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公开(公告)号：KR1019970042491A
公开(公告)日：1997-07-24
申请号：KR1019950048617
申请日：1995-12-12
Applicant: 한국화학연구원
IPC: C07C235/34 , A61K31/165 , C07C235/18 , C07C323/25
Abstract: 하기 일반식(I)의 N-아릴알킬호모바닐릭아미드 유도체 화합물은 보다 적은 용량에서 소염 및 진통효과를 나타내므로 진통 및 소염용 약학 조성물로서 유용하게 사용될 수 있다:
상기식에서, X, Y, Z, W, n, m 및 p는 명세서중에서 정의한 바와 같다.-
公开(公告)号：KR1019960029312A
公开(公告)日：1996-08-17
申请号：KR1019950000299
申请日：1995-01-10
Applicant: 한국화학연구원
IPC: C07C235/34 , A61K31/165 , A61K31/325 , C07C231/02 , C07D207/06
Abstract: 본 발명은 진통 및 소염 작용이 우수한 하기 일반식(Ⅰ)로 표시되는 N-아릴알킬페닐아세트아미드 유도체 또는 그의 약제학적으로 허용가능한 염 및 그의 제조방법에 관한 것이다.
상기 식에서, X는 수소, 할로겐, 히드록시 또는 메톡시이고, Y는 수소, 알킬, 아실, 알킬히드록시, 니트릴, 카르복실, 아미드, 카바메이트 또는 치환되거나 치환도지 않는 아미노 알킬이며, Z는 서로 같거나 다를 수 있으며, 수소, 할로겐, 히드록시, 메틸렌디옥시, 트리플루오로메틸, R
1 또는 OR
1 이고, 이때 R
1 은 C
1-5 의 치환되지 않은 알킬이나 고리알킬, 페닐 또는 벤질기이며, n은 2 내지 5의 정수이고, p는 0 내지 5의 정수이다.-
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公开(公告)号：KR101817311B1
公开(公告)日：2018-02-22
申请号：KR1020150053071
申请日：2015-04-15
Applicant: 한국화학연구원
Abstract: 본발명은투과유량특성이우수한폴리에테르술폰계다공성필름, 이의제조방법및 이의용도에관한것으로, 본발명에따른제조방법은 (i) 폴리에틸렌글리콜의수평균분자량을선택하고, (ii) 전체고분자용액내 상기폴리에틸렌글리콜의함량및 폴리에테르술폰의함량을선택한후, 상기선택된조건하에제1온도에서고분자용액을얻은다음상기고분자용액을필름형태로성형하고, 상기제1온도와동일하거나이보다높은제2온도의수증기에노출시켜상전이시킴으로써증기유도상분리와역열유도상분리가동시에일어나도록유도하여기공형성이우수하면서도기공분포가넓지않아수투과유량이우수한폴리에테르술폰계다공성필름을제공할수 있다.
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15.发明公开
公开(公告)号：KR1020130117526A
公开(公告)日：2013-10-28
申请号：KR1020120040403
申请日：2012-04-18
Applicant: 한국화학연구원
IPC: C07D493/04 , C10M129/42 , C10L1/19
Abstract: PURPOSE: An isosorbide fatty acid ester compound containing succinic acid or maleic acid is provided to show superior biodegradation because the compounds contain ester groups and to have excellent solubility in oil, thereby improving anti-rust performance. CONSTITUTION: An isosorbide fatty acid ester compound contains succinic acid of chemical formula 1 or maleic acid of chemical formula 2. A method for preparing the isosorbide fatty acid ester compounds comprises the step of making isosorbide fatty acid ester of chemical formula 6 react with succinic anhydride of chemical formula 7 or maleic anhydride of chemical formula 8. Oil contains the isosorbide fatty acid ester compounds as an anti-rust agent.
Abstract translation: 目的：提供含有琥珀酸或马来酸的异山梨醇脂肪酸酯化合物，以显示出优异的生物降解性，因为该化合物含有酯基并且在油中具有优异的溶解性，从而提高防锈性能。 构成：异山梨醇脂肪酸酯化合物含有化学式1的琥珀酸或化学式2的马来酸。制备异山梨醇脂肪酸酯化合物的方法包括使化学式6的异山梨醇脂肪酸酯与琥珀酸酐反应的步骤 的化学式7或化学式8的马来酸酐。油含有异山梨醇脂肪酸酯化合物作为防锈剂。
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Patent Agency Ranking
公开(公告)号：KR1020130078171A
公开(公告)日：2013-07-10
申请号：KR1020110146966
申请日：2011-12-30
Applicant: 한국화학연구원
CPC classification number: C07D275/03
Abstract: PURPOSE: A method for preparing metal cyclopentadienide is provided to ensure process safety using safe and cheap ingredients, and to reduce preparation cost and time. CONSTITUTION: A method for preparing metal cyclopentadienide comprises the steps of: putting a solvent, alkali metal hydroxide, and cyclopentadienide in a reaction container with a cooler which is filled with a drying agent, and reacting by stirring at 130-300 deg. C (S1); and refluxing the mixture and removing water generated during the reaction (S2). The alkali metal hydroxide is potassium hydroxide or sodium hydroxide. The solvent is selected from the group consisting of dialkyl ether (alkyl is C1-C20 alkyl), dialkyl ether of mono or diglycols (glycol is C1-C6 glycol, alkyl is C1-C10 alkyl), dimethyl sulfoxide, xylene, and methylene.
Abstract translation: 目的：提供一种制备金属环戊二烯的方法，以确保使用安全和便宜的成分进行工艺安全性，并降低制备成本和时间。 构成：制备金属环戊二烯的方法包括以下步骤：将溶剂，碱金属氢氧化物和环戊二烯在放入装有干燥剂的冷却器的反应容器中，并在130-300度搅拌反应。 C（S1）; 并回流混合物并除去反应期间产生的水（S2）。 碱金属氢氧化物是氢氧化钾或氢氧化钠。 溶剂选自二烷基醚（烷基为C 1 -C 20烷基），一元醇或二甘醇二醇醚（二醇为C 1 -C 6二醇，烷基为C 1 -C 10烷基），二甲基亚砜，二甲苯和亚甲基。
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17.发明公开피페라진-퀴놀린 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 중추신경계 질환의 예방 또는 치료용 약학적 조성물 有权哌嗪 - 喹啉衍生物，其药学上可接受的盐，其制备方法和药物组合物，用于预防或治疗含有作为活性成分的中枢神经系统疾病
公开(公告)号：KR1020100124020A
公开(公告)日：2010-11-26
申请号：KR1020090043051
申请日：2009-05-18
Applicant: 한국화학연구원
IPC: C07D403/06 , C07D403/08 , A61K31/496 , A61P25/28
Abstract: PURPOSE: A pharmaceutical composition containing piperazine-quinoline derivative for preventing or treating central nervous system diseases is provided to enhance high affinity to 5-HT6 receptor. CONSTITUTION: A piperazine-quinoline derivative is denoted by chemical formula 1. A method for preparing piperazine-quinoline derivative comprises: a step of reacting a compound of chemical formula 2 with a compound of chemical formula 3 or 4 to obtain a compound of chemical formula 5; a step of cycling the compound of chemical formula 5 to prepare a compound of chemical formula 6; a step of intoruding piperazinyl group to the compound of chemical formula 6 to obtain a compound of chemical formula 7; and a step of introducing sulfonyl group to the amine group of the compound of chemical formula 7. A pharmaceutical composition for preventing or treating central nervous system(CNS) diseases contains the piperazine-quinoline derivative of chemical formula 1.
Abstract translation: 目的：提供含有用于预防或治疗中枢神经系统疾病的哌嗪 - 喹啉衍生物的药物组合物，以增强对5-HT 6受体的高亲和力。 构成：哌嗪 - 喹啉衍生物由化学式1表示。哌嗪 - 喹啉衍生物的制备方法包括：使化学式2化合物与化学式3或化合物4反应的步骤，得到化学式 5; 循环化学式5的化合物以制备化学式6的化合物的步骤; 向化学式6的化合物中插入哌嗪基以获得化学式7的化合物的步骤; 以及将化学式7化合物的胺基引入磺酰基的步骤。用于预防或治疗中枢神经系统（CNS）疾病的药物组合物含有化学式1的哌嗪 - 喹啉衍生物。
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公开(公告)号：KR1020100023453A
公开(公告)日：2010-03-04
申请号：KR1020080082209
申请日：2008-08-22
CPC classification number: C04B28/006 , C04B2111/1037 , C04B2201/50 , C04B2201/52 , Y02P40/165 , Y02W30/92 , Y02W30/94 , C04B12/04 , C04B14/02 , C04B18/08 , C04B18/141 , C04B20/0076 , C04B20/0096 , C04B22/062 , C04B2103/302 , C04B14/185 , C04B2103/10
Abstract: PURPOSE: A method of manufacturing concrete without using cement is provided to secure a compressive strength into a 20~80 MP range at the room temperature of 5~40 deg C by a mixing ratio of blast furnace slag and fly ash. CONSTITUTION: A method of manufacturing concrete without using cement and using fly ash and blast furnace slag comprises the step of mixing and stirring a binding material, an activation reagent, fine aggregate, heavy aggregate, water, and a water reducing agent as a blending raw material before curing the mixture to make concrete. The binding material is composed with fly ash with a degree of particle size of 2,000~4,000 square centimeters per gram, and blast furnace slag with a degree of particle size of 3,000~5,000 square centimeters per gram in a weight ratio of 90:10~30:70. The activation reagent is composed with 6~12 mole NaOH and sodium silicate in a weight ratio of 0.75:1.25~1.25:0.75.
Abstract translation: 目的：提供一种不使用水泥制造混凝土的方法，通过高炉矿渣和粉煤灰的混合比，在5〜40摄氏度的室温下将压缩强度确保为20〜80 MP。 构成：在不使用水泥并使用粉煤灰和高炉矿渣的情况下制造混凝土的方法包括混合搅拌粘合材料，活化剂，细骨料，重骨料，水和减水剂作为混合原料的步骤 固化混合物之前的材料制成混凝土。 结合材料由粒度为2,000〜4000平方厘米/克的粉煤灰组成，粒度为3000〜5000平方厘米/克的高炉矿渣，重量比为90：10〜 30:70。 活化剂由重量比为0.75：1.25〜1.25：0.75的6〜12摩尔NaOH和硅酸钠组成。
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公开(公告)号：KR1020100023452A
公开(公告)日：2010-03-04
申请号：KR1020080082208
申请日：2008-08-22
CPC classification number: C04B28/006 , C04B2111/1037 , Y02P40/165 , Y02W30/92 , C04B12/04 , C04B14/02 , C04B18/06 , C04B20/0076 , C04B20/0096 , C04B22/062 , C04B2103/302 , C04B2103/10
Abstract: PURPOSE: A method of manufacturing concrete is provided to improve a quality of the concrete when hardening at room temperature by replacing a binder from cement to a binding material consisting fly ash, sodium silicate and NaOH. CONSTITUTION: A method of manufacturing concrete using fly ash comprises the step of mixing and stirring a binding material, an activation reagent, fine aggregate, heavy aggregate, water, and high range water reducing agent before curing the mixture to make concrete. The binding material is composed with fly ash with a degree of particle size of 5,000~10,000 square centimeters per gram. The activation reagent contains 6~15 mole of NaOH and sodium silicate in a weight ratio of 0.75:1.25~1.25:0.75. A step of hardening the mixture is performed at 5~40 deg C.
Abstract translation: 目的：提供一种制造混凝土的方法，以便在室温下硬化时，通过将粘结剂从水泥中替换为由粉煤灰，硅酸钠和NaOH组成的粘结材料来提高混凝土的质量。 构成：使用飞灰制造混凝土的方法包括在固化混合物之前混合和搅拌粘合材料，活化剂，细骨料，重骨料，水和高效减水剂的步骤以制备混凝土。 结合材料由粒度为5,000〜10,000平方厘米/克的粉煤灰组成。 活化剂含有重量比为0.75：1.25〜1.25：0.75的6〜15摩尔的NaOH和硅酸钠。 将混合物硬化的步骤在5〜40℃下进行
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公开(公告)号：KR100245980B1
公开(公告)日：2000-04-01
申请号：KR1019970031451
申请日：1997-07-08
Applicant: 한국화학연구원
IPC: C07C233/04 , A61K31/16
Abstract: 본 발명은 진통작용이 우수한 하기 일반식(I)로 표시되는 N-아릴알킬호모바닐릭아미드 유도체에 관한 것이다:
(I)
상기식에서, X는 C
1-6 알킬, 또는 C
1-6 알킬로 치환되거나 치환되지 않은 아릴 또는 헤테로아릴이고; Y는 수소 또는 2-아미노에틸이며; Z는 서로 같거나 다를 수 있으며 수소, 할로겐, R
1 또는 OR
1 이고, 이때 R
1 은 C
1-5 알킬, 고리알킬, 페닐 또는 벤질이며; p는 0 내지 5의 정수이다.
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