公开(公告)号：KR1020050020179A

公开(公告)日：2005-03-04

申请号：KR1020030057918

申请日：2003-08-21

Applicant: 한국화학연구원

Inventor： 조선행 ,  이해방 ,  강길선 ,  정상영 ,  강복기 ,  김문석

IPC: A61K9/00

CPC classification number: A61K9/5042 ,  A61K9/5026 ,  A61K31/4422

Abstract: PURPOSE: A composition for producing sustained-release porous membrane for oral drug delivery system and the oral drug delivery system using the same sustained-release porous membrane are provided, which oral drug delivery system controllably and continuously releases drugs, reduces the coating cost by using a smaller amount of porous membrane, and has improved storage stability against humidity and temperature. CONSTITUTION: The composition for producing sustained-release porous membrane for oral drug delivery system comprises one or more film forming materials selected from cellulose-based compound, polymethacrylate, semipermeable polyamide and semipermeable sulfonated polystyrene; the film forming material comprises cellulose acetate and polymethylmethacrylate in a weight ratio of 2 -3:1-1.5. The oral drug delivery system comprises 0.1 to 50 parts by weight of a core containing pharmaceutical active components; and the sustained-release porous membrane containing one or more film forming materials selected from cellulose-based compound, polymethacrylate, semipermeable polyamide, semipermeable polyurethane and semipermeable sulfonated polystyrene.

Abstract translation: 目的：提供一种用于口服药物递送系统的缓释多孔膜的制造用组合物和使用该缓释多孔膜的口服药物输送系统，该口服药物输送系统可控地连续地释放药物，通过使用 少量的多孔膜，并且改善了对湿度和温度的储存稳定性。 构成：用于制备口服药物递送系统的缓释多孔膜的组合物包含一种或多种选自纤维素类化合物，聚甲基丙烯酸酯，半透性聚酰胺和半透性磺化聚苯乙烯的成膜材料; 该成膜材料包括重量比为2-3：1-1.5的乙酸纤维素和聚甲基丙烯酸甲酯。 口服药物递送系统包含0.1至50重量份的含有药物活性组分的核心; 以及含有一种或多种选自纤维素类化合物，聚甲基丙烯酸酯，半透性聚酰胺，半透性聚氨酯和半透性磺化聚苯乙烯的成膜材料的缓释多孔膜。

公开(公告)号：KR1020040026374A

公开(公告)日：2004-03-31

申请号：KR1020020057820

申请日：2002-09-24

Applicant: 한국화학연구원

Inventor： 이해방 ,  조선행 ,  강복기

IPC: A61K9/16

CPC classification number: A61K9/5026 ,  A61K9/5047 ,  A61K31/4045 ,  A61K47/32 ,  A61K47/38

Abstract: PURPOSE: Provided is a targeting drug delivery system containing melatonin by using multi-coating methods, thereby effectively regulating the speed of melatonin release. CONSTITUTION: In a targeting drug delivery system containing melatonin, it is characterized by consisting of a crystalline core(1), a coating layer(2) fixed to the outer surface of the crystalline core, an active ingredient layer(3) fixed to the outer surface of the coating layer, a sustained release layer(4) fixed to the outer surface of the active ingredient layer, and an enteric soluble layer(5) fixed to the outer surface of the sustained release layer.

Abstract translation: 目的：提供使用多重涂层方法含有褪黑激素的靶向药物递送系统，从而有效调节褪黑素释放的速度。 构成：在含有褪黑激素的靶向药物递送系统中，其特征在于由结晶核心（1），固定在结晶核心的外表面的涂层（2），固定到结晶核心的活性成分层 涂层的外表面，固定到活性成分层的外表面的缓释层（4）和固定在缓释层的外表面的肠溶性层（5）。