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1.发明专利Dual specificity antibodies, method of making the same, and method of using the same 审中-公开双重特异性抗体，其制备方法及其使用方法
公开(公告)号：JP2012031178A
公开(公告)日：2012-02-16
申请号：JP2011188635
申请日：2011-08-31
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: C07K16/24 , G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68
CPC classification number: C07K16/245 , A61K47/6845 , A61K2039/505 , C07K14/545 , C07K16/46 , C07K16/468 , C07K2317/10 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , G01N33/6869
Abstract: PROBLEM TO BE SOLVED: To provide antibodies having dual specificity for two different but structurally related antigens.SOLUTION: The antibodies have dual specificity for IL-1α and IL-1β and neutralize IL-1α and IL-1β activity in vitro and in vivo. The antibody is a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies are also provided.
Abstract translation: 要解决的问题：提供对两种不同但结构相关的抗原具有双重特异性的抗体。 解决方案：抗体对IL-1α和IL-1β具有双重特异性，并在体外和体内中和IL-1α和IL-1β活性。 抗体是全长抗体或其抗原结合部分。 还提供了制备方法和使用抗体的方法。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：WO0202773A3
公开(公告)日：2002-08-22
申请号：PCT/US0120755
申请日：2001-06-28
Applicant: ABBOTT LAB , COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68 , A61K51/10 , C12N15/63 , G01N33/577
CPC classification number: C07K16/245 , A61K47/6845 , A61K2039/505 , C07K14/545 , C07K16/46 , C07K16/468 , C07K2317/10 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , G01N33/6869
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo . An antibody of the inventi on can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta ) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
Abstract translation: 提供了对两种不同但结构相关抗原具有双重特异性的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对IL-1α和IL-1β具有双重特异性，并在体外和体内中和IL-1α和IL-1β活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测两种不同但结构相关的抗原（例如，IL-1α和IL-1β）并用于抑制抗原的活性（例如，在受试者的受试者中 来自其中IL-1α和/或IL-1β活性是有害的病症。
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公开(公告)号：NO20026239L
公开(公告)日：2003-02-27
申请号：NO20026239
申请日：2002-12-27
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD WOODWARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using these antibodies are also provided. These antibodies, or antibody portions, are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
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公开(公告)号：AT420958T
公开(公告)日：2009-01-15
申请号：AT01950668
申请日：2001-06-28
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: C12N15/13 , G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61K51/10 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/63 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/577 , G01N33/68
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using these antibodies are also provided. These antibodies, or antibody portions, are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
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公开(公告)号：HK1055316A1
公开(公告)日：2004-01-02
申请号：HK03106152
申请日：2003-08-27
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K20090101 , A61K39/395 , A61K47/48 , A61K49/00 , A61P20090101 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K20090101 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N20090101 , G01N33/15 , G01N33/53 , G01N33/68
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using these antibodies are also provided. These antibodies, or antibody portions, are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
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Patent Agency Ranking
公开(公告)号：HU0301002A2
公开(公告)日：2003-07-28
申请号：HU0301002
申请日：2001-06-28
Applicant: ABBOTT LAB
Inventor： AVGERINOS GEORGE , COLLINSON ALBERT , DIXON RICHARD , GHAYUR TARIQ , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using these antibodies are also provided. These antibodies, or antibody portions, are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
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公开(公告)号：NO20026239A
公开(公告)日：2003-02-27
申请号：NO20026239
申请日：2002-12-27
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD WOODWARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68
CPC classification number: C07K16/245 , A61K47/6845 , A61K2039/505 , C07K14/545 , C07K16/46 , C07K16/468 , C07K2317/10 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , G01N33/6869
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公开(公告)号：AU2007202323B9
公开(公告)日：2012-02-02
申请号：AU2007202323
申请日：2007-05-23
Applicant: ABBOTT LAB
Inventor： DIXON RICHARD , GHAYUR TARIQ , COLLINSON ALBERT , KAYMAKCALAN ZEHRA , AVGERINOS GEORGE
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68
Abstract: DUAL SPECIFICITY ANTIBODIES AND METHODS OF MAKING AND USING Abstract Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, 5 recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-la and IL-1# and neutralize IL-la and IL-l# activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for 1o detecting two different but structurally related antigens (e.g., IL-la and IL-1#) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-la and/or IL-13 activity is detrimental.
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公开(公告)号：ES2319866T3
公开(公告)日：2009-05-14
申请号：ES01950668
申请日：2001-06-28
Applicant: ABBOTT LAB
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: C12N15/13 , G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61K51/10 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/63 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/577 , G01N33/68
Abstract: Un método para obtener un anticuerpo de especificidad dual o parte de unión al antígeno del mismo, que se une específicamente a dos proteínas diferentes pero relacionadas estructuralmente, comprendiendo el método: proporcionar un antígeno diseñado sobre la base del corte y empalme de partes solapantes entre sí de las dos proteínas diferentes pero relacionadas estructuralmente para crear un péptido híbrido, donde dicho péptido híbrido tiene una estructura X-Y-Z, en la que Y representa una región de identidad o de fuerte similitud entre las dos proteínas relacionadas, X representa una región de una de las proteínas relacionadas y Z representa una región de la otra de las proteínas relacionadas; exponer un repertorio de anticuerpos al antígeno; y seleccionar del repertorio un anticuerpo que se una específicamente a las dos proteínas diferentes pero relacionadas estructuralmente para obtener de esta manera el anticuerpo de especificidad dual.
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公开(公告)号：AU2007202323A1
公开(公告)日：2007-06-14
申请号：AU2007202323
申请日：2007-05-23
Applicant: ABBOTT LAB
Inventor： DIXON RICHARD , GHAYUR TARIQ , COLLINSON ALBERT , KAYMAKCALAN ZEHRA , AVGERINOS GEORGE
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