颗粒，其中玻璃由金属，玻璃，半导体晶片，石英或塑料制成; 具有四重结构的核酸由包含以并行或反向并行排列的SEQ ID NO：1至SEQ ID NO：3的核苷酸序列的4个核酸链组成; 金属离子为Na +，K ^ +，Mg ^ 2 +，Ca ^ 2 +，Mn ^ 2 +，Ni ^ 2 +，Cd ^ 2 +，Co ^ 2 +或Zn ^ 2 +。 纳米颗粒由Au，Ag，ZnS，CdS，CdSe，SiO2，SnO2，TiO2，GaAs或InP组成。 核酸纳米结构的制造方法包括以下步骤：在基底上引入核酸; 从引入的核酸形成具有四链体结构的核酸; 并将纳米颗粒结合到具有四链体结构的核酸上。

公开(公告)号：KR100479265B1

公开(公告)日：2005-03-28

申请号：KR1020020070645

申请日：2002-11-14

Applicant: 한국전자통신연구원

Inventor： 김용신 ,  정문연 ,  신동호 ,  양해식 ,  김윤태

IPC: C12Q1/68

Abstract: 본 발명의 패턴 광 발생 장치는, 생체 고분자 어레이 형성을 위한 패턴 광 발생 장치이다. 이 패턴 광 발생 장치는 복수개의 단위 광 발생 장치들 및 구동부를 포함하여 구성된다. 복수개의 단위 광 발생 장치들은 동일 평면상에서 어레이 형태로 배열된다. 그리고 구동부는, 복수개의 단위 광 발생 장치들 중에서 원하는 패턴 형상에 대응하는 일부 단위 광 발생 장치들만을 선택적으로 동작시켜 원하는 패턴 형상의 광이 발생되도록 한다.

公开(公告)号：KR1020040038997A

公开(公告)日：2004-05-10

申请号：KR1020020066611

申请日：2002-10-30

Applicant: 한국전자통신연구원

Inventor： 신동호 ,  강선길 ,  김효겸 ,  양해식 ,  김윤태

IPC: G01N33/483

CPC classification number: G01N27/27 ,  B33Y70/00 ,  B33Y80/00 ,  G01N27/3271 ,  Y10T29/49002

Abstract: PURPOSE: A fluid-type multiple electrochemical system and a method for preparing the same are provided, thereby effectively inhibiting problems of electrolyte waste, protein infection, low reproduction of sensor, etc. CONSTITUTION: A fluid-type multiple electrochemical system comprises an electric circuit board(10), a fluid board(20) and a sensor board(30), wherein the electric circuit board(10) contains a plurality of electrode portions having standard electrode and supplement electrode at constant distances; the fluid board(20) contains an fluid inlet(21), an fluid outlet(22) and a plurality of fluid storage vessels(23); the fluid storage vessels(23) are formed at the same distances as the electrode portions; each fluid storage vessel is connected together through the fluid pathway(24); a sensor board(30) contains a plurality of unit sensors(31) at the same distances as the electrode portions; each electrode pad(32. 33) is connected together to approve the voltage and electric current collectively.

Abstract translation: 目的：提供流体型多重电化学系统及其制备方法，从而有效抑制电解质废物，蛋白质感染，传感器再现性差等问题。构成：流体型多电化学系统包括电路 板（10），流体板（20）和传感器板（30），其中电路板（10）包含具有恒定距离的标准电极和补充电极的多个电极部分; 流体板（20）包含流体入口（21），流体出口（22）和多个流体储存容器（23）; 流体存储容器（23）以与电极部分相同的距离形成; 每个流体储存容器通过流体通道（24）连接在一起; 传感器板（30）包含与电极部分相同距离的多个单元传感器（31）; 每个电极焊盘（32.33）被连接在一起，以一致地批准电压和电流。

公开(公告)号：KR1020040038170A

公开(公告)日：2004-05-08

申请号：KR1020020067052

申请日：2002-10-31

Applicant: 한국전자통신연구원

Inventor： 김효겸 ,  강선길 ,  신동호 ,  김윤태 ,  양해식

IPC: G01N27/327

CPC classification number: C12Q1/001

Abstract: PURPOSE: A bio sensor, an array structure thereof and a method for manufacturing a plurality of bio sensors are provided to improve productivity of the bio sensors by fabricating a plurality of bio sensors at one time. CONSTITUTION: A bio sensor(10) includes a detecting section(11), a connecting section(12) and a pad section(13). The detecting section(11) detects a bio material and generates a signal after detecting the bio material. The detecting section(11) has a working electrode, a reference electrode, an auxiliary electrode, and a plurality of conductive patterns for connecting the electrodes to the pad section(13). The connecting section(12) includes a plurality of conductive wirings connected to the electrodes. The electrodes and the electrode pads are aligned on the same plane.

Abstract translation: 目的：提供生物传感器，其阵列结构和制造多个生物传感器的方法，以通过一次制造多个生物传感器来提高生物传感器的生产率。 构成：生物传感器（10）包括检测部分（11），连接部分（12）和垫部分（13）。 检测部分（11）检测生物材料并在检测到生物材料之后产生信号。 检测部分（11）具有工作电极，参考电极，辅助电极和用于将电极连接到焊盘部分（13）的多个导电图案。 连接部分（12）包括连接到电极的多个导电布线。 电极和电极焊盘在同一平面上对齐。

公开(公告)号：KR101923980B1

公开(公告)日：2018-11-30

申请号：KR1020120124921

申请日：2012-11-06

Applicant: 한국전자통신연구원

Inventor： 명남수 ,  정문연 ,  신동호

IPC: A61N5/10

Abstract: 본발명은이온빔 프로파일러, 이온빔 필터, 및이온빔 필터를장착한이온빔 생성장치에관한것이다. 본발명에의한이온빔 프로파일러는이온빔에응답하여광을생성하는섬광검출모듈, 상기광을전기펄스로변환하는광전변환모듈및 상기전기펄스를분석하여상기이온빔의에너지분포및 진행경로를계산하는분석모듈을포함하며, 상기섬광검출모듈은적층된복수의섬광검출레이어들을포함하고, 상기복수의섬광검출레이어들은일방향으로신장되며, 상기이온빔에응답하여상기광을생성하는복수의섬광체들을포함하고, 서로인접한섬광검출레이어들에포함되는섬광체들의신장방향은서로직교방향이다. 본발명의이온빔 프로파일러는실시간으로이온빔의에너지분포를측정할수 있다.