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公开(公告)号：ZA200210109B
公开(公告)日：2004-03-12
申请号：ZA200210109
申请日：2002-12-12
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , AVGERINOS GEORGE , KAYMAKCALAN ZEHRA , GHAYUR TARIQ , DIXON RICHARD
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68 , C12N , C07K , G01N , A61K , A61P , A01K
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using these antibodies are also provided. These antibodies, or antibody portions, are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
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公开(公告)号：CZ2003291A3
公开(公告)日：2003-05-14
申请号：CZ2003291
申请日：2001-06-28
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68 , G01N33/577 , A61K51/10 , C12N15/63
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using these antibodies are also provided. These antibodies, or antibody portions, are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
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公开(公告)号：AU7163601A
公开(公告)日：2002-01-14
申请号：AU7163601
申请日：2001-06-28
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68 , G01N33/577 , A61K51/10 , C12N15/63 , C07K14/545 , A01K67/027
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using these antibodies are also provided. These antibodies, or antibody portions, are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
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公开(公告)号：CA2411374C
公开(公告)日：2012-10-30
申请号：CA2411374
申请日：2001-06-28
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: C12N15/13 , G01N33/50 , A01K67/027 , A61K39/395 , A61K47/48 , A61K49/00 , A61K51/10 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K14/545 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/63 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/577 , G01N33/68
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1.alpha. and IL-1.beta. and neutralize IL-1.alpha. and IL-1.beta. activity in vitroand in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1.alpha. and IL-1.beta.) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1.alpha. and/or IL-1.beta. activity is detrimental.
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公开(公告)号：BG66209B1
公开(公告)日：2012-04-30
申请号：BG10748303
申请日：2003-01-21
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: C12N15/13 , G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61K51/10 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/577 , G01N33/68
Abstract: Предоставятсеметодизаполучаваненаантителас двойнаспецифичностсъгласноизобретението. Антителатаилиучастъцитенаантителасъгласноизобретениетосеизползватзаоткриваненадваразлични, ноструктурносвързаниантигена (например IL-1алфаи IL-1бета) изаинхибираненаактивносттанаантигените (напримерприсубектчовек, страдащотнарушение, прикоетосеопределя IL-1алфаи/или IL-1бетаактивността.
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Patent Agency Ranking16.发明专利
公开(公告)号：NZ523080A
公开(公告)日：2004-11-26
申请号：NZ52308001
申请日：2001-06-28
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68 , G01N33/577 , A61K51/10 , C12N15/63
Abstract: A dual-specificity antibody or antigen-binding portion thereof specifically binds interleukin-1alpha and interleukin-1beta wherein the antibody is not a fully mouse antibody. The antibody can be used in diagnostic methods for detecting IL-á or IL-â and in the manufacture of a medicament for treating interlauikin-1-related disorders such as inflammatory disorder, autoimmune disorder i.e. rheumatoid arthritis, Crohn's disease, multiple sclerosis, insulin dependant diabetes mellitus and psoriasis. Methods of obtaining dual-specificity antibodies and methods of making an antibody are also described.
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公开(公告)号：PL359995A1
公开(公告)日：2004-09-06
申请号：PL35999501
申请日：2001-06-28
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68 , A61K51/10
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using these antibodies are also provided. These antibodies, or antibody portions, are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
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公开(公告)号：CZ20030291A3
公开(公告)日：2003-05-14
申请号：CZ20030291
申请日：2001-06-28
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68 , A61K51/10 , C12N15/63 , G01N33/577
CPC classification number: C07K16/245 , A61K47/6845 , A61K2039/505 , C07K14/545 , C07K16/46 , C07K16/468 , C07K2317/10 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , G01N33/6869
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公开(公告)号：NO20026239D0
公开(公告)日：2002-12-27
申请号：NO20026239
申请日：2002-12-27
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD WOODWARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68 , C12N
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using these antibodies are also provided. These antibodies, or antibody portions, are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
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公开(公告)号：PE01322002A1
公开(公告)日：2002-03-04
申请号：PE0006412001
申请日：2001-06-28
Applicant: ABBOTT LAB
Inventor： AVGERINOS GEORGE , COLLINSON ALBERT , GHAYUR TARIQ , KAYMAKCALAN ZEHRA , DIXON RICHARD
IPC: G01N33/50 , A01K67/027 , A61K39/395 , A61K47/48 , A61K49/00 , A61K51/10 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K14/545 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/63 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/577 , G01N33/68
CPC classification number: C07K16/245 , A61K47/6845 , A61K2039/505 , C07K14/545 , C07K16/46 , C07K16/468 , C07K2317/10 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , G01N33/6869
Abstract: SE REFIERE A UN ANTICUERPO DE ESPECIFIDAD DOBLE O UNA PORCION DEL MISMO DE UNION A ANTIGENO CARACTERIZADO PORQUE SE UNE A LA INTERLEUQUINA 1a Y INTERLUQUINA-1b CON UNA CONSTANTE DE VELOCIDAD Koff DE 0,1s-1 O MENOS O QUE INHIBE LA ACTIVIDAD DE INTERLEUQUINA-1a CON UNA IC50 DE 1*10-5 O MENOS. TAMBIEN SE REFIERE A UN METODO PARA OBTENER UN ANTICUERPO DE ESPECIFICIDAD DOBLE QUE SE UNE ESPECIFICAMENTE A INTERLEUQUINA-1a Y INTERLEUQUINA-1b O DOS MOLECULAS DIFERENTES PERO RELACIONADAS DESDE EL PUNTO DE VISTA ESTRUCTURAL QUE COMPRENDE PROVEER UN ANTIGENO CON UNA CARACTERISTICA ESTRUCTURAL COMUN DE IL-1a E IL-1b; EXPONER UN REPERTORIO DE ANTICUERPOS AL ANTIGENO IN VIVO INMUNIZANDO AL ANIMAL O PONER EN CONTACTO LA MUESTRA O TEJIDO BIOLOGICO SOSPECHADO DE CONTENER IL-1a E IL-1b CON EL ANTICUERPO DE ESPECIFICIDAD DOBLE
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