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    페닐테트라졸 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 골다공증 또는 비만의 예방 또는 치료용 약학적 조성물
    12.
    发明公开
    페닐테트라졸 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 골다공증 또는 비만의 예방 또는 치료용 약학적 조성물 失效
    用于预防或治疗包含苯并噻唑衍生物的药物或药物的药物组合物或其作为活性成分的药物可接受的盐

    公开(公告)号：KR1020100130139A

    公开(公告)日：2010-12-10

    申请号：KR1020090121291

    申请日：2009-12-08

    Applicant: 한국화학연구원

    Inventor： 김낙정 ,  배명애 ,  유성은 ,  강남숙 ,  허정녕 ,  이규양 ,  서지희 ,  장성연 ,  황은숙 ,  홍정호

    IPC: C07D487/04 ,  A61K31/437 ,  A61P19/08 ,  A61P3/04

    Abstract: PURPOSE: A pharmaceutical composition containing phenyltetrazole derivatives for preventing or treating osteoporosis, obesity, diabetes or hyperlipidemia is provided to control TAZ(transcriptional coactivator with PDZbinding motif) protein. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoporosis contains a compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. A pharmaceutical composition for preventing or treating obesity, diabetes or hyperlipidemia contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The compound is phenyltetrazole derivatives.

    Abstract translation: 目的：提供含有苯基四唑衍生物用于预防或治疗骨质疏松症，肥胖症，糖尿病或高脂血症的药物组合物以控制TAZ（具有PDZ结合基序的转录共激活物）蛋白质。 构成：用于预防或治疗骨质疏松症的药物组合物含有化学式1的化合物或其药学上可接受的盐作为活性成分。 用于预防或治疗肥胖症，糖尿病或高脂血症的药物组合物含有化学式1的化合物或其药学上可接受的盐作为活性成分。 该化合物是苯基四唑衍生物。

    카르복사미드 유도체, 이의 제조 방법 및 이를 포함하는 살균제 조성물
    13.
    发明公开
    카르복사미드 유도체, 이의 제조 방법 및 이를 포함하는 살균제 조성물 失效
    羧酰胺衍生物，其制备方法和含有其的抗菌组合物

    公开(公告)号：KR1020100026221A

    公开(公告)日：2010-03-10

    申请号：KR1020080085138

    申请日：2008-08-29

    Applicant: 한국화학연구원

    Inventor： 김범태 ,  허정녕 ,  이혁 ,  장성연 ,  박노균 ,  최경자

    IPC: C07C235/12 ,  C07C235/24

    Abstract: PURPOSE: A carboxamide derivative is provided to bactericidal activity against plant epidemic, especially tomato epidemic and to have no crossed resistance to existing fungicide. CONSTITUTION: A carboxamide derivative has a structure of chemical formula 1 or optical isomer. In chemical formula 1, V is H or C2-C10 alkanyl, W is substituted or unsubstituted C6-C14 aryl or C7-C20 aryloxyalkyl or C1-C12 heteroaryl containing at least one N, S or O in a ring; n is an integer of 0-4; m is 0 or 1; R1, R2, R3 and R4 are independently H or C1-C6 alkyl; X is O, NH or S; Y is H or halogen; and Z is H or C1-C6 alkyl substituted or unsubstituted with cyano or C6-C12 aryl, or C2-C10 alkynyl.

    Abstract translation: 目的：提供甲酰胺衍生物对植物疫病，特别是番茄疫病的杀菌活性，对现有杀真菌剂无交叉抗性。 构成：甲酰胺衍生物具有化学式1或光学异构体的结构。 在化学式1中，V是H或C 2 -C 10烷基，W是在环中含有至少一个N，S或O的取代或未取代的C 6 -C 14芳基或C 7 -C 20芳氧基烷基或C 1 -C 12杂芳基。 n是0-4的整数; m为0或1; R 1，R 2，R 3和R 4独立地为H或C 1 -C 6烷基; X是O，NH或S; Y为H或卤素; Z为H或被氰基或C6-C12芳基或C2-C10炔基取代或未取代的C1-C6烷基。

    β-아미노알콜 유도체, 이의 제조방법 및 이를유효성분으로 함유하는 ＴＮＦ-α 매개성 질환의 예방 및치료용 약학적 조성물
    15.
    发明公开
    β-아미노알콜 유도체, 이의 제조방법 및 이를유효성분으로 함유하는 ＴＮＦ-α 매개성 질환의 예방 및치료용 약학적 조성물 失效
    β-氨基醇衍生物，其制备方法和药物组合物，用于预防和治疗作为其主要成分的TNF-α介导性疾病

    公开(公告)号：KR1020090014538A

    公开(公告)日：2009-02-11

    申请号：KR1020070078575

    申请日：2007-08-06

    Applicant: 주식회사 오스코텍 ,  한국화학연구원

    Inventor： 김범태 ,  이혁 ,  민용기 ,  허정녕 ,  장성연 ,  박노균 ,  김정근 ,  김세원 ,  심성보 ,  장순화 ,  이재상

    IPC: C07D401/12 ,  C07D409/12 ,  C07D407/12

    Abstract: A beta-aminoalcohol derivatives or pharmaceutically acceptable salts thereof are provided to inhibit the secretion of tumor necrosis factor-alpha(TNF-alpha), thereby preventing and treating TNF- alpha mediated disease. The beta-aminoalcohol derivatives represented by the chemical formula(1) or pharmaceutically acceptable salts thereof are useful for preventing and treating TNF- alpha mediated disease, wherein R1 is C4-C10 aryl or heteroaryl unsubstituted or substituted by 1 or 2 or more halogen, or C5-C10 cycloalkyl unsubstituted or substituted by 1 or 2 or more halogen; R2 is C4-C10 aryl or heteroaryl which is unsubstituted or substituted by 1 or 2 or more C1-C3 linear or branched alkyl, cyano or halogen; R3 is H or C1-C4 linear or branched alkyl; m is an integer from 0 to 3; and n is an integer from 1 to 5.

    Abstract translation: 提供β-氨基醇衍生物或其药学上可接受的盐以抑制肿瘤坏死因子-α（TNF-α）的分泌，从而预防和治疗TNF-α介导的疾病。 由化学式（1）表示的β-氨基醇衍生物或其药学上可接受的盐可用于预防和治疗TNF-α介导的疾病，其中R1是C4-C10芳基或未取代或被1或2个或更多个卤素取代的杂芳基， 或未被取代或被1或2个或更多个卤素取代的C 5 -C 10环烷基; R 2是未被取代或被1或2个或更多个C 1 -C 3直链或支链烷基，氰基或卤素取代的C 4 -C 10芳基或杂芳基; R3是H或C1-C4直链或支链烷基; m是0至3的整数; n为1〜5的整数。

    페난트렌 유도체의 제조방법
    16.
    发明公开
    페난트렌 유도체의 제조방법 无效
    制备衍生物衍生物的方法

    公开(公告)号：KR1020080093792A

    公开(公告)日：2008-10-22

    申请号：KR1020070038001

    申请日：2007-04-18

    Applicant: 한국화학연구원

    Inventor： 허정녕 ,  김범태 ,  민용기 ,  이혁 ,  장성연 ,  박노균 ,  김영하

    IPC: C07C49/675 ,  C07C49/737 ,  C07C321/22 ,  C07F5/02

    Abstract: A method for preparing phenanthrene derivatives is provided to obtain various phenanthrene derivatives useful in various industrial fields with high yield in a simple manner. A method for preparing phenanthrene derivatives comprises a step of reacting a compound represented by the following formula 2 with a compound represented by the following formula 3 in a solvent in the presence of a palladium compound and a base. In the formulae, Y is C=O or SO2; R1 is H, OH, C1-C6 alkyl, C1-C6 alkoxy, NR11R12, or substituted or non-substituted C3-C7 aryl, or Y-R1 is cyano, if appropriate; each of R2, R3, R4, R5, R6, R7, R8 and R9 is H, halogen, OH, cyano, nitro, NR11R12, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C2-C8 alkenyl, C2-C4 alkynyl, C3-C8 cycloalkyl, C1-C4 alkoxy, C1-C4 alkyl, C3-C8 cycloalkoxy-C1-C4 alkyl, C1-C6 alkoxycarbonyl, C1-C6 alkylaminocarbonyl or C1-C8 alkylsulfonyl; R10 is H, OH, C1-C6 alkyl, C1-C6 haloalkyl, or substituted or non-substituted C3-C7 aryl; each of R11 and R12 is H, C1-C6 alkyl, C1-C6 alkoxy or C3-C7 cycloalkyl, or R11 and R12 form a 3- to-7-membered non-aromatic heterocyclic ring together with the nitrogen atom to which they are attached; aromatic rings A and D each represent a heteroaryl; and each of X and M represents a selected from halogen, C1-C6 alkylsulfonyloxy and arylsulfonyloxy, or b selected from B(OH)2 and B(OR13)2, wherein R13 is C1-C4 alkyl or two R13s are linked to each other to form a methyl-substituted heterocyclic ring together with B and O, with the proviso that when X is a, M is b, and when x is b, M is a.

    Abstract translation: 提供一种制备菲衍生物的方法，以简单的方式获得在各种工业领域中用于高产率的各种菲衍生物。 制备菲衍生物的方法包括在溶剂中，在钯化合物和碱的存在下，使由下式2表示的化合物与下式3表示的化合物反应的步骤。 在式中，Y为C = O或SO 2; R 1为H，OH，C 1 -C 6烷基，C 1 -C 6烷氧基，NR 11 R 12或取代或未取代的C 3 -C 7芳基，或Y-R 1为氰基; R2，R3，R4，R5，R6，R7，R8和R9中的每一个为H，卤素，OH，氰基，硝基，NR11R12，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基，C2-C8烯基， C 2 -C 4炔基，C 3 -C 8环烷基，C 1 -C 4烷氧基，C 1 -C 4烷基，C 3 -C 8环烷氧基-C 1 -C 4烷基，C 1 -C 6烷氧基羰基，C 1 -C 6烷基氨基羰基或C 1 -C 8烷基磺酰基; R 10是H，OH，C 1 -C 6烷基，C 1 -C 6卤代烷基或取代或未取代的C 3 -C 7芳基; R 11和R 12中的每一个是H，C 1 -C 6烷基，C 1 -C 6烷氧基或C 3 -C 7环烷基，或者R 11和R 12与它们所在的氮原子一起形成3至7元非芳族杂环 连接; 芳环A和D各自表示杂芳基; 并且X和M各自表示选自卤素，C 1 -C 6烷基磺酰氧基和芳基磺酰氧基或选自B（OH）2和B（OR 13）2）的b，其中R 13是C 1 -C 4烷基或两个R 13彼此连接 与B和O一起形成甲基取代的杂环，条件是当X为a时，M为b，当x为b时，M为a。

    1,3-디페닐-2-부텐류 화합물 제조용 촉매
    19.
    发明授权
    1,3-디페닐-2-부텐류 화합물 제조용 촉매 有权
    用于生产1,3-二苯基-2-丁烯衍生物的催化剂

    公开(公告)号：KR101418829B1

    公开(公告)日：2014-07-16

    申请号：KR1020130035402

    申请日：2013-04-01

    Applicant: 한국화학연구원

    Inventor： 임환정 ,  허정녕 ,  김범태 ,  이혁 ,  장성연

    IPC: B01J31/12 ,  B01J23/44 ,  C07C15/12 ,  C07C7/20

    CPC classification number: B01J31/12 ,  B01J23/44 ,  C07C15/12

    Abstract: The present invention relates to a catalyst for preparing 1,3-diphenyl-2-butene type compound represented by the following formula 1. The catalyst has a selective C-C bond forming specificity, and illustrates high transformation ratio to a target compound with high selectivity. Thus, the catalyst of the present invention can be favorably used in a process for preparing 1,3-diphenyl-2-butene type compound.

    Abstract translation: 本发明涉及一种用于制备由下式1表示的1,3-二苯基-2-丁烯型化合物的催化剂。该催化剂具有选择性C-C键形成特异性，并且说明了与目标化合物的高选择性的高转化率。 因此，本发明的催化剂可以有利地用于制备1,3-二苯基-2-丁烯型化合物的方法中。

    인다졸 유도체 및 이를 함유하는 살충제 조성물
    20.
    发明公开
    인다졸 유도체 및 이를 함유하는 살충제 조성물 有权
    异吲哚衍生物和包含其的杀虫剂组合物

    公开(公告)号：KR1020120068723A

    公开(公告)日：2012-06-27

    申请号：KR1020110135571

    申请日：2011-12-15

    Applicant: 한국화학연구원 ,  주식회사경농

    Inventor： 장성연 ,  허정녕 ,  이혁 ,  김범태 ,  황인천 ,  김종관

    IPC: C07D231/56 ,  A01N43/56 ,  A01P7/04

    CPC classification number: C07D401/04 ,  A01N43/56 ,  C07D231/56

    Abstract: PURPOSE: An indazole derivative or salt thereof and an insecticidal composition containing the same are provided to eliminate various pests. CONSTITUTION: An indazole derivative is denoted by chemical formula 1. In chemical formula 1, A is N or CH; n and m are individually integer 0-4; V and W are individually hydroxyl, cyano, halogen, C1-6 alkyl, or C1-6 alkoxy; and X, Y, and Z are individually H, hydroxyl, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, , -C(=O)-NH-R1, or -NHC(=O)-O-R2. An insecticidal composition contains the compound of chemical formula 1 as an active ingredient. A method for illuminating mite or insects comprises a step of treating the compound of chemical formula 1 to crops or habitat thereof.

    Abstract translation: 目的：提供吲唑衍生物或其盐和含有它们的杀虫组合物以消除各种害虫。 构成：吲唑衍生物由化学式1表示。在化学式1中，A为N或CH; n和m分别是整数0-4; V和W分别是羟基，氰基，卤素，C 1-6烷基或C 1-6烷氧基; 并且X，Y和Z各自为H，羟基，氰基，卤素，C 1-6烷基，C 1-6烷氧基，-C（= O）-NH-R 1或-NHC（= O） 。 杀虫组合物含有化学式1的化合物作为活性成分。 用于照射螨虫或昆虫的方法包括将化学式1的化合物处理成作物或栖息地的步骤。

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